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The map label for this gene is lpxD [H]

Identifier: 157825135

GI number: 157825135

Start: 7480

End: 8520

Strand: Reverse

Name: lpxD [H]

Synonym: A1C_00050

Alternate gene names: 157825135

Gene position: 8520-7480 (Counterclockwise)

Preceding gene: 157825137

Following gene: 157825134

Centisome position: 0.69

GC content: 34.87

Gene sequence:

>1041_bases
ATGGTAAGTAGTAATTTTTATAAAAATCTAGGACCACGAAAACTAATGGCAATTATAGATTTTTTACACGATATTATAGA
ACCTCCTAAGGTTCATGAAGATATAGTTATTCATGATATTAAGATTCTACAAGAAGCATCTTCAAACGACATTAGCTTTT
TAAGTAATCATAAATACTCCGAATTTTTAAAAACTACTAAAGCTGCTGCTTGTATAGTGCCGAAAAATTTTACTGGAGAA
GCAAATCCAAATACTGTTTTAATACGTGCTGAGAATTCATATTTTGCTTACGGCAAATTAATAGATTTTTTCTATGCTCC
TATTAAATCATACCATGCTAAAATAATGAAATCCGCTATTGTTGCAGATTCGGCAACTATCGGAAAAAATTGTTATATAG
GTCATAATGTAGTTATTGAAGACGATGTTATTATAGGTGATGATAGTATTATAGAATCCGGAAGTTTTATAGGTAGAGGC
GTAAATATCGGCAAAAATGCTAGAATAGAGCAACACGTTTCAATAAATTATGCAATTATAGGCGACGACGCCTTAATACT
CGCAGGGGCAAAAATTGGACAAGAGGGGTTTGGGTTTTCTACCGAAAAAGGCGTACATCATAAAATATTTCATATAGGAG
TAGTTAAAATCGGCAATAATGTTGAAATTGGTAGCAATACTACTATTGATAGAGGTTCGCTTCAAGATACTATTATAGAA
GATTTATGCCGCATAGATAATTTAGTCCAAATCGGGCATGGCGTAAAAATAGGTAAAGGCTCTATTATCGTAGCACAGGC
AGGTATAGCAGGAAGTAGCACGATCGGTAAGTATTGTGCTCTTGGAGGACAAGTAGGCATCGCTGGACATCTAAATATAT
GCGACGGGGTACAGGTGGCGGCACAAGGCGGTGTCCTACAAAATATAGAAGCATGTAAAATTGTTGGTGGTAGCCCTGCA
GTTCCTATTATGGACTGGCATAGACAATCTGTTATTATGAAACAATTAGTCAAGACATCTAATAGCAAATTAAAAAAGTA
G

Upstream 100 bases:

>100_bases
TCTACTTAGCAATACCTTTTATGCAACCTGTAAATTTTGTTGCATAATAAAACTATCACTTATATACTGTAGCTAATGAT
TAATTTGCTTAAAGTTTAAT

Downstream 100 bases:

>100_bases
TTTGCTATTGAAAAAATACTGAGTCATCGTTGCGATGATGCGTAGCCGACGTGGCAATCTAGAAAATAATAAAAAAATTC
TTTAAATCAGAATTTTTTAA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MVSSNFYKNLGPRKLMAIIDFLHDIIEPPKVHEDIVIHDIKILQEASSNDISFLSNHKYSEFLKTTKAAACIVPKNFTGE
ANPNTVLIRAENSYFAYGKLIDFFYAPIKSYHAKIMKSAIVADSATIGKNCYIGHNVVIEDDVIIGDDSIIESGSFIGRG
VNIGKNARIEQHVSINYAIIGDDALILAGAKIGQEGFGFSTEKGVHHKIFHIGVVKIGNNVEIGSNTTIDRGSLQDTIIE
DLCRIDNLVQIGHGVKIGKGSIIVAQAGIAGSSTIGKYCALGGQVGIAGHLNICDGVQVAAQGGVLQNIEACKIVGGSPA
VPIMDWHRQSVIMKQLVKTSNSKLKK

Sequences:

>Translated_346_residues
MVSSNFYKNLGPRKLMAIIDFLHDIIEPPKVHEDIVIHDIKILQEASSNDISFLSNHKYSEFLKTTKAAACIVPKNFTGE
ANPNTVLIRAENSYFAYGKLIDFFYAPIKSYHAKIMKSAIVADSATIGKNCYIGHNVVIEDDVIIGDDSIIESGSFIGRG
VNIGKNARIEQHVSINYAIIGDDALILAGAKIGQEGFGFSTEKGVHHKIFHIGVVKIGNNVEIGSNTTIDRGSLQDTIIE
DLCRIDNLVQIGHGVKIGKGSIIVAQAGIAGSSTIGKYCALGGQVGIAGHLNICDGVQVAAQGGVLQNIEACKIVGGSPA
VPIMDWHRQSVIMKQLVKTSNSKLKK
>Mature_346_residues
MVSSNFYKNLGPRKLMAIIDFLHDIIEPPKVHEDIVIHDIKILQEASSNDISFLSNHKYSEFLKTTKAAACIVPKNFTGE
ANPNTVLIRAENSYFAYGKLIDFFYAPIKSYHAKIMKSAIVADSATIGKNCYIGHNVVIEDDVIIGDDSIIESGSFIGRG
VNIGKNARIEQHVSINYAIIGDDALILAGAKIGQEGFGFSTEKGVHHKIFHIGVVKIGNNVEIGSNTTIDRGSLQDTIIE
DLCRIDNLVQIGHGVKIGKGSIIVAQAGIAGSSTIGKYCALGGQVGIAGHLNICDGVQVAAQGGVLQNIEACKIVGGSPA
VPIMDWHRQSVIMKQLVKTSNSKLKK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=305, Percent_Identity=36.3934426229508, Blast_Score=177, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37176; Mature: 37176

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSNFYKNLGPRKLMAIIDFLHDIIEPPKVHEDIVIHDIKILQEASSNDISFLSNHKYS
CCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHCCCCCCHHHHCCCHH
EFLKTTKAAACIVPKNFTGEANPNTVLIRAENSYFAYGKLIDFFYAPIKSYHAKIMKSAI
HHHHHHHHEEEEECCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
VADSATIGKNCYIGHNVVIEDDVIIGDDSIIESGSFIGRGVNIGKNARIEQHVSINYAII
HHCCCCCCCCEEECCEEEEECCEEECCCCCCCCCCCEECCCCCCCCCCEEEEEEEEEEEE
GDDALILAGAKIGQEGFGFSTEKGVHHKIFHIGVVKIGNNVEIGSNTTIDRGSLQDTIIE
CCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEECCCCCCCCCCHHHHHHH
DLCRIDNLVQIGHGVKIGKGSIIVAQAGIAGSSTIGKYCALGGQVGIAGHLNICDGVQVA
HHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCEEE
AQGGVLQNIEACKIVGGSPAVPIMDWHRQSVIMKQLVKTSNSKLKK
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MVSSNFYKNLGPRKLMAIIDFLHDIIEPPKVHEDIVIHDIKILQEASSNDISFLSNHKYS
CCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHCCCCCCHHHHCCCHH
EFLKTTKAAACIVPKNFTGEANPNTVLIRAENSYFAYGKLIDFFYAPIKSYHAKIMKSAI
HHHHHHHHEEEEECCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
VADSATIGKNCYIGHNVVIEDDVIIGDDSIIESGSFIGRGVNIGKNARIEQHVSINYAII
HHCCCCCCCCEEECCEEEEECCEEECCCCCCCCCCCEECCCCCCCCCCEEEEEEEEEEEE
GDDALILAGAKIGQEGFGFSTEKGVHHKIFHIGVVKIGNNVEIGSNTTIDRGSLQDTIIE
CCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEECCCCCCCCCCHHHHHHH
DLCRIDNLVQIGHGVKIGKGSIIVAQAGIAGSSTIGKYCALGGQVGIAGHLNICDGVQVA
HHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCEEE
AQGGVLQNIEACKIVGGSPAVPIMDWHRQSVIMKQLVKTSNSKLKK
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA