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The map label for this gene is tcmA [H]

Identifier: 157373097

GI number: 157373097

Start: 5386892

End: 5388463

Strand: Direct

Name: tcmA [H]

Synonym: Spro_4865

Alternate gene names: 157373097

Gene position: 5386892-5388463 (Clockwise)

Preceding gene: 157373095

Following gene: 157373098

Centisome position: 98.86

GC content: 57.63

Gene sequence:

>1572_bases
ATGACCACCCCTTTACGTCTGCCAACCCTTCCCCCAGCCCTGTCTGAGCACCCACAGCGTTGGGTTACCCTGTTCTCAGT
CTGCCTCGCCGGATTGATCATGCCGATTAACTTTACTGGCCCGGCAGTCTCTCTACCCGCTATCGCCACCAGCTTGGGTG
GCAGTGTCATCGCCCTCAGTTGGGTCACTAATGCCTTTATGCTGACCTTTGGCTGCAGCCTGATGATTGCCGGTGCGCTC
GCCGATCGCTTTGGCCGTAAACGCGTGTTCATCAGCGGCCTGATGGTGATGACCCTAAGCTCACTGGCTATGCTGATGGT
GCAGGACATCATCTCCTTTGATTTGATCCGTGCGTTGCAGGGTATTGCCGCCGCAGCGGCGTTTGCCGGGGGAACCGCCG
GCCTGGCTCAGGTATTCGATGGCGCAGAACGCGCCAAGGCCTTCAGCCTGCTGGGCACCACCTTTGGCATCGGTCTGGCA
TTTGGCCCGCTGCTGGCAGGGTTTCTGGGGCAGCATTTTGGCTGGCACTCAATTTTTATCAGCGTGTCGCTGCTCAGTGC
CATCGCCTTGTTCACCGGAATGCGTTATATGCATGAGTCGCGCGATCCTTCAGCGGCCAAACTTGACTGGCCCGGCGCGA
CCACTTTTACGCTGGCTCTGACGTTGTTGACCTATGCCGTACTGCAGGCCCCCGACAGCGGTTGGGGCAGCCGCGAAGTC
TTCGTCCTGTTCAGCGGCGCGCTGCTTTTTATGGTTGCCTTTATCCTGATAGAGAATCGCGTGCGCAGGCCAATGCTTGA
TCTGTCTTTATTCCGTTATCCACGCTTTATTGGCGTGCAGTTTTTGGCGGCTGCCCCGGCCTATTCCTATGTGGTACTGC
TGGTTTTACTCCCGCTGCGCTTTATTGGCATCGAAGGTTACAGCACCCTGGAGGCGGGTATCATTATGTTCGCACTCTCA
GCGCCAATGCTGGTACTGCCGATGTTGGCCGGCATGTTGGCTCACCGGTTTTCCGCCGGCGTCATTTCCAGCCTGGGCCT
GCTGATCTGCGCCTTCGGCCTGCTATGGCTGGCGCAATATTCGCCTGGCCAGCCGTTCCTGCTGCTTATCTTGCCGCTGT
TGACCATTGGCTGTGGCATCAGCCTGCCCTGGGGATTAATGGATGGCCTGGCGGTCAGCGTGGTACCGAAGGATCGCGCA
GGCATGGCTACGGGTATTTTTAGCACCATTCGGGTGGCGGGCGAAGGCATCGCACTCGCCGTGGTGGGCGCATTGTTGGC
CACTTTGGTTGAACAGCACCTACCGGGCACCGCGCTGACTAACGCAGCCGCTGGTGCCCATCGGCTGGCAATGGGTGACC
TACCGCAAGCGGCTGCATTGCTGAATATCGATACTGCAACGTTGAAGCAGAGCTACGAAGCCGCATTTCATAACCTGCTG
TATATTCTGGCGCTAATGACAGCGATTTCAGCAGGCGTCGTTTTTATTTTCCTGCGCCATGCCTTGCCTCCGCCGATCGC
CAACACTTTGACGACAACCGTAAACTCGCTTGTTGAGAAACCTACGGAGTAA

Upstream 100 bases:

>100_bases
GAGTTATTGTCCTTAAAGAGTGGAGTAAAGCCCCATTTTTGGCCAATTAAATCCTCTTTATCATCCAATCCAGCCAACAA
TACTTTCGCTGGAGTCAATC

Downstream 100 bases:

>100_bases
ATACCTCATTAATGGGTTCTGCAAAACCGGTTATTTGCTGGGATGCCAGCGTGCTGACCAGGGCCAGCAGTGGCGGGTGT
TGAAGAAAATCGACAACCTG

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MTTPLRLPTLPPALSEHPQRWVTLFSVCLAGLIMPINFTGPAVSLPAIATSLGGSVIALSWVTNAFMLTFGCSLMIAGAL
ADRFGRKRVFISGLMVMTLSSLAMLMVQDIISFDLIRALQGIAAAAAFAGGTAGLAQVFDGAERAKAFSLLGTTFGIGLA
FGPLLAGFLGQHFGWHSIFISVSLLSAIALFTGMRYMHESRDPSAAKLDWPGATTFTLALTLLTYAVLQAPDSGWGSREV
FVLFSGALLFMVAFILIENRVRRPMLDLSLFRYPRFIGVQFLAAAPAYSYVVLLVLLPLRFIGIEGYSTLEAGIIMFALS
APMLVLPMLAGMLAHRFSAGVISSLGLLICAFGLLWLAQYSPGQPFLLLILPLLTIGCGISLPWGLMDGLAVSVVPKDRA
GMATGIFSTIRVAGEGIALAVVGALLATLVEQHLPGTALTNAAAGAHRLAMGDLPQAAALLNIDTATLKQSYEAAFHNLL
YILALMTAISAGVVFIFLRHALPPPIANTLTTTVNSLVEKPTE

Sequences:

>Translated_523_residues
MTTPLRLPTLPPALSEHPQRWVTLFSVCLAGLIMPINFTGPAVSLPAIATSLGGSVIALSWVTNAFMLTFGCSLMIAGAL
ADRFGRKRVFISGLMVMTLSSLAMLMVQDIISFDLIRALQGIAAAAAFAGGTAGLAQVFDGAERAKAFSLLGTTFGIGLA
FGPLLAGFLGQHFGWHSIFISVSLLSAIALFTGMRYMHESRDPSAAKLDWPGATTFTLALTLLTYAVLQAPDSGWGSREV
FVLFSGALLFMVAFILIENRVRRPMLDLSLFRYPRFIGVQFLAAAPAYSYVVLLVLLPLRFIGIEGYSTLEAGIIMFALS
APMLVLPMLAGMLAHRFSAGVISSLGLLICAFGLLWLAQYSPGQPFLLLILPLLTIGCGISLPWGLMDGLAVSVVPKDRA
GMATGIFSTIRVAGEGIALAVVGALLATLVEQHLPGTALTNAAAGAHRLAMGDLPQAAALLNIDTATLKQSYEAAFHNLL
YILALMTAISAGVVFIFLRHALPPPIANTLTTTVNSLVEKPTE
>Mature_522_residues
TTPLRLPTLPPALSEHPQRWVTLFSVCLAGLIMPINFTGPAVSLPAIATSLGGSVIALSWVTNAFMLTFGCSLMIAGALA
DRFGRKRVFISGLMVMTLSSLAMLMVQDIISFDLIRALQGIAAAAAFAGGTAGLAQVFDGAERAKAFSLLGTTFGIGLAF
GPLLAGFLGQHFGWHSIFISVSLLSAIALFTGMRYMHESRDPSAAKLDWPGATTFTLALTLLTYAVLQAPDSGWGSREVF
VLFSGALLFMVAFILIENRVRRPMLDLSLFRYPRFIGVQFLAAAPAYSYVVLLVLLPLRFIGIEGYSTLEAGIIMFALSA
PMLVLPMLAGMLAHRFSAGVISSLGLLICAFGLLWLAQYSPGQPFLLLILPLLTIGCGISLPWGLMDGLAVSVVPKDRAG
MATGIFSTIRVAGEGIALAVVGALLATLVEQHLPGTALTNAAAGAHRLAMGDLPQAAALLNIDTATLKQSYEAAFHNLLY
ILALMTAISAGVVFIFLRHALPPPIANTLTTTVNSLVEKPTE

Specific function: Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=415, Percent_Identity=26.5060240963855, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789042, Length=426, Percent_Identity=23.0046948356808, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788710, Length=399, Percent_Identity=23.5588972431078, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790195, Length=403, Percent_Identity=26.0545905707196, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI48994889, Length=158, Percent_Identity=31.0126582278481, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790146, Length=176, Percent_Identity=27.8409090909091, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324954, Length=268, Percent_Identity=29.8507462686567, Blast_Score=84, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55326; Mature: 55194

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTPLRLPTLPPALSEHPQRWVTLFSVCLAGLIMPINFTGPAVSLPAIATSLGGSVIALS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEHH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HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1592819 [H]