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The map label for this gene is adiA [H]

Identifier: 157373054

GI number: 157373054

Start: 5340226

End: 5342511

Strand: Direct

Name: adiA [H]

Synonym: Spro_4822

Alternate gene names: 157373054

Gene position: 5340226-5342511 (Clockwise)

Preceding gene: 157373053

Following gene: 157373057

Centisome position: 98.01

GC content: 52.19

Gene sequence:

>2286_bases
ATGAAAGCATTACTGGTAGAAAGCGAGTTTACAACACCGGGCGGTTACCCCACCGCCGCCATTGGACGCCTGATTGAGCA
GTTGAATGGCCGTGATGTTGAAGTCATGCGCGCCACTTCTTTGCAGGACGGTGAGTCCATTATTGACGCTAACGAACCCA
TTGATTGTCTGCTGCTGGCCCGCAGCATGCCTGATAAGAAAGCAGCCGATCCCGCACAGAAATTATTGGATAAACTGCAT
GAGCGCCAAGAAAATGCACCAGTGTTTCTGCTGAGCGACCGCGGCACCGTCACCAAAGAACTCAGCCTCGACATGATGGA
ACAAATCAGTGAGTTCGCCTGGATCCTGGAAGACTCGGCTGATTTTATCGCCGGGCGCATTATGGCCGCCATTAGACGCT
ATCGGCAGCTGCTACTGCCGCCGCTGATGTCGGCCATAATGAAATACAACCAGACCCATGAATATTCCTGGGCGGTGCCA
GGGCACCAGGGCGGGGTCGGCTTTACCAAAACGCCGGCCGGCCGCGTATTTCACGATTTCTATGGCGAGAACCTGTTTCG
TACCGATTCAGGCATCGAGCGAACCGCGCTGGGCTCATTGCTGGATCACACCGGCTCTTTCAAAGACAGCGAAACAAATA
TTGCCCGCGTGTTTGGCGCTGAAAAATCCTATTCCGGCGTGGTGGGTACCTCTGGCTCCAATCGCAGCGTGATGCAGGCC
TGCTTAACCGAAGATCGTGGGGCGGTGGTTGACCGCAACTGCCATAAATCGATCGAGCAGGGGCTGATCCTCACCGGTGC
TACACCGACCTACATGATCCCCAGCCGCAACCCTTATGGGATTATCGGCCCGGTGCCAAAATCAGAGATGCTCCCTGATA
CCATAAAGACTAAAATGGATGAAAATCCACTTGGCATCACATCAATAGATTACTTTGTATTAACCAACTGCACTTATGAC
GGTATTTGCTATAACGCGGCAGAGGTAGTAAACGTTATCGAGGGTAAGGGGACTTTTATCCCAGTAGTTCACTTCGATGA
AGCCTGGTACGGCTATGCACGCTTTAACCCGATGTATAACAACTACTTTGCTATGCGCGGCGACCCAAAAGATCATACCT
CGGATTTATCAACGGTCGTCGCTACCCAGTCCAGCCATAAAATGCTCAATGCGCTGTCACCCGCCTCATATATCCATATC
CGTAACGGTAAGAAACCCTTAGATTTCCCACGCTTTAACCAAGCCTATATGATGCACACCACCACCTCACCGTCTTATAT
CATTGCCGCGTCTAACGACATTGCCGCAAATATGATGGATGGCGAATCAGGCCAATCGCTGACCCAAGAGGCCATCAATG
AAGCAGTGGACTTCCGTCAGGCATTAGCCCGTCTGCATACTGAATTCAAGGCGAAGGAAGAGTGGTTCTTTAAACCCTGG
AATATCGAAAAAGGTCGCAAACCCGGGGAAGAAAAAGACGTCCCATTCCAAGATATCCCCGCAGAGGCTCTGGCTACCGA
TCAAAGCTACTGGGTGATGAAGCCAGAAGATAAGTGGCATGGTTTCAAAAATCTCGACGCGGATTGGGCAATGATCGACC
CGGTCAAAGTCAGCATCCTGGCTCCAGGCATTAAAGTGGACGGTACGCTGGAAGATACCGGGGTACCGGCAGCATTGGTT
AATGCCTGGTTAGCCCGCAACGGCATTGTGCCAACCCGCACCACCGACTTCCAACTGATGTTCCTGTTCTCTATGGGGGT
GACCAAAGGGAAATGGGGTACCCTACTGGAAGCGCTGCTGTCCTTTAAACGTCATTATGACGCCAACACCCCGCTGTCCG
AAGTGCTGCCGGATCTCGCCGCAAAATACAGCGCGGAGTATGGCGCCCTGGGCCTGAAAGATCTCGGCGATAAGATGTTT
GCCTTCCTGAAACAAGATGACCTCGGCAAGTTGCTTAACCAGGCCTATGACGCTCTGCCAACACCGGTATTAACACCGCG
TGCCGCGTACCAAAAACTGGTTCGCTACGACGTTGAACCGGTCAGCCTTAAGGACCTGCATGGCAGGATAGCAGCCAATG
CGGTTCTTCCTTACCCACCCGGCATTCCTATGCTGATGTCCGGTGAGAAGTTCGGTGAACGCGTGGGCGACAAGGAAAGT
GCGCAAATTGCCTACCTGCTCGCATTGCAAAAATGGGATGACACCTTCGCAGGGTTTGAACACGAAACCGCAGGTATTAC
CATTACCGATAAGGGCGAGTACCAGGTGTTGTGTATTAAATCCTAA

Upstream 100 bases:

>100_bases
ACCACCGCGAATATTAATTTTTATTAATCTATATCAATAATACGTCGGCAAAACAGGCATAGGTTAAACAACGATCAATA
CATAAATGGAGTTTATTGAT

Downstream 100 bases:

>100_bases
CTGACTGAAGCACCATACATGGCCCGTGCAATTAATACTTGAGCACGCATTCAGGGCCGGAAATTCCGGCCCTTTTTATC
CACATCGACCCGGATTTAAA

Product: lysine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 761; Mature: 761

Protein sequence:

>761_residues
MKALLVESEFTTPGGYPTAAIGRLIEQLNGRDVEVMRATSLQDGESIIDANEPIDCLLLARSMPDKKAADPAQKLLDKLH
ERQENAPVFLLSDRGTVTKELSLDMMEQISEFAWILEDSADFIAGRIMAAIRRYRQLLLPPLMSAIMKYNQTHEYSWAVP
GHQGGVGFTKTPAGRVFHDFYGENLFRTDSGIERTALGSLLDHTGSFKDSETNIARVFGAEKSYSGVVGTSGSNRSVMQA
CLTEDRGAVVDRNCHKSIEQGLILTGATPTYMIPSRNPYGIIGPVPKSEMLPDTIKTKMDENPLGITSIDYFVLTNCTYD
GICYNAAEVVNVIEGKGTFIPVVHFDEAWYGYARFNPMYNNYFAMRGDPKDHTSDLSTVVATQSSHKMLNALSPASYIHI
RNGKKPLDFPRFNQAYMMHTTTSPSYIIAASNDIAANMMDGESGQSLTQEAINEAVDFRQALARLHTEFKAKEEWFFKPW
NIEKGRKPGEEKDVPFQDIPAEALATDQSYWVMKPEDKWHGFKNLDADWAMIDPVKVSILAPGIKVDGTLEDTGVPAALV
NAWLARNGIVPTRTTDFQLMFLFSMGVTKGKWGTLLEALLSFKRHYDANTPLSEVLPDLAAKYSAEYGALGLKDLGDKMF
AFLKQDDLGKLLNQAYDALPTPVLTPRAAYQKLVRYDVEPVSLKDLHGRIAANAVLPYPPGIPMLMSGEKFGERVGDKES
AQIAYLLALQKWDDTFAGFEHETAGITITDKGEYQVLCIKS

Sequences:

>Translated_761_residues
MKALLVESEFTTPGGYPTAAIGRLIEQLNGRDVEVMRATSLQDGESIIDANEPIDCLLLARSMPDKKAADPAQKLLDKLH
ERQENAPVFLLSDRGTVTKELSLDMMEQISEFAWILEDSADFIAGRIMAAIRRYRQLLLPPLMSAIMKYNQTHEYSWAVP
GHQGGVGFTKTPAGRVFHDFYGENLFRTDSGIERTALGSLLDHTGSFKDSETNIARVFGAEKSYSGVVGTSGSNRSVMQA
CLTEDRGAVVDRNCHKSIEQGLILTGATPTYMIPSRNPYGIIGPVPKSEMLPDTIKTKMDENPLGITSIDYFVLTNCTYD
GICYNAAEVVNVIEGKGTFIPVVHFDEAWYGYARFNPMYNNYFAMRGDPKDHTSDLSTVVATQSSHKMLNALSPASYIHI
RNGKKPLDFPRFNQAYMMHTTTSPSYIIAASNDIAANMMDGESGQSLTQEAINEAVDFRQALARLHTEFKAKEEWFFKPW
NIEKGRKPGEEKDVPFQDIPAEALATDQSYWVMKPEDKWHGFKNLDADWAMIDPVKVSILAPGIKVDGTLEDTGVPAALV
NAWLARNGIVPTRTTDFQLMFLFSMGVTKGKWGTLLEALLSFKRHYDANTPLSEVLPDLAAKYSAEYGALGLKDLGDKMF
AFLKQDDLGKLLNQAYDALPTPVLTPRAAYQKLVRYDVEPVSLKDLHGRIAANAVLPYPPGIPMLMSGEKFGERVGDKES
AQIAYLLALQKWDDTFAGFEHETAGITITDKGEYQVLCIKS
>Mature_761_residues
MKALLVESEFTTPGGYPTAAIGRLIEQLNGRDVEVMRATSLQDGESIIDANEPIDCLLLARSMPDKKAADPAQKLLDKLH
ERQENAPVFLLSDRGTVTKELSLDMMEQISEFAWILEDSADFIAGRIMAAIRRYRQLLLPPLMSAIMKYNQTHEYSWAVP
GHQGGVGFTKTPAGRVFHDFYGENLFRTDSGIERTALGSLLDHTGSFKDSETNIARVFGAEKSYSGVVGTSGSNRSVMQA
CLTEDRGAVVDRNCHKSIEQGLILTGATPTYMIPSRNPYGIIGPVPKSEMLPDTIKTKMDENPLGITSIDYFVLTNCTYD
GICYNAAEVVNVIEGKGTFIPVVHFDEAWYGYARFNPMYNNYFAMRGDPKDHTSDLSTVVATQSSHKMLNALSPASYIHI
RNGKKPLDFPRFNQAYMMHTTTSPSYIIAASNDIAANMMDGESGQSLTQEAINEAVDFRQALARLHTEFKAKEEWFFKPW
NIEKGRKPGEEKDVPFQDIPAEALATDQSYWVMKPEDKWHGFKNLDADWAMIDPVKVSILAPGIKVDGTLEDTGVPAALV
NAWLARNGIVPTRTTDFQLMFLFSMGVTKGKWGTLLEALLSFKRHYDANTPLSEVLPDLAAKYSAEYGALGLKDLGDKMF
AFLKQDDLGKLLNQAYDALPTPVLTPRAAYQKLVRYDVEPVSLKDLHGRIAANAVLPYPPGIPMLMSGEKFGERVGDKES
AQIAYLLALQKWDDTFAGFEHETAGITITDKGEYQVLCIKS

Specific function: ADC can be found in two forms:biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI221142684, Length=765, Percent_Identity=60, Blast_Score=962, Evalue=0.0,
Organism=Escherichia coli, GI1790573, Length=688, Percent_Identity=36.6279069767442, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1786384, Length=687, Percent_Identity=36.5356622998544, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI87082193, Length=695, Percent_Identity=33.3812949640288, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1786909, Length=725, Percent_Identity=29.2413793103448, Blast_Score=303, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 84383; Mature: 84383

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALLVESEFTTPGGYPTAAIGRLIEQLNGRDVEVMRATSLQDGESIIDANEPIDCLLLA
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCCEEEEEE
RSMPDKKAADPAQKLLDKLHERQENAPVFLLSDRGTVTKELSLDMMEQISEFAWILEDSA
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCH
DFIAGRIMAAIRRYRQLLLPPLMSAIMKYNQTHEYSWAVPGHQGGVGFTKTPAGRVFHDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHH
YGENLFRTDSGIERTALGSLLDHTGSFKDSETNIARVFGAEKSYSGVVGTSGSNRSVMQA
HCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCEEECCCCCHHHHHH
CLTEDRGAVVDRNCHKSIEQGLILTGATPTYMIPSRNPYGIIGPVPKSEMLPDTIKTKMD
HHHCCCCCEECCHHHHHHHCCEEEECCCCEEECCCCCCCEEECCCCCCCCCCHHHHHCCC
ENPLGITSIDYFVLTNCTYDGICYNAAEVVNVIEGKGTFIPVVHFDEAWYGYARFNPMYN
CCCCCEEEEEEEEEECCCCCCEECCHHHHHHHHCCCCCEEEEEEECCCCCCCEECCCCCC
NYFAMRGDPKDHTSDLSTVVATQSSHKMLNALSPASYIHIRNGKKPLDFPRFNQAYMMHT
CEEEECCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEE
TTSPSYIIAASNDIAANMMDGESGQSLTQEAINEAVDFRQALARLHTEFKAKEEWFFKPW
CCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCC
NIEKGRKPGEEKDVPFQDIPAEALATDQSYWVMKPEDKWHGFKNLDADWAMIDPVKVSIL
CCCCCCCCCCCCCCCHHCCCHHHHHCCCCEEEECCCHHCCCCCCCCCCEEEECCEEEEEE
APGIKVDGTLEDTGVPAALVNAWLARNGIVPTRTTDFQLMFLFSMGVTKGKWGTLLEALL
ECCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHH
SFKRHYDANTPLSEVLPDLAAKYSAEYGALGLKDLGDKMFAFLKQDDLGKLLNQAYDALP
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPVLTPRAAYQKLVRYDVEPVSLKDLHGRIAANAVLPYPPGIPMLMSGEKFGERVGDKES
CCCCCCHHHHHHHHHCCCCCCCHHHHCCHHEECEECCCCCCCCEEECCHHHHHHCCCCCC
AQIAYLLALQKWDDTFAGFEHETAGITITDKGEYQVLCIKS
CEEEEEEEHHHCCHHHCCCCCCCCCEEEECCCCEEEEEECC
>Mature Secondary Structure
MKALLVESEFTTPGGYPTAAIGRLIEQLNGRDVEVMRATSLQDGESIIDANEPIDCLLLA
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHCCCCCCCEEEEEE
RSMPDKKAADPAQKLLDKLHERQENAPVFLLSDRGTVTKELSLDMMEQISEFAWILEDSA
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCH
DFIAGRIMAAIRRYRQLLLPPLMSAIMKYNQTHEYSWAVPGHQGGVGFTKTPAGRVFHDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHH
YGENLFRTDSGIERTALGSLLDHTGSFKDSETNIARVFGAEKSYSGVVGTSGSNRSVMQA
HCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCEEECCCCCHHHHHH
CLTEDRGAVVDRNCHKSIEQGLILTGATPTYMIPSRNPYGIIGPVPKSEMLPDTIKTKMD
HHHCCCCCEECCHHHHHHHCCEEEECCCCEEECCCCCCCEEECCCCCCCCCCHHHHHCCC
ENPLGITSIDYFVLTNCTYDGICYNAAEVVNVIEGKGTFIPVVHFDEAWYGYARFNPMYN
CCCCCEEEEEEEEEECCCCCCEECCHHHHHHHHCCCCCEEEEEEECCCCCCCEECCCCCC
NYFAMRGDPKDHTSDLSTVVATQSSHKMLNALSPASYIHIRNGKKPLDFPRFNQAYMMHT
CEEEECCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEEE
TTSPSYIIAASNDIAANMMDGESGQSLTQEAINEAVDFRQALARLHTEFKAKEEWFFKPW
CCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCC
NIEKGRKPGEEKDVPFQDIPAEALATDQSYWVMKPEDKWHGFKNLDADWAMIDPVKVSIL
CCCCCCCCCCCCCCCHHCCCHHHHHCCCCEEEECCCHHCCCCCCCCCCEEEECCEEEEEE
APGIKVDGTLEDTGVPAALVNAWLARNGIVPTRTTDFQLMFLFSMGVTKGKWGTLLEALL
ECCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHH
SFKRHYDANTPLSEVLPDLAAKYSAEYGALGLKDLGDKMFAFLKQDDLGKLLNQAYDALP
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPVLTPRAAYQKLVRYDVEPVSLKDLHGRIAANAVLPYPPGIPMLMSGEKFGERVGDKES
CCCCCCHHHHHHHHHCCCCCCCHHHHCCHHEECEECCCCCCCCEEECCHHHHHHCCCCCC
AQIAYLLALQKWDDTFAGFEHETAGITITDKGEYQVLCIKS
CEEEEEEEHHHCCHHHCCCCCCCCCEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8383109; 7610040; 9278503; 2830169; 4204273 [H]