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The map label for this gene is metA

Identifier: 157372737

GI number: 157372737

Start: 4992491

End: 4993420

Strand: Reverse

Name: metA

Synonym: Spro_4504

Alternate gene names: 157372737

Gene position: 4993420-4992491 (Counterclockwise)

Preceding gene: 157372739

Following gene: 157372736

Centisome position: 91.64

GC content: 51.08

Gene sequence:

>930_bases
ATGCCGATTCGTGTTCCTGATGAGTTACCTGCAGTCAGTTTTTTGCGCAATGAGAATGTCTTTGTCATGGCATCCTCTCG
GGCAAAAACACAGGAAATCAGGCCATTGAAAGTATTGATCCTCAACCTGATGCCAAAAAAGATCGAGACGGAAAACCAGT
TTTTACGTCTACTTTCCAACTCTCCGCTGCAAATCGACATTCAGCTGCTGCGTATCGACAGCCGTGAGTCAAAGAACACG
CCGGCGGAGCATTTGAATAACTTTTACTGTGATTTTGAAGATATTCAGGATGAGAATTTCGACGGATTGATTGTCACCGG
GGCGCCGCTGGGGCTGGTCGATTTCTGTGACGTTGCCTACTGGCCACAGATCGAACGGGTGATTGACTGGGCCAAGAATC
ACGTCACCTCCACGCTGTTTGTATGCTGGGCGGTGCAGGCGGCATTGAACATTCTGTATGGTATTCCAAAGATGACGCGC
GAAGTGAAACTGTCGGGGGTTTATCAGCACCAGACGCTGCAGCAGCACGCCTTGCTGACTCGCGGTTTTGATGAGACCTT
CCTCGCGCCTCACTCACGCTATGCAGACTTTCCTACGGAGATTATCCGTCAGTATACGGATCTGGATATCCTGGCCGAAT
CAGAACAAACCGGGGCCTATTTGTTCGCCAGTAAGGACAAGCGGCTGGCGTTTGTGACCGGTCACCCGGAGTATGATGCG
CTAACGTTAGCTGGCGAGTATTGTCGCGATAACGATGCCGGTCTTAATCCTGTGGTACCGCTGAATTACTTCCCCGATGA
TAACCCCGAACTCACCCCCAAAGCGTCCTGGCGCAGCCATGGTCATCTGTTGTTTGCCAACTGGCTCAACTACTACGTTT
ACCAGATCACGCCGTACGATCTGCGTCATATGAACCCTACCCTCGAGTAA

Upstream 100 bases:

>100_bases
TTTTCACCTTCCGGTTGAACGCTCGACATCCTGCTAAAAAAACGCTATCTTCGGGCATCTAGAAGTCTAAACGTTTAAAT
GGATGTGTGAGGGTTAAGCA

Downstream 100 bases:

>100_bases
TCCTTTTTCCCTAATCGGCGGCTGAATCGAGGCCGCCGACGCAATCTCTTCCCCATCCGTCTTCCTCATTTCACTCTCTT
TTCTAGCAAAAACCATTGTT

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQIDIQLLRIDSRESKNT
PAEHLNNFYCDFEDIQDENFDGLIVTGAPLGLVDFCDVAYWPQIERVIDWAKNHVTSTLFVCWAVQAALNILYGIPKMTR
EVKLSGVYQHQTLQQHALLTRGFDETFLAPHSRYADFPTEIIRQYTDLDILAESEQTGAYLFASKDKRLAFVTGHPEYDA
LTLAGEYCRDNDAGLNPVVPLNYFPDDNPELTPKASWRSHGHLLFANWLNYYVYQITPYDLRHMNPTLE

Sequences:

>Translated_309_residues
MPIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQIDIQLLRIDSRESKNT
PAEHLNNFYCDFEDIQDENFDGLIVTGAPLGLVDFCDVAYWPQIERVIDWAKNHVTSTLFVCWAVQAALNILYGIPKMTR
EVKLSGVYQHQTLQQHALLTRGFDETFLAPHSRYADFPTEIIRQYTDLDILAESEQTGAYLFASKDKRLAFVTGHPEYDA
LTLAGEYCRDNDAGLNPVVPLNYFPDDNPELTPKASWRSHGHLLFANWLNYYVYQITPYDLRHMNPTLE
>Mature_308_residues
PIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQIDIQLLRIDSRESKNTP
AEHLNNFYCDFEDIQDENFDGLIVTGAPLGLVDFCDVAYWPQIERVIDWAKNHVTSTLFVCWAVQAALNILYGIPKMTRE
VKLSGVYQHQTLQQHALLTRGFDETFLAPHSRYADFPTEIIRQYTDLDILAESEQTGAYLFASKDKRLAFVTGHPEYDAL
TLAGEYCRDNDAGLNPVVPLNYFPDDNPELTPKASWRSHGHLLFANWLNYYVYQITPYDLRHMNPTLE

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=309, Percent_Identity=81.8770226537217, Blast_Score=535, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_SERP5 (A8GKF8)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480726.1
- ProteinModelPortal:   A8GKF8
- SMR:   A8GKF8
- STRING:   A8GKF8
- GeneID:   5606217
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4504
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- ProtClustDB:   PRK05368
- BioCyc:   SPRO399741:SPRO_4504-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35552; Mature: 35421

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSN
CCCCCCCCCCHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHHHCCCCCCHHHHHHHHHCC
SPLQIDIQLLRIDSRESKNTPAEHLNNFYCDFEDIQDENFDGLIVTGAPLGLVDFCDVAY
CCCEEEEEEEEECCCCCCCCCHHHHHCEECCHHHCCCCCCCEEEEECCCCCHHHHHHHHH
WPQIERVIDWAKNHVTSTLFVCWAVQAALNILYGIPKMTREVKLSGVYQHQTLQQHALLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCHHHHHHHHHHHHHH
RGFDETFLAPHSRYADFPTEIIRQYTDLDILAESEQTGAYLFASKDKRLAFVTGHPEYDA
CCCCHHHCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCEEEEEECCCEEEEEECCCCCCE
LTLAGEYCRDNDAGLNPVVPLNYFPDDNPELTPKASWRSHGHLLFANWLNYYVYQITPYD
EEEEHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCHH
LRHMNPTLE
HHCCCCCCC
>Mature Secondary Structure 
PIRVPDELPAVSFLRNENVFVMASSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSN
CCCCCCCCCHHHHHCCCCEEEEECCCCCCHHCCHHHHHHHHHCCCCCCHHHHHHHHHCC
SPLQIDIQLLRIDSRESKNTPAEHLNNFYCDFEDIQDENFDGLIVTGAPLGLVDFCDVAY
CCCEEEEEEEEECCCCCCCCCHHHHHCEECCHHHCCCCCCCEEEEECCCCCHHHHHHHHH
WPQIERVIDWAKNHVTSTLFVCWAVQAALNILYGIPKMTREVKLSGVYQHQTLQQHALLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCHHHHHHHHHHHHHH
RGFDETFLAPHSRYADFPTEIIRQYTDLDILAESEQTGAYLFASKDKRLAFVTGHPEYDA
CCCCHHHCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCEEEEEECCCEEEEEECCCCCCE
LTLAGEYCRDNDAGLNPVVPLNYFPDDNPELTPKASWRSHGHLLFANWLNYYVYQITPYD
EEEEHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCHH
LRHMNPTLE
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA