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The map label for this gene is aceB [H]

Identifier: 157372736

GI number: 157372736

Start: 4990506

End: 4992104

Strand: Reverse

Name: aceB [H]

Synonym: Spro_4503

Alternate gene names: 157372736

Gene position: 4992104-4990506 (Counterclockwise)

Preceding gene: 157372737

Following gene: 157372735

Centisome position: 91.62

GC content: 55.16

Gene sequence:

>1599_bases
ATGACGCAACAGATAGTAGGCACGGAATTAACGTTTACGCAGGGTTTTAGCGCTGCTGAACGACAGGTGTTGACGGATGA
CGCGGTCGAATTCCTGGCGGAATTGGTGAGTAAATTTACTCCACAGCGTAACAAACTGTTGGCTGCGCGTGCCTGCTGGC
AGCAGAAGATCGATCAAGGTGAACGTCCAGACTTCATTTCGGAAACTAATTCCATTCGCAATGAAAAGTGGTCGATCCGT
GGCATACCAGAGGATCTTCGCGACCGCCGGGTGGAAATCACCGGTCCGGTTGAACGCAAGATGGTCATCAACGCCCTGAA
CGCCAATGTGAAGGTGTTTATGGCGGACTTCGAAGACTCACTGGCACCGAGCTGGGACAAAGTCATCGACGGCCAAATCA
ACCTGCATGACGCGGTGAACGGCACCATCTCTTACACCAATGAAGCCGGCAAGATTTATCAGTTAAAGCCGAACCCGGCG
GTATTGATTGCTCGCGTACGCGGCCTGCATTTGCCGGAAAAACACGTGCAATGGCAGGGGGAAGCGATCCCCGGTGGCCT
GTTCGATTTTGCGCTGTATTTCTTCCATAACTATCGTCAACTGCTGGCTAAAGGCAGTGGCCCTTATTTCTACCTGCCAA
AAACCCAGTCCTGGCAGGAAGCGGCCTGGTGGAGCGAAGTCTTCAGCTTTGCCGAGGATCGTTTCTCCCTGCCACGCGGC
ACGATCAAAGCCACGGTGCTGATCGAAACGCTGCCGGCAGTATTCCAGATGGACGAGATCCTCTACCACCTGCGCGATCA
TATCGTCGGCTTGAACTGCGGCCGTTGGGATTACATCTTCAGCTACATCAAGACGCTGAAAAACCATGCTGACCGGGTAT
TGCCGGATCGTCAGTCGGTCACCATGGACAAGTCATTCCTTAGCGCCTATTCCCGATTGCTGATCAAGACCTGCCACAAG
CGCGGTGCCTTTGCCATGGGCGGCATGGCGGCGTTTATCCCGAGCAAAGACGCCGAGAAAAATGCCTGGGTGCTGAACAA
GGTGCGGGCGGATAAAGAGCTGGAGGCCAATAACGGCCACGACGGTACCTGGGTGGCCCATCCAGGGCTGGCGGATACCG
TAATGGAAGTCTTCAGCCGGGTGCTCGGTGAGCGCCGTAACCAACTCGAAGTGCTGCGTGAAAACGACGCGCTAATCAGT
GCTGCGCAGTTGCTTGAACCTTGTGACGGGGAGCGTACCGAAGCCGGCATGCGCGCCAATATCCGCGTGGCGGTGCAGTA
CATCGAAGCCTGGATCTCCGGCAATGGCTGCGTCCCGATTTATGGCCTGATGGAAGACGCGGCGACGGCGGAAATTTCCC
GTACCTCTATCTGGCAGTGGATCCACCATGAAAAGAGCCTGAGTGATGGCCAACTGGTCACCAAGGCGCTGTTCCGTCAG
ATGCTGAAAGAAGAAATGCTGGTAGTACGTGAAGAGTTGGGTGAGGCACGCTTTAACGCTGGCCGCTTCGACGAAGCGGC
ACGCCTGATGGAGCGTATCACTACGCAAGACGAATTAATCGATTTCCTGACTTTACCTGGCTATGAGCTACTGGCCTGA

Upstream 100 bases:

>100_bases
TTAAGGATCGTTTTATACGCCCTGATCCACACTGATTTCTGATGAAGATGCGCCGGCTGAATGGCAACGGTGGTGCGCAA
CGATAGGAAGGAGCAAGACA

Downstream 100 bases:

>100_bases
ATCCGTTCCTGACCATTAACCCTACATTATTGAAAAGGATAAAAATTATGTCTACCTCTCGTGCTCAACAGATTCAACAA
CTGGAACAGGAATGGAAATC

Product: malate synthase

Products: NA

Alternate protein names: MSA [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTQQIVGTELTFTQGFSAAERQVLTDDAVEFLAELVSKFTPQRNKLLAARACWQQKIDQGERPDFISETNSIRNEKWSIR
GIPEDLRDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPSWDKVIDGQINLHDAVNGTISYTNEAGKIYQLKPNPA
VLIARVRGLHLPEKHVQWQGEAIPGGLFDFALYFFHNYRQLLAKGSGPYFYLPKTQSWQEAAWWSEVFSFAEDRFSLPRG
TIKATVLIETLPAVFQMDEILYHLRDHIVGLNCGRWDYIFSYIKTLKNHADRVLPDRQSVTMDKSFLSAYSRLLIKTCHK
RGAFAMGGMAAFIPSKDAEKNAWVLNKVRADKELEANNGHDGTWVAHPGLADTVMEVFSRVLGERRNQLEVLRENDALIS
AAQLLEPCDGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKSLSDGQLVTKALFRQ
MLKEEMLVVREELGEARFNAGRFDEAARLMERITTQDELIDFLTLPGYELLA

Sequences:

>Translated_532_residues
MTQQIVGTELTFTQGFSAAERQVLTDDAVEFLAELVSKFTPQRNKLLAARACWQQKIDQGERPDFISETNSIRNEKWSIR
GIPEDLRDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPSWDKVIDGQINLHDAVNGTISYTNEAGKIYQLKPNPA
VLIARVRGLHLPEKHVQWQGEAIPGGLFDFALYFFHNYRQLLAKGSGPYFYLPKTQSWQEAAWWSEVFSFAEDRFSLPRG
TIKATVLIETLPAVFQMDEILYHLRDHIVGLNCGRWDYIFSYIKTLKNHADRVLPDRQSVTMDKSFLSAYSRLLIKTCHK
RGAFAMGGMAAFIPSKDAEKNAWVLNKVRADKELEANNGHDGTWVAHPGLADTVMEVFSRVLGERRNQLEVLRENDALIS
AAQLLEPCDGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKSLSDGQLVTKALFRQ
MLKEEMLVVREELGEARFNAGRFDEAARLMERITTQDELIDFLTLPGYELLA
>Mature_531_residues
TQQIVGTELTFTQGFSAAERQVLTDDAVEFLAELVSKFTPQRNKLLAARACWQQKIDQGERPDFISETNSIRNEKWSIRG
IPEDLRDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPSWDKVIDGQINLHDAVNGTISYTNEAGKIYQLKPNPAV
LIARVRGLHLPEKHVQWQGEAIPGGLFDFALYFFHNYRQLLAKGSGPYFYLPKTQSWQEAAWWSEVFSFAEDRFSLPRGT
IKATVLIETLPAVFQMDEILYHLRDHIVGLNCGRWDYIFSYIKTLKNHADRVLPDRQSVTMDKSFLSAYSRLLIKTCHKR
GAFAMGGMAAFIPSKDAEKNAWVLNKVRADKELEANNGHDGTWVAHPGLADTVMEVFSRVLGERRNQLEVLRENDALISA
AQLLEPCDGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKSLSDGQLVTKALFRQM
LKEEMLVVREELGEARFNAGRFDEAARLMERITTQDELIDFLTLPGYELLA

Specific function: Glyoxylate bypass; second step. [C]

COG id: COG2225

COG function: function code C; Malate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790444, Length=533, Percent_Identity=83.1144465290807, Blast_Score=924, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17561814, Length=528, Percent_Identity=49.8106060606061, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71982926, Length=422, Percent_Identity=51.4218009478673, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322222, Length=518, Percent_Identity=47.6833976833977, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6324212, Length=527, Percent_Identity=46.1100569259962, Blast_Score=446, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011076
- InterPro:   IPR006252
- InterPro:   IPR001465
- InterPro:   IPR019830 [H]

Pfam domain/function: PF01274 Malate_synthase [H]

EC number: =2.3.3.9 [H]

Molecular weight: Translated: 60418; Mature: 60286

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00510 MALATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQIVGTELTFTQGFSAAERQVLTDDAVEFLAELVSKFTPQRNKLLAARACWQQKIDQG
CCCCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
ERPDFISETNSIRNEKWSIRGIPEDLRDRRVEITGPVERKMVINALNANVKVFMADFEDS
CCCCHHHHHHHHCCCCCEECCCCHHHHCCEEEECCCHHHHHHHHHHCCCEEEEEECCCCC
LAPSWDKVIDGQINLHDAVNGTISYTNEAGKIYQLKPNPAVLIARVRGLHLPEKHVQWQG
CCCCHHHHHCCCEEEECCCCCEEEEECCCCEEEEECCCCEEEEEEHHCCCCCHHHHCCCC
EAIPGGLFDFALYFFHNYRQLLAKGSGPYFYLPKTQSWQEAAWWSEVFSFAEDRFSLPRG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TIKATVLIETLPAVFQMDEILYHLRDHIVGLNCGRWDYIFSYIKTLKNHADRVLPDRQSV
CEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHH
TMDKSFLSAYSRLLIKTCHKRGAFAMGGMAAFIPSKDAEKNAWVLNKVRADKELEANNGH
HHHHHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCC
DGTWVAHPGLADTVMEVFSRVLGERRNQLEVLRENDALISAAQLLEPCDGERTEAGMRAN
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCH
IRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKSLSDGQLVTKALFRQ
HHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MLKEEMLVVREELGEARFNAGRFDEAARLMERITTQDELIDFLTLPGYELLA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHCC
>Mature Secondary Structure 
TQQIVGTELTFTQGFSAAERQVLTDDAVEFLAELVSKFTPQRNKLLAARACWQQKIDQG
CCCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
ERPDFISETNSIRNEKWSIRGIPEDLRDRRVEITGPVERKMVINALNANVKVFMADFEDS
CCCCHHHHHHHHCCCCCEECCCCHHHHCCEEEECCCHHHHHHHHHHCCCEEEEEECCCCC
LAPSWDKVIDGQINLHDAVNGTISYTNEAGKIYQLKPNPAVLIARVRGLHLPEKHVQWQG
CCCCHHHHHCCCEEEECCCCCEEEEECCCCEEEEECCCCEEEEEEHHCCCCCHHHHCCCC
EAIPGGLFDFALYFFHNYRQLLAKGSGPYFYLPKTQSWQEAAWWSEVFSFAEDRFSLPRG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TIKATVLIETLPAVFQMDEILYHLRDHIVGLNCGRWDYIFSYIKTLKNHADRVLPDRQSV
CEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHH
TMDKSFLSAYSRLLIKTCHKRGAFAMGGMAAFIPSKDAEKNAWVLNKVRADKELEANNGH
HHHHHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCC
DGTWVAHPGLADTVMEVFSRVLGERRNQLEVLRENDALISAAQLLEPCDGERTEAGMRAN
CCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCH
IRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKSLSDGQLVTKALFRQ
HHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MLKEEMLVVREELGEARFNAGRFDEAARLMERITTQDELIDFLTLPGYELLA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3050899; 3060852; 8265357; 9278503 [H]