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The map label for this gene is guaA [H]

Identifier: 157372550

GI number: 157372550

Start: 4786469

End: 4787200

Strand: Direct

Name: guaA [H]

Synonym: Spro_4317

Alternate gene names: 157372550

Gene position: 4786469-4787200 (Clockwise)

Preceding gene: 157372549

Following gene: 157372551

Centisome position: 87.84

GC content: 59.43

Gene sequence:

>732_bases
ATGAAACCGTTATTACTGATGCAGACCGGCGACGCGCCGGAAGTTATCCGCCAGGAAAAGGCCAATTTCGATGGTATGTT
CCTGCAACAGGGGAATATCGACGCCGATCGCGTGCAGATCGTGCACCTACCCGCCGGCCAACAGCCGCTGCCACCGCAAC
ACTACTCTGGGGTGGTGATCACCGGTTCACCGGCGATGGTCACCGAGCAACTGCCGTGGAGCGAACAGGCCGCCGAATGG
CTGCGTCAGGCGATGCTGATCAAACTGCCGATTTTTGGCGCCTGCTACGGTCATCAGTTGCTGGCCTATGCGCTTGGCGG
GGAAGTTGGCTATCACCCGCAGGGCATGGAGGTAGGAACGCTGGATATCGAGCTGTTGCCCGCCGCCGCCCATGACCGGC
GAATGGCGATGCTGCCGCCGCGCTTCAAGGCGAATCTGATCCACTCGCAGAGCGTATTGACGCCCCCTGCCGGTGCCGTA
GTGCTGGCACGTTCGCAACAGGATGCTTATCAGATCCTCAGTTATGGCGATAACGTGCTGACCACCCAGTTCCACCCAGA
GTTTAACGGCGCGGTGATGCACCAGTATCTAAGTTGGCTCGGTGAGCTGTATCCGCAGCAACAGGCGGAGTATCAGCTTA
AGCAACAGCAGGTTAGCGATACCCCCTTCAGCCGACTGCTGTTGCAAGGGTTTGTCGTCAGCCTGGGCGCGCAAAAAGCC
CTGGCCGGGTAA

Upstream 100 bases:

>100_bases
GTAGAACATCCGGGGCTGGAAAACTCGCTGATTATCGCCCGCCTGCTGACCGAAATCCGCCGCCAGACCGGCGTAGTGTT
TCCTGCCGACGGAGAATGAC

Downstream 100 bases:

>100_bases
TGTAATAAACGTTGACCGCTGACACATTTTGCATTACTTTCTGCCGTGCAAAGGGGAGTAACTTCATTGCCGGTTAATCG
TCATTACGGTGCGCAAGCAC

Product: glutamine amidotransferase class-I

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKPLLLMQTGDAPEVIRQEKANFDGMFLQQGNIDADRVQIVHLPAGQQPLPPQHYSGVVITGSPAMVTEQLPWSEQAAEW
LRQAMLIKLPIFGACYGHQLLAYALGGEVGYHPQGMEVGTLDIELLPAAAHDRRMAMLPPRFKANLIHSQSVLTPPAGAV
VLARSQQDAYQILSYGDNVLTTQFHPEFNGAVMHQYLSWLGELYPQQQAEYQLKQQQVSDTPFSRLLLQGFVVSLGAQKA
LAG

Sequences:

>Translated_243_residues
MKPLLLMQTGDAPEVIRQEKANFDGMFLQQGNIDADRVQIVHLPAGQQPLPPQHYSGVVITGSPAMVTEQLPWSEQAAEW
LRQAMLIKLPIFGACYGHQLLAYALGGEVGYHPQGMEVGTLDIELLPAAAHDRRMAMLPPRFKANLIHSQSVLTPPAGAV
VLARSQQDAYQILSYGDNVLTTQFHPEFNGAVMHQYLSWLGELYPQQQAEYQLKQQQVSDTPFSRLLLQGFVVSLGAQKA
LAG
>Mature_243_residues
MKPLLLMQTGDAPEVIRQEKANFDGMFLQQGNIDADRVQIVHLPAGQQPLPPQHYSGVVITGSPAMVTEQLPWSEQAAEW
LRQAMLIKLPIFGACYGHQLLAYALGGEVGYHPQGMEVGTLDIELLPAAAHDRRMAMLPPRFKANLIHSQSVLTPPAGAV
VLARSQQDAYQILSYGDNVLTTQFHPEFNGAVMHQYLSWLGELYPQQQAEYQLKQQQVSDTPFSRLLLQGFVVSLGAQKA
LAG

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323155, Length=152, Percent_Identity=30.2631578947368, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 26782; Mature: 26782

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLLLMQTGDAPEVIRQEKANFDGMFLQQGNIDADRVQIVHLPAGQQPLPPQHYSGVVI
CCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEE
TGSPAMVTEQLPWSEQAAEWLRQAMLIKLPIFGACYGHQLLAYALGGEVGYHPQGMEVGT
ECCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
LDIELLPAAAHDRRMAMLPPRFKANLIHSQSVLTPPAGAVVLARSQQDAYQILSYGDNVL
EEEEEECCCCCCCEEEECCCCHHHHEEECCCCCCCCCCEEEEEECCHHHHHHHHCCCCEE
TTQFHPEFNGAVMHQYLSWLGELYPQQQAEYQLKQQQVSDTPFSRLLLQGFVVSLGAQKA
EEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHH
LAG
CCC
>Mature Secondary Structure
MKPLLLMQTGDAPEVIRQEKANFDGMFLQQGNIDADRVQIVHLPAGQQPLPPQHYSGVVI
CCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEE
TGSPAMVTEQLPWSEQAAEWLRQAMLIKLPIFGACYGHQLLAYALGGEVGYHPQGMEVGT
ECCCCEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
LDIELLPAAAHDRRMAMLPPRFKANLIHSQSVLTPPAGAVVLARSQQDAYQILSYGDNVL
EEEEEECCCCCCCEEEECCCCHHHHEEECCCCCCCCCCEEEEEECCHHHHHHHHCCCCEE
TTQFHPEFNGAVMHQYLSWLGELYPQQQAEYQLKQQQVSDTPFSRLLLQGFVVSLGAQKA
EEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHH
LAG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]