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The map label for this gene is metC [H]

Identifier: 157372445

GI number: 157372445

Start: 4669055

End: 4670251

Strand: Direct

Name: metC [H]

Synonym: Spro_4212

Alternate gene names: 157372445

Gene position: 4669055-4670251 (Clockwise)

Preceding gene: 157372440

Following gene: 157372446

Centisome position: 85.69

GC content: 58.65

Gene sequence:

>1197_bases
ATGACGTCAAAAAACATCGAAACCACCCTGATCGGCGCAGGACGCAGCAAGCGCTATACCCAGGGTTCCGTCAATCCCGT
CACCCAACGCGCTTCTTCACTGGTATTTGATTCGGTGGCGGCCAAAAAGCACGCCACTGCCAGGCGGGCCCATGGCGAAC
TGTTTTATGGCCGGCGCGGCACCCTGACCCACTTTGCGTTACAGGATGCGATGGTTGAGCTGGAAGGCGGCGCAGGTTGT
GTACTTTACCCTTGTGGCGCGGCTGCGGTCTCCAACGCTATCCTTTCGTTTGTCAGCGCCGGCGATCACCTGCTGATGAC
CGGCTCGGTGTATGAACCCACGCAGGATTTTTGCAGCCATATTCTGAGCCGCATGAACGTGGCAACCACCTATTTCGACC
CGCTGATCGGAGCCGATATCGCCGGGCTTATTCAGCCCAATACCCGCGTGGTGTTTCTGGAGTCACCCGGATCGATCACC
ATGGAAGTTCAGGATATCCCGGCCATGGTGCAGGCCATTCGCGCGGTGGCACCGGAAGTGGTGATCATGATCGACAATAC
CTGGGCGGCCGGTGTGCTGTTCAAGGCGCTGGACTTCGACATTGATATTTCGATTCAGGCAGGGACCAAATACATTATCG
GCCACTCCGATTACATGCTCGGCACCGCCGTGGCAAACCAGCGCTGTTGGGATCAACTGCGCGAATACTCTTATCTGATG
GGCCAGATGGTGGACGCCGATACCGCCTATATGGCCAGCCGTGGCCTGCGCACGCTGGGCGTACGCCTGAAGCAACATCA
GCAAGGCAGCATCGAAGTCGCCAACTGGCTGGCCGAACGGCCGGAGGTGGCAGTGGTCAATCACCCGGAGCTGCCCAGCT
GCAAGGGCCACGAATTTTACCGCCGCGATTTCAGCGGCTGCAACGGCCTGTTCTCTTTCGTGCTGAAACAGCGTCTGAGC
GACGCACAGTTGGCCGAGTATCTGGACAACTTCAACCATTTCAGCATGGCCTATTCCTGGGGCGGTTATGAATCGCTGAT
CCTGGCCAACCAACCGGAAGAACTGGAAGCCATTCGTCCGGCCGGCGGCGTCGACTTCTCCGGCACCCTGGTGCGCCTGC
ATATCGGACTGGAGAACGTGCAGGATCTGATTGACGACCTCGCCGCCGGATTCGAGCGTATCGCCAACGCACACTGA

Upstream 100 bases:

>100_bases
TTTGGCGGTTAAAACGTCTGGATGGCTATCATATGTCATGCTAACGTAAGGGCTATCGCAAACAACCCGTGAAGACCCAG
CCAAAGGTGAGCCTGCTCCT

Downstream 100 bases:

>100_bases
CGCGCCACCTGTTGCAATGGCAACTTTATTCGCCTTGTTTAATGTGTGCTTAAGCTATTAGCGTTACACTAGCCGGGTAA
CTGTCAGATACGGTCAACAC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTSKNIETTLIGAGRSKRYTQGSVNPVTQRASSLVFDSVAAKKHATARRAHGELFYGRRGTLTHFALQDAMVELEGGAGC
VLYPCGAAAVSNAILSFVSAGDHLLMTGSVYEPTQDFCSHILSRMNVATTYFDPLIGADIAGLIQPNTRVVFLESPGSIT
MEVQDIPAMVQAIRAVAPEVVIMIDNTWAAGVLFKALDFDIDISIQAGTKYIIGHSDYMLGTAVANQRCWDQLREYSYLM
GQMVDADTAYMASRGLRTLGVRLKQHQQGSIEVANWLAERPEVAVVNHPELPSCKGHEFYRRDFSGCNGLFSFVLKQRLS
DAQLAEYLDNFNHFSMAYSWGGYESLILANQPEELEAIRPAGGVDFSGTLVRLHIGLENVQDLIDDLAAGFERIANAH

Sequences:

>Translated_398_residues
MTSKNIETTLIGAGRSKRYTQGSVNPVTQRASSLVFDSVAAKKHATARRAHGELFYGRRGTLTHFALQDAMVELEGGAGC
VLYPCGAAAVSNAILSFVSAGDHLLMTGSVYEPTQDFCSHILSRMNVATTYFDPLIGADIAGLIQPNTRVVFLESPGSIT
MEVQDIPAMVQAIRAVAPEVVIMIDNTWAAGVLFKALDFDIDISIQAGTKYIIGHSDYMLGTAVANQRCWDQLREYSYLM
GQMVDADTAYMASRGLRTLGVRLKQHQQGSIEVANWLAERPEVAVVNHPELPSCKGHEFYRRDFSGCNGLFSFVLKQRLS
DAQLAEYLDNFNHFSMAYSWGGYESLILANQPEELEAIRPAGGVDFSGTLVRLHIGLENVQDLIDDLAAGFERIANAH
>Mature_397_residues
TSKNIETTLIGAGRSKRYTQGSVNPVTQRASSLVFDSVAAKKHATARRAHGELFYGRRGTLTHFALQDAMVELEGGAGCV
LYPCGAAAVSNAILSFVSAGDHLLMTGSVYEPTQDFCSHILSRMNVATTYFDPLIGADIAGLIQPNTRVVFLESPGSITM
EVQDIPAMVQAIRAVAPEVVIMIDNTWAAGVLFKALDFDIDISIQAGTKYIIGHSDYMLGTAVANQRCWDQLREYSYLMG
QMVDADTAYMASRGLRTLGVRLKQHQQGSIEVANWLAERPEVAVVNHPELPSCKGHEFYRRDFSGCNGLFSFVLKQRLSD
AQLAEYLDNFNHFSMAYSWGGYESLILANQPEELEAIRPAGGVDFSGTLVRLHIGLENVQDLIDDLAAGFERIANAH

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=335, Percent_Identity=30.1492537313433, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI299473759, Length=335, Percent_Identity=27.4626865671642, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI25453487, Length=335, Percent_Identity=27.7611940298507, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789383, Length=394, Percent_Identity=72.5888324873096, Blast_Score=626, Evalue=0.0,
Organism=Escherichia coli, GI1790375, Length=354, Percent_Identity=31.638418079096, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17538055, Length=336, Percent_Identity=29.4642857142857, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=354, Percent_Identity=30.7909604519774, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=336, Percent_Identity=30.3571428571429, Blast_Score=157, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6321170, Length=337, Percent_Identity=42.1364985163205, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6319307, Length=369, Percent_Identity=28.1842818428184, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321904, Length=255, Percent_Identity=28.2352941176471, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321254, Length=264, Percent_Identity=26.8939393939394, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323333, Length=368, Percent_Identity=23.9130434782609, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19922554, Length=348, Percent_Identity=31.0344827586207, Blast_Score=178, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43550; Mature: 43419

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKNIETTLIGAGRSKRYTQGSVNPVTQRASSLVFDSVAAKKHATARRAHGELFYGRRG
CCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCC
TLTHFALQDAMVELEGGAGCVLYPCGAAAVSNAILSFVSAGDHLLMTGSVYEPTQDFCSH
CHHHHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
ILSRMNVATTYFDPLIGADIAGLIQPNTRVVFLESPGSITMEVQDIPAMVQAIRAVAPEV
HHHHHHHHHHHHHHHHCCCHHHEECCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCEE
VIMIDNTWAAGVLFKALDFDIDISIQAGTKYIIGHSDYMLGTAVANQRCWDQLREYSYLM
EEEEECCHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GQMVDADTAYMASRGLRTLGVRLKQHQQGSIEVANWLAERPEVAVVNHPELPSCKGHEFY
HHHHCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCHHH
RRDFSGCNGLFSFVLKQRLSDAQLAEYLDNFNHFSMAYSWGGYESLILANQPEELEAIRP
HHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHCCC
AGGVDFSGTLVRLHIGLENVQDLIDDLAAGFERIANAH
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSKNIETTLIGAGRSKRYTQGSVNPVTQRASSLVFDSVAAKKHATARRAHGELFYGRRG
CCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCC
TLTHFALQDAMVELEGGAGCVLYPCGAAAVSNAILSFVSAGDHLLMTGSVYEPTQDFCSH
CHHHHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
ILSRMNVATTYFDPLIGADIAGLIQPNTRVVFLESPGSITMEVQDIPAMVQAIRAVAPEV
HHHHHHHHHHHHHHHHCCCHHHEECCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCEE
VIMIDNTWAAGVLFKALDFDIDISIQAGTKYIIGHSDYMLGTAVANQRCWDQLREYSYLM
EEEEECCHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
GQMVDADTAYMASRGLRTLGVRLKQHQQGSIEVANWLAERPEVAVVNHPELPSCKGHEFY
HHHHCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCHHH
RRDFSGCNGLFSFVLKQRLSDAQLAEYLDNFNHFSMAYSWGGYESLILANQPEELEAIRP
HHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHCCC
AGGVDFSGTLVRLHIGLENVQDLIDDLAAGFERIANAH
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659970; 11677609 [H]