Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 157372265

GI number: 157372265

Start: 4472479

End: 4473300

Strand: Direct

Name: proC [H]

Synonym: Spro_4031

Alternate gene names: 157372265

Gene position: 4472479-4473300 (Clockwise)

Preceding gene: 157372264

Following gene: 157372266

Centisome position: 82.08

GC content: 59.37

Gene sequence:

>822_bases
ATGCAGCATCGCAAGATCACCTTTATTGGCGCCGGCAACATGGCGCGCGCTATCATCGCCGGCCTGGTGGCGGGCGGTTA
TCCGGCCAAATTCATTAGCGTCTGCGCACCTTCGGCTAAAAACCGTGATGCGCTGGCGGCGGACTACGGCATCGTCAGCA
GCAGCGACAATCTGGCCTGCACACAAGCCGCCGATGTGGTGGTGCTGGCAGTCAAACCGCAAATGATGGCCGACGTCTGC
CAGCCGTTGCGCGAAGGCGTCGATTTCAGCGCCAAGCTGGTTCTGTCGATCGCCGCCGGTATCCAGGTCAGCCGTTTTTA
TCAACTGCTGGGTGACAAGCTGAACATCGTGCGCATCATGCCCAATACCCCATCGCTGGTGGGCAAAGGCATGAGCGGCC
TGTATGCGCCGCAGCAGGTCAGCCAACAGGACCGCGACTACACCAGAGATTTGATGGCATCAGTCGGCAAGGTGTGTTGG
GTGGAAGATGAAAACGGCATTAATAGCGTGATCGCCGCAGCAGGCAGCGCACCGGCTTATTTCTTCCTGTTTATGGAAGC
CATGCAACAGGAAGCCGAACGTATGGGCTTCGACAGCCAGACCGCCCGTAATCTGGTGCAGCAGGCTGCCTCCGGCGCGG
CTGCGCTGGTGGAAGCCAACCCGGATACGCCATTGTCGACCTTGCGTGAGCAGGTCACCTCCAAAGGCGGCACCACCGCC
GAAGCACTGCGCGTTTTCAACGAGCAACAGCTGCCGGCAACCGTGGCCAAAGCCATGCAGGCGGCAGTATCCCGCGCGCA
GGAAATGGAAAAATCATTTTAA

Upstream 100 bases:

>100_bases
CGGCGGCAATTGCCGCAGGCAGCACCATGGTGCGTATTGGCACCGCCATTTTTGGCGCCCGTGATTATTCACAGGCCTAA
TATACTGACGAGGGATTCTA

Downstream 100 bases:

>100_bases
ATAATCGAGAGTTAAGGAGAAGGGCTACTACATGCTAACGCTGACTTTTTTGGTCAAAACCGTTATTGATCTGTACGTCA
TGGTACTGCTGCTGCGTATC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MQHRKITFIGAGNMARAIIAGLVAGGYPAKFISVCAPSAKNRDALAADYGIVSSSDNLACTQAADVVVLAVKPQMMADVC
QPLREGVDFSAKLVLSIAAGIQVSRFYQLLGDKLNIVRIMPNTPSLVGKGMSGLYAPQQVSQQDRDYTRDLMASVGKVCW
VEDENGINSVIAAAGSAPAYFFLFMEAMQQEAERMGFDSQTARNLVQQAASGAAALVEANPDTPLSTLREQVTSKGGTTA
EALRVFNEQQLPATVAKAMQAAVSRAQEMEKSF

Sequences:

>Translated_273_residues
MQHRKITFIGAGNMARAIIAGLVAGGYPAKFISVCAPSAKNRDALAADYGIVSSSDNLACTQAADVVVLAVKPQMMADVC
QPLREGVDFSAKLVLSIAAGIQVSRFYQLLGDKLNIVRIMPNTPSLVGKGMSGLYAPQQVSQQDRDYTRDLMASVGKVCW
VEDENGINSVIAAAGSAPAYFFLFMEAMQQEAERMGFDSQTARNLVQQAASGAAALVEANPDTPLSTLREQVTSKGGTTA
EALRVFNEQQLPATVAKAMQAAVSRAQEMEKSF
>Mature_273_residues
MQHRKITFIGAGNMARAIIAGLVAGGYPAKFISVCAPSAKNRDALAADYGIVSSSDNLACTQAADVVVLAVKPQMMADVC
QPLREGVDFSAKLVLSIAAGIQVSRFYQLLGDKLNIVRIMPNTPSLVGKGMSGLYAPQQVSQQDRDYTRDLMASVGKVCW
VEDENGINSVIAAAGSAPAYFFLFMEAMQQEAERMGFDSQTARNLVQQAASGAAALVEANPDTPLSTLREQVTSKGGTTA
EALRVFNEQQLPATVAKAMQAAVSRAQEMEKSF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=269, Percent_Identity=28.6245353159851, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=28.4132841328413, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI24797097, Length=272, Percent_Identity=29.4117647058824, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI24797095, Length=272, Percent_Identity=29.4117647058824, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786585, Length=272, Percent_Identity=35.2941176470588, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=31.3432835820896, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17540664, Length=286, Percent_Identity=29.020979020979, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=25.2631578947368, Blast_Score=93, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=34.3173431734317, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=30.6859205776173, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=33.5294117647059, Blast_Score=88, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29032; Mature: 29032

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00521 P5CR ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHRKITFIGAGNMARAIIAGLVAGGYPAKFISVCAPSAKNRDALAADYGIVSSSDNLAC
CCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHCCCCEECCCCEEE
TQAADVVVLAVKPQMMADVCQPLREGVDFSAKLVLSIAAGIQVSRFYQLLGDKLNIVRIM
ECCCCEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
PNTPSLVGKGMSGLYAPQQVSQQDRDYTRDLMASVGKVCWVEDENGINSVIAAAGSAPAY
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCHHH
FFLFMEAMQQEAERMGFDSQTARNLVQQAASGAAALVEANPDTPLSTLREQVTSKGGTTA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCHH
EALRVFNEQQLPATVAKAMQAAVSRAQEMEKSF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHRKITFIGAGNMARAIIAGLVAGGYPAKFISVCAPSAKNRDALAADYGIVSSSDNLAC
CCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHCCCCEECCCCEEE
TQAADVVVLAVKPQMMADVCQPLREGVDFSAKLVLSIAAGIQVSRFYQLLGDKLNIVRIM
ECCCCEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
PNTPSLVGKGMSGLYAPQQVSQQDRDYTRDLMASVGKVCWVEDENGINSVIAAAGSAPAY
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCHHH
FFLFMEAMQQEAERMGFDSQTARNLVQQAASGAAALVEANPDTPLSTLREQVTSKGGTTA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCHH
EALRVFNEQQLPATVAKAMQAAVSRAQEMEKSF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]