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The map label for this gene is csdA [H]

Identifier: 157372042

GI number: 157372042

Start: 4206834

End: 4208039

Strand: Direct

Name: csdA [H]

Synonym: Spro_3807

Alternate gene names: 157372042

Gene position: 4206834-4208039 (Clockwise)

Preceding gene: 157372037

Following gene: 157372043

Centisome position: 77.21

GC content: 61.03

Gene sequence:

>1206_bases
ATGACACCTTTTAATCCCATCGTTTTTCGTAATCAGTTTCCTGCCTTGCAGCAAGCGGGCATTTATCTCGACAGCGCCGC
CACCGCGTTGAAGCCGCTGGCGGTCATCAATGCCACGCAGCAGTTTTACCGCGACGATGCCGCTACCGTGCACCGCAGCC
AGCACCGGGCGGCGCAGGATCTGACTGCACGCTTCGAGCAGGCTCGCCAACAGGTCGCGACGCTGGTCAATGCTCCTTCA
GCCGACGACATTATCTGGACCCGCGGCACCACCGAAGCGATCAATTTGGTAGCGCAGAGCTATGCCCGCCCCCGGTTGCA
GCCCGGTGACGAAATCCTGGTGAGCGAGGCCGAACACCACGCCAACCTGATCCCCTGGCTGATGGTGGCGGAACAAACCG
GCGCTCGGGTGGTAAAACTGCCACTGGGTGCAGACCGCCTGCCGGATCTGGCCCAGTTACCCAGCCTGCTGAGTGATAAA
ACCCGCCTGCTGGCACTGGGCCAAATGTCCAACGTCACCGGCGGCTGTCCGGATCTGGATCTGGCCATCCGGCTTGCCCA
TAGTGCCGGCGCTCTGGTGATGATCGACGGCGCGCAGGGCATCGTTCACTGTCCGGCTGACGTTCAGCGACTAGACATTG
ATTTCTACGCTTTCTCCGGCCACAAATTATATGGCCCGACCGGCATCGGTGCGCTATACGGTAAAAGCGAATTGCTGGCG
CAGATGGCCCCCTGGCAAGGCGGCGGCAAGATGCTGACTCAGGCCTCCTTCGACGGCTTCACGCCGCAAAAACCACCGCA
CTGTTTTGAAGCCGGTACGCCGAATATCGCCGGTGTGCTGGGGTTGGCCGCCGCATTGGAATGGCTTGGCACCCAGGATC
TGGCGGCAGCCGAGCAATACAGCCGCGAACTGGCCGATCTCGCCGAGAAACAATTGGCGCAACTGCCGGGGTTCCGCAGC
TTCCGTTGTTCGGGCTCCAGCTTACTGGCGTTTGATATTGCCGGTATCCATCACAGCGATATCGTCACCCTGCTGGCAGA
ACAAGGCATCGCACTGCGAGCCGGTCAGCACTGCGCTCAACCGCTGATGGCGGCGCTGGGTGTCAGTGGGACACTACGCG
CCTCCTTTGCGCCATACAACACGCGGGAAGACGTCGATACCCTGGTAACCGCCCTGCACAACGCCATCGACCTGTTGGCC
GATTAA

Upstream 100 bases:

>100_bases
ATAATTTCCAGACGATGAATCCTAATATGCGGGATAGCTTGTCTCTGGCGGTAAAATAAGACAGGATCGGCCATTGACTC
AAGCCAGTGACAATCAGGTT

Downstream 100 bases:

>100_bases
ATGAACCCCGGAGACGCTATGCTTGCCCCCCATCCCTTTGGCCATGAAATCACCGCCGAAGCGCTGATCGAGAAATTTAC
CGAGCTGAAACAATGGGAAG

Product: cysteine sulfinate desulfinase

Products: @ALAN01txt*L-Alanine! [C]

Alternate protein names: CSD [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTPFNPIVFRNQFPALQQAGIYLDSAATALKPLAVINATQQFYRDDAATVHRSQHRAAQDLTARFEQARQQVATLVNAPS
ADDIIWTRGTTEAINLVAQSYARPRLQPGDEILVSEAEHHANLIPWLMVAEQTGARVVKLPLGADRLPDLAQLPSLLSDK
TRLLALGQMSNVTGGCPDLDLAIRLAHSAGALVMIDGAQGIVHCPADVQRLDIDFYAFSGHKLYGPTGIGALYGKSELLA
QMAPWQGGGKMLTQASFDGFTPQKPPHCFEAGTPNIAGVLGLAAALEWLGTQDLAAAEQYSRELADLAEKQLAQLPGFRS
FRCSGSSLLAFDIAGIHHSDIVTLLAEQGIALRAGQHCAQPLMAALGVSGTLRASFAPYNTREDVDTLVTALHNAIDLLA
D

Sequences:

>Translated_401_residues
MTPFNPIVFRNQFPALQQAGIYLDSAATALKPLAVINATQQFYRDDAATVHRSQHRAAQDLTARFEQARQQVATLVNAPS
ADDIIWTRGTTEAINLVAQSYARPRLQPGDEILVSEAEHHANLIPWLMVAEQTGARVVKLPLGADRLPDLAQLPSLLSDK
TRLLALGQMSNVTGGCPDLDLAIRLAHSAGALVMIDGAQGIVHCPADVQRLDIDFYAFSGHKLYGPTGIGALYGKSELLA
QMAPWQGGGKMLTQASFDGFTPQKPPHCFEAGTPNIAGVLGLAAALEWLGTQDLAAAEQYSRELADLAEKQLAQLPGFRS
FRCSGSSLLAFDIAGIHHSDIVTLLAEQGIALRAGQHCAQPLMAALGVSGTLRASFAPYNTREDVDTLVTALHNAIDLLA
D
>Mature_400_residues
TPFNPIVFRNQFPALQQAGIYLDSAATALKPLAVINATQQFYRDDAATVHRSQHRAAQDLTARFEQARQQVATLVNAPSA
DDIIWTRGTTEAINLVAQSYARPRLQPGDEILVSEAEHHANLIPWLMVAEQTGARVVKLPLGADRLPDLAQLPSLLSDKT
RLLALGQMSNVTGGCPDLDLAIRLAHSAGALVMIDGAQGIVHCPADVQRLDIDFYAFSGHKLYGPTGIGALYGKSELLAQ
MAPWQGGGKMLTQASFDGFTPQKPPHCFEAGTPNIAGVLGLAAALEWLGTQDLAAAEQYSRELADLAEKQLAQLPGFRSF
RCSGSSLLAFDIAGIHHSDIVTLLAEQGIALRAGQHCAQPLMAALGVSGTLRASFAPYNTREDVDTLVTALHNAIDLLAD

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine. L-cysteine sulfinic acid is the best substrate. Functions as a selenium delivery protein in the pathway f

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=386, Percent_Identity=25.3886010362694, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156713448, Length=439, Percent_Identity=25.9681093394077, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1789175, Length=401, Percent_Identity=72.3192019950125, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1787970, Length=397, Percent_Identity=45.5919395465995, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI48994898, Length=400, Percent_Identity=24.5, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=234, Percent_Identity=31.6239316239316, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193211090, Length=383, Percent_Identity=25.5874673629243, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319831, Length=393, Percent_Identity=24.9363867684478, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI20129463, Length=229, Percent_Identity=31.0043668122271, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022471
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: 4.4.1.- [C]

Molecular weight: Translated: 42896; Mature: 42765

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPFNPIVFRNQFPALQQAGIYLDSAATALKPLAVINATQQFYRDDAATVHRSQHRAAQD
CCCCCCEEECCCCCHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
LTARFEQARQQVATLVNAPSADDIIWTRGTTEAINLVAQSYARPRLQPGDEILVSEAEHH
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHCHHHH
ANLIPWLMVAEQTGARVVKLPLGADRLPDLAQLPSLLSDKTRLLALGQMSNVTGGCPDLD
CCHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHEEEECCCCCCCCCCCCHH
LAIRLAHSAGALVMIDGAQGIVHCPADVQRLDIDFYAFSGHKLYGPTGIGALYGKSELLA
HHEEEECCCCCEEEEECCCCEEECCCCCEEEEEEEEEECCCEEECCCCCHHHHCHHHHHH
QMAPWQGGGKMLTQASFDGFTPQKPPHCFEAGTPNIAGVLGLAAALEWLGTQDLAAAEQY
HHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
SRELADLAEKQLAQLPGFRSFRCSGSSLLAFDIAGIHHSDIVTLLAEQGIALRAGQHCAQ
HHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHCCCEECCCHHHHH
PLMAALGVSGTLRASFAPYNTREDVDTLVTALHNAIDLLAD
HHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPFNPIVFRNQFPALQQAGIYLDSAATALKPLAVINATQQFYRDDAATVHRSQHRAAQD
CCCCCEEECCCCCHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
LTARFEQARQQVATLVNAPSADDIIWTRGTTEAINLVAQSYARPRLQPGDEILVSEAEHH
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHCHHHH
ANLIPWLMVAEQTGARVVKLPLGADRLPDLAQLPSLLSDKTRLLALGQMSNVTGGCPDLD
CCHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHCCCHHEEEECCCCCCCCCCCCHH
LAIRLAHSAGALVMIDGAQGIVHCPADVQRLDIDFYAFSGHKLYGPTGIGALYGKSELLA
HHEEEECCCCCEEEEECCCCEEECCCCCEEEEEEEEEECCCEEECCCCCHHHHCHHHHHH
QMAPWQGGGKMLTQASFDGFTPQKPPHCFEAGTPNIAGVLGLAAALEWLGTQDLAAAEQY
HHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
SRELADLAEKQLAQLPGFRSFRCSGSSLLAFDIAGIHHSDIVTLLAEQGIALRAGQHCAQ
HHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHCCCEECCCHHHHH
PLMAALGVSGTLRASFAPYNTREDVDTLVTALHNAIDLLAD
HHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-cystine; L-selenocystine [C]

Specific reaction: Catalyzes the removal of elemental sulfur and selenium atoms from l-cysteine, l-cystine, l-selenocysteine, and l- selenocystine to produce @ALAN01.txt*l-Alanine! [C]

General reaction: Remove sulfur and selenium atoms [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278392; 9278503; 10829016; 10739946 [H]