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The map label for this gene is map [H]

Identifier: 157372026

GI number: 157372026

Start: 4191046

End: 4191840

Strand: Direct

Name: map [H]

Synonym: Spro_3791

Alternate gene names: 157372026

Gene position: 4191046-4191840 (Clockwise)

Preceding gene: 157372007

Following gene: 157372027

Centisome position: 76.92

GC content: 54.72

Gene sequence:

>795_bases
ATGGCAATCTCAATTAAAACACCTGATGACATCCAAAAAATGCGCGTGGCCGGCCGACTGGCTGCCGAAGTGCTGGAAAT
CATTGAGCCGCACGTCAAACCTGGCGTGACCACCGGCGAACTCGATCGTATCTGTCACGATCACATCACCAACCAGCAGC
AGGCGATCTCTGCCTGTCTGGGCTACCACGGTTTCCCGAAATCCGTGTGTATCTCGGTGAATGAAGTGGTCTGCCACGGC
ATCCCGAGCGATGACAAGGTCCTGAAAGACGGCGACATCGTTAATATCGACGTTACCGTCATCAAAGACGGTTTCCACGG
TGATACTTCTAAAATGTTCATCGCCGGTAAACCGACCATTCTGGGCGAGCGCCTGTGCCGCATCACTCAGGAAAGCCTGT
ATCTGTCGCTGAAAATGGTGAAGCCGGGTATCCGCCTGCGCACGCTGGGCAAAGAGATCCAGAAATTCGTCGAGGCCGAG
AATTTCTCGGTGGTTCGCGAGTACTGCGGCCACGGCATTGGCGAGGTGTTCCACGAGGAACCACAGGTGCTGCACTATGA
CGCTGACGACGGCGGCGTGGTGCTGCAGGCTGGTATGGCCTTCACCATCGAGCCGATGGTCAATGCCGGTGATTACCGCA
TTCGCACCATGAAAGACGGCTGGACGGTAAAAACCAAAGATCGCAGCTTGTCGGCGCAGTATGAGCATACTATTGTGGTC
ACGGATAACGGCTGCGAGATAATGACGTTGCGCAAGGATGACACCATCCCCAACATCATTACGCACGAGATGTAA

Upstream 100 bases:

>100_bases
AGAAATCAAATTTGGCAGCCTCAGGCCGGGCTGATACCATAAGAGACTGCTTCTTATTTCTTTCTGTTGTCGGCGAGCAC
GACACCTGCGGACGAATTTC

Downstream 100 bases:

>100_bases
GCACCGCGGCGTTTTGCCGCGATGCATGATGTCACAGGCCGGCTTTTGCCGGCCTTTTTTATGGGCTGCGTATTATGTCT
GAAAACTTTCGCCAACAAGA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MAISIKTPDDIQKMRVAGRLAAEVLEIIEPHVKPGVTTGELDRICHDHITNQQQAISACLGYHGFPKSVCISVNEVVCHG
IPSDDKVLKDGDIVNIDVTVIKDGFHGDTSKMFIAGKPTILGERLCRITQESLYLSLKMVKPGIRLRTLGKEIQKFVEAE
NFSVVREYCGHGIGEVFHEEPQVLHYDADDGGVVLQAGMAFTIEPMVNAGDYRIRTMKDGWTVKTKDRSLSAQYEHTIVV
TDNGCEIMTLRKDDTIPNIITHEM

Sequences:

>Translated_264_residues
MAISIKTPDDIQKMRVAGRLAAEVLEIIEPHVKPGVTTGELDRICHDHITNQQQAISACLGYHGFPKSVCISVNEVVCHG
IPSDDKVLKDGDIVNIDVTVIKDGFHGDTSKMFIAGKPTILGERLCRITQESLYLSLKMVKPGIRLRTLGKEIQKFVEAE
NFSVVREYCGHGIGEVFHEEPQVLHYDADDGGVVLQAGMAFTIEPMVNAGDYRIRTMKDGWTVKTKDRSLSAQYEHTIVV
TDNGCEIMTLRKDDTIPNIITHEM
>Mature_263_residues
AISIKTPDDIQKMRVAGRLAAEVLEIIEPHVKPGVTTGELDRICHDHITNQQQAISACLGYHGFPKSVCISVNEVVCHGI
PSDDKVLKDGDIVNIDVTVIKDGFHGDTSKMFIAGKPTILGERLCRITQESLYLSLKMVKPGIRLRTLGKEIQKFVEAEN
FSVVREYCGHGIGEVFHEEPQVLHYDADDGGVVLQAGMAFTIEPMVNAGDYRIRTMKDGWTVKTKDRSLSAQYEHTIVVT
DNGCEIMTLRKDDTIPNIITHEM

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=260, Percent_Identity=45.7692307692308, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=39.9193548387097, Blast_Score=194, Evalue=5e-50,
Organism=Escherichia coli, GI1786364, Length=263, Percent_Identity=83.6501901140685, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71996291, Length=250, Percent_Identity=45.2, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6323273, Length=251, Percent_Identity=47.0119521912351, Blast_Score=228, Evalue=5e-61,
Organism=Drosophila melanogaster, GI21355531, Length=247, Percent_Identity=45.3441295546559, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=41.2244897959184, Blast_Score=197, Evalue=5e-51,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29316; Mature: 29185

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISIKTPDDIQKMRVAGRLAAEVLEIIEPHVKPGVTTGELDRICHDHITNQQQAISACL
CEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
GYHGFPKSVCISVNEVVCHGIPSDDKVLKDGDIVNIDVTVIKDGFHGDTSKMFIAGKPTI
CCCCCCHHHEEEECHHEECCCCCCCCEECCCCEEEEEEEEEECCCCCCCCEEEEECCCCH
LGERLCRITQESLYLSLKMVKPGIRLRTLGKEIQKFVEAENFSVVREYCGHGIGEVFHEE
HHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCC
PQVLHYDADDGGVVLQAGMAFTIEPMVNAGDYRIRTMKDGWTVKTKDRSLSAQYEHTIVV
CCEEEEECCCCCEEEECCCEEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCEEEEEEE
TDNGCEIMTLRKDDTIPNIITHEM
ECCCCEEEEEECCCCCCCHHCCCC
>Mature Secondary Structure 
AISIKTPDDIQKMRVAGRLAAEVLEIIEPHVKPGVTTGELDRICHDHITNQQQAISACL
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
GYHGFPKSVCISVNEVVCHGIPSDDKVLKDGDIVNIDVTVIKDGFHGDTSKMFIAGKPTI
CCCCCCHHHEEEECHHEECCCCCCCCEECCCCEEEEEEEEEECCCCCCCCEEEEECCCCH
LGERLCRITQESLYLSLKMVKPGIRLRTLGKEIQKFVEAENFSVVREYCGHGIGEVFHEE
HHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCC
PQVLHYDADDGGVVLQAGMAFTIEPMVNAGDYRIRTMKDGWTVKTKDRSLSAQYEHTIVV
CCEEEEECCCCCEEEECCCEEEEEECCCCCCEEEEEECCCCEEEECCCCCCCCEEEEEEE
TDNGCEIMTLRKDDTIPNIITHEM
ECCCCEEEEEECCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]