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The map label for this gene is trxC [H]

Identifier: 157371981

GI number: 157371981

Start: 4136321

End: 4136740

Strand: Direct

Name: trxC [H]

Synonym: Spro_3746

Alternate gene names: 157371981

Gene position: 4136321-4136740 (Clockwise)

Preceding gene: 157371979

Following gene: 157371982

Centisome position: 75.91

GC content: 56.67

Gene sequence:

>420_bases
ATGAATACAGTTTGTCCAGCTTGTAATGCCACCAACCGCGTGCCTGAAGAACGAGTGGCTGACGGCGCGAAATGCGGCCG
TTGCGGCCATGCGCTCTTTGACGGCGAGGTGATCAACGCCACCGCCGCCACACTGGACTCGTTGTTGCAGGATGGTCTGC
CAGTGGTGGTCGATTTTTGGGCGCCATGGTGCGGCCCCTGCGTCAGTTTTGCCCCGATCTTTGAAGACGTCGCCGAAGAG
CGCGCCGGCAAAGTTCGCTTCGTTAAAGTCAACACCGAGGCAGAACCCGAACTGAGCGCCCGTTTCCGCATCCGCAGCAT
TCCAACCATTATGCTGTTCCGCGAAGGGAAAATGGTCGACATGCTCAACGGTGCTATGCCGAAAACGCCGTTCGATAACT
GGCTCAATGAACTAGTTTAA

Upstream 100 bases:

>100_bases
TTGTCCATTGCCCTACTTTTAACGATAATAAGCAGCATTAAAGATACATATCCGCAACCCGAGTGCGGCATGTCGTGCAT
TCTCAGTATCCGAGGTCATC

Downstream 100 bases:

>100_bases
CGCAGAAAGTCTATACCCGTCGCCTTTCAATAGGCGGTGTTGTCCATTGCCCGTGACACCGCCGTGACGCAATCCAGCCC
GAACGCTCCCGTCGGGCTTT

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MNTVCPACNATNRVPEERVADGAKCGRCGHALFDGEVINATAATLDSLLQDGLPVVVDFWAPWCGPCVSFAPIFEDVAEE
RAGKVRFVKVNTEAEPELSARFRIRSIPTIMLFREGKMVDMLNGAMPKTPFDNWLNELV

Sequences:

>Translated_139_residues
MNTVCPACNATNRVPEERVADGAKCGRCGHALFDGEVINATAATLDSLLQDGLPVVVDFWAPWCGPCVSFAPIFEDVAEE
RAGKVRFVKVNTEAEPELSARFRIRSIPTIMLFREGKMVDMLNGAMPKTPFDNWLNELV
>Mature_139_residues
MNTVCPACNATNRVPEERVADGAKCGRCGHALFDGEVINATAATLDSLLQDGLPVVVDFWAPWCGPCVSFAPIFEDVAEE
RAGKVRFVKVNTEAEPELSARFRIRSIPTIMLFREGKMVDMLNGAMPKTPFDNWLNELV

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758304, Length=100, Percent_Identity=34, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=30.8510638297872, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788936, Length=137, Percent_Identity=76.6423357664234, Blast_Score=230, Evalue=2e-62,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=36.8932038834951, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=111, Percent_Identity=28.8288288288288, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115532378, Length=67, Percent_Identity=43.2835820895522, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=78, Percent_Identity=39.7435897435897, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17544108, Length=102, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=71, Percent_Identity=38.0281690140845, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=104, Percent_Identity=31.7307692307692, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=104, Percent_Identity=31.7307692307692, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=104, Percent_Identity=31.7307692307692, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=88, Percent_Identity=31.8181818181818, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=37.037037037037, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=87, Percent_Identity=35.632183908046, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=36.3636363636364, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573567, Length=86, Percent_Identity=36.046511627907, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647799, Length=91, Percent_Identity=35.1648351648352, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921434, Length=100, Percent_Identity=37, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15287; Mature: 15287

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVCPACNATNRVPEERVADGAKCGRCGHALFDGEVINATAATLDSLLQDGLPVVVDFW
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEHH
APWCGPCVSFAPIFEDVAEERAGKVRFVKVNTEAEPELSARFRIRSIPTIMLFREGKMVD
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHEECCCCCEEEEEECCCCHH
MLNGAMPKTPFDNWLNELV
HHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MNTVCPACNATNRVPEERVADGAKCGRCGHALFDGEVINATAATLDSLLQDGLPVVVDFW
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCEEEEHH
APWCGPCVSFAPIFEDVAEERAGKVRFVKVNTEAEPELSARFRIRSIPTIMLFREGKMVD
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHEECCCCCEEEEEECCCCHH
MLNGAMPKTPFDNWLNELV
HHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]