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The map label for this gene is hscB

Identifier: 157371859

GI number: 157371859

Start: 4010383

End: 4010904

Strand: Reverse

Name: hscB

Synonym: Spro_3624

Alternate gene names: 157371859

Gene position: 4010904-4010383 (Counterclockwise)

Preceding gene: 157371860

Following gene: 157371858

Centisome position: 73.61

GC content: 52.87

Gene sequence:

>522_bases
ATGGATTACTTTACTTTATTCGGGCTGCCAGTTCGCTATCCCGTGGACGGCAGCCTGCTTGCTTCTCGCTATCAGGATCT
GCAGCGCCAATTCCATCCCGATCGTTTTGCAAGTCAGCCAGAACGCGAACGCCTGATGGCGTTGCAACAGGCAGCGACTA
TCAATGAAGCCTACCAAACGCTGAAGCACCCATTAAAACGCGCGGAGTATATGCTATCTTTGCACGGCTTTGATTTGGGC
AACGAGCAGCACACTATGCGTGATACCGCGTTCCTGATGGAACAGTTGGAACTGCGCGAGGAGCTCGACGCCATTGAGCG
CAAAGCAGATGCACAAACCCAGTTGGCCAGCTTTGGCGCGCGGGTGAACGAGACGGTCAAACAACGCAGCGCTCTGATGA
TTCAGCAACTCGATAGCCAGCAGTGGATGGATGCCGCTGACACCGTGCGTAAGCTGCGTTTTTTGGACAAACTCCAGCAA
CAGGTTGAACAACTCGAAGAAAAACTGCTGGGTTTTGAGTAA

Upstream 100 bases:

>100_bases
AAGCGAGTGTGGCTGCGGCGAAAGTTTCAACGTCTGACAGTCCATCGTGCTCCCCCGCCAGGTGCGGGGGAACTTCATCC
GATAACGCCCAGAGCACGCT

Downstream 100 bases:

>100_bases
CACATTTTTGCTTGTGGAAGCTTCAATATGGCCTTATTACAAATTAGTGAGCCCGGCCTCAGCGCTGCGCCGCACCAGCG
CCGTCTGGCTGCCGGTATTG

Product: co-chaperone HscB

Products: NA

Alternate protein names: Hsc20

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MDYFTLFGLPVRYPVDGSLLASRYQDLQRQFHPDRFASQPERERLMALQQAATINEAYQTLKHPLKRAEYMLSLHGFDLG
NEQHTMRDTAFLMEQLELREELDAIERKADAQTQLASFGARVNETVKQRSALMIQQLDSQQWMDAADTVRKLRFLDKLQQ
QVEQLEEKLLGFE

Sequences:

>Translated_173_residues
MDYFTLFGLPVRYPVDGSLLASRYQDLQRQFHPDRFASQPERERLMALQQAATINEAYQTLKHPLKRAEYMLSLHGFDLG
NEQHTMRDTAFLMEQLELREELDAIERKADAQTQLASFGARVNETVKQRSALMIQQLDSQQWMDAADTVRKLRFLDKLQQ
QVEQLEEKLLGFE
>Mature_173_residues
MDYFTLFGLPVRYPVDGSLLASRYQDLQRQFHPDRFASQPERERLMALQQAATINEAYQTLKHPLKRAEYMLSLHGFDLG
NEQHTMRDTAFLMEQLELREELDAIERKADAQTQLASFGARVNETVKQRSALMIQQLDSQQWMDAADTVRKLRFLDKLQQ
QVEQLEEKLLGFE

Specific function: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward hscA

COG id: COG1076

COG function: function code O; DnaJ-domain-containing proteins 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 J domain

Homologues:

Organism=Homo sapiens, GI50301234, Length=162, Percent_Identity=29.0123456790123, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1788876, Length=172, Percent_Identity=66.2790697674419, Blast_Score=228, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17541320, Length=142, Percent_Identity=26.056338028169, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161084223, Length=171, Percent_Identity=25.7309941520468, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSCB_SERP5 (A8GHY0)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479848.1
- ProteinModelPortal:   A8GHY0
- SMR:   A8GHY0
- STRING:   A8GHY0
- GeneID:   5605948
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3624
- eggNOG:   COG1076
- HOGENOM:   HBG751004
- OMA:   LNDAYQT
- ProtClustDB:   PRK05014
- BioCyc:   SPRO399741:SPRO_3624-MONOMER
- HAMAP:   MF_00682
- InterPro:   IPR001623
- InterPro:   IPR009073
- InterPro:   IPR004640
- InterPro:   IPR015609
- Gene3D:   G3DSA:1.10.287.110
- Gene3D:   G3DSA:1.20.1280.20
- PANTHER:   PTHR11821
- SMART:   SM00271
- TIGRFAMs:   TIGR00714

Pfam domain/function: PF00226 DnaJ; PF07743 HSCB_C; SSF46565 DnaJ_N; SSF47144 HSC20_C

EC number: NA

Molecular weight: Translated: 20265; Mature: 20265

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00636 DNAJ_1; PS50076 DNAJ_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYFTLFGLPVRYPVDGSLLASRYQDLQRQFHPDRFASQPERERLMALQQAATINEAYQT
CCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
LKHPLKRAEYMLSLHGFDLGNEQHTMRDTAFLMEQLELREELDAIERKADAQTQLASFGA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVNETVKQRSALMIQQLDSQQWMDAADTVRKLRFLDKLQQQVEQLEEKLLGFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDYFTLFGLPVRYPVDGSLLASRYQDLQRQFHPDRFASQPERERLMALQQAATINEAYQT
CCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
LKHPLKRAEYMLSLHGFDLGNEQHTMRDTAFLMEQLELREELDAIERKADAQTQLASFGA
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVNETVKQRSALMIQQLDSQQWMDAADTVRKLRFLDKLQQQVEQLEEKLLGFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA