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The map label for this gene is ndk [H]

Identifier: 157371848

GI number: 157371848

Start: 3992804

End: 3993229

Strand: Reverse

Name: ndk [H]

Synonym: Spro_3613

Alternate gene names: 157371848

Gene position: 3993229-3992804 (Counterclockwise)

Preceding gene: 157371849

Following gene: 157371847

Centisome position: 73.29

GC content: 52.35

Gene sequence:

>426_bases
ATGACCGTAGAACGTACCTTTTCCATCATTAAACCAAACGCTGTAGCTAACAACGACATCGGCGCAATCTATGCTCGCTT
TGAGCGTGCCGGTTTCAAAATCATCGCATCCAAAATGCTGCGTCTGACTCGCGAACAAGCCGAAGGCTTCTACGCTGAGC
ACAAAGGTCGCCCATTCTTCGATGGCCTGGTTGAGTTCATGACCTCTGGCCCGATCGTGGTTCAGGTTCTGGAAGCAGAA
AACGCAGTACAGCGTAACCGTGACATCATGGGCGCAACCAACCCGGACAACGCACTGGCTGGCACCCTGCGTGCTGACTA
CGCGGACAGCTTCACTGCCAACGCCGTACACGGTTCTGATGCAGTAGAATCTGCACAGCGCGAAATCGCGTATTTCTTTA
ATGAGAGCGAAATCTGCTCACGTTAA

Upstream 100 bases:

>100_bases
GTAGGCAAGCGTTGGCAGCACACATATAATCTGCGCCACTTGAGAAGGCCGGCACCCTGTTTGCAGACCGGCCTGTTTTG
GAAGTTATACAGAGGCCATC

Downstream 100 bases:

>100_bases
TTTGCTCGTCGCCTTTCAAGCTGTAGGGGGCGATATATTCGCCCCGATTGGCTCAGGCGCAGCATGCAGCGCCGCTACTC
GAATTTTTCATTCATCGGCT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MTVERTFSIIKPNAVANNDIGAIYARFERAGFKIIASKMLRLTREQAEGFYAEHKGRPFFDGLVEFMTSGPIVVQVLEAE
NAVQRNRDIMGATNPDNALAGTLRADYADSFTANAVHGSDAVESAQREIAYFFNESEICSR

Sequences:

>Translated_141_residues
MTVERTFSIIKPNAVANNDIGAIYARFERAGFKIIASKMLRLTREQAEGFYAEHKGRPFFDGLVEFMTSGPIVVQVLEAE
NAVQRNRDIMGATNPDNALAGTLRADYADSFTANAVHGSDAVESAQREIAYFFNESEICSR
>Mature_140_residues
TVERTFSIIKPNAVANNDIGAIYARFERAGFKIIASKMLRLTREQAEGFYAEHKGRPFFDGLVEFMTSGPIVVQVLEAEN
AVQRNRDIMGATNPDNALAGTLRADYADSFTANAVHGSDAVESAQREIAYFFNESEICSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=43.3823529411765, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=43.3823529411765, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=43.3823529411765, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=43.3823529411765, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=43.3823529411765, Blast_Score=130, Evalue=4e-31,
Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=44.4444444444444, Blast_Score=128, Evalue=1e-30,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=41.1764705882353, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=41.1764705882353, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=37.8571428571429, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI37574614, Length=144, Percent_Identity=34.7222222222222, Blast_Score=93, Evalue=9e-20,
Organism=Homo sapiens, GI7019465, Length=144, Percent_Identity=34.7222222222222, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=37.956204379562, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI4505413, Length=139, Percent_Identity=36.6906474820144, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=35.5555555555556, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI148839372, Length=139, Percent_Identity=30.9352517985612, Blast_Score=73, Evalue=9e-14,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=78.0141843971631, Blast_Score=233, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=43.7037037037037, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=42.6470588235294, Blast_Score=130, Evalue=6e-32,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=47.4452554744526, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI18860097, Length=140, Percent_Identity=37.8571428571429, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15601; Mature: 15469

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVERTFSIIKPNAVANNDIGAIYARFERAGFKIIASKMLRLTREQAEGFYAEHKGRPFF
CCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHH
DGLVEFMTSGPIVVQVLEAENAVQRNRDIMGATNPDNALAGTLRADYADSFTANAVHGSD
HHHHHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCH
AVESAQREIAYFFNESEICSR
HHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
TVERTFSIIKPNAVANNDIGAIYARFERAGFKIIASKMLRLTREQAEGFYAEHKGRPFF
CCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHH
DGLVEFMTSGPIVVQVLEAENAVQRNRDIMGATNPDNALAGTLRADYADSFTANAVHGSD
HHHHHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCH
AVESAQREIAYFFNESEICSR
HHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]