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The map label for this gene is mdtD

Identifier: 157371790

GI number: 157371790

Start: 3931750

End: 3933183

Strand: Direct

Name: mdtD

Synonym: Spro_3555

Alternate gene names: 157371790

Gene position: 3931750-3933183 (Clockwise)

Preceding gene: 157371789

Following gene: 157371791

Centisome position: 72.16

GC content: 60.74

Gene sequence:

>1434_bases
ATGCTTATAAAACACACCGCCTCGGTACAGTGGCAACTCTGGATTGTGGCATTCGGCTTTTTTATGCAGACGCTGGACAC
CACCATCGTCAACACCGCCCTGCCGTCGATGGCCGTCAGCCTGGGAGAGAACCCGCTGCGCATGCAGTCGGTGATCGTCT
CCTATGTGCTGACGGTGGCAGTAATGTTGCCTGCCAGCGGCTGGCTGGCGGATCGGGTTGGCGTCCAGCGAGTGTTCTTC
AGCGCCATCGTGCTGTTCACTCTGGGATCGATCCTGTGTGCCCGTTCCGAAACGCTGAACGAACTGATCGCCTCACGCGT
GGTTCAGGGTATCGGGGGCGCAATGATGGTGCCGGTCGGTCGGTTGACGGTGATGAAAATCGTCCCGCGCGAACAGTATA
TGGCGGCGATGACCTTCGTCACCCTGCCCGGCCAAATCGGCCCGCTGATGGGGCCGGCGCTGGGTGGTTTTTTGGTGCAG
TACGCCAGCTGGCACTGGATTTTCCTGATTAATATTCCGGTGGGGATCGCCGGGGCCATCGCCACGCTGCTGCTAATGCC
CAACTACCGCATGCAGACCCGGCGCTTCGACATCAGCGGCTTTATCCTGCTGGCAGTCGGGATGGCGACGCTGACGCTGG
CGCTTGACGGCCACAAAGGCATGGGGCTATCCGCTACCGCCATCGCCGGGCTGGTGGTGGCTGGCGTAGCGGCGCTAGCG
GGATACTGGTGGCATGCACACGGCAACAGCCGGGCCCTGTTCTCGCTGCGGCTGTTCAAAACCCGGACCTATAAGGTCGG
GCTGACAGCCAGCCTGCTGGGCCGTATCGGCAGCGGCATGCTGCCGTTTATGACACCGCTGTTTATGCAGGTCGGGATGG
GCTTTTCCCCGTTCCACGCCGGGCTGATGATGATCCCGATGATCATCGGCAGCATGGGGATGAAACGCATAGTGGTGCGC
GTGGTTAACCGTTTTGGGTACCGCAACGTGCTGGTAGCCGCGACGCTGATGCTGGCGCTGATCAGCCTGAGTTTCCCGCT
GGTGGCCATGCTCGGCTGGATCTGGCTGCTGCCGGTGGTGCTGTTCTTCCAGGGCATGGTTAACTCACTGCGCTTCTCGG
CGATGAATACCCTGACGCTGAAAGATTTACCGGACCGGTTGGCCAGCAGCGGCAACAGCCTGCTGTCGATGGTGATGCAA
CTGTCGATGAGCCTTGGCGTCAGTATCGCCGGTATTCTGATCGGCAGCTTCGCCCATCATCAGGTGGTCACCGACAGCCC
GGCTATCCACAGCGCGTTTATTTACAGCTACTGCTGCATGGCATTAATCATCGCCCTGCCCGCGTTGGCCTTCGCCCGCG
TCCCGGCTGATACCACCACTAACCGCACGCTGACCAAAGAGCCGGGCACAGGCTCCACGAGGTTGCAACAATGA

Upstream 100 bases:

>100_bases
CTCTACACCACCCCGGTGGTTTACCTGTATTTTGACCGGCTGCAGATGAAATTCCGTCGCGGCAAGAAACTGGATCCTTT
GCCCCAATAATGGCTGATTG

Downstream 100 bases:

>100_bases
AAATAGGCATTACCGGTAAACTGTTCATGGCGATTTTCGCCACCTGCATGCTGGTGTTAATCACCATGCACTGGGGTGTG
CGTGTCAGCTTCGAACGCGG

Product: multidrug efflux system protein MdtE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MLIKHTASVQWQLWIVAFGFFMQTLDTTIVNTALPSMAVSLGENPLRMQSVIVSYVLTVAVMLPASGWLADRVGVQRVFF
SAIVLFTLGSILCARSETLNELIASRVVQGIGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQIGPLMGPALGGFLVQ
YASWHWIFLINIPVGIAGAIATLLLMPNYRMQTRRFDISGFILLAVGMATLTLALDGHKGMGLSATAIAGLVVAGVAALA
GYWWHAHGNSRALFSLRLFKTRTYKVGLTASLLGRIGSGMLPFMTPLFMQVGMGFSPFHAGLMMIPMIIGSMGMKRIVVR
VVNRFGYRNVLVAATLMLALISLSFPLVAMLGWIWLLPVVLFFQGMVNSLRFSAMNTLTLKDLPDRLASSGNSLLSMVMQ
LSMSLGVSIAGILIGSFAHHQVVTDSPAIHSAFIYSYCCMALIIALPALAFARVPADTTTNRTLTKEPGTGSTRLQQ

Sequences:

>Translated_477_residues
MLIKHTASVQWQLWIVAFGFFMQTLDTTIVNTALPSMAVSLGENPLRMQSVIVSYVLTVAVMLPASGWLADRVGVQRVFF
SAIVLFTLGSILCARSETLNELIASRVVQGIGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQIGPLMGPALGGFLVQ
YASWHWIFLINIPVGIAGAIATLLLMPNYRMQTRRFDISGFILLAVGMATLTLALDGHKGMGLSATAIAGLVVAGVAALA
GYWWHAHGNSRALFSLRLFKTRTYKVGLTASLLGRIGSGMLPFMTPLFMQVGMGFSPFHAGLMMIPMIIGSMGMKRIVVR
VVNRFGYRNVLVAATLMLALISLSFPLVAMLGWIWLLPVVLFFQGMVNSLRFSAMNTLTLKDLPDRLASSGNSLLSMVMQ
LSMSLGVSIAGILIGSFAHHQVVTDSPAIHSAFIYSYCCMALIIALPALAFARVPADTTTNRTLTKEPGTGSTRLQQ
>Mature_477_residues
MLIKHTASVQWQLWIVAFGFFMQTLDTTIVNTALPSMAVSLGENPLRMQSVIVSYVLTVAVMLPASGWLADRVGVQRVFF
SAIVLFTLGSILCARSETLNELIASRVVQGIGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQIGPLMGPALGGFLVQ
YASWHWIFLINIPVGIAGAIATLLLMPNYRMQTRRFDISGFILLAVGMATLTLALDGHKGMGLSATAIAGLVVAGVAALA
GYWWHAHGNSRALFSLRLFKTRTYKVGLTASLLGRIGSGMLPFMTPLFMQVGMGFSPFHAGLMMIPMIIGSMGMKRIVVR
VVNRFGYRNVLVAATLMLALISLSFPLVAMLGWIWLLPVVLFFQGMVNSLRFSAMNTLTLKDLPDRLASSGNSLLSMVMQ
LSMSLGVSIAGILIGSFAHHQVVTDSPAIHSAFIYSYCCMALIIALPALAFARVPADTTTNRTLTKEPGTGSTRLQQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family

Homologues:

Organism=Escherichia coli, GI1788392, Length=460, Percent_Identity=74.7826086956522, Blast_Score=651, Evalue=0.0,
Organism=Escherichia coli, GI1790195, Length=457, Percent_Identity=44.8577680525164, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1788710, Length=438, Percent_Identity=29.6803652968037, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1789042, Length=417, Percent_Identity=29.7362110311751, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87081983, Length=314, Percent_Identity=28.0254777070064, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788509, Length=136, Percent_Identity=30.8823529411765, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=174, Percent_Identity=25.8620689655172, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=126, Percent_Identity=31.7460317460317, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323735, Length=164, Percent_Identity=26.219512195122, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319770, Length=282, Percent_Identity=26.5957446808511, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=26.6666666666667, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MDTD_SERP5 (A8GHR1)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479779.1
- ProteinModelPortal:   A8GHR1
- STRING:   A8GHR1
- GeneID:   5605457
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3555
- eggNOG:   COG0477
- HOGENOM:   HBG679341
- OMA:   CARSETL
- ProtClustDB:   PRK10504
- BioCyc:   SPRO399741:SPRO_3555-MONOMER
- HAMAP:   MF_01577
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411
- PRINTS:   PR01036

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 51514; Mature: 51514

Theoretical pI: Translated: 11.05; Mature: 11.05

Prosite motif: PS50850 MFS; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xed358ec)-; HASH(0x11182e4c)-; HASH(0x11187dec)-; HASH(0x1118a084)-; HASH(0x1116dcb8)-; HASH(0x11187ea0)-; HASH(0xea882d4)-; HASH(0x11187bb8)-; HASH(0x10e3bec4)-; HASH(0x107c7250)-; HASH(0x408e5ce4)-; HASH(0x11187cb4)-; HASH(0x11185714)-; HASH(0x10caa830)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.7 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.7 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKHTASVQWQLWIVAFGFFMQTLDTTIVNTALPSMAVSLGENPLRMQSVIVSYVLTVA
CCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VMLPASGWLADRVGVQRVFFSAIVLFTLGSILCARSETLNELIASRVVQGIGGAMMVPVG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
RLTVMKIVPREQYMAAMTFVTLPGQIGPLMGPALGGFLVQYASWHWIFLINIPVGIAGAI
HHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHH
ATLLLMPNYRMQTRRFDISGFILLAVGMATLTLALDGHKGMGLSATAIAGLVVAGVAALA
HHHHHCCCCCHHHHEECCCHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHH
GYWWHAHGNSRALFSLRLFKTRTYKVGLTASLLGRIGSGMLPFMTPLFMQVGMGFSPFHA
HHHEEECCCCCEEEEEEEHHEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHH
GLMMIPMIIGSMGMKRIVVRVVNRFGYRNVLVAATLMLALISLSFPLVAMLGWIWLLPVV
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFFQGMVNSLRFSAMNTLTLKDLPDRLASSGNSLLSMVMQLSMSLGVSIAGILIGSFAHH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHC
QVVTDSPAIHSAFIYSYCCMALIIALPALAFARVPADTTTNRTLTKEPGTGSTRLQQ
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCH
>Mature Secondary Structure
MLIKHTASVQWQLWIVAFGFFMQTLDTTIVNTALPSMAVSLGENPLRMQSVIVSYVLTVA
CCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VMLPASGWLADRVGVQRVFFSAIVLFTLGSILCARSETLNELIASRVVQGIGGAMMVPVG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
RLTVMKIVPREQYMAAMTFVTLPGQIGPLMGPALGGFLVQYASWHWIFLINIPVGIAGAI
HHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHH
ATLLLMPNYRMQTRRFDISGFILLAVGMATLTLALDGHKGMGLSATAIAGLVVAGVAALA
HHHHHCCCCCHHHHEECCCHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHH
GYWWHAHGNSRALFSLRLFKTRTYKVGLTASLLGRIGSGMLPFMTPLFMQVGMGFSPFHA
HHHEEECCCCCEEEEEEEHHEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHH
GLMMIPMIIGSMGMKRIVVRVVNRFGYRNVLVAATLMLALISLSFPLVAMLGWIWLLPVV
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFFQGMVNSLRFSAMNTLTLKDLPDRLASSGNSLLSMVMQLSMSLGVSIAGILIGSFAHH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHC
QVVTDSPAIHSAFIYSYCCMALIIALPALAFARVPADTTTNRTLTKEPGTGSTRLQQ
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA