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The map label for this gene is lysN [H]

Identifier: 157371584

GI number: 157371584

Start: 3703202

End: 3704704

Strand: Direct

Name: lysN [H]

Synonym: Spro_3347

Alternate gene names: 157371584

Gene position: 3703202-3704704 (Clockwise)

Preceding gene: 157371581

Following gene: 157371589

Centisome position: 67.96

GC content: 59.21

Gene sequence:

>1503_bases
ATGGGGTATAGTAAAAAGTGCCACCAACTACCGAGCCAATTTTGCATGCATATTCCGTTAGACCGTCAGCAGGATGTTCC
GCTGTATCTGCAAATTGAGGAGGCGTTGCGGCGGGCAATCCTGAGCGGCGTATTTGTTGATGGTGACAAACTGCCCTCCA
CGCGCCAGCTTGCCGGCGAATTGGCCGTCAGCCGGTTGACGGTGGACAACGCCTATGCCGAATTGGCAGCCAAAGGCTTT
TTACGCCAGCGACGCGGCAGCGGTGCCTATGTCCAGCACCCGCTGGCACAGCCCGCACAGCCACAACCGGCAACCGATGT
CCCTTTCCCGGCGGAGCGTTTTACCACCCTGACCTCACGGCTGGATGGTTACCCCGATATCCCGCTGCCGGACAGCATCA
TCAACTTTGCTGCCGGTGTCGGCAGTCCGAAAGTTTTCCCACAGGAAGAGTTCCGCAAGATCTTGCTGTCGGTGCTCAGC
CGCCATGCGGAAGAGGCTTTCAGCTATGGCGAATACTGTGGCTACTACCCGCTGCGCGATACGCTGGGGCGGATCCTCAC
CGCGCAGGGCATTCCGACCCATGCGGAACAATTGCTGATCACCAACGGTTCACAACACGCCATCAGCCTGATTGTGCAAA
GCCTACTGGAGCCGGGCGATACGGTGATCGTCGAACAGCCGACCTACGCCGAAGCCCTGGGGCTACTGCGCCTGCACCGC
ATCAATATTGTCACCATTCCCAGCGATCGGCACGGCATGCTGGTTGACCAACTGCCAGCCCTGCTGGAAAAACACCGGCC
GAAGCTGATTTACACCATCCCCAATTTCCATAACCCTACCGGGCGCTGCATGAGTGAAGCCCGGCGGCGTCGCCTGTTGG
CACTGGCTCAGCATGCCGGGGTGGTGATCCTCGAGGACGATTTTGTCGGCGATTTGCGCTACAACGGCAAGCAATTGCCC
TCGCTGCGGGCGCTTGCGCAGCCGGGGGCGGTGATTTATGTCAGCACATTTTCCAAAATGCTGTTGCCCAGCATGCGCAT
CGGCTATCTGGTGGCGGACAGCGAACACTATCAATGCATCGCCCGATTGAAACACGTCGACAGTTTTACCAGTTCCAATC
TGATCCAGCGCGCGCTGGACGCCTTCGTCACCATCGGGCGCTACGACAAGCAACTGCGGCGTGCCGGACGAGTCTATCGC
CAGCACCGGGATGTGATGGTCGCTGCATTACAGCAGCAACTGCCGCCAGGCTGCCGGTTTGAAACGCCGGAGGGCGGACT
GTTTATCTGGCTGACGCTGCCCGCCGCCGTTAGCACCGAAGCACTGATGCCGGTGGCCTGGCGAGAAGGCGTAACTTTTG
CGCGCGGAGAGTGTTTTTATGCCGAGGAACAGCGTGGCGCGCACGGCCTGCGATTGAATTTCGCCGCCAACACGCCGCCG
CTGATTGAAGAAGGTATCGCCCGGCTGTGCCGGGCGATTAGTCAGGTGATAGATTCAGAATAA

Upstream 100 bases:

>100_bases
AGACTCAGGCAGAGATTCTAACGCCGCGCGATTTTGCCGCCAGAGCCACTTTCCCCCGATGTTATACAGGCCACTTTTAT
CCGCTTGAAGGCCTGCTGCT

Downstream 100 bases:

>100_bases
ACCGGTGATTACAGCCCGGCCCACCACAGCCGCAGCTTCATGCCCCAATAGCTGGTCCAGCCGGTGGTGCTCTGCACCAC
CTGGCCTTTGGAGATAATCA

Product: transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MGYSKKCHQLPSQFCMHIPLDRQQDVPLYLQIEEALRRAILSGVFVDGDKLPSTRQLAGELAVSRLTVDNAYAELAAKGF
LRQRRGSGAYVQHPLAQPAQPQPATDVPFPAERFTTLTSRLDGYPDIPLPDSIINFAAGVGSPKVFPQEEFRKILLSVLS
RHAEEAFSYGEYCGYYPLRDTLGRILTAQGIPTHAEQLLITNGSQHAISLIVQSLLEPGDTVIVEQPTYAEALGLLRLHR
INIVTIPSDRHGMLVDQLPALLEKHRPKLIYTIPNFHNPTGRCMSEARRRRLLALAQHAGVVILEDDFVGDLRYNGKQLP
SLRALAQPGAVIYVSTFSKMLLPSMRIGYLVADSEHYQCIARLKHVDSFTSSNLIQRALDAFVTIGRYDKQLRRAGRVYR
QHRDVMVAALQQQLPPGCRFETPEGGLFIWLTLPAAVSTEALMPVAWREGVTFARGECFYAEEQRGAHGLRLNFAANTPP
LIEEGIARLCRAISQVIDSE

Sequences:

>Translated_500_residues
MGYSKKCHQLPSQFCMHIPLDRQQDVPLYLQIEEALRRAILSGVFVDGDKLPSTRQLAGELAVSRLTVDNAYAELAAKGF
LRQRRGSGAYVQHPLAQPAQPQPATDVPFPAERFTTLTSRLDGYPDIPLPDSIINFAAGVGSPKVFPQEEFRKILLSVLS
RHAEEAFSYGEYCGYYPLRDTLGRILTAQGIPTHAEQLLITNGSQHAISLIVQSLLEPGDTVIVEQPTYAEALGLLRLHR
INIVTIPSDRHGMLVDQLPALLEKHRPKLIYTIPNFHNPTGRCMSEARRRRLLALAQHAGVVILEDDFVGDLRYNGKQLP
SLRALAQPGAVIYVSTFSKMLLPSMRIGYLVADSEHYQCIARLKHVDSFTSSNLIQRALDAFVTIGRYDKQLRRAGRVYR
QHRDVMVAALQQQLPPGCRFETPEGGLFIWLTLPAAVSTEALMPVAWREGVTFARGECFYAEEQRGAHGLRLNFAANTPP
LIEEGIARLCRAISQVIDSE
>Mature_499_residues
GYSKKCHQLPSQFCMHIPLDRQQDVPLYLQIEEALRRAILSGVFVDGDKLPSTRQLAGELAVSRLTVDNAYAELAAKGFL
RQRRGSGAYVQHPLAQPAQPQPATDVPFPAERFTTLTSRLDGYPDIPLPDSIINFAAGVGSPKVFPQEEFRKILLSVLSR
HAEEAFSYGEYCGYYPLRDTLGRILTAQGIPTHAEQLLITNGSQHAISLIVQSLLEPGDTVIVEQPTYAEALGLLRLHRI
NIVTIPSDRHGMLVDQLPALLEKHRPKLIYTIPNFHNPTGRCMSEARRRRLLALAQHAGVVILEDDFVGDLRYNGKQLPS
LRALAQPGAVIYVSTFSKMLLPSMRIGYLVADSEHYQCIARLKHVDSFTSSNLIQRALDAFVTIGRYDKQLRRAGRVYRQ
HRDVMVAALQQQLPPGCRFETPEGGLFIWLTLPAAVSTEALMPVAWREGVTFARGECFYAEEQRGAHGLRLNFAANTPPL
IEEGIARLCRAISQVIDSE

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=397, Percent_Identity=24.6851385390428, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI33469970, Length=397, Percent_Identity=24.6851385390428, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4507369, Length=257, Percent_Identity=23.3463035019455, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787710, Length=472, Percent_Identity=29.2372881355932, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1790797, Length=476, Percent_Identity=27.7310924369748, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788722, Length=241, Percent_Identity=23.2365145228216, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321236, Length=280, Percent_Identity=24.6428571428571, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321000, Length=251, Percent_Identity=27.8884462151394, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321929, Length=305, Percent_Identity=20.983606557377, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21356535, Length=399, Percent_Identity=25.8145363408521, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 55706; Mature: 55575

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYSKKCHQLPSQFCMHIPLDRQQDVPLYLQIEEALRRAILSGVFVDGDKLPSTRQLAGE
CCCCCHHHHCHHHHHEECCCCCCCCCCEEEEHHHHHHHHHHHCEEECCCCCCHHHHHHHH
LAVSRLTVDNAYAELAAKGFLRQRRGSGAYVQHPLAQPAQPQPATDVPFPAERFTTLTSR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
LDGYPDIPLPDSIINFAAGVGSPKVFPQEEFRKILLSVLSRHAEEAFSYGEYCGYYPLRD
CCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TLGRILTAQGIPTHAEQLLITNGSQHAISLIVQSLLEPGDTVIVEQPTYAEALGLLRLHR
HHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHEEE
INIVTIPSDRHGMLVDQLPALLEKHRPKLIYTIPNFHNPTGRCMSEARRRRLLALAQHAG
EEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
VVILEDDFVGDLRYNGKQLPSLRALAQPGAVIYVSTFSKMLLPSMRIGYLVADSEHYQCI
EEEEECCCCCCCCCCCCCCCHHHHHCCCCCEEEEEHHHHHHCCCCCEEEEEECCHHHHHH
ARLKHVDSFTSSNLIQRALDAFVTIGRYDKQLRRAGRVYRQHRDVMVAALQQQLPPGCRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ETPEGGLFIWLTLPAAVSTEALMPVAWREGVTFARGECFYAEEQRGAHGLRLNFAANTPP
CCCCCCEEEEEECCCHHCHHHHCCHHHHCCCCEECCCEEEEHHCCCCCCEEEEECCCCCH
LIEEGIARLCRAISQVIDSE
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GYSKKCHQLPSQFCMHIPLDRQQDVPLYLQIEEALRRAILSGVFVDGDKLPSTRQLAGE
CCCCHHHHCHHHHHEECCCCCCCCCCEEEEHHHHHHHHHHHCEEECCCCCCHHHHHHHH
LAVSRLTVDNAYAELAAKGFLRQRRGSGAYVQHPLAQPAQPQPATDVPFPAERFTTLTSR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
LDGYPDIPLPDSIINFAAGVGSPKVFPQEEFRKILLSVLSRHAEEAFSYGEYCGYYPLRD
CCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TLGRILTAQGIPTHAEQLLITNGSQHAISLIVQSLLEPGDTVIVEQPTYAEALGLLRLHR
HHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHEEE
INIVTIPSDRHGMLVDQLPALLEKHRPKLIYTIPNFHNPTGRCMSEARRRRLLALAQHAG
EEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
VVILEDDFVGDLRYNGKQLPSLRALAQPGAVIYVSTFSKMLLPSMRIGYLVADSEHYQCI
EEEEECCCCCCCCCCCCCCCHHHHHCCCCCEEEEEHHHHHHCCCCCEEEEEECCHHHHHH
ARLKHVDSFTSSNLIQRALDAFVTIGRYDKQLRRAGRVYRQHRDVMVAALQQQLPPGCRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ETPEGGLFIWLTLPAAVSTEALMPVAWREGVTFARGECFYAEEQRGAHGLRLNFAANTPP
CCCCCCEEEEEECCCHHCHHHHCCHHHHCCCCEECCCEEEEHHCCCCCCEEEEECCCCCH
LIEEGIARLCRAISQVIDSE
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA