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The map label for this gene is irgA [H]

Identifier: 157371457

GI number: 157371457

Start: 3547944

End: 3549941

Strand: Direct

Name: irgA [H]

Synonym: Spro_3220

Alternate gene names: 157371457

Gene position: 3547944-3549941 (Clockwise)

Preceding gene: 157371456

Following gene: 157371460

Centisome position: 65.11

GC content: 55.86

Gene sequence:

>1998_bases
ATGGAAAAGCCACGTTATAACCAGCTCACCGCACTGATTATTGCCTCACTCGGCAGCGCCGGCGCGTTCGCCGCACCGCA
GAATGACGCTCAGGACACCATGGTGGTGACCGCCTCGGGTTTCCAGCAAAAAATCCAGGACTCGCCCGCCTCTATCTCGG
TGATCCCGCGCCAACAGATTGAAGACAAAGCCTACCGCGACATTACCGACGCGTTGAAAGACGTACCGGGCGTGGTGGTA
ACCGGCGGGGCCAGCAACAGCGATATCAGCATCCGCGGCATGTCCTCTAAATACACCCTGATTCTGGTCGATGGCAAACG
CGTGGACACCCGTGGCACCCGCCCGAACAGCGATAACTCGGGTATTGAGCAGGGCTGGCTGCCACCGCTGGAAGCCATTG
AGCGCATTGAAGTGGTGCGCGGCCCGATGTCTTCGCTGTACGGTTCTGACGCCATGGGCGGCGTGATCAACGTGATCACC
CGCAAAACCTCCAATACCCAGGGCTGGAAAGGTTCATTGCACGGCGATGCCACCTTCCAGGAGAACAGCAACTCCGGCGA
TCTGTTCCAGACTAACGCCTACGCTTCCGGTCCGCTGATTGAAGGCCTGCTGGGTCTGCGGGTCAATGGCCTGCTGTCCC
GCCGCGCCGAGGACCAAATCCTCAATGGCTACAGCGAGCAGCGCATGCGCAGCGGCACCGCGGTATTCAACCTGACGCCA
AACGAACAGAACGATTTTGATTTCGAAATTGGCCGCTCTTTGCAGGATCGTGACAGTACGCCGGGCAAATCCATGGCGAC
TGAAAACTGCCGTAACAATAAATGCACGGCTAACAGCGCCAGCGACAGCCTCTACACCCGGACCAACTACGCCGTAACCC
ATAACGGTTATTACGACTTCGGCAATACCACCAGCTACATTCAGCGCGAAGAAACCAATAACCCGGGCCGCGACATGAAG
ATGTACAACACTATCTTCAATACGCAAACCCAGTTTGACCTCGGCGACCATATGCTGAATCTCGGCGGCCAGTACCGTTA
CGAAAAATTGAGCGACGGTGGCAATCAGTTGGCAGCAGCGGATGGGTTGAACAAACTGACGCGCTGGAGCTGGGCGCTGT
TTGCCGAAGACGAATGGGCGATGACCAACGATTTCAGCCTGACCAGCGGCATCCGTATGGATCAGGACCAGAACTACGGC
AACCACTGGACACCGCGCATGTACGGCGTCTGGCACCTGGCCGAGCAATGGACGCTGAAAGGCGGCGTTTCTGCCGGTTA
CCGTTCACCGGATCTGCGTCAATCCTCAGCCAATTGGGGGCAAATCACCGGCGGTGGCCGCACTTCAATCATCATCGGCA
ATCCGGACCTGCAGCCAGAAAAAAGCCTGAGCGAAGAGATCGGGGTGATGTGGGATAACCAGCAAAACCTGAACGCCGGC
GTTACCCTGTTTAACACCGACTTCAAAGATAAAATTACCGAAGTGCGCCGCTGCGACAGTGGCGACGGCGACGCGCAATG
CATGATCGGCGACACGCCTTATTACTTTATCAGCGACCGTACTAACGTCGATAAAGCCAATATGCGTGGCGTAGAGGCCA
CCTTTGGCTGGCAAATCAGCAAAGACTGGAAGTGGAACACCAACTACACCTATACCTCATCAGAGCAAAAAAGTGGGGAT
TTCCAGGGCAAACCACTGAACCAGATGCCGAAGCATATGGTTAACAGCGTGCTGGACTGGCAGGCCACTCACGATGTCAG
CCTGTGGTCCCGCGTTAACTTCCGCAGTAAGACATCGGACTACATGAGCCGAGCATCAATGGCCAAGAGCACGCCGTCTT
ACACCTTTGTTGACGCTGGCCTTAGCTACCAGGCGAATAAAAACCTGCAGGTTACCGGTGGGGTTTACAACATCCTCGAT
AAAACCGTCGATTACGATAACTACAATACCGTGTTGGATGGCCGTCGTTACACCGTCGGCATGACCTACAACTTCTGA

Upstream 100 bases:

>100_bases
ACGACGAATCTCGCAACGACGAGGCTCCGTTTCTACTTATTATTCAAAACGTTAAAGCGACATTTTGTCGATTTACATCA
GACCAGGAAAGGTTTGCCTC

Downstream 100 bases:

>100_bases
TGCGATAAAAAAGGCCCCGAGATCGGGTAATGCCGGTCAGTTAAGTACAGTTCTGAATATGAATGTACGACGTTGTTTAA
GTGGGCGTCCCCCTCTCCCG

Product: putative outer membrane receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 665; Mature: 665

Protein sequence:

>665_residues
MEKPRYNQLTALIIASLGSAGAFAAPQNDAQDTMVVTASGFQQKIQDSPASISVIPRQQIEDKAYRDITDALKDVPGVVV
TGGASNSDISIRGMSSKYTLILVDGKRVDTRGTRPNSDNSGIEQGWLPPLEAIERIEVVRGPMSSLYGSDAMGGVINVIT
RKTSNTQGWKGSLHGDATFQENSNSGDLFQTNAYASGPLIEGLLGLRVNGLLSRRAEDQILNGYSEQRMRSGTAVFNLTP
NEQNDFDFEIGRSLQDRDSTPGKSMATENCRNNKCTANSASDSLYTRTNYAVTHNGYYDFGNTTSYIQREETNNPGRDMK
MYNTIFNTQTQFDLGDHMLNLGGQYRYEKLSDGGNQLAAADGLNKLTRWSWALFAEDEWAMTNDFSLTSGIRMDQDQNYG
NHWTPRMYGVWHLAEQWTLKGGVSAGYRSPDLRQSSANWGQITGGGRTSIIIGNPDLQPEKSLSEEIGVMWDNQQNLNAG
VTLFNTDFKDKITEVRRCDSGDGDAQCMIGDTPYYFISDRTNVDKANMRGVEATFGWQISKDWKWNTNYTYTSSEQKSGD
FQGKPLNQMPKHMVNSVLDWQATHDVSLWSRVNFRSKTSDYMSRASMAKSTPSYTFVDAGLSYQANKNLQVTGGVYNILD
KTVDYDNYNTVLDGRRYTVGMTYNF

Sequences:

>Translated_665_residues
MEKPRYNQLTALIIASLGSAGAFAAPQNDAQDTMVVTASGFQQKIQDSPASISVIPRQQIEDKAYRDITDALKDVPGVVV
TGGASNSDISIRGMSSKYTLILVDGKRVDTRGTRPNSDNSGIEQGWLPPLEAIERIEVVRGPMSSLYGSDAMGGVINVIT
RKTSNTQGWKGSLHGDATFQENSNSGDLFQTNAYASGPLIEGLLGLRVNGLLSRRAEDQILNGYSEQRMRSGTAVFNLTP
NEQNDFDFEIGRSLQDRDSTPGKSMATENCRNNKCTANSASDSLYTRTNYAVTHNGYYDFGNTTSYIQREETNNPGRDMK
MYNTIFNTQTQFDLGDHMLNLGGQYRYEKLSDGGNQLAAADGLNKLTRWSWALFAEDEWAMTNDFSLTSGIRMDQDQNYG
NHWTPRMYGVWHLAEQWTLKGGVSAGYRSPDLRQSSANWGQITGGGRTSIIIGNPDLQPEKSLSEEIGVMWDNQQNLNAG
VTLFNTDFKDKITEVRRCDSGDGDAQCMIGDTPYYFISDRTNVDKANMRGVEATFGWQISKDWKWNTNYTYTSSEQKSGD
FQGKPLNQMPKHMVNSVLDWQATHDVSLWSRVNFRSKTSDYMSRASMAKSTPSYTFVDAGLSYQANKNLQVTGGVYNILD
KTVDYDNYNTVLDGRRYTVGMTYNF
>Mature_665_residues
MEKPRYNQLTALIIASLGSAGAFAAPQNDAQDTMVVTASGFQQKIQDSPASISVIPRQQIEDKAYRDITDALKDVPGVVV
TGGASNSDISIRGMSSKYTLILVDGKRVDTRGTRPNSDNSGIEQGWLPPLEAIERIEVVRGPMSSLYGSDAMGGVINVIT
RKTSNTQGWKGSLHGDATFQENSNSGDLFQTNAYASGPLIEGLLGLRVNGLLSRRAEDQILNGYSEQRMRSGTAVFNLTP
NEQNDFDFEIGRSLQDRDSTPGKSMATENCRNNKCTANSASDSLYTRTNYAVTHNGYYDFGNTTSYIQREETNNPGRDMK
MYNTIFNTQTQFDLGDHMLNLGGQYRYEKLSDGGNQLAAADGLNKLTRWSWALFAEDEWAMTNDFSLTSGIRMDQDQNYG
NHWTPRMYGVWHLAEQWTLKGGVSAGYRSPDLRQSSANWGQITGGGRTSIIIGNPDLQPEKSLSEEIGVMWDNQQNLNAG
VTLFNTDFKDKITEVRRCDSGDGDAQCMIGDTPYYFISDRTNVDKANMRGVEATFGWQISKDWKWNTNYTYTSSEQKSGD
FQGKPLNQMPKHMVNSVLDWQATHDVSLWSRVNFRSKTSDYMSRASMAKSTPSYTFVDAGLSYQANKNLQVTGGVYNILD
KTVDYDNYNTVLDGRRYTVGMTYNF

Specific function: Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=688, Percent_Identity=34.8837209302326, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1786798, Length=695, Percent_Identity=30.3597122302158, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI1790405, Length=159, Percent_Identity=37.1069182389937, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 74013; Mature: 74013

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPRYNQLTALIIASLGSAGAFAAPQNDAQDTMVVTASGFQQKIQDSPASISVIPRQQI
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCEEEEECHHHH
EDKAYRDITDALKDVPGVVVTGGASNSDISIRGMSSKYTLILVDGKRVDTRGTRPNSDNS
HHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCEEEEEEECCEECCCCCCCCCCCC
GIEQGWLPPLEAIERIEVVRGPMSSLYGSDAMGGVINVITRKTSNTQGWKGSLHGDATFQ
CCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEC
ENSNSGDLFQTNAYASGPLIEGLLGLRVNGLLSRRAEDQILNGYSEQRMRSGTAVFNLTP
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEECC
NEQNDFDFEIGRSLQDRDSTPGKSMATENCRNNKCTANSASDSLYTRTNYAVTHNGYYDF
CCCCCCCHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCEEEEECCEECC
GNTTSYIQREETNNPGRDMKMYNTIFNTQTQFDLGDHMLNLGGQYRYEKLSDGGNQLAAA
CCCHHHEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCEEEHHHCCCCCEEEHH
DGLNKLTRWSWALFAEDEWAMTNDFSLTSGIRMDQDQNYGNHWTPRMYGVWHLAEQWTLK
HCHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEHHHHHEEC
GGVSAGYRSPDLRQSSANWGQITGGGRTSIIIGNPDLQPEKSLSEEIGVMWDNQQNLNAG
CCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHCEEECCCCCCCCC
VTLFNTDFKDKITEVRRCDSGDGDAQCMIGDTPYYFISDRTNVDKANMRGVEATFGWQIS
EEEEECCHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCEEEECEEEC
KDWKWNTNYTYTSSEQKSGDFQGKPLNQMPKHMVNSVLDWQATHDVSLWSRVNFRSKTSD
CCCEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHH
YMSRASMAKSTPSYTFVDAGLSYQANKNLQVTGGVYNILDKTVDYDNYNTVLDGRRYTVG
HHHHHHHHCCCCCEEEEECCCCEECCCCEEEECCHHHHHHHHCCCCCCCEEECCCEEEEE
MTYNF
EEECC
>Mature Secondary Structure
MEKPRYNQLTALIIASLGSAGAFAAPQNDAQDTMVVTASGFQQKIQDSPASISVIPRQQI
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHCCCCCEEEEECHHHH
EDKAYRDITDALKDVPGVVVTGGASNSDISIRGMSSKYTLILVDGKRVDTRGTRPNSDNS
HHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCEEEEEEECCEECCCCCCCCCCCC
GIEQGWLPPLEAIERIEVVRGPMSSLYGSDAMGGVINVITRKTSNTQGWKGSLHGDATFQ
CCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEC
ENSNSGDLFQTNAYASGPLIEGLLGLRVNGLLSRRAEDQILNGYSEQRMRSGTAVFNLTP
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCEEEEECC
NEQNDFDFEIGRSLQDRDSTPGKSMATENCRNNKCTANSASDSLYTRTNYAVTHNGYYDF
CCCCCCCHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCEEEEECCEECC
GNTTSYIQREETNNPGRDMKMYNTIFNTQTQFDLGDHMLNLGGQYRYEKLSDGGNQLAAA
CCCHHHEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCEEEHHHCCCCCEEEHH
DGLNKLTRWSWALFAEDEWAMTNDFSLTSGIRMDQDQNYGNHWTPRMYGVWHLAEQWTLK
HCHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEEHHHHHEEC
GGVSAGYRSPDLRQSSANWGQITGGGRTSIIIGNPDLQPEKSLSEEIGVMWDNQQNLNAG
CCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHCEEECCCCCCCCC
VTLFNTDFKDKITEVRRCDSGDGDAQCMIGDTPYYFISDRTNVDKANMRGVEATFGWQIS
EEEEECCHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCEEEECEEEC
KDWKWNTNYTYTSSEQKSGDFQGKPLNQMPKHMVNSVLDWQATHDVSLWSRVNFRSKTSD
CCCEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHH
YMSRASMAKSTPSYTFVDAGLSYQANKNLQVTGGVYNILDKTVDYDNYNTVLDGRRYTVG
HHHHHHHHCCCCCEEEEECCCCEECCCCEEEECCHHHHHHHHCCCCCCCEEECCCEEEEE
MTYNF
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1406279; 2174861 [H]