Click here to switch to the map view.

The map label for this gene is paaH [H]

Identifier: 157371319

GI number: 157371319

Start: 3388195

End: 3389715

Strand: Direct

Name: paaH [H]

Synonym: Spro_3079

Alternate gene names: 157371319

Gene position: 3388195-3389715 (Clockwise)

Preceding gene: 157371318

Following gene: 157371320

Centisome position: 62.18

GC content: 61.08

Gene sequence:

>1521_bases
ATGAACCAGCCGAACTTAAACCTCAGGGTGGCGGTGATTGGTGCCGGTACCATGGGTATCGGTATTGCTCAGGTGGCCGC
CGCCGCCGGGCATCAGGTGCAGCTGTTTGATATTGCCGCCTCTGCTGCCCGGCAGGCACTCGGCGCTCTCGCCCAACGGC
TGCGTCAGCGTGTTGCGGCCGGCAAGGCCGATGCCACCACCACCGAAGCCCTGCTGGCGCGCATTCAGCCGGCAGAGTCG
CTTAACTCGCTGGCCGACAGCGGTCTGGTGATAGAAGCGGTGGCGGAAAAGCTGGCAATCAAACAAAGCCTGTTCCGTGA
GCTGGAAGCCCTGTGCTCACCCGCCACGCTGTTTGCCAGCAACACCTCCTCGCTGTCGATTACCGCCATCGCCGGTGCGC
TGCAACATCCACAGCGTCTGGCCGGGCTGCACTTCTTCAACCCGGCACCGCTGATGAAGCTGGTGGAGATCGTCAGCGGG
CTGGACACCAGCACCGAAACCGTCGCCACACTGCAAAGACTAACCCGGCAATGGGGCAAACAAAGCGTGCTGTGCCGCTC
CACGCCGGGGTTCATCGTTAACCGGGTGGCGCGACCGTTTTATGCCGAGGCCCTGCGCGCGCTGGAAGAACAGGTCGCTG
ACGCCGCCACGCTGGATGCGGTGATACGCGACGCGGGTGGCTTCGTCATGGGGCCACTGCAACTGACCGATATGATTGGT
CAGGATATCAATTATGCCGTGACCGAATCGGTGTTTCAGGCTTTCTTCCAGGATCCCCGGTTTACCCCGTCGCTGGTACA
GCAGGAACTGGTGGCGGCCGGGCGTCTTGGCCGCAAAAGTGGCCGTGGTTTTTATCGCTATGGCGATCATCAGCCGCCGG
TCGCTGCCGTTCTGCCTGCCTCTACGGCAGCATTGCCGCGCAGCATCACACTGCATGGCGATGCCGCCGGTATCGCGCTA
CTGAGCAAATTACTGAGCGGAAATGCGCAGTCGATCAAACAATCTGGCCAGACCAGCGCCTACGCCCGGATCGATGAAGT
TACACTTATGTTAACTAATGGTAAAACAGCCAGCCAGGTGGCCGATGAAACCGCAACTCCGGTGGTGCTGTTTGATCTGT
CTGCCGACTACTCGCAGGCCACCACCGTCGCTATCAGCTGCGCGGCGCAAAACGATGACCGGCACAACGCCACCATCATG
CGTCTGCTGCAATCTCTCGGCAAGAAGGTGATCGCTTTGCCGGACTATCCCGGCCTGCTGGTGATGCGCACCCTCGCCAT
GTTGGCCAATGAGGCGCTCGACGTGGTGAACAAAGGCGTCGCCAGTGCCGAGGATACCGACCACGCCATGCGCTACGGCG
TCAATTACCCACGCGGCCCGCTGGAATGGGGGACGGCTCTGGGTTGGCGACACATCCTCACCACGCTGGAAAACCTGCAA
CTCTACTACGGTGAGCCACGTTATCGCCCAATGCCGCTGCTGCGTCATTACGCATCCCTCTCTTCAGGAGCCCAACCATG
A

Upstream 100 bases:

>100_bases
AACGCGATCTGCAGCGTCTGGGCGGTCGCAGCGACGACTACCGCGAGGGCGTCAGCGCCTTCTTCGCCAAACGCGCGCCC
AATTTCAGCGGGAAATAACC

Downstream 100 bases:

>100_bases
ACGCCAATACGCCACAGGCACTGGCGCAACGCTGCGCCGAACAGATGTTTCAACAGGATACCTGTGCCCAGGCGATGGGG
ATGCGGGTGGATGCGGTTGA

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MNQPNLNLRVAVIGAGTMGIGIAQVAAAAGHQVQLFDIAASAARQALGALAQRLRQRVAAGKADATTTEALLARIQPAES
LNSLADSGLVIEAVAEKLAIKQSLFRELEALCSPATLFASNTSSLSITAIAGALQHPQRLAGLHFFNPAPLMKLVEIVSG
LDTSTETVATLQRLTRQWGKQSVLCRSTPGFIVNRVARPFYAEALRALEEQVADAATLDAVIRDAGGFVMGPLQLTDMIG
QDINYAVTESVFQAFFQDPRFTPSLVQQELVAAGRLGRKSGRGFYRYGDHQPPVAAVLPASTAALPRSITLHGDAAGIAL
LSKLLSGNAQSIKQSGQTSAYARIDEVTLMLTNGKTASQVADETATPVVLFDLSADYSQATTVAISCAAQNDDRHNATIM
RLLQSLGKKVIALPDYPGLLVMRTLAMLANEALDVVNKGVASAEDTDHAMRYGVNYPRGPLEWGTALGWRHILTTLENLQ
LYYGEPRYRPMPLLRHYASLSSGAQP

Sequences:

>Translated_506_residues
MNQPNLNLRVAVIGAGTMGIGIAQVAAAAGHQVQLFDIAASAARQALGALAQRLRQRVAAGKADATTTEALLARIQPAES
LNSLADSGLVIEAVAEKLAIKQSLFRELEALCSPATLFASNTSSLSITAIAGALQHPQRLAGLHFFNPAPLMKLVEIVSG
LDTSTETVATLQRLTRQWGKQSVLCRSTPGFIVNRVARPFYAEALRALEEQVADAATLDAVIRDAGGFVMGPLQLTDMIG
QDINYAVTESVFQAFFQDPRFTPSLVQQELVAAGRLGRKSGRGFYRYGDHQPPVAAVLPASTAALPRSITLHGDAAGIAL
LSKLLSGNAQSIKQSGQTSAYARIDEVTLMLTNGKTASQVADETATPVVLFDLSADYSQATTVAISCAAQNDDRHNATIM
RLLQSLGKKVIALPDYPGLLVMRTLAMLANEALDVVNKGVASAEDTDHAMRYGVNYPRGPLEWGTALGWRHILTTLENLQ
LYYGEPRYRPMPLLRHYASLSSGAQP
>Mature_506_residues
MNQPNLNLRVAVIGAGTMGIGIAQVAAAAGHQVQLFDIAASAARQALGALAQRLRQRVAAGKADATTTEALLARIQPAES
LNSLADSGLVIEAVAEKLAIKQSLFRELEALCSPATLFASNTSSLSITAIAGALQHPQRLAGLHFFNPAPLMKLVEIVSG
LDTSTETVATLQRLTRQWGKQSVLCRSTPGFIVNRVARPFYAEALRALEEQVADAATLDAVIRDAGGFVMGPLQLTDMIG
QDINYAVTESVFQAFFQDPRFTPSLVQQELVAAGRLGRKSGRGFYRYGDHQPPVAAVLPASTAALPRSITLHGDAAGIAL
LSKLLSGNAQSIKQSGQTSAYARIDEVTLMLTNGKTASQVADETATPVVLFDLSADYSQATTVAISCAAQNDDRHNATIM
RLLQSLGKKVIALPDYPGLLVMRTLAMLANEALDVVNKGVASAEDTDHAMRYGVNYPRGPLEWGTALGWRHILTTLENLQ
LYYGEPRYRPMPLLRHYASLSSGAQP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=40, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=37.7483443708609, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI20127408, Length=281, Percent_Identity=33.0960854092527, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI261878539, Length=303, Percent_Identity=29.7029702970297, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI68989263, Length=303, Percent_Identity=29.7029702970297, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI115430219, Length=265, Percent_Identity=26.0377358490566, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1787661, Length=496, Percent_Identity=51.6129032258064, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1788682, Length=263, Percent_Identity=36.8821292775665, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1790281, Length=271, Percent_Identity=31.7343173431734, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=40.2097902097902, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=37.2822299651568, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=36.5853658536585, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71985923, Length=278, Percent_Identity=31.6546762589928, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI25144276, Length=283, Percent_Identity=35.3356890459364, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=283, Percent_Identity=35.3356890459364, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17508953, Length=301, Percent_Identity=34.21926910299, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=30, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=34.0425531914894, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI193203623, Length=192, Percent_Identity=26.5625, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533614, Length=192, Percent_Identity=26.5625, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583077, Length=280, Percent_Identity=32.8571428571429, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24583079, Length=280, Percent_Identity=32.8571428571429, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI19921000, Length=280, Percent_Identity=32.8571428571429, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI45549573, Length=234, Percent_Identity=28.2051282051282, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI20129993, Length=234, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53995; Mature: 53995

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPNLNLRVAVIGAGTMGIGIAQVAAAAGHQVQLFDIAASAARQALGALAQRLRQRVAA
CCCCCCEEEEEEEECCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
GKADATTTEALLARIQPAESLNSLADSGLVIEAVAEKLAIKQSLFRELEALCSPATLFAS
CCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
NTSSLSITAIAGALQHPQRLAGLHFFNPAPLMKLVEIVSGLDTSTETVATLQRLTRQWGK
CCCCEEHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
QSVLCRSTPGFIVNRVARPFYAEALRALEEQVADAATLDAVIRDAGGFVMGPLQLTDMIG
CCEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHC
QDINYAVTESVFQAFFQDPRFTPSLVQQELVAAGRLGRKSGRGFYRYGDHQPPVAAVLPA
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
STAALPRSITLHGDAAGIALLSKLLSGNAQSIKQSGQTSAYARIDEVTLMLTNGKTASQV
CHHHCCCEEEECCCHHHHHHHHHHHCCCHHHHHHCCCCHHHEEEEEEEEEEECCCHHHHH
ADETATPVVLFDLSADYSQATTVAISCAAQNDDRHNATIMRLLQSLGKKVIALPDYPGLL
HHCCCCCEEEEECCCCCCHHEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCHHH
VMRTLAMLANEALDVVNKGVASAEDTDHAMRYGVNYPRGPLEWGTALGWRHILTTLENLQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LYYGEPRYRPMPLLRHYASLSSGAQP
EEECCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNQPNLNLRVAVIGAGTMGIGIAQVAAAAGHQVQLFDIAASAARQALGALAQRLRQRVAA
CCCCCCEEEEEEEECCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
GKADATTTEALLARIQPAESLNSLADSGLVIEAVAEKLAIKQSLFRELEALCSPATLFAS
CCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
NTSSLSITAIAGALQHPQRLAGLHFFNPAPLMKLVEIVSGLDTSTETVATLQRLTRQWGK
CCCCEEHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
QSVLCRSTPGFIVNRVARPFYAEALRALEEQVADAATLDAVIRDAGGFVMGPLQLTDMIG
CCEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHC
QDINYAVTESVFQAFFQDPRFTPSLVQQELVAAGRLGRKSGRGFYRYGDHQPPVAAVLPA
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCC
STAALPRSITLHGDAAGIALLSKLLSGNAQSIKQSGQTSAYARIDEVTLMLTNGKTASQV
CHHHCCCEEEECCCHHHHHHHHHHHCCCHHHHHHCCCCHHHEEEEEEEEEEECCCHHHHH
ADETATPVVLFDLSADYSQATTVAISCAAQNDDRHNATIMRLLQSLGKKVIALPDYPGLL
HHCCCCCEEEEECCCCCCHHEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCHHH
VMRTLAMLANEALDVVNKGVASAEDTDHAMRYGVNYPRGPLEWGTALGWRHILTTLENLQ
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LYYGEPRYRPMPLLRHYASLSSGAQP
EEECCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]