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The map label for this gene is catF [H]

Identifier: 157371279

GI number: 157371279

Start: 3347791

End: 3348993

Strand: Direct

Name: catF [H]

Synonym: Spro_3039

Alternate gene names: 157371279

Gene position: 3347791-3348993 (Clockwise)

Preceding gene: 157371278

Following gene: 157371280

Centisome position: 61.44

GC content: 60.93

Gene sequence:

>1203_bases
ATGATCCCCGCTTACCTGTGTGATGCCGTCCGTACGCCTTTTGGTCGACTCAACGGCAGCCTGGCCAGCATTCGCGCCGA
CGACCTGGCCGCCCTGCCGCTCAAAGCGTTGCAGGCGCGCCACCCACAACTTGACTGGGCGGCAGTGGACGACGTGCTGC
TTGGCTGTGCCAATCAGGCCGGAGAGGATAACCGCAACGTGGCGCGCATGGCGTTGCTGCTGGCCGGGCTGCCGGTACAG
ATCCCCGGTTGTACCCTCAACCGCCTGTGCGGCTCCAGTCTGGACGCCGTGGCGATGGCGGCCCGGGCGATCAAAACCGG
CGAAAGTGAACTGATGATCGCCGGCGGTGTAGAAAGCATGTCCCGTGCGCCCTTCGTGATGGGCAAGGCGGAAAGCGCCT
TCAGCCGAATGATGAAACTGGAAGACACCACCATGGGCTGGCGGTTTATCAACCCACAGATGCAGGCGCTATATGGCGTG
GAGTCGATGCCGCAAACCGCCGAAAACGTCGCCCTCAAATTCGGGATTAACCGCCAGGATCAGGACGCCTTTGCCCTGCG
CAGCCAGCAGCGCACCGCTAGCGCGCAGGAAAGCGGCTTTTTCGCCGAACAGTTGATTGAAGTCAGCGTTGCGCAGAAAA
AAGGTGCACCGTTACTGTTCACTCAGGACGAACACCCGCGCGCCACCACGCTGGAAGCCCTGTCGAAGCTGAAACCGGTG
GTTAACCCTCAGGGAACAGTGACCGCCGGTAATGCTTCCGGGCTGAACGACGGTACCTGCGCGCTGCTGCTGGCCAGCGA
AACCGGGATGACTCGCCACGGACTGCAACCCATGGCCCGTATTATCGCCAGCGCCGTTACCGGTATTGAGCCTTCAATTA
TGGGCTTTGCCCCGGCTCAAGCGGTACGCAAGGTATTAAAAATTGCCGGGCTGAGCCTCGACCAAATGGACGTGATTGAG
CTTAACGAAGCTTTTGCGGCACAGGCATTGGCGGTGACGCGTGAACTGGGGCTGAGTGACGACGCCGCTCAGGTGAATCC
CAATGGCGGTGCGATCGCCCTCGGTCATCCGCTGGGTGCTTCCGGTGGCAGGCTGGTGATGAACGCCGCCTGGCAATTGC
AAAAGACGCGCGGCCGCTATGGCTTGTGCACTATGTGTATTGGCGTCGGCCAGGGCATTGCACTGATTATCGAACGGGTA
TGA

Upstream 100 bases:

>100_bases
CTGGTGGTACGCGAAATATTTGGTGGGCTGACCCCGCAGCAATTGCAAGCAGTCACCCCGGTCGAACTGACCTTTGCCCT
TCAGCACGGAGAACCACCGC

Downstream 100 bases:

>100_bases
GACGGAGAAGCAGCATGGATATCGACTATCGCCTTGATGGCCACGCCGGAGCGCCGCTGTTGGTGCTGTCCAACTCGCTC
GGTACCACCTTCGACATGTG

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MIPAYLCDAVRTPFGRLNGSLASIRADDLAALPLKALQARHPQLDWAAVDDVLLGCANQAGEDNRNVARMALLLAGLPVQ
IPGCTLNRLCGSSLDAVAMAARAIKTGESELMIAGGVESMSRAPFVMGKAESAFSRMMKLEDTTMGWRFINPQMQALYGV
ESMPQTAENVALKFGINRQDQDAFALRSQQRTASAQESGFFAEQLIEVSVAQKKGAPLLFTQDEHPRATTLEALSKLKPV
VNPQGTVTAGNASGLNDGTCALLLASETGMTRHGLQPMARIIASAVTGIEPSIMGFAPAQAVRKVLKIAGLSLDQMDVIE
LNEAFAAQALAVTRELGLSDDAAQVNPNGGAIALGHPLGASGGRLVMNAAWQLQKTRGRYGLCTMCIGVGQGIALIIERV

Sequences:

>Translated_400_residues
MIPAYLCDAVRTPFGRLNGSLASIRADDLAALPLKALQARHPQLDWAAVDDVLLGCANQAGEDNRNVARMALLLAGLPVQ
IPGCTLNRLCGSSLDAVAMAARAIKTGESELMIAGGVESMSRAPFVMGKAESAFSRMMKLEDTTMGWRFINPQMQALYGV
ESMPQTAENVALKFGINRQDQDAFALRSQQRTASAQESGFFAEQLIEVSVAQKKGAPLLFTQDEHPRATTLEALSKLKPV
VNPQGTVTAGNASGLNDGTCALLLASETGMTRHGLQPMARIIASAVTGIEPSIMGFAPAQAVRKVLKIAGLSLDQMDVIE
LNEAFAAQALAVTRELGLSDDAAQVNPNGGAIALGHPLGASGGRLVMNAAWQLQKTRGRYGLCTMCIGVGQGIALIIERV
>Mature_400_residues
MIPAYLCDAVRTPFGRLNGSLASIRADDLAALPLKALQARHPQLDWAAVDDVLLGCANQAGEDNRNVARMALLLAGLPVQ
IPGCTLNRLCGSSLDAVAMAARAIKTGESELMIAGGVESMSRAPFVMGKAESAFSRMMKLEDTTMGWRFINPQMQALYGV
ESMPQTAENVALKFGINRQDQDAFALRSQQRTASAQESGFFAEQLIEVSVAQKKGAPLLFTQDEHPRATTLEALSKLKPV
VNPQGTVTAGNASGLNDGTCALLLASETGMTRHGLQPMARIIASAVTGIEPSIMGFAPAQAVRKVLKIAGLSLDQMDVIE
LNEAFAAQALAVTRELGLSDDAAQVNPNGGAIALGHPLGASGGRLVMNAAWQLQKTRGRYGLCTMCIGVGQGIALIIERV

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=42.3173803526448, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=38.5, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=35.929648241206, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI4501853, Length=372, Percent_Identity=40.0537634408602, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=32.7868852459016, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI194353979, Length=334, Percent_Identity=29.3413173652695, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI19923233, Length=368, Percent_Identity=23.9130434782609, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=63.3416458852868, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1788554, Length=399, Percent_Identity=46.3659147869674, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=42.75, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87082165, Length=400, Percent_Identity=41.25, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1788683, Length=428, Percent_Identity=30.3738317757009, Blast_Score=147, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=396, Percent_Identity=41.9191919191919, Blast_Score=305, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=32.8320802005013, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=33.6658354114713, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=422, Percent_Identity=32.9383886255924, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17535917, Length=403, Percent_Identity=29.2803970223325, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=35, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=35.25, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=41.8952618453865, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI17648125, Length=400, Percent_Identity=38.25, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24640423, Length=398, Percent_Identity=33.9195979899498, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=32.4705882352941, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI19921506, Length=328, Percent_Identity=25.3048780487805, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585051, Length=328, Percent_Identity=25.3048780487805, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 42208; Mature: 42208

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPAYLCDAVRTPFGRLNGSLASIRADDLAALPLKALQARHPQLDWAAVDDVLLGCANQA
CCHHHHHHHHHCCHHHCCCCHHCCCCCCHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCC
GEDNRNVARMALLLAGLPVQIPGCTLNRLCGSSLDAVAMAARAIKTGESELMIAGGVESM
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SRAPFVMGKAESAFSRMMKLEDTTMGWRFINPQMQALYGVESMPQTAENVALKFGINRQD
CCCCEEECCHHHHHHHHHHHHCCCCCEEEECHHHHHHHCHHHCCCHHHHEEEEECCCCCC
QDAFALRSQQRTASAQESGFFAEQLIEVSVAQKKGAPLLFTQDEHPRATTLEALSKLKPV
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCC
VNPQGTVTAGNASGLNDGTCALLLASETGMTRHGLQPMARIIASAVTGIEPSIMGFAPAQ
CCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCHHH
AVRKVLKIAGLSLDQMDVIELNEAFAAQALAVTRELGLSDDAAQVNPNGGAIALGHPLGA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCCCC
SGGRLVMNAAWQLQKTRGRYGLCTMCIGVGQGIALIIERV
CCCEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCEEHEECC
>Mature Secondary Structure
MIPAYLCDAVRTPFGRLNGSLASIRADDLAALPLKALQARHPQLDWAAVDDVLLGCANQA
CCHHHHHHHHHCCHHHCCCCHHCCCCCCHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCC
GEDNRNVARMALLLAGLPVQIPGCTLNRLCGSSLDAVAMAARAIKTGESELMIAGGVESM
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SRAPFVMGKAESAFSRMMKLEDTTMGWRFINPQMQALYGVESMPQTAENVALKFGINRQD
CCCCEEECCHHHHHHHHHHHHCCCCCEEEECHHHHHHHCHHHCCCHHHHEEEEECCCCCC
QDAFALRSQQRTASAQESGFFAEQLIEVSVAQKKGAPLLFTQDEHPRATTLEALSKLKPV
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCC
VNPQGTVTAGNASGLNDGTCALLLASETGMTRHGLQPMARIIASAVTGIEPSIMGFAPAQ
CCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCHHH
AVRKVLKIAGLSLDQMDVIELNEAFAAQALAVTRELGLSDDAAQVNPNGGAIALGHPLGA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCCCC
SGGRLVMNAAWQLQKTRGRYGLCTMCIGVGQGIALIIERV
CCCEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCEEHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]