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The map label for this gene is mmr [H]

Identifier: 157371058

GI number: 157371058

Start: 3098944

End: 3100335

Strand: Reverse

Name: mmr [H]

Synonym: Spro_2818

Alternate gene names: 157371058

Gene position: 3100335-3098944 (Counterclockwise)

Preceding gene: 157371060

Following gene: 157371052

Centisome position: 56.9

GC content: 59.34

Gene sequence:

>1392_bases
GTGGCAAGCTTGAATCAACATCAAAAATCGGTCCTGATGGCGACCAGCCTCAGTTATGTCATCGTTATTCTCGATACTTC
GATTGTAAACGTTGCTCTGCCGTCGATCGCTGGCGAACTTGGGGCAGGGTTGAGTGGCCTGCAGTGGGTAGTCAATGCCT
ACACGTTGGCGTTTGCCAGCCTGTTACTGAGCGGCGGAGCACTGGGGGATCGGTTGGGGGCCACAAGGCTATACCTTGGC
GGGCTGGCGGTTTTTGCCGGCGCTTCGGTCATTTGCGGCCTGGCTGAAACCCTGCCCGTACTGGTGGCGGCCAGAGTCTG
CCAGGGGGTTGGCGCCGCGTTGCTGGTACCCAGTTCATTGATGCTGCTTAATGCGGCATTCGGCGATGCCAGGCTGCGGG
CAGGGGCGATTGGCGTGTGGGCCGGATGTGGTGGCGTGGCGATGGCGGCGGGACCGCTGGTCGGCGGCTTGCTTATCGAA
CTATGGGGCTGGCGCAGCCTGTTTTGGATCAATCTTCCGGTGATTGTGCTGGGGATAGGTCTTACCCTGCGAATTGAAGT
TCGGCGTCCGGTACCGGCCTTGCGACAAATGGATTATGCCGGGCAGGGCGCGGTGATCCTGGCGTTAGCCAGCTCAGTGT
GGGTGCTGATCGAAGGCACCAGGCTTGGCTGGTGTTCTGGCTGGATCCTCGGCGGTATGGCTATCGCTGCTCTGAGTTGG
TGGCGATTTGTGGTTATCGAACGGCGGCACCGGCAGCCGATGCTGCCGCTGACATTGTTCCGTAGCACCCTGTTTTCTGC
CTCTGCGCTGGTTTCGTTAGTCTCGGCGCTGGTGTTCTACGGCGTATTTTTTCTGCTTAGCCTCTATTTTCAGCGGGTGC
GAGGCTGGACGCCATTACAGTCTGGCCTGGCGTTTCTCCCCCTGACGATGATGGTCACGCTGGGCAGTTTTATTTCTGGC
AGGCTGGTGCGGGCATGGGGGGGCGGGCGAGTGGTTTATTGCAGTTTGTTGCTCTATGCGCTGGGTTTTGTCGGTTTACT
GGCGCTGGCGGAAAGCCCGCCCTACTGGCGCATTGCCTTGTCTTTTCCGTTGCTTGGTCTGGCGGCCGGTATCATTACCC
CGGCGGCCACATCGGCATTGATGAATGATGTCGCGAATGAACGGGCGGGGATTGCAGCCGGCGTACTCAATGCCGCCCGT
CAGAGCGGTTCGGCCTTTGGCGTGGCCATCTTTGGGGCGCTGATGTCGACCTCCCTTTCGCAGGCCGGCGGTATTCAGAC
TGCGGTGTACGGTGCCCTTGGGCTGTCATTATTCACCGCCATTGGTTGGCGTTTAGCGATAAATTTAGCGGCTCGTCCAG
GTGCGTCGGTGAGGAATGAGCAAAGAGAGTGA

Upstream 100 bases:

>100_bases
ATTTTAAGCGCTTAAGGCACACTTCGATACAGCTCGAACTATTCCAGGCTAATCGTTGTTTATAGTCAACGCCTATTTCT
TCAGCCGGGAGCCGCTGCGA

Downstream 100 bases:

>100_bases
CGGGCCACAAACAAAAAAACCTGCCGTTGGGCAGGTTTTCTTTGGGTTCAGCGCTATCAGGCCAGATAGCCCAAATGCTC
CAGCAGGATGTTCACACCGA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: MMR peptide [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MASLNQHQKSVLMATSLSYVIVILDTSIVNVALPSIAGELGAGLSGLQWVVNAYTLAFASLLLSGGALGDRLGATRLYLG
GLAVFAGASVICGLAETLPVLVAARVCQGVGAALLVPSSLMLLNAAFGDARLRAGAIGVWAGCGGVAMAAGPLVGGLLIE
LWGWRSLFWINLPVIVLGIGLTLRIEVRRPVPALRQMDYAGQGAVILALASSVWVLIEGTRLGWCSGWILGGMAIAALSW
WRFVVIERRHRQPMLPLTLFRSTLFSASALVSLVSALVFYGVFFLLSLYFQRVRGWTPLQSGLAFLPLTMMVTLGSFISG
RLVRAWGGGRVVYCSLLLYALGFVGLLALAESPPYWRIALSFPLLGLAAGIITPAATSALMNDVANERAGIAAGVLNAAR
QSGSAFGVAIFGALMSTSLSQAGGIQTAVYGALGLSLFTAIGWRLAINLAARPGASVRNEQRE

Sequences:

>Translated_463_residues
MASLNQHQKSVLMATSLSYVIVILDTSIVNVALPSIAGELGAGLSGLQWVVNAYTLAFASLLLSGGALGDRLGATRLYLG
GLAVFAGASVICGLAETLPVLVAARVCQGVGAALLVPSSLMLLNAAFGDARLRAGAIGVWAGCGGVAMAAGPLVGGLLIE
LWGWRSLFWINLPVIVLGIGLTLRIEVRRPVPALRQMDYAGQGAVILALASSVWVLIEGTRLGWCSGWILGGMAIAALSW
WRFVVIERRHRQPMLPLTLFRSTLFSASALVSLVSALVFYGVFFLLSLYFQRVRGWTPLQSGLAFLPLTMMVTLGSFISG
RLVRAWGGGRVVYCSLLLYALGFVGLLALAESPPYWRIALSFPLLGLAAGIITPAATSALMNDVANERAGIAAGVLNAAR
QSGSAFGVAIFGALMSTSLSQAGGIQTAVYGALGLSLFTAIGWRLAINLAARPGASVRNEQRE
>Mature_462_residues
ASLNQHQKSVLMATSLSYVIVILDTSIVNVALPSIAGELGAGLSGLQWVVNAYTLAFASLLLSGGALGDRLGATRLYLGG
LAVFAGASVICGLAETLPVLVAARVCQGVGAALLVPSSLMLLNAAFGDARLRAGAIGVWAGCGGVAMAAGPLVGGLLIEL
WGWRSLFWINLPVIVLGIGLTLRIEVRRPVPALRQMDYAGQGAVILALASSVWVLIEGTRLGWCSGWILGGMAIAALSWW
RFVVIERRHRQPMLPLTLFRSTLFSASALVSLVSALVFYGVFFLLSLYFQRVRGWTPLQSGLAFLPLTMMVTLGSFISGR
LVRAWGGGRVVYCSLLLYALGFVGLLALAESPPYWRIALSFPLLGLAAGIITPAATSALMNDVANERAGIAAGVLNAARQ
SGSAFGVAIFGALMSTSLSQAGGIQTAVYGALGLSLFTAIGWRLAINLAARPGASVRNEQRE

Specific function: Resistance to the epoxide antibiotic methylenomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=414, Percent_Identity=29.2270531400966, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788710, Length=368, Percent_Identity=30.9782608695652, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI87081983, Length=408, Percent_Identity=29.4117647058824, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1790195, Length=459, Percent_Identity=25.4901960784314, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788392, Length=452, Percent_Identity=27.212389380531, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1790146, Length=165, Percent_Identity=32.1212121212121, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=385, Percent_Identity=22.8571428571429, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323735, Length=318, Percent_Identity=23.5849056603774, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319770, Length=416, Percent_Identity=23.5576923076923, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48415; Mature: 48284

Theoretical pI: Translated: 10.55; Mature: 10.55

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLNQHQKSVLMATSLSYVIVILDTSIVNVALPSIAGELGAGLSGLQWVVNAYTLAFAS
CCCCCHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LLLSGGALGDRLGATRLYLGGLAVFAGASVICGLAETLPVLVAARVCQGVGAALLVPSSL
HHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MLLNAAFGDARLRAGAIGVWAGCGGVAMAAGPLVGGLLIELWGWRSLFWINLPVIVLGIG
HHHHHHCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCCC
LTLRIEVRRPVPALRQMDYAGQGAVILALASSVWVLIEGTRLGWCSGWILGGMAIAALSW
CEEEEEECCCCHHHHHCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
WRFVVIERRHRQPMLPLTLFRSTLFSASALVSLVSALVFYGVFFLLSLYFQRVRGWTPLQ
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
SGLAFLPLTMMVTLGSFISGRLVRAWGGGRVVYCSLLLYALGFVGLLALAESPPYWRIAL
HCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
SFPLLGLAAGIITPAATSALMNDVANERAGIAAGVLNAARQSGSAFGVAIFGALMSTSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QAGGIQTAVYGALGLSLFTAIGWRLAINLAARPGASVRNEQRE
HCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
ASLNQHQKSVLMATSLSYVIVILDTSIVNVALPSIAGELGAGLSGLQWVVNAYTLAFAS
CCCCHHHHHHHHHHHHEEEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LLLSGGALGDRLGATRLYLGGLAVFAGASVICGLAETLPVLVAARVCQGVGAALLVPSSL
HHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MLLNAAFGDARLRAGAIGVWAGCGGVAMAAGPLVGGLLIELWGWRSLFWINLPVIVLGIG
HHHHHHCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCCC
LTLRIEVRRPVPALRQMDYAGQGAVILALASSVWVLIEGTRLGWCSGWILGGMAIAALSW
CEEEEEECCCCHHHHHCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
WRFVVIERRHRQPMLPLTLFRSTLFSASALVSLVSALVFYGVFFLLSLYFQRVRGWTPLQ
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
SGLAFLPLTMMVTLGSFISGRLVRAWGGGRVVYCSLLLYALGFVGLLALAESPPYWRIAL
HCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
SFPLLGLAAGIITPAATSALMNDVANERAGIAAGVLNAARQSGSAFGVAIFGALMSTSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
QAGGIQTAVYGALGLSLFTAIGWRLAINLAARPGASVRNEQRE
HCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1379177; 9384377 [H]