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The map label for this gene is zwf [H]

Identifier: 157371008

GI number: 157371008

Start: 3047135

End: 3048610

Strand: Reverse

Name: zwf [H]

Synonym: Spro_2768

Alternate gene names: 157371008

Gene position: 3048610-3047135 (Counterclockwise)

Preceding gene: 157371011

Following gene: 157371007

Centisome position: 55.95

GC content: 54.54

Gene sequence:

>1476_bases
ATGGCGGTAACCTCTACAGCCCAGGCGTGTGACCTGGTTATTTTCGGCGCGAAAGGCGATTTGGCGCGTCGTAAGCTGTT
GCCTTCCCTGTACCAGTTAGAGAAAGCCGGTCATATCCACCCGGATACCCGTATTATCGGCGTCGGCCGTGCCGAGTGGG
ATAAAGATGCCTATATCAAGGTGGTCAAGGAAGCGCTTGGCACCTTTATGAAAGAAAAACTCGATGACGAACTTTGGGCC
ACGCTGAGTGCGCGCCTGGACTTCTGCAACCTGGATGTGAACGACAGCAAAAATTTTGCCAAATTGGGCAAAATGCTGGA
TCAGAAACATCGCACCACCATCAACTATTTTGCCATGCCGCCCAGCACTTTCGGCGCGATCTGCAAAGGGTTGGGTGAAG
CCAAGCTGAACCACGAGCCGGCACGCGTCGTGATGGAAAAACCACTAGGTACCGATCTGGCCTCTTCGCGCGTGATCAAC
GATCAGGTGGCGGAGTATTTCAACGAGTCTCAGGTTTACCGTATTGACCACTATCTTGGCAAAGAGACGGTGTTGAACCT
GCTGGCACTGCGTTTTGCCAACTCACTGTTTGCCTCCAACTGGGACAATCGTACCATCGACTCGGTGCAAATTACCGTAG
CGGAAGAGGTGGGTATTGAAGGGCGCTGGGGTTACTTTGACCAGGCCGGCCAGATGCGCGACATGATCCAGAACCACCTG
TTGCAAATTCTGACCATGATTGCCATGTCACCTCCGGCGGATCTGACCACTGACCGTATTCGCGATGAGAAAGTGAAGGT
GCTGCGCTCACTGCGTCGTATCAATCAGACCAATGTGCGCGAAACCACGGTGCGTGGCCAATATACTGCCGGTTTTGTGC
AGGGCAAAAAGGTTCCTGGTTACCTGGAAGAGGAAGGGGCGAACAAAAGCAGCAACACCGAAACCTTCGTCTCTATCCGT
GTCGATATCGACAACTGGCAGTGGGCCGGCGTGCCGTTTTACCTGCGAACCGGTAAGCGCTTGCCGACCAAGTGCTCTGA
AGTGGTGGTCTACTTCAAGAACCCACCGCTGAACCTGTTCAGCGATTCTTACCAGCAACTGCCGCAGAACAAATTGACCA
TTCGTCTGCAGCCGGATGAAGGCATCGAGATCCAGGTATTGAACAAGGTCCCTGGCCTGGATCACAAACACCGCCTGCAA
ACCACCAAGCTGGATCTGAGTTTCTCAGAGACCTTCAACCAGGAGCACGTGGCAGACGCCTACGAGCGTCTGTTGCTGGA
GACCATGCGTGGTATCCAGGCGCTGTTTGTGCGCCGTGACGAAGTGGAAGAAGCCTGGAAGTGGGTTGACTCCATCATGG
ACGCCTGGAAAGCGGATAACGAAGCGCCGAAGCCGTATCAGTCCGGTACCTGGGGCCCGGTAGCCTCTGTGGCGATGATC
ACCCGCGATGGCCGTTCCTGGAACGAGTTCGAATAA

Upstream 100 bases:

>100_bases
GCTTTTTTTCTACTTTTGATCCGGGTTTACTGGCTGTAGTTAAAGAGAGTACATTAGTAATGTAAGAAAATTACAAATAT
CCTGCAACGAGGAGATGAAC

Downstream 100 bases:

>100_bases
CGACCCGGCCGGCAGTTTATCTGCCGGCATTTTTTTGCCTGCACGACCGGGGCGCAACATCACTTGGGGTACGGCCGGAC
GCCCGCGAGACTCCGTGGGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MAVTSTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYIKVVKEALGTFMKEKLDDELWA
TLSARLDFCNLDVNDSKNFAKLGKMLDQKHRTTINYFAMPPSTFGAICKGLGEAKLNHEPARVVMEKPLGTDLASSRVIN
DQVAEYFNESQVYRIDHYLGKETVLNLLALRFANSLFASNWDNRTIDSVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
LQILTMIAMSPPADLTTDRIRDEKVKVLRSLRRINQTNVRETTVRGQYTAGFVQGKKVPGYLEEEGANKSSNTETFVSIR
VDIDNWQWAGVPFYLRTGKRLPTKCSEVVVYFKNPPLNLFSDSYQQLPQNKLTIRLQPDEGIEIQVLNKVPGLDHKHRLQ
TTKLDLSFSETFNQEHVADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMDAWKADNEAPKPYQSGTWGPVASVAMI
TRDGRSWNEFE

Sequences:

>Translated_491_residues
MAVTSTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYIKVVKEALGTFMKEKLDDELWA
TLSARLDFCNLDVNDSKNFAKLGKMLDQKHRTTINYFAMPPSTFGAICKGLGEAKLNHEPARVVMEKPLGTDLASSRVIN
DQVAEYFNESQVYRIDHYLGKETVLNLLALRFANSLFASNWDNRTIDSVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
LQILTMIAMSPPADLTTDRIRDEKVKVLRSLRRINQTNVRETTVRGQYTAGFVQGKKVPGYLEEEGANKSSNTETFVSIR
VDIDNWQWAGVPFYLRTGKRLPTKCSEVVVYFKNPPLNLFSDSYQQLPQNKLTIRLQPDEGIEIQVLNKVPGLDHKHRLQ
TTKLDLSFSETFNQEHVADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMDAWKADNEAPKPYQSGTWGPVASVAMI
TRDGRSWNEFE
>Mature_490_residues
AVTSTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYIKVVKEALGTFMKEKLDDELWAT
LSARLDFCNLDVNDSKNFAKLGKMLDQKHRTTINYFAMPPSTFGAICKGLGEAKLNHEPARVVMEKPLGTDLASSRVIND
QVAEYFNESQVYRIDHYLGKETVLNLLALRFANSLFASNWDNRTIDSVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHLL
QILTMIAMSPPADLTTDRIRDEKVKVLRSLRRINQTNVRETTVRGQYTAGFVQGKKVPGYLEEEGANKSSNTETFVSIRV
DIDNWQWAGVPFYLRTGKRLPTKCSEVVVYFKNPPLNLFSDSYQQLPQNKLTIRLQPDEGIEIQVLNKVPGLDHKHRLQT
TKLDLSFSETFNQEHVADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSIMDAWKADNEAPKPYQSGTWGPVASVAMIT
RDGRSWNEFE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=34.3685300207039, Blast_Score=302, Evalue=5e-82,
Organism=Homo sapiens, GI109389365, Length=480, Percent_Identity=34.5833333333333, Blast_Score=302, Evalue=5e-82,
Organism=Homo sapiens, GI52145310, Length=501, Percent_Identity=25.3493013972056, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=86.1507128309572, Blast_Score=895, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=35.2577319587629, Blast_Score=301, Evalue=6e-82,
Organism=Saccharomyces cerevisiae, GI6324088, Length=474, Percent_Identity=33.5443037974684, Blast_Score=273, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24643350, Length=478, Percent_Identity=37.0292887029289, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24643352, Length=478, Percent_Identity=37.0292887029289, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI221513548, Length=497, Percent_Identity=27.9678068410463, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55885; Mature: 55754

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTSTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYIK
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHH
VVKEALGTFMKEKLDDELWATLSARLDFCNLDVNDSKNFAKLGKMLDQKHRTTINYFAMP
HHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECC
PSTFGAICKGLGEAKLNHEPARVVMEKPLGTDLASSRVINDQVAEYFNESQVYRIDHYLG
CHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHC
KETVLNLLALRFANSLFASNWDNRTIDSVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCCCCCCHHCCHHHHHHHHHHH
LQILTMIAMSPPADLTTDRIRDEKVKVLRSLRRINQTNVRETTVRGQYTAGFVQGKKVPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCEEEHEEECCCCCC
YLEEEGANKSSNTETFVSIRVDIDNWQWAGVPFYLRTGKRLPTKCSEVVVYFKNPPLNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCEEEECCCCCCCCCCCEEEEECCCCCCHH
SDSYQQLPQNKLTIRLQPDEGIEIQVLNKVPGLDHKHRLQTTKLDLSFSETFNQEHVADA
HHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCHHHCCCEEEEEEHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSIMDAWKADNEAPKPYQSGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEEE
TRDGRSWNEFE
EECCCCCCCCC
>Mature Secondary Structure 
AVTSTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGHIHPDTRIIGVGRAEWDKDAYIK
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHH
VVKEALGTFMKEKLDDELWATLSARLDFCNLDVNDSKNFAKLGKMLDQKHRTTINYFAMP
HHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECC
PSTFGAICKGLGEAKLNHEPARVVMEKPLGTDLASSRVINDQVAEYFNESQVYRIDHYLG
CHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHC
KETVLNLLALRFANSLFASNWDNRTIDSVQITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHCCCCCCCCCHHCCHHHHHHHHHHH
LQILTMIAMSPPADLTTDRIRDEKVKVLRSLRRINQTNVRETTVRGQYTAGFVQGKKVPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCEEEHEEECCCCCC
YLEEEGANKSSNTETFVSIRVDIDNWQWAGVPFYLRTGKRLPTKCSEVVVYFKNPPLNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCEEEECCCCCCCCCCCEEEEECCCCCCHH
SDSYQQLPQNKLTIRLQPDEGIEIQVLNKVPGLDHKHRLQTTKLDLSFSETFNQEHVADA
HHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCHHHCCCEEEEEEHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSIMDAWKADNEAPKPYQSGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEEE
TRDGRSWNEFE
EECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]