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The map label for this gene is folE2

Identifier: 157370868

GI number: 157370868

Start: 2891509

End: 2892438

Strand: Reverse

Name: folE2

Synonym: Spro_2628

Alternate gene names: 157370868

Gene position: 2892438-2891509 (Counterclockwise)

Preceding gene: 157370875

Following gene: 157370867

Centisome position: 53.08

GC content: 59.25

Gene sequence:

>930_bases
ATGAACAAGGTTGCACTTCCACCAACCCAGCCGCTGCCGGATGCACAGGCCTGGCAGGGGGCAATGAGTGATGTCGGACT
CGATTGGGTAGGGATGCAAGGGATCGCACTGCCGCTGGAGTTGGCGGGCAAGCCGCTGATGGCAAAAGTTAATGCCGGGA
TCAATCTGCGTGCCAGTCGCCATGGCGCGCGTGGAATACATATGTCGCGCCTGTACCTGACGCTGGATGAATTGACTCAG
GGCGAACTGACGCCGCAACGTATTGCTGATTCGCTGCGGGCTTTTCTGGCGTCACAGCCGGAACACAGCGACAGTGCCAG
CCTGAGTATCAGTGGCGAACTGATGTTGTCGCGTCCGGCGCTGCTGTCGGCACATCGCGGCTGGAAAGCTTACCCACTGA
AAATTGACGCCAGCCTAACCACCGGGTTAACCCTGTCGCTGACGGTGGGCGTGCCCTATTCCTCCACCTGTCCAAGTTCG
GCAGCGCTAAGCCGCCAACTGGCACAGCAGCAGTTTCAGTTTGATTTCGAACAGGCGCCGGACAAAGTCAGTCAACAGCA
GGTGATTGACTGGCTGGGCGAACAGGGCATGCCGGGCACCCCGCATAGCCAGCGCAGTTGGGCCTGGGTGACGGTCACGC
TCAATGAAGGCGAAGCCGAATTGCCGGTGGTCAATTTAATCGATCGCATCGAGCATGCGCTGGGCACACCGCTGCAGACG
CTGGTGAAACGTCAGGACGAGCAGGCATTTGCCCTGGCGAATGGCCAGAACCTGATGTTCTGTGAGGATGCCGCGCGCCG
TTTGTATCGGATGTTGCGCAGTCAGTGCCACCACCGCGCATTTTCATTGCGTGTGGAGCACCAGGAAAGCCTGCACGCGC
ACAATGCGGTGGCGGAATTAAGCTGGCAGGAGGCTGGAAATGCTGCGTAA

Upstream 100 bases:

>100_bases
ATTCGCCGTCATGAGCAAAAAAAGTTTAATTGATATGTTATAACATAACAAAATAATGTTACCTTTCTCTGGCAATGTAT
CAATAATCGCAAGGGGATGT

Downstream 100 bases:

>100_bases
AAACCCCAGTGGCCATCTGCCACAGGTTTCACCGAAAGCCTACATCGATCCTACCGCCATTATTTGCGGCCGGGTGATTG
TCGAAGATTTTGTCTACGTT

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNKVALPPTQPLPDAQAWQGAMSDVGLDWVGMQGIALPLELAGKPLMAKVNAGINLRASRHGARGIHMSRLYLTLDELTQ
GELTPQRIADSLRAFLASQPEHSDSASLSISGELMLSRPALLSAHRGWKAYPLKIDASLTTGLTLSLTVGVPYSSTCPSS
AALSRQLAQQQFQFDFEQAPDKVSQQQVIDWLGEQGMPGTPHSQRSWAWVTVTLNEGEAELPVVNLIDRIEHALGTPLQT
LVKRQDEQAFALANGQNLMFCEDAARRLYRMLRSQCHHRAFSLRVEHQESLHAHNAVAELSWQEAGNAA

Sequences:

>Translated_309_residues
MNKVALPPTQPLPDAQAWQGAMSDVGLDWVGMQGIALPLELAGKPLMAKVNAGINLRASRHGARGIHMSRLYLTLDELTQ
GELTPQRIADSLRAFLASQPEHSDSASLSISGELMLSRPALLSAHRGWKAYPLKIDASLTTGLTLSLTVGVPYSSTCPSS
AALSRQLAQQQFQFDFEQAPDKVSQQQVIDWLGEQGMPGTPHSQRSWAWVTVTLNEGEAELPVVNLIDRIEHALGTPLQT
LVKRQDEQAFALANGQNLMFCEDAARRLYRMLRSQCHHRAFSLRVEHQESLHAHNAVAELSWQEAGNAA
>Mature_309_residues
MNKVALPPTQPLPDAQAWQGAMSDVGLDWVGMQGIALPLELAGKPLMAKVNAGINLRASRHGARGIHMSRLYLTLDELTQ
GELTPQRIADSLRAFLASQPEHSDSASLSISGELMLSRPALLSAHRGWKAYPLKIDASLTTGLTLSLTVGVPYSSTCPSS
AALSRQLAQQQFQFDFEQAPDKVSQQQVIDWLGEQGMPGTPHSQRSWAWVTVTLNEGEAELPVVNLIDRIEHALGTPLQT
LVKRQDEQAFALANGQNLMFCEDAARRLYRMLRSQCHHRAFSLRVEHQESLHAHNAVAELSWQEAGNAA

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_SERP5 (A8GF39)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478857.1
- ProteinModelPortal:   A8GF39
- SMR:   A8GF39
- STRING:   A8GF39
- GeneID:   5605259
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2628
- eggNOG:   COG1469
- HOGENOM:   HBG466315
- OMA:   FCEDAAR
- ProtClustDB:   PRK13674
- BioCyc:   SPRO399741:SPRO_2628-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 33880; Mature: 33880

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVALPPTQPLPDAQAWQGAMSDVGLDWVGMQGIALPLELAGKPLMAKVNAGINLRASR
CCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCEEEHHHCCCCEEEEECCCEEEEECC
HGARGIHMSRLYLTLDELTQGELTPQRIADSLRAFLASQPEHSDSASLSISGELMLSRPA
CCCCCEEHHHHEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECEEEECCCH
LLSAHRGWKAYPLKIDASLTTGLTLSLTVGVPYSSTCPSSAALSRQLAQQQFQFDFEQAP
HHHHCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHCC
DKVSQQQVIDWLGEQGMPGTPHSQRSWAWVTVTLNEGEAELPVVNLIDRIEHALGTPLQT
HHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHH
LVKRQDEQAFALANGQNLMFCEDAARRLYRMLRSQCHHRAFSLRVEHQESLHAHNAVAEL
HHHCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHH
SWQEAGNAA
HHHHCCCCC
>Mature Secondary Structure
MNKVALPPTQPLPDAQAWQGAMSDVGLDWVGMQGIALPLELAGKPLMAKVNAGINLRASR
CCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCEEEHHHCCCCEEEEECCCEEEEECC
HGARGIHMSRLYLTLDELTQGELTPQRIADSLRAFLASQPEHSDSASLSISGELMLSRPA
CCCCCEEHHHHEEEHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECEEEECCCH
LLSAHRGWKAYPLKIDASLTTGLTLSLTVGVPYSSTCPSSAALSRQLAQQQFQFDFEQAP
HHHHCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHCC
DKVSQQQVIDWLGEQGMPGTPHSQRSWAWVTVTLNEGEAELPVVNLIDRIEHALGTPLQT
HHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHH
LVKRQDEQAFALANGQNLMFCEDAARRLYRMLRSQCHHRAFSLRVEHQESLHAHNAVAEL
HHHCCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHH
SWQEAGNAA
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA