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The map label for this gene is tyrR [H]

Identifier: 157370857

GI number: 157370857

Start: 2880171

End: 2881742

Strand: Reverse

Name: tyrR [H]

Synonym: Spro_2617

Alternate gene names: 157370857

Gene position: 2881742-2880171 (Counterclockwise)

Preceding gene: 157370858

Following gene: 157370855

Centisome position: 52.89

GC content: 56.17

Gene sequence:

>1572_bases
ATGCGTTTGGAAGTTTTTTGCGAAGACCGGATCGGTCTGACTCGAGAGTTACTCGATCTTTTGGTATTGCGCAGCATAGA
TTTACGTGGCATCGAAATCGATCCCATCGGCCGCATTTACCTCAATTTTTCCCAACTGGATTTTGACACCTTCCGCGCGC
TGATGGTGGAAATCCGCCGCATTGCCGGCGTGACCGATGTTCGCACCGTGAATTTCATGCCGTCTGAACGCGAACACCGC
GCACTGCGTGCGTTGCTGGAGTCGATGCCTGAGCCGGTGTTCTCGATTGATATGAAAGGCAAAGTTGAACTGGCCAATCC
GGCAGCGCAGGCGCTGTTCGGGCTTAGCGAAGACAAAATTCGCAACCAGACGGCCACCGCATTGATTGGCGGTTATAACT
TCAACCGTTGGCTCGAGAGCGAACAGACGGCGCCCCAATCTGAGCGGGTGGTGATCCGCAGTCAGGACTTCCTGATGGAT
ATCACGCCAATCTACCTGGAGGACGAAAACCAGCAGAATGCCGCCGTAGGCGCGGTAGTGATGCTGAAGTCCACGGCTCG
TATGGGGCGTCAGTTACAGAATCTGTCGGTGAACGACGATACCGAGTTTGATCATATCGTTGCCGCCAGTCCGAAAATGC
GCCAGGTGCTGGAGCAGGCGCGCAAGTTGGCGATGCTGGATGCGCCACTGTTGATTGTGGGCGACACCGGCACCGGCAAA
GATATTCTGGCCCGGGCCTGCCATTTGCGCAGCCCGCGTGGCAAGCAGCCGTTCCTGGCGCTCAATTGCGCCGCACTGCC
GGATGACGTAGCGGAAAGCGAGCTGTTCGGCCATGCGCCGGGGGCTTACCCGAATGCGCTGGAAGGCAAGAAGGGCTTCT
TTGAACAGGCGCACGGTGGCTCGGTGCTGCTGGATGAAATCGGTGAGATGTCGCCGCGCATGCAGACCAAACTGCTGCGT
TTCATTAACGATGGCACTTTCCGCCGCGTGGGTGAAGAACATGAAGTCCATGTAGATGTGCGGGTAATTTGCGCGACGCA
GAAAAACCTGACCGAACTGGTGCAGCGTGGTGAGTTCCGTGAGGATCTCTATTATCGACTTAACGTGTTGACCATCACCA
TTCCACCACTGCGTGAGCGTCCGCAGGACATCATGCCGCTGACTGAACTGTTTGTGGCGCGTTTTGCCGATGAACAGGGC
GTGGCGCGGCCGAAACTGGCGGGCGATCTGGGCAGTTTCCTCAGTAAATATGGCTGGCCGGGCAACGTGCGACAGTTAAA
AAACGCCATTTACCGGGCGTTGACGCAAACCGAAGGTTTCGAACTTCGCCCGCAGGACATTGTACTGCCGGAGTTCGAGG
TTGAAATGTCGCTGGGCGATGAGGTGATGGACGGCTCGCTTGATGATATCAGCAAGCGTTTCGAACGTTCGGTGCTGACC
CGTTTGTACCGTACTTACCCGAGTACCAGAAAACTGGCGAAACGCCTGGGGGTTTCACATACCGCGATCGCCAATAAGTT
GCGCGAATATGGGCTCAGCAGCCGTAAGCCTTCCGGGGAAAACGAAGAATAA

Upstream 100 bases:

>100_bases
TTCTGTCAACTTTTGCTGACAGATTGCTTCTACCGCTCGGGGTGAGAGAGTATCATCATCTTCAGTCATCCCCGCACCTG
CAGAGATAAGGCCAATACTG

Downstream 100 bases:

>100_bases
AAAAACGGGCGCCATAAGCGCCCGTTTCAACGTTTAGAGGCCGGCAATCGTCGGCCTTCTGGCATTACTTCAATGCAGCC
AGCGCCGCATCGTAGTTAGG

Product: DNA-binding transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MRLEVFCEDRIGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSQLDFDTFRALMVEIRRIAGVTDVRTVNFMPSEREHR
ALRALLESMPEPVFSIDMKGKVELANPAAQALFGLSEDKIRNQTATALIGGYNFNRWLESEQTAPQSERVVIRSQDFLMD
ITPIYLEDENQQNAAVGAVVMLKSTARMGRQLQNLSVNDDTEFDHIVAASPKMRQVLEQARKLAMLDAPLLIVGDTGTGK
DILARACHLRSPRGKQPFLALNCAALPDDVAESELFGHAPGAYPNALEGKKGFFEQAHGGSVLLDEIGEMSPRMQTKLLR
FINDGTFRRVGEEHEVHVDVRVICATQKNLTELVQRGEFREDLYYRLNVLTITIPPLRERPQDIMPLTELFVARFADEQG
VARPKLAGDLGSFLSKYGWPGNVRQLKNAIYRALTQTEGFELRPQDIVLPEFEVEMSLGDEVMDGSLDDISKRFERSVLT
RLYRTYPSTRKLAKRLGVSHTAIANKLREYGLSSRKPSGENEE

Sequences:

>Translated_523_residues
MRLEVFCEDRIGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSQLDFDTFRALMVEIRRIAGVTDVRTVNFMPSEREHR
ALRALLESMPEPVFSIDMKGKVELANPAAQALFGLSEDKIRNQTATALIGGYNFNRWLESEQTAPQSERVVIRSQDFLMD
ITPIYLEDENQQNAAVGAVVMLKSTARMGRQLQNLSVNDDTEFDHIVAASPKMRQVLEQARKLAMLDAPLLIVGDTGTGK
DILARACHLRSPRGKQPFLALNCAALPDDVAESELFGHAPGAYPNALEGKKGFFEQAHGGSVLLDEIGEMSPRMQTKLLR
FINDGTFRRVGEEHEVHVDVRVICATQKNLTELVQRGEFREDLYYRLNVLTITIPPLRERPQDIMPLTELFVARFADEQG
VARPKLAGDLGSFLSKYGWPGNVRQLKNAIYRALTQTEGFELRPQDIVLPEFEVEMSLGDEVMDGSLDDISKRFERSVLT
RLYRTYPSTRKLAKRLGVSHTAIANKLREYGLSSRKPSGENEE
>Mature_523_residues
MRLEVFCEDRIGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSQLDFDTFRALMVEIRRIAGVTDVRTVNFMPSEREHR
ALRALLESMPEPVFSIDMKGKVELANPAAQALFGLSEDKIRNQTATALIGGYNFNRWLESEQTAPQSERVVIRSQDFLMD
ITPIYLEDENQQNAAVGAVVMLKSTARMGRQLQNLSVNDDTEFDHIVAASPKMRQVLEQARKLAMLDAPLLIVGDTGTGK
DILARACHLRSPRGKQPFLALNCAALPDDVAESELFGHAPGAYPNALEGKKGFFEQAHGGSVLLDEIGEMSPRMQTKLLR
FINDGTFRRVGEEHEVHVDVRVICATQKNLTELVQRGEFREDLYYRLNVLTITIPPLRERPQDIMPLTELFVARFADEQG
VARPKLAGDLGSFLSKYGWPGNVRQLKNAIYRALTQTEGFELRPQDIVLPEFEVEMSLGDEVMDGSLDDISKRFERSVLT
RLYRTYPSTRKLAKRLGVSHTAIANKLREYGLSSRKPSGENEE

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=524, Percent_Identity=73.2824427480916, Blast_Score=785, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=351, Percent_Identity=37.037037037037, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1790299, Length=345, Percent_Identity=38.8405797101449, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=39.4321766561514, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1790437, Length=302, Percent_Identity=39.0728476821192, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87082152, Length=248, Percent_Identity=43.9516129032258, Blast_Score=212, Evalue=6e-56,
Organism=Escherichia coli, GI1788905, Length=331, Percent_Identity=37.7643504531722, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1789233, Length=455, Percent_Identity=29.8901098901099, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87082117, Length=337, Percent_Identity=36.2017804154303, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87081872, Length=251, Percent_Identity=39.4422310756972, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1786524, Length=269, Percent_Identity=41.2639405204461, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789828, Length=239, Percent_Identity=37.2384937238494, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI87081858, Length=448, Percent_Identity=25.4464285714286, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 59005; Mature: 59005

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVFCEDRIGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSQLDFDTFRALMVEIRR
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEHHCCHHHHHHHHHHHHH
IAGVTDVRTVNFMPSEREHRALRALLESMPEPVFSIDMKGKVELANPAAQALFGLSEDKI
HCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEECCHHHHHHHCCCHHHH
RNQTATALIGGYNFNRWLESEQTAPQSERVVIRSQDFLMDITPIYLEDENQQNAAVGAVV
HHHHHHEEEECCCHHHHHCCCCCCCCCCEEEEECCCCEEECCEEEEECCCCCCHHHHHHH
MLKSTARMGRQLQNLSVNDDTEFDHIVAASPKMRQVLEQARKLAMLDAPLLIVGDTGTGK
HHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
DILARACHLRSPRGKQPFLALNCAALPDDVAESELFGHAPGAYPNALEGKKGFFEQAHGG
HHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCC
SVLLDEIGEMSPRMQTKLLRFINDGTFRRVGEEHEVHVDVRVICATQKNLTELVQRGEFR
CCHHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCCEEEEEEEEEEECHHHHHHHHHCCCHH
EDLYYRLNVLTITIPPLRERPQDIMPLTELFVARFADEQGVARPKLAGDLGSFLSKYGWP
HHHEEEEEEEEEEECCHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
GNVRQLKNAIYRALTQTEGFELRPQDIVLPEFEVEMSLGDEVMDGSLDDISKRFERSVLT
CCHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEECCCCCHHHCCCHHHHHHHHHHHHHH
RLYRTYPSTRKLAKRLGVSHTAIANKLREYGLSSRKPSGENEE
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLEVFCEDRIGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSQLDFDTFRALMVEIRR
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEHHCCHHHHHHHHHHHHH
IAGVTDVRTVNFMPSEREHRALRALLESMPEPVFSIDMKGKVELANPAAQALFGLSEDKI
HCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEECCHHHHHHHCCCHHHH
RNQTATALIGGYNFNRWLESEQTAPQSERVVIRSQDFLMDITPIYLEDENQQNAAVGAVV
HHHHHHEEEECCCHHHHHCCCCCCCCCCEEEEECCCCEEECCEEEEECCCCCCHHHHHHH
MLKSTARMGRQLQNLSVNDDTEFDHIVAASPKMRQVLEQARKLAMLDAPLLIVGDTGTGK
HHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
DILARACHLRSPRGKQPFLALNCAALPDDVAESELFGHAPGAYPNALEGKKGFFEQAHGG
HHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCC
SVLLDEIGEMSPRMQTKLLRFINDGTFRRVGEEHEVHVDVRVICATQKNLTELVQRGEFR
CCHHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCCEEEEEEEEEEECHHHHHHHHHCCCHH
EDLYYRLNVLTITIPPLRERPQDIMPLTELFVARFADEQGVARPKLAGDLGSFLSKYGWP
HHHEEEEEEEEEEECCHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
GNVRQLKNAIYRALTQTEGFELRPQDIVLPEFEVEMSLGDEVMDGSLDDISKRFERSVLT
CCHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEECCCCCHHHCCCHHHHHHHHHHHHHH
RLYRTYPSTRKLAKRLGVSHTAIANKLREYGLSSRKPSGENEE
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]