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The map label for this gene is pcaK [H]

Identifier: 157370747

GI number: 157370747

Start: 2752865

End: 2754220

Strand: Reverse

Name: pcaK [H]

Synonym: Spro_2507

Alternate gene names: 157370747

Gene position: 2754220-2752865 (Counterclockwise)

Preceding gene: 157370752

Following gene: 157370746

Centisome position: 50.55

GC content: 58.19

Gene sequence:

>1356_bases
ATGTCCCAGTCAAATACCATAGAAATTCAATCATTTATTAATAACAACCCGTTCTCCCGCTACCAGTGGCTGATCCTCAT
TTTGTGTTTTCTTACCGTGGCGCTGGACGGTTTCGACACTGCGATCATCGGTTTTATCGCCACCTCGTTGGTACAGGACT
GGGGAATAGAGAAAACCTCGCTGGGGCCGGTGATGAGTGCGGCGCTGGTGGGGCTAGCCGTGGGGGCGTTGACCGCTGGG
CCGTTGGCGGATCGCATCGGTCGCAAGAAGGTGTTGGTGCTGTCGCTGGTGCTGTTCGGCGGTTTCAGCCTGTTGACGGC
GTTCGCCACCACCTTGCCAATGCTGACATTATTGCGCTTCTTAACCGGGCTGGGACTGGGTGCGGCAATGCCAAACGCGG
CAACCCTGATGTCGGAATATGCGCCGGAGCGCAAGCGTGCGCTGCTGGTCAACCTGATGTTCTGCGGCTTTCCGCTCGGG
TCATCGATGGGCGGTTTCGTTTCCGCCTGGTTGATCCCGCACTTCGGTTGGCAGAGCGTGATGGTGCTGGGCGGCGTGAT
GCCGCTGCTGTTGGCGGTGGTGCTGATCGTCGCGCTGCCGGAGTCCGCCCGTTTTATGGTGGTGCGTGGCTACCCGGCAC
AGCGTATTGCCGCGGTGCTTAAGCGCATTGCACCGCTTAATTTAACCGAACTGCCGCGCTTTAGCCTGGTTGAAGAGGGC
CTGGTGAAAGCCAAATCGGCACTGGGGGTGATTTTCTCTCCACGCTATCTGTTGGGCACCCTGATGCTGTGCCTGACCTA
CTTTATGGGCCTGATGATCTTCTATCTGCTGACCAGTTGGTTACCGCTGCTGATCCGTGAAACCGGCGCATCCATTCGCC
AGGCATCATTGATTACCGCGCTGTTTCCTTTGGGCGGTGGCATTGGCGTGCTGATCATCGGTTGGCTGATGGATCGAATG
AATCCGCACAAGGTGGTGGCGGTGGGCTATCTGTTGACCGCGATGTTTGTCTGCGCCATTGGCTACGTTTATACCGATCC
CATATTGATGGCGGTGACGGTGTTTATCGCCGGTACCTGCATGAACGGCGCACAGTCCTCAATGCCGGCGCTGGCCGCCG
GTTTTTACCCGACGCAGGGACGGGCGACCGGTGTCGCCTGGATGCTGGGGCTGGGGCGTTTCGGGGGCATTCTTGGCGCG
ATGAGCGGCGGGGTGCTGATGCAAATGCAGCTGTCATTCAGCACCATTTTCACCCTGCTGGCGATCCCGGCGCTGGTGGC
AGCACTGGCGCTGATAGTCAAACATTTTGCTACCAGGGCAACGGCATTGGCCGGCTCGCTCAATAAGGCTTTATAA

Upstream 100 bases:

>100_bases
CGAACCAAGTTTCGATAATCGCACAAATGCGACTTTGCCAGGGATAGGCCTGGCCGTTACCGCCGGGGCTATTTAGCCTG
GCCAACCCAGGAAGCGCACT

Downstream 100 bases:

>100_bases
GGAGATAACCATGCGTACACAAATAGCAATTATTGGTGCCGGCCCGGCCGGATTGATGCTGTCGCATCTGCTGCATTTGC
AGGGCATTGAGTCAGTGGTA

Product: benzoate transport

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSQSNTIEIQSFINNNPFSRYQWLILILCFLTVALDGFDTAIIGFIATSLVQDWGIEKTSLGPVMSAALVGLAVGALTAG
PLADRIGRKKVLVLSLVLFGGFSLLTAFATTLPMLTLLRFLTGLGLGAAMPNAATLMSEYAPERKRALLVNLMFCGFPLG
SSMGGFVSAWLIPHFGWQSVMVLGGVMPLLLAVVLIVALPESARFMVVRGYPAQRIAAVLKRIAPLNLTELPRFSLVEEG
LVKAKSALGVIFSPRYLLGTLMLCLTYFMGLMIFYLLTSWLPLLIRETGASIRQASLITALFPLGGGIGVLIIGWLMDRM
NPHKVVAVGYLLTAMFVCAIGYVYTDPILMAVTVFIAGTCMNGAQSSMPALAAGFYPTQGRATGVAWMLGLGRFGGILGA
MSGGVLMQMQLSFSTIFTLLAIPALVAALALIVKHFATRATALAGSLNKAL

Sequences:

>Translated_451_residues
MSQSNTIEIQSFINNNPFSRYQWLILILCFLTVALDGFDTAIIGFIATSLVQDWGIEKTSLGPVMSAALVGLAVGALTAG
PLADRIGRKKVLVLSLVLFGGFSLLTAFATTLPMLTLLRFLTGLGLGAAMPNAATLMSEYAPERKRALLVNLMFCGFPLG
SSMGGFVSAWLIPHFGWQSVMVLGGVMPLLLAVVLIVALPESARFMVVRGYPAQRIAAVLKRIAPLNLTELPRFSLVEEG
LVKAKSALGVIFSPRYLLGTLMLCLTYFMGLMIFYLLTSWLPLLIRETGASIRQASLITALFPLGGGIGVLIIGWLMDRM
NPHKVVAVGYLLTAMFVCAIGYVYTDPILMAVTVFIAGTCMNGAQSSMPALAAGFYPTQGRATGVAWMLGLGRFGGILGA
MSGGVLMQMQLSFSTIFTLLAIPALVAALALIVKHFATRATALAGSLNKAL
>Mature_450_residues
SQSNTIEIQSFINNNPFSRYQWLILILCFLTVALDGFDTAIIGFIATSLVQDWGIEKTSLGPVMSAALVGLAVGALTAGP
LADRIGRKKVLVLSLVLFGGFSLLTAFATTLPMLTLLRFLTGLGLGAAMPNAATLMSEYAPERKRALLVNLMFCGFPLGS
SMGGFVSAWLIPHFGWQSVMVLGGVMPLLLAVVLIVALPESARFMVVRGYPAQRIAAVLKRIAPLNLTELPRFSLVEEGL
VKAKSALGVIFSPRYLLGTLMLCLTYFMGLMIFYLLTSWLPLLIRETGASIRQASLITALFPLGGGIGVLIIGWLMDRMN
PHKVVAVGYLLTAMFVCAIGYVYTDPILMAVTVFIAGTCMNGAQSSMPALAAGFYPTQGRATGVAWMLGLGRFGGILGAM
SGGVLMQMQLSFSTIFTLLAIPALVAALALIVKHFATRATALAGSLNKAL

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=478, Percent_Identity=25.9414225941423, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI7662270, Length=327, Percent_Identity=24.1590214067278, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI216548223, Length=330, Percent_Identity=26.3636363636364, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI213021148, Length=263, Percent_Identity=25.0950570342205, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI262399383, Length=265, Percent_Identity=26.0377358490566, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI73695465, Length=313, Percent_Identity=24.9201277955272, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI166064021, Length=339, Percent_Identity=27.4336283185841, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI154350196, Length=397, Percent_Identity=24.4332493702771, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI296080721, Length=262, Percent_Identity=27.4809160305344, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI8923870, Length=429, Percent_Identity=23.5431235431235, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI296080719, Length=263, Percent_Identity=27.3764258555133, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI24497499, Length=263, Percent_Identity=27.3764258555133, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI296080734, Length=180, Percent_Identity=29.4444444444444, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI256219598, Length=303, Percent_Identity=21.7821782178218, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI4503847, Length=303, Percent_Identity=21.7821782178218, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI256219483, Length=303, Percent_Identity=21.7821782178218, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI256219543, Length=303, Percent_Identity=21.7821782178218, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87081723, Length=392, Percent_Identity=37.7551020408163, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87082231, Length=458, Percent_Identity=23.3624454148472, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082404, Length=387, Percent_Identity=22.7390180878553, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87082159, Length=408, Percent_Identity=24.7549019607843, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1789152, Length=461, Percent_Identity=22.5596529284165, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788068, Length=460, Percent_Identity=23.9130434782609, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788074, Length=290, Percent_Identity=24.8275862068966, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786229, Length=176, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789207, Length=314, Percent_Identity=26.1146496815287, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789515, Length=324, Percent_Identity=22.5308641975309, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082320, Length=352, Percent_Identity=21.5909090909091, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994889, Length=172, Percent_Identity=28.4883720930233, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789312, Length=269, Percent_Identity=27.8810408921933, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=458, Percent_Identity=24.8908296943231, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17565978, Length=211, Percent_Identity=27.4881516587678, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI19922874, Length=451, Percent_Identity=24.6119733924612, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24640198, Length=453, Percent_Identity=23.841059602649, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24640196, Length=453, Percent_Identity=23.841059602649, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24640200, Length=453, Percent_Identity=23.841059602649, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48016; Mature: 47884

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSNTIEIQSFINNNPFSRYQWLILILCFLTVALDGFDTAIIGFIATSLVQDWGIEKTS
CCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
LGPVMSAALVGLAVGALTAGPLADRIGRKKVLVLSLVLFGGFSLLTAFATTLPMLTLLRF
CHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGLGLGAAMPNAATLMSEYAPERKRALLVNLMFCGFPLGSSMGGFVSAWLIPHFGWQSV
HHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHH
MVLGGVMPLLLAVVLIVALPESARFMVVRGYPAQRIAAVLKRIAPLNLTELPRFSLVEEG
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHCCCHHHHHHHH
LVKAKSALGVIFSPRYLLGTLMLCLTYFMGLMIFYLLTSWLPLLIRETGASIRQASLITA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LFPLGGGIGVLIIGWLMDRMNPHKVVAVGYLLTAMFVCAIGYVYTDPILMAVTVFIAGTC
HHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNGAQSSMPALAAGFYPTQGRATGVAWMLGLGRFGGILGAMSGGVLMQMQLSFSTIFTLL
CCCCHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHH
AIPALVAALALIVKHFATRATALAGSLNKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQSNTIEIQSFINNNPFSRYQWLILILCFLTVALDGFDTAIIGFIATSLVQDWGIEKTS
CCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]