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The map label for this gene is hycC [H]

Identifier: 157370672

GI number: 157370672

Start: 2665454

End: 2667322

Strand: Reverse

Name: hycC [H]

Synonym: Spro_2432

Alternate gene names: 157370672

Gene position: 2667322-2665454 (Counterclockwise)

Preceding gene: 157370673

Following gene: 157370671

Centisome position: 48.95

GC content: 60.3

Gene sequence:

>1869_bases
ATGATATATGCCCTGTTGCCCGACCCGTTGTTACTGCTGACTTCGGCCCTGGTCGGGTATTTGCTCTGCGCCCTGTTGGG
CTGGCTACTGGCCCCCTGGTCGCGTGTCAGCACTTTGCTGAGCGGCGTTACCTTAATCTGTGCCATCGCTACCCTGCTGG
CCGCGGTGCAAATGCTGTTTGCGCCACTGCACAGCGCCCATTTACCGTGGCTGCATTACGCGGTGGAAATCAGTGGCCTT
AACGCCCTGTTACTGCTGGTGATGGCTCTGTGCGGGGTCTTTGCCGCGCTGTATCACGCCGGTAGCTTATCCAGGCTGAA
CCCGCGTGCTCGCGGCCGATTGGCTGGCTTAAGCAACCTGATGCTGGCGGCCTTAAGCGCTGCGGTGATGGCCGATAATG
CCCTGGCCTTGCTGTTGCTGCTGGAGTTGGCGGCACTGTGCGGCTATTTCCTGATTGTCCATGCCCCAAGCGCTAAAAGC
CTGCGTGCCGGACATAGCCAGTTCTTGCTGATGCGCTCAGGCACCCTGTTGTTGGTGGTCGCCTTCGCGCTGATCTATTG
CCATAGCCACAGCCTGCAATTCAGCGTGATCCGCGCGACGCCACTGCCGGATGCATTGCGTAATGCGGTATTCCTGCTGG
CATTGGCCGGGTTTGGCATTTTTGCCGGGCTGATGCCGTTACATGCCTGGGTGCCGCAATCCCACAGCAGTGCGCCCGCC
TCCGCCGCCATGTTGTTTTCCAGTGCGCTGATGAAGGTCGGCCTGCTGGGCATACTGAAAATAGGGCTGGATCTGCTGGG
TACGCCGCCGCTGTGGTGGGGATTACTGGTCTTGCTGTTGGCTGCCGGTACGGCTTTCTTCGGCGGGCTGTATGCGCTGA
TGGAGCACGATCTGCGCCGCTTGCTGGCTTACCACACGCTGGAGAACATCGGCATTATCCTGCTGGGCATCGGGGGCGCG
ATGGTCGGTACGGCGCTGCAACAGCCGTTATTGACCGCCTTTGCCCTGATTGGTGGCCTGTTCCACCTGCTGAACCACAG
CCTGTTTAAAAGCGCATTGCTGCTGGCAGCCGGCGCCATTGAACAACAGACCGGGCTGAAAGACATGGAGAAAATGGGCG
GTTTGGCGCGGCTGATGCCCTGGACCGCCGTTTCTCTGCTGATTGGCCTGGTGGCGATGGCCGCATTACCGCCGTTGAAC
GGTTTTGCCAGTGAATGGTTGATCTACCAGGGACTGTTCCACTTCAGCGCGGCACCCGGTTTTATTGGCCATCTGTTTGG
CCCGCTGCTGGCGGTGGCATTAGCCCTGACCGGTGCGCTGGCGGTGATGTGCGTCAGCAAAGTGTTTGGCGTGGCTTTTC
TGGGCGCTCCGCGCTGCGACGCTGCAGCAAACGCGGTTCAGGCCAATGTTTGGATGACGCTAAGCCATGCGCTGCCGGCT
CTGTTGTGTCTGGTTTGCGGTCTGGGTGCGCCCTGGATCATTCCACTGTTTGCCCGCCTGATCGGCCTGACGTCCGAACA
GACGCTCTCCTTGTCCGATACGCTGGTTTCCACCCCGCTGATCGCCATTTTATTGCTGGCGATGCCGCTACTGCCGTTGT
TGATCGCTGCGCGTTACCAGACGCGTCGGCAACCTCGACGGGTACAAGGCAGCGCCTGGGCCTGTGGTTATGGGCATGAG
GACGCGATGGTGATCACCGCCACCGGTTTTGCTCAACCGTTGCGAGTGATGTTTGCCCCACTGTATCAACTGCGCCGCTG
GCTACCGGGATCCTTCGGTGACCGGTTACACCGTAACGCATTCGTTGCCTTCTGCCGCGGTCTGGCCGCCGTAGAGTTGG
CGGTGCTGCTGGTCGTGGCTTTTGCCTGA

Upstream 100 bases:

>100_bases
TGCGCAACGCCAGCGAACAGAAAAGGCGCAATGCGATGCAGGCGCTCAGCGCCGAGTTGCCGTTTGCGGCCGTCCCTGGA
TCCCACAAGGAGCCAAATTG

Downstream 100 bases:

>100_bases
GGAGATAACGATGACCTATCCCTATGTGTTACTCGGTTTGCTGCAGGCTCTGCTGTTACTGGCTGTTGCCCCGCTGTTTG
CCGGCATCAGCCGGGTGCTG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: FHL subunit 3; Hydrogenase-3 component C [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MIYALLPDPLLLLTSALVGYLLCALLGWLLAPWSRVSTLLSGVTLICAIATLLAAVQMLFAPLHSAHLPWLHYAVEISGL
NALLLLVMALCGVFAALYHAGSLSRLNPRARGRLAGLSNLMLAALSAAVMADNALALLLLLELAALCGYFLIVHAPSAKS
LRAGHSQFLLMRSGTLLLVVAFALIYCHSHSLQFSVIRATPLPDALRNAVFLLALAGFGIFAGLMPLHAWVPQSHSSAPA
SAAMLFSSALMKVGLLGILKIGLDLLGTPPLWWGLLVLLLAAGTAFFGGLYALMEHDLRRLLAYHTLENIGIILLGIGGA
MVGTALQQPLLTAFALIGGLFHLLNHSLFKSALLLAAGAIEQQTGLKDMEKMGGLARLMPWTAVSLLIGLVAMAALPPLN
GFASEWLIYQGLFHFSAAPGFIGHLFGPLLAVALALTGALAVMCVSKVFGVAFLGAPRCDAAANAVQANVWMTLSHALPA
LLCLVCGLGAPWIIPLFARLIGLTSEQTLSLSDTLVSTPLIAILLLAMPLLPLLIAARYQTRRQPRRVQGSAWACGYGHE
DAMVITATGFAQPLRVMFAPLYQLRRWLPGSFGDRLHRNAFVAFCRGLAAVELAVLLVVAFA

Sequences:

>Translated_622_residues
MIYALLPDPLLLLTSALVGYLLCALLGWLLAPWSRVSTLLSGVTLICAIATLLAAVQMLFAPLHSAHLPWLHYAVEISGL
NALLLLVMALCGVFAALYHAGSLSRLNPRARGRLAGLSNLMLAALSAAVMADNALALLLLLELAALCGYFLIVHAPSAKS
LRAGHSQFLLMRSGTLLLVVAFALIYCHSHSLQFSVIRATPLPDALRNAVFLLALAGFGIFAGLMPLHAWVPQSHSSAPA
SAAMLFSSALMKVGLLGILKIGLDLLGTPPLWWGLLVLLLAAGTAFFGGLYALMEHDLRRLLAYHTLENIGIILLGIGGA
MVGTALQQPLLTAFALIGGLFHLLNHSLFKSALLLAAGAIEQQTGLKDMEKMGGLARLMPWTAVSLLIGLVAMAALPPLN
GFASEWLIYQGLFHFSAAPGFIGHLFGPLLAVALALTGALAVMCVSKVFGVAFLGAPRCDAAANAVQANVWMTLSHALPA
LLCLVCGLGAPWIIPLFARLIGLTSEQTLSLSDTLVSTPLIAILLLAMPLLPLLIAARYQTRRQPRRVQGSAWACGYGHE
DAMVITATGFAQPLRVMFAPLYQLRRWLPGSFGDRLHRNAFVAFCRGLAAVELAVLLVVAFA
>Mature_622_residues
MIYALLPDPLLLLTSALVGYLLCALLGWLLAPWSRVSTLLSGVTLICAIATLLAAVQMLFAPLHSAHLPWLHYAVEISGL
NALLLLVMALCGVFAALYHAGSLSRLNPRARGRLAGLSNLMLAALSAAVMADNALALLLLLELAALCGYFLIVHAPSAKS
LRAGHSQFLLMRSGTLLLVVAFALIYCHSHSLQFSVIRATPLPDALRNAVFLLALAGFGIFAGLMPLHAWVPQSHSSAPA
SAAMLFSSALMKVGLLGILKIGLDLLGTPPLWWGLLVLLLAAGTAFFGGLYALMEHDLRRLLAYHTLENIGIILLGIGGA
MVGTALQQPLLTAFALIGGLFHLLNHSLFKSALLLAAGAIEQQTGLKDMEKMGGLARLMPWTAVSLLIGLVAMAALPPLN
GFASEWLIYQGLFHFSAAPGFIGHLFGPLLAVALALTGALAVMCVSKVFGVAFLGAPRCDAAANAVQANVWMTLSHALPA
LLCLVCGLGAPWIIPLFARLIGLTSEQTLSLSDTLVSTPLIAILLLAMPLLPLLIAARYQTRRQPRRVQGSAWACGYGHE
DAMVITATGFAQPLRVMFAPLYQLRRWLPGSFGDRLHRNAFVAFCRGLAAVELAVLLVVAFA

Specific function: Hydrogen metabolism; FHL pathway. [C]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=348, Percent_Identity=25.8620689655172, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI2367154, Length=559, Percent_Identity=47.5849731663685, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1788827, Length=614, Percent_Identity=39.9022801302932, Blast_Score=374, Evalue=1e-104,
Organism=Escherichia coli, GI1788831, Length=364, Percent_Identity=29.1208791208791, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788829, Length=349, Percent_Identity=25.214899713467, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1788613, Length=351, Percent_Identity=23.9316239316239, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788614, Length=503, Percent_Identity=26.2425447316103, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: NA

Molecular weight: Translated: 65935; Mature: 65935

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYALLPDPLLLLTSALVGYLLCALLGWLLAPWSRVSTLLSGVTLICAIATLLAAVQMLF
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APLHSAHLPWLHYAVEISGLNALLLLVMALCGVFAALYHAGSLSRLNPRARGRLAGLSNL
HHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHH
MLAALSAAVMADNALALLLLLELAALCGYFLIVHAPSAKSLRAGHSQFLLMRSGTLLLVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHEEHHHCCHHHHHH
AFALIYCHSHSLQFSVIRATPLPDALRNAVFLLALAGFGIFAGLMPLHAWVPQSHSSAPA
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SAAMLFSSALMKVGLLGILKIGLDLLGTPPLWWGLLVLLLAAGTAFFGGLYALMEHDLRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAYHTLENIGIILLGIGGAMVGTALQQPLLTAFALIGGLFHLLNHSLFKSALLLAAGAI
HHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQQTGLKDMEKMGGLARLMPWTAVSLLIGLVAMAALPPLNGFASEWLIYQGLFHFSAAPG
HHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCH
FIGHLFGPLLAVALALTGALAVMCVSKVFGVAFLGAPRCDAAANAVQANVWMTLSHALPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLCLVCGLGAPWIIPLFARLIGLTSEQTLSLSDTLVSTPLIAILLLAMPLLPLLIAARYQ
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRRQPRRVQGSAWACGYGHEDAMVITATGFAQPLRVMFAPLYQLRRWLPGSFGDRLHRNA
HHCCCCCCCCCCEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FVAFCRGLAAVELAVLLVVAFA
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIYALLPDPLLLLTSALVGYLLCALLGWLLAPWSRVSTLLSGVTLICAIATLLAAVQMLF
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APLHSAHLPWLHYAVEISGLNALLLLVMALCGVFAALYHAGSLSRLNPRARGRLAGLSNL
HHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHH
MLAALSAAVMADNALALLLLLELAALCGYFLIVHAPSAKSLRAGHSQFLLMRSGTLLLVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHEEHHHCCHHHHHH
AFALIYCHSHSLQFSVIRATPLPDALRNAVFLLALAGFGIFAGLMPLHAWVPQSHSSAPA
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SAAMLFSSALMKVGLLGILKIGLDLLGTPPLWWGLLVLLLAAGTAFFGGLYALMEHDLRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAYHTLENIGIILLGIGGAMVGTALQQPLLTAFALIGGLFHLLNHSLFKSALLLAAGAI
HHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQQTGLKDMEKMGGLARLMPWTAVSLLIGLVAMAALPPLNGFASEWLIYQGLFHFSAAPG
HHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCH
FIGHLFGPLLAVALALTGALAVMCVSKVFGVAFLGAPRCDAAANAVQANVWMTLSHALPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLCLVCGLGAPWIIPLFARLIGLTSEQTLSLSDTLVSTPLIAILLLAMPLLPLLIAARYQ
HHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRRQPRRVQGSAWACGYGHEDAMVITATGFAQPLRVMFAPLYQLRRWLPGSFGDRLHRNA
HHCCCCCCCCCCEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FVAFCRGLAAVELAVLLVVAFA
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2187144; 9278503 [H]