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The map label for this gene is adhA [H]

Identifier: 157370643

GI number: 157370643

Start: 2625325

End: 2626338

Strand: Direct

Name: adhA [H]

Synonym: Spro_2403

Alternate gene names: 157370643

Gene position: 2625325-2626338 (Clockwise)

Preceding gene: 157370642

Following gene: 157370651

Centisome position: 48.18

GC content: 55.82

Gene sequence:

>1014_bases
ATGAAAGCTGCCGTAGTTACTAAAAACCACAGTGTAGATATTCAGGAAAAGCAGCTTCGCCCACTGAAATATGGCGAAGC
GGCACTCAAGATGGAGTGTTGTGGGGTCTGTCACACCGATCTTCACGTCAAGAATGGCGATTTTGGCGAAGTCCCCGGCA
TCACCCTGGGCCATGAAGGGGTCGGGGTGGTCACTGCCGTCGGCGAGGGCGTAACCTCGTTAAAAGTCGGGGACCGTGCC
AGCGTCGCCTGGTTCTATCAGGGCTGTGGCCATTGCGAATATTGCGTCAACGGTAACGAAACCCTGTGCCGTTCGGTTAA
AAATGCCGGTTTCAGCGTGGACGGCGGCATGGCGGAAGAGTGCATCGTGGTGGCGGACTATGCGGTCAAGGTGCCCGACG
GCCTGGACTCGTTTGCCGCCAGCAGCATCACCTGCGCCGGGGTCACCACCTATAAGGCGGTTAAAATTTCCGACATCAAA
CCGGGGCAATGGATCGCGATTTATGGCCTGGGCGGATTGGGCAATCTGGCGTTGCAGTATGCCAAGAACGTGTTTAATGC
CAAAGTGATCGCCATTGACGTTAATCAGGGGCAGTTGGATTTCGCCAAAGAAATTGGGGCGGATCTGGTTATCAACTCTA
AAACTGAAAACGCCGAAGAAATTATTCAGCAAAAAGTCGGTGGCGCACATGCCGCCGTGGTTACCGCCGTGGCGCGTTCG
GCCTTTAACTCTGCGGTGAATGCCGTGCGTGCCGGGGGTAAGGTCGTGGCCGTGGGCCTGCCGCCAGAGAGTATGGACCT
GAGCATTCCGCGTTTGGTACTGGACGGGATCCAGGTAGTGGGGTCGCTGGTCGGGACCCGGGAAGATCTGAAAGAAGCCT
TCCAGTTTGCCGCCGAAGGCAAAGTGACGCCGAAAGTCACCAAAAGGCCGCTGGGTGACATCAACGCCATCTTTGAAGAG
ATGAAATCCGGCACCATTCGTGGCCGTATGGTTATCGATCTTTCCGCCTCTTAA

Upstream 100 bases:

>100_bases
AACTTTCTGTTTTTAAAGTAAACGCCAGACTTCTTGCCCTCAGGGGGGACAGTAACTACATTAACAGCTGTACTTCAACT
CACCTGAGGAGAGACATCCT

Downstream 100 bases:

>100_bases
TCCTGCTCTGTTGAGGTGACTTATTCCCTCTTCCAATGAAGAGGGAATATCGGGTTAACCCGCCGACGTCTTAAAAACCT
GCCCCCAGTTGGCCAACAGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase I; ADH I [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKAAVVTKNHSVDIQEKQLRPLKYGEAALKMECCGVCHTDLHVKNGDFGEVPGITLGHEGVGVVTAVGEGVTSLKVGDRA
SVAWFYQGCGHCEYCVNGNETLCRSVKNAGFSVDGGMAEECIVVADYAVKVPDGLDSFAASSITCAGVTTYKAVKISDIK
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNQGQLDFAKEIGADLVINSKTENAEEIIQQKVGGAHAAVVTAVARS
AFNSAVNAVRAGGKVVAVGLPPESMDLSIPRLVLDGIQVVGSLVGTREDLKEAFQFAAEGKVTPKVTKRPLGDINAIFEE
MKSGTIRGRMVIDLSAS

Sequences:

>Translated_337_residues
MKAAVVTKNHSVDIQEKQLRPLKYGEAALKMECCGVCHTDLHVKNGDFGEVPGITLGHEGVGVVTAVGEGVTSLKVGDRA
SVAWFYQGCGHCEYCVNGNETLCRSVKNAGFSVDGGMAEECIVVADYAVKVPDGLDSFAASSITCAGVTTYKAVKISDIK
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNQGQLDFAKEIGADLVINSKTENAEEIIQQKVGGAHAAVVTAVARS
AFNSAVNAVRAGGKVVAVGLPPESMDLSIPRLVLDGIQVVGSLVGTREDLKEAFQFAAEGKVTPKVTKRPLGDINAIFEE
MKSGTIRGRMVIDLSAS
>Mature_337_residues
MKAAVVTKNHSVDIQEKQLRPLKYGEAALKMECCGVCHTDLHVKNGDFGEVPGITLGHEGVGVVTAVGEGVTSLKVGDRA
SVAWFYQGCGHCEYCVNGNETLCRSVKNAGFSVDGGMAEECIVVADYAVKVPDGLDSFAASSITCAGVTTYKAVKISDIK
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNQGQLDFAKEIGADLVINSKTENAEEIIQQKVGGAHAAVVTAVARS
AFNSAVNAVRAGGKVVAVGLPPESMDLSIPRLVLDGIQVVGSLVGTREDLKEAFQFAAEGKVTPKVTKRPLGDINAIFEE
MKSGTIRGRMVIDLSAS

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=366, Percent_Identity=30.0546448087432, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI34577061, Length=366, Percent_Identity=30.327868852459, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4501929, Length=364, Percent_Identity=29.9450549450549, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI71743840, Length=356, Percent_Identity=27.8089887640449, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI262073058, Length=356, Percent_Identity=27.8089887640449, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI71565154, Length=238, Percent_Identity=32.3529411764706, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=26.9444444444444, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=26.9444444444444, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI71565152, Length=304, Percent_Identity=25.9868421052632, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI156627571, Length=312, Percent_Identity=27.8846153846154, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI87081918, Length=334, Percent_Identity=82.0359281437126, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI1790045, Length=315, Percent_Identity=27.3015873015873, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87082401, Length=324, Percent_Identity=28.3950617283951, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787863, Length=274, Percent_Identity=31.021897810219, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786518, Length=339, Percent_Identity=28.3185840707965, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1788073, Length=251, Percent_Identity=31.8725099601594, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI226510992, Length=282, Percent_Identity=28.3687943262411, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788075, Length=304, Percent_Identity=26.9736842105263, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082125, Length=345, Percent_Identity=25.5072463768116, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=350, Percent_Identity=30.2857142857143, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790718, Length=279, Percent_Identity=26.1648745519713, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=29.4642857142857, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786825, Length=249, Percent_Identity=27.3092369477912, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=34.3108504398827, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17562584, Length=351, Percent_Identity=33.3333333333333, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17562582, Length=335, Percent_Identity=34.9253731343284, Blast_Score=170, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17562876, Length=269, Percent_Identity=28.996282527881, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=201, Percent_Identity=30.8457711442786, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=243, Percent_Identity=31.6872427983539, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=240, Percent_Identity=31.6666666666667, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=239, Percent_Identity=31.3807531380753, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=36.7781155015198, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324486, Length=341, Percent_Identity=35.1906158357771, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=35.9281437125749, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319621, Length=319, Percent_Identity=35.7366771159875, Blast_Score=189, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6319949, Length=327, Percent_Identity=26.2996941896024, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=326, Percent_Identity=26.9938650306748, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=352, Percent_Identity=27.8409090909091, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=323, Percent_Identity=26.0061919504644, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=323, Percent_Identity=26.0061919504644, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=313, Percent_Identity=24.2811501597444, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=308, Percent_Identity=24.6753246753247, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17137530, Length=231, Percent_Identity=29.4372294372294, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17737897, Length=226, Percent_Identity=27.8761061946903, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17737895, Length=224, Percent_Identity=29.0178571428571, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35342; Mature: 35342

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVVTKNHSVDIQEKQLRPLKYGEAALKMECCGVCHTDLHVKNGDFGEVPGITLGHEG
CCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCCCCEEECCCC
VGVVTAVGEGVTSLKVGDRASVAWFYQGCGHCEYCVNGNETLCRSVKNAGFSVDGGMAEE
CEEEEECCCCCEEEECCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCC
CIVVADYAVKVPDGLDSFAASSITCAGVTTYKAVKISDIKPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCHHHHHCCEEEECEEEEEEEEEECCCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNQGQLDFAKEIGADLVINSKTENAEEIIQQKVGGAHAAVVTAVARS
HHHHCCCEEEEEECCCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHH
AFNSAVNAVRAGGKVVAVGLPPESMDLSIPRLVLDGIQVVGSLVGTREDLKEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVTPKVTKRPLGDINAIFEEMKSGTIRGRMVIDLSAS
CCCCHHHCCCCHHHHHHHHHHHCCCEEEEEEEEEECC
>Mature Secondary Structure
MKAAVVTKNHSVDIQEKQLRPLKYGEAALKMECCGVCHTDLHVKNGDFGEVPGITLGHEG
CCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCCCCEEECCCC
VGVVTAVGEGVTSLKVGDRASVAWFYQGCGHCEYCVNGNETLCRSVKNAGFSVDGGMAEE
CEEEEECCCCCEEEECCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCC
CIVVADYAVKVPDGLDSFAASSITCAGVTTYKAVKISDIKPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCHHHHHCCEEEECEEEEEEEEEECCCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNQGQLDFAKEIGADLVINSKTENAEEIIQQKVGGAHAAVVTAVARS
HHHHCCCEEEEEECCCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHH
AFNSAVNAVRAGGKVVAVGLPPESMDLSIPRLVLDGIQVVGSLVGTREDLKEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVTPKVTKRPLGDINAIFEEMKSGTIRGRMVIDLSAS
CCCCHHHCCCCHHHHHHHHHHHCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185223; 8320209; 2935393 [H]