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The map label for this gene is lrp [H]

Identifier: 157370640

GI number: 157370640

Start: 2621031

End: 2621486

Strand: Reverse

Name: lrp [H]

Synonym: Spro_2400

Alternate gene names: 157370640

Gene position: 2621486-2621031 (Counterclockwise)

Preceding gene: 157370644

Following gene: 157370632

Centisome position: 48.11

GC content: 56.36

Gene sequence:

>456_bases
GTGGAAAAGAAAGCCCGGCTTGATCGCATCGACAAAAAAATCCTTGAAATACTGTGCCGGGATGGCCGCATTTCGTTTCA
GAAACTGTCCGAACAGGTCAATCTGACCGCCCGCCCTTGCCTGGAGCGGGTTCGCGGGCTGGAGCGCGACGGAATTATTC
GTGGCTACAGCGCCATAATCGAACTGCCGGAGCCGGAACATGCGTTTGTGATCCAGGCGCAGATCGCATTGGCCGATCAC
GGCCACTCCCAACCGGCCTTCGAGCAGGAAATGCGTAATACCCCCGAGGTATTGGATTGCTGGCTGGTCAGCGGCAACTT
CGATTTTCTGGTGCGCATTGGCTGCCGCAGCATGGAAAACTACCGGCTGCTGGCCGATACCTGGCTGACCAGCAAGAAAT
TTCGGGTGGATAAAATCGTCACCCTGACCGAGCTGCAGTCGATCAAACGCTCCTGA

Upstream 100 bases:

>100_bases
TTACCCGGCTGGCCGAAATGAAAACTGGTGAATTGGCGCTGCCCACCCAGAGCATGTTCAGGTAACTTATGATGATTAGT
TTTCATTGGACGCCCTATCT

Downstream 100 bases:

>100_bases
ACTGCATCAATCGCGGCGGATAAACGCCAGCCAGCGACGCTCTGCCCGTGAAAACATGAAGATCAGCAGGAAAGTGCACA
GCAAATACAGTGCCGCCGCC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MEKKARLDRIDKKILEILCRDGRISFQKLSEQVNLTARPCLERVRGLERDGIIRGYSAIIELPEPEHAFVIQAQIALADH
GHSQPAFEQEMRNTPEVLDCWLVSGNFDFLVRIGCRSMENYRLLADTWLTSKKFRVDKIVTLTELQSIKRS

Sequences:

>Translated_151_residues
MEKKARLDRIDKKILEILCRDGRISFQKLSEQVNLTARPCLERVRGLERDGIIRGYSAIIELPEPEHAFVIQAQIALADH
GHSQPAFEQEMRNTPEVLDCWLVSGNFDFLVRIGCRSMENYRLLADTWLTSKKFRVDKIVTLTELQSIKRS
>Mature_151_residues
MEKKARLDRIDKKILEILCRDGRISFQKLSEQVNLTARPCLERVRGLERDGIIRGYSAIIELPEPEHAFVIQAQIALADH
GHSQPAFEQEMRNTPEVLDCWLVSGNFDFLVRIGCRSMENYRLLADTWLTSKKFRVDKIVTLTELQSIKRS

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=127, Percent_Identity=41.7322834645669, Blast_Score=89, Evalue=1e-19,
Organism=Escherichia coli, GI87081742, Length=118, Percent_Identity=36.4406779661017, Blast_Score=77, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17485; Mature: 17485

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKARLDRIDKKILEILCRDGRISFQKLSEQVNLTARPCLERVRGLERDGIIRGYSAII
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHEE
ELPEPEHAFVIQAQIALADHGHSQPAFEQEMRNTPEVLDCWLVSGNFDFLVRIGCRSMEN
ECCCCCCEEEEEEEEEEECCCCCCCHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCC
YRLLADTWLTSKKFRVDKIVTLTELQSIKRS
CEEEHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKKARLDRIDKKILEILCRDGRISFQKLSEQVNLTARPCLERVRGLERDGIIRGYSAII
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHEE
ELPEPEHAFVIQAQIALADHGHSQPAFEQEMRNTPEVLDCWLVSGNFDFLVRIGCRSMEN
ECCCCCCEEEEEEEEEEECCCCCCCHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCC
YRLLADTWLTSKKFRVDKIVTLTELQSIKRS
CEEEHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]