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The map label for this gene is mrdA [H]

Identifier: 157370596

GI number: 157370596

Start: 2568363

End: 2570288

Strand: Direct

Name: mrdA [H]

Synonym: Spro_2356

Alternate gene names: 157370596

Gene position: 2568363-2570288 (Clockwise)

Preceding gene: 157370594

Following gene: 157370597

Centisome position: 47.14

GC content: 55.45

Gene sequence:

>1926_bases
ATGGCCCTATTAAAAGATAAAATTCGTGACCATTCCGCAGAGGAAATGCTGTTTATTCGCCGTGCCGGCGTGGCAATGGT
GCTGGTTGTCGCCTGTTTTGGCGTGCTGGTCGCCAACCTGTATCGATTACAGGTCAAACAGCATGGGTTCTACCAAACTC
GCTCCAATCAGAACGACATTAAAATGGTGCCGATTGCCCCGAGTCGTGGGCTGATCTTCGACCGCAATGGCACCCCGCTG
GTGCGTAACATCACGCTGTACCAAATCCAGATCATTCCCAGCAAAATCGAAAACATGACCGCGTTGCTGCAAGAGCTGAC
GCCGATTGTCGATCTGACCCCGGAAGATATCACCGCCTTTCGCGATGATATGCACCATAACGGTCGCTACAAGCCGGTGA
CGCTGAAAAGCGGGCTGACCGAGACCGAGGTGGCGCGCTTTGCGGTCAATCAGTACCGCTTTGATGGGGTAACCATCGAT
ACCTATCAGCAACGGGAATATCCGTACGGTGCCGAACTGGCTCATGTGGTGGGCTACGTATCGAAAATCAACGATAGTGA
CTTGAAGCGGCTGGATAAAGCCGGTCTGAGTGAGAACTATGCCGCCGACCACAATATCGGCAAGCAGGGCATTGAGGCTT
ATTACGAGTCTGAACTGCACGGCACCACCGGCTATCAGGAAGTGGAGGTAGATAACCACGGCCGGGTGATACGCCTGTTG
AAAGAACAACCGCCACAGGCGGGCAAAAATATTTACCTGACGCTCGATCTGCCGCTGCAGCAATATATCGAATCGGTGCT
CAAAGGGCAGCGAGCGGCAGTGGTGGTTGAAGACCCGCGTGACGGCGGCATTCTGGCGATGGTTTCCAGCCCCAGCTACG
ATCCCAATCCTTTCGTGAAGGGCATCAGTTACTCCGCCTATAAATCGCTGTTGGCCAACCCCGACCTGCCGCTGATAAAC
CGCGTAACCCAGGGGCTGTACCCACCGGCATCCACAGTGAAACCCTACATGGCGACCTCTGCACTGTTTGCCGGGGTGAT
CACCCCCAATACCACCTTCTTTGGCGCCCCGACCTGGACGTTGCCGGGTACCCAACGCCGTTATCGCGACTGGCTTAAAA
CCGGTCATGGGATGCTGAACGTGACCAAGGCGATTGAAGAGTCCGCCGATACTTTCTTCTATCAGGTGGCCTATGAAATG
GGCATTGACCGCATTCATAGCTGGCTGAGCAAGTTTGGTTACGGCCAGGCTACCGGAATTGACCTTAACGAAGAATATCG
CGGTGTCTTGCCAAGCCGCGAATGGAAGCAGCGGGTGCATAAAAAAACCTGGTACCAGGGGGACACTATCTCGGTGGGCA
TCGGCCAGGGTTATTGGGTCGCCACGCCAATCCAGATGGTGAAGGCACTCACCACGCTTATCAATAACGGCAAGGTGAAG
ACGCCTCATCTGTTGTATTCCATGCGTCAGGGGCGCCAGGTGAACCTCTATCAACCGCCGAAGCAGGCCGCGCAGATTGG
CGATGCCAAATCGCCGTATTGGGGCATTGTGCGCAACGGCATGTATGGCATGGCCAACCTGCCAAACGGGACCGGCTACA
AGCTGTTCCACACCGCGCCGTACCAAATCGCCGCCAAGTCCGGGACTTCGCAGGTGTTTGGGCTGAAAGAAAATCAGACC
TATAACGCCAAAATGATCCCGGTGCGGCTGCGTGACCATATCTTCTATACGCTGTTTGCCCCCTATAAAAACCCACGGGT
GGCGATGGCGCTGATTCTGGAAAACGGCGGTGGCGACGGTGTTGTGGCAGGGCCGACCGCGCGGGCGATCCTCGACCATA
TATTTGACCCGGCCAACGCCCCGCAGCCTGAACAAGGGCAAGAAGTTAAACCGGAGTTAAACGACAGCGCGGATGTGCAA
CAGTAA

Upstream 100 bases:

>100_bases
TTTAATGGGGAGCCTTTGCCAATAACGCTATGCTTGCCGACTTTTCACTGCCCTGATTTATCTTGGGAAATTGTGACGTC
TGACAGGTAACTCGCCACGC

Downstream 100 bases:

>100_bases
ACGCGTTTGTTTTTACTTTCTTACAAACTGCAATCTTCTAAAGATTTTCGTCAGGTTAGACTGAAATCATTACATAACCT
TAATAAAAACGCAGGGTTAA

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MALLKDKIRDHSAEEMLFIRRAGVAMVLVVACFGVLVANLYRLQVKQHGFYQTRSNQNDIKMVPIAPSRGLIFDRNGTPL
VRNITLYQIQIIPSKIENMTALLQELTPIVDLTPEDITAFRDDMHHNGRYKPVTLKSGLTETEVARFAVNQYRFDGVTID
TYQQREYPYGAELAHVVGYVSKINDSDLKRLDKAGLSENYAADHNIGKQGIEAYYESELHGTTGYQEVEVDNHGRVIRLL
KEQPPQAGKNIYLTLDLPLQQYIESVLKGQRAAVVVEDPRDGGILAMVSSPSYDPNPFVKGISYSAYKSLLANPDLPLIN
RVTQGLYPPASTVKPYMATSALFAGVITPNTTFFGAPTWTLPGTQRRYRDWLKTGHGMLNVTKAIEESADTFFYQVAYEM
GIDRIHSWLSKFGYGQATGIDLNEEYRGVLPSREWKQRVHKKTWYQGDTISVGIGQGYWVATPIQMVKALTTLINNGKVK
TPHLLYSMRQGRQVNLYQPPKQAAQIGDAKSPYWGIVRNGMYGMANLPNGTGYKLFHTAPYQIAAKSGTSQVFGLKENQT
YNAKMIPVRLRDHIFYTLFAPYKNPRVAMALILENGGGDGVVAGPTARAILDHIFDPANAPQPEQGQEVKPELNDSADVQ
Q

Sequences:

>Translated_641_residues
MALLKDKIRDHSAEEMLFIRRAGVAMVLVVACFGVLVANLYRLQVKQHGFYQTRSNQNDIKMVPIAPSRGLIFDRNGTPL
VRNITLYQIQIIPSKIENMTALLQELTPIVDLTPEDITAFRDDMHHNGRYKPVTLKSGLTETEVARFAVNQYRFDGVTID
TYQQREYPYGAELAHVVGYVSKINDSDLKRLDKAGLSENYAADHNIGKQGIEAYYESELHGTTGYQEVEVDNHGRVIRLL
KEQPPQAGKNIYLTLDLPLQQYIESVLKGQRAAVVVEDPRDGGILAMVSSPSYDPNPFVKGISYSAYKSLLANPDLPLIN
RVTQGLYPPASTVKPYMATSALFAGVITPNTTFFGAPTWTLPGTQRRYRDWLKTGHGMLNVTKAIEESADTFFYQVAYEM
GIDRIHSWLSKFGYGQATGIDLNEEYRGVLPSREWKQRVHKKTWYQGDTISVGIGQGYWVATPIQMVKALTTLINNGKVK
TPHLLYSMRQGRQVNLYQPPKQAAQIGDAKSPYWGIVRNGMYGMANLPNGTGYKLFHTAPYQIAAKSGTSQVFGLKENQT
YNAKMIPVRLRDHIFYTLFAPYKNPRVAMALILENGGGDGVVAGPTARAILDHIFDPANAPQPEQGQEVKPELNDSADVQ
Q
>Mature_640_residues
ALLKDKIRDHSAEEMLFIRRAGVAMVLVVACFGVLVANLYRLQVKQHGFYQTRSNQNDIKMVPIAPSRGLIFDRNGTPLV
RNITLYQIQIIPSKIENMTALLQELTPIVDLTPEDITAFRDDMHHNGRYKPVTLKSGLTETEVARFAVNQYRFDGVTIDT
YQQREYPYGAELAHVVGYVSKINDSDLKRLDKAGLSENYAADHNIGKQGIEAYYESELHGTTGYQEVEVDNHGRVIRLLK
EQPPQAGKNIYLTLDLPLQQYIESVLKGQRAAVVVEDPRDGGILAMVSSPSYDPNPFVKGISYSAYKSLLANPDLPLINR
VTQGLYPPASTVKPYMATSALFAGVITPNTTFFGAPTWTLPGTQRRYRDWLKTGHGMLNVTKAIEESADTFFYQVAYEMG
IDRIHSWLSKFGYGQATGIDLNEEYRGVLPSREWKQRVHKKTWYQGDTISVGIGQGYWVATPIQMVKALTTLINNGKVKT
PHLLYSMRQGRQVNLYQPPKQAAQIGDAKSPYWGIVRNGMYGMANLPNGTGYKLFHTAPYQIAAKSGTSQVFGLKENQTY
NAKMIPVRLRDHIFYTLFAPYKNPRVAMALILENGGGDGVVAGPTARAILDHIFDPANAPQPEQGQEVKPELNDSADVQQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=613, Percent_Identity=62.1533442088091, Blast_Score=777, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=611, Percent_Identity=22.9132569558101, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71657; Mature: 71525

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLKDKIRDHSAEEMLFIRRAGVAMVLVVACFGVLVANLYRLQVKQHGFYQTRSNQNDI
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCE
KMVPIAPSRGLIFDRNGTPLVRNITLYQIQIIPSKIENMTALLQELTPIVDLTPEDITAF
EEEEECCCCCEEECCCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHCHHHCCCHHHHHHH
RDDMHHNGRYKPVTLKSGLTETEVARFAVNQYRFDGVTIDTYQQREYPYGAELAHVVGYV
HHHHCCCCCCCEEEECCCCCHHHHHHHHHHHEEECCEEEECHHCCCCCCCHHHHHHHHHH
SKINDSDLKRLDKAGLSENYAADHNIGKQGIEAYYESELHGTTGYQEVEVDNHGRVIRLL
HHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEE
KEQPPQAGKNIYLTLDLPLQQYIESVLKGQRAAVVVEDPRDGGILAMVSSPSYDPNPFVK
HHCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHC
GISYSAYKSLLANPDLPLINRVTQGLYPPASTVKPYMATSALFAGVITPNTTFFGAPTWT
CCCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHCCHHHHHHHHHHEEECCCCEEECCCCCC
LPGTQRRYRDWLKTGHGMLNVTKAIEESADTFFYQVAYEMGIDRIHSWLSKFGYGQATGI
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCC
DLNEEYRGVLPSREWKQRVHKKTWYQGDTISVGIGQGYWVATPIQMVKALTTLINNGKVK
CCCHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECHHHHHHHHHHHHCCCCCC
TPHLLYSMRQGRQVNLYQPPKQAAQIGDAKSPYWGIVRNGMYGMANLPNGTGYKLFHTAP
CHHHHHHHHCCCEEECCCCCHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCC
YQIAAKSGTSQVFGLKENQTYNAKMIPVRLRDHIFYTLFAPYKNPRVAMALILENGGGDG
CEEEECCCCCEEEEECCCCCCCEEEEEEEECCEEEEEEECCCCCCCEEEEEEEECCCCCC
VVAGPTARAILDHIFDPANAPQPEQGQEVKPELNDSADVQQ
EEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALLKDKIRDHSAEEMLFIRRAGVAMVLVVACFGVLVANLYRLQVKQHGFYQTRSNQNDI
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCE
KMVPIAPSRGLIFDRNGTPLVRNITLYQIQIIPSKIENMTALLQELTPIVDLTPEDITAF
EEEEECCCCCEEECCCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHCHHHCCCHHHHHHH
RDDMHHNGRYKPVTLKSGLTETEVARFAVNQYRFDGVTIDTYQQREYPYGAELAHVVGYV
HHHHCCCCCCCEEEECCCCCHHHHHHHHHHHEEECCEEEECHHCCCCCCCHHHHHHHHHH
SKINDSDLKRLDKAGLSENYAADHNIGKQGIEAYYESELHGTTGYQEVEVDNHGRVIRLL
HHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEE
KEQPPQAGKNIYLTLDLPLQQYIESVLKGQRAAVVVEDPRDGGILAMVSSPSYDPNPFVK
HHCCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHC
GISYSAYKSLLANPDLPLINRVTQGLYPPASTVKPYMATSALFAGVITPNTTFFGAPTWT
CCCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHCCHHHHHHHHHHEEECCCCEEECCCCCC
LPGTQRRYRDWLKTGHGMLNVTKAIEESADTFFYQVAYEMGIDRIHSWLSKFGYGQATGI
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCC
DLNEEYRGVLPSREWKQRVHKKTWYQGDTISVGIGQGYWVATPIQMVKALTTLINNGKVK
CCCHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECHHHHHHHHHHHHCCCCCC
TPHLLYSMRQGRQVNLYQPPKQAAQIGDAKSPYWGIVRNGMYGMANLPNGTGYKLFHTAP
CHHHHHHHHCCCEEECCCCCHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEECCC
YQIAAKSGTSQVFGLKENQTYNAKMIPVRLRDHIFYTLFAPYKNPRVAMALILENGGGDG
CEEEECCCCCEEEEECCCCCCCEEEEEEEECCEEEEEEECCCCCCCEEEEEEEECCCCCC
VVAGPTARAILDHIFDPANAPQPEQGQEVKPELNDSADVQQ
EEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 8930920 [H]