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The map label for this gene is clcB [H]

Identifier: 157370525

GI number: 157370525

Start: 2488569

End: 2489849

Strand: Reverse

Name: clcB [H]

Synonym: Spro_2285

Alternate gene names: 157370525

Gene position: 2489849-2488569 (Counterclockwise)

Preceding gene: 157370527

Following gene: 157370521

Centisome position: 45.69

GC content: 61.98

Gene sequence:

>1281_bases
ATGAAACGATTGGTCCACCTGCACCACTATCGCGCCCTGCTGCGCCGCCTGTTTATCGCCATCTTTCTTGGTATTGCCGC
TGCGTTGGTGGTTTGGCTGTTTCACCGTGCGATGCTCGGGCTGGAATGGTTATTGCTCGATCATGAAGACGGCAGCCTGG
TGGCCGCCGCCGCCGCATTGCCCGGCTGGCGCAGAGCGTTAACCCCGGCGCTGGGTGGGCTGGCGGCAGGCCTGCTATTG
TGGGTTTATCAGCGCTATCAGCACCAGCGGCAGGTTGCTCCCACTGATTATATGGAGGCGATCGAAACCGGTGATGGCCG
CCTGGACGTCAGCGCCAGCCTGGTGAAATGCCTGGCCTCACTGCTGGTGGTCTCCAGCGGCAGCGCTATCGGCCGCGAGG
GCGCGATGATCCTGCTGGCGGCATTGGTAGGTTCCGTCTTTGCCCAGCGCTTCACCCATGAGAAAGAGTGGAAACTGTGG
GTGGCCTGCGGTGCCGCAGCCGGTATGGCCAGCGCTTATCACGCCCCACTGGCCGGCAGTCTGTTTATCGCCGAAATTCT
GTTTGGCACACTGATGCTGGCCTCACTGGGTCCGGTGGTGATTGCCGCCGTCAGCGCCCTGCTGGTGACCAATCTGCTCA
ACGGCGGCCAGGCGCCGCTGTATCTGGTAGAGCCGCTGCCCGCCCCCTGGCCGGTGCAATATCTGTTGATGGCACTGCTC
GGCGTTTTAGCCGGGGTCTGCGGCCCGTTGTTCCTGTGGGCAATGTCTTCTTCCGGTCGCGCATTCCGTTCGCTACGGCT
AAAACCGCCGCTGCAATTGGCGTTAGGGGGGCTGATTGTCGGGCTGCTGTCGCTGCTGTTTCCTGAGGTATGGGGCAATG
GCTACAGTGTGGTGCAGGCGCTGCTCAGTGCGCCCCCCGGCGTATTGCTGGTAGGCGCCATTCTGATCTGCAAGTTGCTG
GCGGTGCTCGCCAGTAGCGGATCCGGTGCGCCTGGCGGTGTGTTCACACCCACGCTGTTTGTCGGAGCGGCGCTCGGTTC
GTTAGTTGGGCAACTCTGCGCCATCTGGCCGGAGTTGGGCAGTGCGGTACCGATTCTGATGGCGTTAACCGGCATGGCTA
CGCTTTTGGCGGCCACCACCCACGCGCCGATAATGGCTGCGCTGATGGTGTTCGAAATGACCGGTGAATATACCCTGCTA
CCGGGGATCCTGTTGGCCTGTGTGATCGCCACCACCGTCTCACGCGGTTTACGTTCGGTGTCGGTCTATCACAACGCCTA
A

Upstream 100 bases:

>100_bases
GAGCCTGTCTGCGGATTTGTAAAGATTCTCTGGTCTTCGGCCGGGGTGGCAAGCACAATGCTCAGCGACCCTTTCATTTT
TCTCACGATTTTACTGACGC

Downstream 100 bases:

>100_bases
CGGTTTAGCAGTGGAGAGATATCCAGATAACGTGCCAGTTCCCGCTGTTCGGCGCGTGGCAGATAAGGTATTTCACCCAG
CAGCGGCGCAGGAATGCGTT

Product: putative voltage-gated ClC-type chloride channel ClcB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKRLVHLHHYRALLRRLFIAIFLGIAAALVVWLFHRAMLGLEWLLLDHEDGSLVAAAAALPGWRRALTPALGGLAAGLLL
WVYQRYQHQRQVAPTDYMEAIETGDGRLDVSASLVKCLASLLVVSSGSAIGREGAMILLAALVGSVFAQRFTHEKEWKLW
VACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLVTNLLNGGQAPLYLVEPLPAPWPVQYLLMALL
GVLAGVCGPLFLWAMSSSGRAFRSLRLKPPLQLALGGLIVGLLSLLFPEVWGNGYSVVQALLSAPPGVLLVGAILICKLL
AVLASSGSGAPGGVFTPTLFVGAALGSLVGQLCAIWPELGSAVPILMALTGMATLLAATTHAPIMAALMVFEMTGEYTLL
PGILLACVIATTVSRGLRSVSVYHNA

Sequences:

>Translated_426_residues
MKRLVHLHHYRALLRRLFIAIFLGIAAALVVWLFHRAMLGLEWLLLDHEDGSLVAAAAALPGWRRALTPALGGLAAGLLL
WVYQRYQHQRQVAPTDYMEAIETGDGRLDVSASLVKCLASLLVVSSGSAIGREGAMILLAALVGSVFAQRFTHEKEWKLW
VACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLVTNLLNGGQAPLYLVEPLPAPWPVQYLLMALL
GVLAGVCGPLFLWAMSSSGRAFRSLRLKPPLQLALGGLIVGLLSLLFPEVWGNGYSVVQALLSAPPGVLLVGAILICKLL
AVLASSGSGAPGGVFTPTLFVGAALGSLVGQLCAIWPELGSAVPILMALTGMATLLAATTHAPIMAALMVFEMTGEYTLL
PGILLACVIATTVSRGLRSVSVYHNA
>Mature_426_residues
MKRLVHLHHYRALLRRLFIAIFLGIAAALVVWLFHRAMLGLEWLLLDHEDGSLVAAAAALPGWRRALTPALGGLAAGLLL
WVYQRYQHQRQVAPTDYMEAIETGDGRLDVSASLVKCLASLLVVSSGSAIGREGAMILLAALVGSVFAQRFTHEKEWKLW
VACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLVTNLLNGGQAPLYLVEPLPAPWPVQYLLMALL
GVLAGVCGPLFLWAMSSSGRAFRSLRLKPPLQLALGGLIVGLLSLLFPEVWGNGYSVVQALLSAPPGVLLVGAILICKLL
AVLASSGSGAPGGVFTPTLFVGAALGSLVGQLCAIWPELGSAVPILMALTGMATLLAATTHAPIMAALMVFEMTGEYTLL
PGILLACVIATTVSRGLRSVSVYHNA

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=413, Percent_Identity=64.4067796610169, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1786350, Length=239, Percent_Identity=28.4518828451883, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532615, Length=357, Percent_Identity=21.8487394957983, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 44629; Mature: 44629

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLVHLHHYRALLRRLFIAIFLGIAAALVVWLFHRAMLGLEWLLLDHEDGSLVAAAAAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEECCCCCEEHHHHHC
PGWRRALTPALGGLAAGLLLWVYQRYQHQRQVAPTDYMEAIETGDGRLDVSASLVKCLAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
LLVVSSGSAIGREGAMILLAALVGSVFAQRFTHEKEWKLWVACGAAAGMASAYHAPLAGS
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCCHHH
LFIAEILFGTLMLASLGPVVIAAVSALLVTNLLNGGQAPLYLVEPLPAPWPVQYLLMALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHH
GVLAGVCGPLFLWAMSSSGRAFRSLRLKPPLQLALGGLIVGLLSLLFPEVWGNGYSVVQA
HHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LLSAPPGVLLVGAILICKLLAVLASSGSGAPGGVFTPTLFVGAALGSLVGQLCAIWPELG
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
SAVPILMALTGMATLLAATTHAPIMAALMVFEMTGEYTLLPGILLACVIATTVSRGLRSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SVYHNA
HHHCCC
>Mature Secondary Structure
MKRLVHLHHYRALLRRLFIAIFLGIAAALVVWLFHRAMLGLEWLLLDHEDGSLVAAAAAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEECCCCCEEHHHHHC
PGWRRALTPALGGLAAGLLLWVYQRYQHQRQVAPTDYMEAIETGDGRLDVSASLVKCLAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
LLVVSSGSAIGREGAMILLAALVGSVFAQRFTHEKEWKLWVACGAAAGMASAYHAPLAGS
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCCHHH
LFIAEILFGTLMLASLGPVVIAAVSALLVTNLLNGGQAPLYLVEPLPAPWPVQYLLMALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHH
GVLAGVCGPLFLWAMSSSGRAFRSLRLKPPLQLALGGLIVGLLSLLFPEVWGNGYSVVQA
HHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LLSAPPGVLLVGAILICKLLAVLASSGSGAPGGVFTPTLFVGAALGSLVGQLCAIWPELG
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
SAVPILMALTGMATLLAATTHAPIMAALMVFEMTGEYTLLPGILLACVIATTVSRGLRSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SVYHNA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA