Click here to switch to the map view.

The map label for this gene is sdaC [H]

Identifier: 157370379

GI number: 157370379

Start: 2334971

End: 2336254

Strand: Direct

Name: sdaC [H]

Synonym: Spro_2139

Alternate gene names: 157370379

Gene position: 2334971-2336254 (Clockwise)

Preceding gene: 157370378

Following gene: 157370380

Centisome position: 42.85

GC content: 55.92

Gene sequence:

>1284_bases
ATGAGTACGATTTCTCCCGATTCAGGCACGCTGGCTTCCGCCCAGCCGGGCAAATGGAACAAGACGGACACCGTCTGGAT
GTTTGGTCTCTACGCCACTGCGGTGGGGGCAGGTACGTTGTTTCTGCCGATCAATGCCGGCTTAAACGGCCCACTGGTGC
TGTTGCTGATGGCCGTGTTTGCCTTCCCTCTGACTTATTTACCGCATCGCGCACTGAGCCGCTTTGTGCTTTCCGGCTCC
AGCCGTGACGGCAATATCCATGATGTGGTGGTTGAGCACTTTGGCGTGCTGGCCGGTAAAATCATCATGGTGCTGTACCT
GATGGCGTTCTTCCCGATCGTGCTGGTGTACAGCATTTCGATCACCAACGCGCTGGACAGTTTCCTGACTCATCAGTTTC
ACCTGACGCCGCTACCGCGTATCTGGCTGAGCCTGGCGGTGGTAGTGGTGCTGAACCTGGTGCTGCTGCGCGGTAAAGAC
GCCATTGTTTCGGCGATGGGTATGCTGGTATTCCCGTTGCTGGTATTTTTGATGGGTATTTCGCTGTACCTGATGCCGAC
CTGGCAAACCGCCAACTTTGTCAGTGGCCTGGCCAACACTCAGTTCAGTAGCCCGGACCTGTGGCATTCGTTGTGGCTGG
CGGTGCCGGTGATGGTGTTTTCCTTTAGCCATGCGCCGATTATTTCGTCCTTCGCTTCGACCCAAAAGAGCCTGTATGGC
GAACTGGCTGAACGCCGCTGCGCGCGAATTATGCGCTACAGCTACGTGCTGATCTGCGTCACCGTATTGTTCTTTGTTTT
CAGCTGCGTGCTGAGCCTGTCCCACGAGGATATGCAGCAGGCGAAAGATCAAAACATTACCGTGCTGACCACGCTGGCGA
ACAAATTTTCCAACCCGTTGATCGCTTATTTGGGGCCGATGATGGCGATGCTGGCAATGGCCAAGTCCTATCTGGGCACC
TCATTGGGGGTGACCGAAGGAGCGACCAGCCTGATTGACGGCCTGACGCGCGCGGTCGGTAAACCGCTAAGCTCACGTAT
TACACACCGTATTTCTGCCGTGTTGCTGTTCCTGCTGACCTGGGCGGCGACGGTCTGGAACCCGAGTGCGTTGCATATTA
TTGAAACCATCAGCGGCCCGCTGATCGCGGCAATCCTGTTTATTTTGCCGATGTATGCGGTGCGTAGGGTACCCGCCATG
CGTCGTTACCGTGCGCTGAGCAATGTATTTGTGCTGGTGATGGGGCTGATTGCGCTGTCGGCGCTGATTTACGGCCTGAT
TTAA

Upstream 100 bases:

>100_bases
GAAATTCTGAGTTAACTAACTGATTATTATTAAAAATTCGCGGAGAAGGATATCCCGTTAGGCGCAATCGTTGTCGTTGC
AGATTAAGGTAAGCTTTCCT

Downstream 100 bases:

>100_bases
CCTGACTGGTGCGCCGGTTCCGGCGCACCACCTTGTTGCTGTTCACATCTCTTTTCAATTAACCGAAAACACGCCCGGCG
TTCTCTTTGATAATGGGAGC

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSTISPDSGTLASAQPGKWNKTDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLLLMAVFAFPLTYLPHRALSRFVLSGS
SRDGNIHDVVVEHFGVLAGKIIMVLYLMAFFPIVLVYSISITNALDSFLTHQFHLTPLPRIWLSLAVVVVLNLVLLRGKD
AIVSAMGMLVFPLLVFLMGISLYLMPTWQTANFVSGLANTQFSSPDLWHSLWLAVPVMVFSFSHAPIISSFASTQKSLYG
ELAERRCARIMRYSYVLICVTVLFFVFSCVLSLSHEDMQQAKDQNITVLTTLANKFSNPLIAYLGPMMAMLAMAKSYLGT
SLGVTEGATSLIDGLTRAVGKPLSSRITHRISAVLLFLLTWAATVWNPSALHIIETISGPLIAAILFILPMYAVRRVPAM
RRYRALSNVFVLVMGLIALSALIYGLI

Sequences:

>Translated_427_residues
MSTISPDSGTLASAQPGKWNKTDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLLLMAVFAFPLTYLPHRALSRFVLSGS
SRDGNIHDVVVEHFGVLAGKIIMVLYLMAFFPIVLVYSISITNALDSFLTHQFHLTPLPRIWLSLAVVVVLNLVLLRGKD
AIVSAMGMLVFPLLVFLMGISLYLMPTWQTANFVSGLANTQFSSPDLWHSLWLAVPVMVFSFSHAPIISSFASTQKSLYG
ELAERRCARIMRYSYVLICVTVLFFVFSCVLSLSHEDMQQAKDQNITVLTTLANKFSNPLIAYLGPMMAMLAMAKSYLGT
SLGVTEGATSLIDGLTRAVGKPLSSRITHRISAVLLFLLTWAATVWNPSALHIIETISGPLIAAILFILPMYAVRRVPAM
RRYRALSNVFVLVMGLIALSALIYGLI
>Mature_426_residues
STISPDSGTLASAQPGKWNKTDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLLLMAVFAFPLTYLPHRALSRFVLSGSS
RDGNIHDVVVEHFGVLAGKIIMVLYLMAFFPIVLVYSISITNALDSFLTHQFHLTPLPRIWLSLAVVVVLNLVLLRGKDA
IVSAMGMLVFPLLVFLMGISLYLMPTWQTANFVSGLANTQFSSPDLWHSLWLAVPVMVFSFSHAPIISSFASTQKSLYGE
LAERRCARIMRYSYVLICVTVLFFVFSCVLSLSHEDMQQAKDQNITVLTTLANKFSNPLIAYLGPMMAMLAMAKSYLGTS
LGVTEGATSLIDGLTRAVGKPLSSRITHRISAVLLFLLTWAATVWNPSALHIIETISGPLIAAILFILPMYAVRRVPAMR
RYRALSNVFVLVMGLIALSALIYGLI

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=425, Percent_Identity=48.7058823529412, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1789211, Length=411, Percent_Identity=41.3625304136253, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI1789504, Length=444, Percent_Identity=36.7117117117117, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI145693183, Length=410, Percent_Identity=26.5853658536585, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1789961, Length=411, Percent_Identity=23.8442822384428, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46712; Mature: 46581

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTISPDSGTLASAQPGKWNKTDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLLLMAVF
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
AFPLTYLPHRALSRFVLSGSSRDGNIHDVVVEHFGVLAGKIIMVLYLMAFFPIVLVYSIS
HHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITNALDSFLTHQFHLTPLPRIWLSLAVVVVLNLVLLRGKDAIVSAMGMLVFPLLVFLMGI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SLYLMPTWQTANFVSGLANTQFSSPDLWHSLWLAVPVMVFSFSHAPIISSFASTQKSLYG
HHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ELAERRCARIMRYSYVLICVTVLFFVFSCVLSLSHEDMQQAKDQNITVLTTLANKFSNPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEEHHHHHHHHCCCH
IAYLGPMMAMLAMAKSYLGTSLGVTEGATSLIDGLTRAVGKPLSSRITHRISAVLLFLLT
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
WAATVWNPSALHIIETISGPLIAAILFILPMYAVRRVPAMRRYRALSNVFVLVMGLIALS
HHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIYGLI
HHHHHCC
>Mature Secondary Structure 
STISPDSGTLASAQPGKWNKTDTVWMFGLYATAVGAGTLFLPINAGLNGPLVLLLMAVF
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH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HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]