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The map label for this gene is phoP [H]

Identifier: 157370255

GI number: 157370255

Start: 2206069

End: 2206740

Strand: Reverse

Name: phoP [H]

Synonym: Spro_2013

Alternate gene names: 157370255

Gene position: 2206740-2206069 (Counterclockwise)

Preceding gene: 157370256

Following gene: 157370254

Centisome position: 40.5

GC content: 54.91

Gene sequence:

>672_bases
ATGCGAGTACTGGTTGTTGAAGATAATGGTTTACTGCGCCACCACCTCTCCGTACAGATGCGTGAAATGGGTCATCAGGT
TGATGCAGCAGAAGATGCCAAGGAAGCCGATTATTTCCTACAGGAACATGCGCCGGACATCGCGATTGTCGATCTCGGCC
TGCCGGGTGAAGACGGCCTGAGCCTGATCCGCCGCTGGCGCGCCCACCAAATGAAATTACCGATCCTGGTGCTGACCGCC
CGTGAAAGCTGGCAAGACAAGGTAGCGGTGCTGGAAGCCGGTGCCGATGACTACGTCACCAAGCCGTTTCATTTGGAAGA
AGTGATTGCCCGCATGCAGGCGTTGATGCGCCGTAACAGCGGCCTGGCTTCCCAGGTGATCGTCTTGCCGCCGTTCCAAA
TCGACCTTTCGCGCCGTGAGCTGAGCGTCAACGAGCAGCAAATCAAACTGACCGCATTTGAATACACCATTATCGAAACC
TTAATCCGCAACGCGGGTAAAGTGGTCAGTAAAGACTCGCTGATGTTGCAGTTGTATCCGGATGCCGAGCTGCGTGAAAG
CCACACCATCGACGTACTGATGGGCCGTTTGCGTAAAAAGGTGCAGGCCGAATACCCACAGGAAGTGATCACCACGGTTC
GTGGCCAGGGCTATCGTTTTGATGCGAAGTGA

Upstream 100 bases:

>100_bases
GGCCAAGGTTGTTGCACGCTATCCCTCACACGCTGCCGAGCGTGTTACCTTTACAGCGTGGGTGACAGGATGTTCACCCG
CAGATTTACAGGAGTCCGCC

Downstream 100 bases:

>100_bases
ACATGATGTTCAACAAAAATAAAAAGCCTTTTTCCCTACGAGCCCGCTTTTTGATGGCTACCGCCGGGGTGATCCTGGCG
CTGTCGCTGTCCTATGGTCT

Product: DNA-binding transcriptional regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRVLVVEDNGLLRHHLSVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIVDLGLPGEDGLSLIRRWRAHQMKLPILVLTA
RESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNSGLASQVIVLPPFQIDLSRRELSVNEQQIKLTAFEYTIIET
LIRNAGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKVQAEYPQEVITTVRGQGYRFDAK

Sequences:

>Translated_223_residues
MRVLVVEDNGLLRHHLSVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIVDLGLPGEDGLSLIRRWRAHQMKLPILVLTA
RESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNSGLASQVIVLPPFQIDLSRRELSVNEQQIKLTAFEYTIIET
LIRNAGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKVQAEYPQEVITTVRGQGYRFDAK
>Mature_223_residues
MRVLVVEDNGLLRHHLSVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIVDLGLPGEDGLSLIRRWRAHQMKLPILVLTA
RESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNSGLASQVIVLPPFQIDLSRRELSVNEQQIKLTAFEYTIIET
LIRNAGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKVQAEYPQEVITTVRGQGYRFDAK

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=84.7533632286996, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=35.4260089686099, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.9775784753363, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=35.1111111111111, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=35.0877192982456, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=30.6306306306306, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=32.7354260089686, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=34.2465753424658, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.0357142857143, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.4410480349345, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.1310043668122, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=29.2576419213974, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=26.7241379310345, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=33.0188679245283, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=30.5555555555556, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25453; Mature: 25453

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVEDNGLLRHHLSVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIVDLGLPGEDGL
CEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
SLIRRWRAHQMKLPILVLTARESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNS
HHHHHHHHHCCCCCEEEEECCCCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQVIVLPPFQIDLSRRELSVNEQQIKLTAFEYTIIETLIRNAGKVVSKDSLMLQLYP
CCCCEEEEECCCEECCCHHHCCCCHHEEEEEHHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKVQAEYPQEVITTVRGQGYRFDAK
CCHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MRVLVVEDNGLLRHHLSVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIVDLGLPGEDGL
CEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
SLIRRWRAHQMKLPILVLTARESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNS
HHHHHHHHHCCCCCEEEEECCCCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQVIVLPPFQIDLSRRELSVNEQQIKLTAFEYTIIETLIRNAGKVVSKDSLMLQLYP
CCCCEEEEECCCEECCCHHHCCCCHHEEEEEHHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKVQAEYPQEVITTVRGQGYRFDAK
CCHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA