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The map label for this gene is phoQ [H]

Identifier: 157370254

GI number: 157370254

Start: 2204606

End: 2206063

Strand: Reverse

Name: phoQ [H]

Synonym: Spro_2012

Alternate gene names: 157370254

Gene position: 2206063-2204606 (Counterclockwise)

Preceding gene: 157370255

Following gene: 157370253

Centisome position: 40.49

GC content: 55.42

Gene sequence:

>1458_bases
ATGTTCAACAAAAATAAAAAGCCTTTTTCCCTACGAGCCCGCTTTTTGATGGCTACCGCCGGGGTGATCCTGGCGCTGTC
GCTGTCCTATGGTCTGGTCGCGGTCGTGGGTTATATCGTCAGCTTCGACAAAACCGCCTTCCGCCTGCTGCGTGGCGAAA
GCAACCTGTTCTTCAGCCTGGCCCAGTGGAAAGACAACAAGCTCACCATCGCCATTCCGCCCGATATCGATCTCAACTTC
CCTACCCTGGTGTTTATTTACGACGATAAGGGCAAGCTGCTGTGGAGCCAGCGCCAGGTACCGGAACTGGAAAAACGGAT
CAACAAAGAGTGGCTGGAAGAGTCCGGTTTCTACGAAATTGACACCGATACCCGCATCAGTAGCGAAGTCCTGGGGAACA
ACCCCAAGGCGCAAGATCAACTCAAAGACTATGACGACAACGACCAGAATGCGCTGACCCACTCCGTGGCGGTCAACACC
TACGCGGCGACCGCAAGATTGCCGGCGCTAAGCATCGTGGTGGTCGACACTATCCCGCAAGAGCTTCAGCGTTCAGACGT
CGTCTGGGAATGGTTCAGCTATGTGTTGCTGGCTAACCTGCTGTTGGTGGTGCCCCTGCTGTGGCTGGCGGCCTATTGGA
GCCTGCGACCGATCCAGGCGTTGGTGAATCAGGTCGGCGAACTGGAAAACGGTGAGCGAGAACAACTCGATGAGAACCCC
CCCAGCGAACTGCGCGGGCTGGTACGCAATCTGAATATTCTGGTTCGCAACGAACGCCAGCGCTATACCAAATACCGCAC
CACGCTTTCCGATCTGACCCACAGTCTGAAAACCCCGCTGGCGGTACTGCAAACCACATTGCGCTCACTGCGCACCGGCA
AGCAAACCACCATTGAGGAAGTCGAGCCGATCATGCTGGATCAGATCGGACGTATCTCTCAGCAAATTGGCTACTACCTG
CACCGCGCCAGCATCAACTCCGGGCAAACGGTGCTGACACGCGAGATCCATTCGGTACCGGCCCTGCTGGACAGCCTGAC
GGTGGCGCTGAACAAGGTATATCAGCGCAAAGGCGTGGTGATCACGCTGGATATCTCGCCGGAAGTAACCTTTATGGGTG
AAAAAAACGACTTTATGGAAGTGATGGGCAACGTACTTGAAAATGCCTGTAAGTACTGCCTGGAATTCGTTGAAATCACC
TCCCTCCACTCCGATAAATATCTCACCATCGTCATCGATGACGACGGCCCGGGTATTCCGGAAAGCAAACGCGAGTTGAT
TTTCCAGCGCGGCCAGCGGGTAGACACTTTGCGCCCCGGTCAGGGCTTGGGATTATCGGTAGCAGCGGAGATTATTGAGC
AGTACGAGGGCTCCATTACCATCAGTGACAGCCCGCTGGGCGGCGCACGTATGCAGGTCACTTTCGCTCGTCAGCACGAC
TCCCACCATAACGAGTAA

Upstream 100 bases:

>100_bases
TGATGGGCCGTTTGCGTAAAAAGGTGCAGGCCGAATACCCACAGGAAGTGATCACCACGGTTCGTGGCCAGGGCTATCGT
TTTGATGCGAAGTGAACATG

Downstream 100 bases:

>100_bases
ATTCTGTTGCTCAGGCCCCGATCCACGGGGCCAAACTTCCGTTATAATCGCACTCAGGCTCACTCCTCTATCCTGGAATA
GAACATGGATTATCAATTAG

Product: sensor protein PhoQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MFNKNKKPFSLRARFLMATAGVILALSLSYGLVAVVGYIVSFDKTAFRLLRGESNLFFSLAQWKDNKLTIAIPPDIDLNF
PTLVFIYDDKGKLLWSQRQVPELEKRINKEWLEESGFYEIDTDTRISSEVLGNNPKAQDQLKDYDDNDQNALTHSVAVNT
YAATARLPALSIVVVDTIPQELQRSDVVWEWFSYVLLANLLLVVPLLWLAAYWSLRPIQALVNQVGELENGEREQLDENP
PSELRGLVRNLNILVRNERQRYTKYRTTLSDLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLDQIGRISQQIGYYL
HRASINSGQTVLTREIHSVPALLDSLTVALNKVYQRKGVVITLDISPEVTFMGEKNDFMEVMGNVLENACKYCLEFVEIT
SLHSDKYLTIVIDDDGPGIPESKRELIFQRGQRVDTLRPGQGLGLSVAAEIIEQYEGSITISDSPLGGARMQVTFARQHD
SHHNE

Sequences:

>Translated_485_residues
MFNKNKKPFSLRARFLMATAGVILALSLSYGLVAVVGYIVSFDKTAFRLLRGESNLFFSLAQWKDNKLTIAIPPDIDLNF
PTLVFIYDDKGKLLWSQRQVPELEKRINKEWLEESGFYEIDTDTRISSEVLGNNPKAQDQLKDYDDNDQNALTHSVAVNT
YAATARLPALSIVVVDTIPQELQRSDVVWEWFSYVLLANLLLVVPLLWLAAYWSLRPIQALVNQVGELENGEREQLDENP
PSELRGLVRNLNILVRNERQRYTKYRTTLSDLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLDQIGRISQQIGYYL
HRASINSGQTVLTREIHSVPALLDSLTVALNKVYQRKGVVITLDISPEVTFMGEKNDFMEVMGNVLENACKYCLEFVEIT
SLHSDKYLTIVIDDDGPGIPESKRELIFQRGQRVDTLRPGQGLGLSVAAEIIEQYEGSITISDSPLGGARMQVTFARQHD
SHHNE
>Mature_485_residues
MFNKNKKPFSLRARFLMATAGVILALSLSYGLVAVVGYIVSFDKTAFRLLRGESNLFFSLAQWKDNKLTIAIPPDIDLNF
PTLVFIYDDKGKLLWSQRQVPELEKRINKEWLEESGFYEIDTDTRISSEVLGNNPKAQDQLKDYDDNDQNALTHSVAVNT
YAATARLPALSIVVVDTIPQELQRSDVVWEWFSYVLLANLLLVVPLLWLAAYWSLRPIQALVNQVGELENGEREQLDENP
PSELRGLVRNLNILVRNERQRYTKYRTTLSDLTHSLKTPLAVLQTTLRSLRTGKQTTIEEVEPIMLDQIGRISQQIGYYL
HRASINSGQTVLTREIHSVPALLDSLTVALNKVYQRKGVVITLDISPEVTFMGEKNDFMEVMGNVLENACKYCLEFVEIT
SLHSDKYLTIVIDDDGPGIPESKRELIFQRGQRVDTLRPGQGLGLSVAAEIIEQYEGSITISDSPLGGARMQVTFARQHD
SHHNE

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=479, Percent_Identity=63.6743215031315, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=24.0875912408759, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=284, Percent_Identity=28.5211267605634, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1787894, Length=286, Percent_Identity=26.5734265734266, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=402, Percent_Identity=25.1243781094527, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=28.8990825688073, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786783, Length=292, Percent_Identity=20.8904109589041, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790551, Length=221, Percent_Identity=28.9592760180996, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789808, Length=280, Percent_Identity=24.2857142857143, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54882; Mature: 54882

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKNKKPFSLRARFLMATAGVILALSLSYGLVAVVGYIVSFDKTAFRLLRGESNLFFSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEE
AQWKDNKLTIAIPPDIDLNFPTLVFIYDDKGKLLWSQRQVPELEKRINKEWLEESGFYEI
EECCCCEEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEE
DTDTRISSEVLGNNPKAQDQLKDYDDNDQNALTHSVAVNTYAATARLPALSIVVVDTIPQ
CCCCCHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCHH
ELQRSDVVWEWFSYVLLANLLLVVPLLWLAAYWSLRPIQALVNQVGELENGEREQLDENP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCCCC
PSELRGLVRNLNILVRNERQRYTKYRTTLSDLTHSLKTPLAVLQTTLRSLRTGKQTTIEE
CHHHHHHHHHCHHEEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHH
VEPIMLDQIGRISQQIGYYLHRASINSGQTVLTREIHSVPALLDSLTVALNKVYQRKGVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
ITLDISPEVTFMGEKNDFMEVMGNVLENACKYCLEFVEITSLHSDKYLTIVIDDDGPGIP
EEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
ESKRELIFQRGQRVDTLRPGQGLGLSVAAEIIEQYEGSITISDSPLGGARMQVTFARQHD
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECCC
SHHNE
CCCCC
>Mature Secondary Structure
MFNKNKKPFSLRARFLMATAGVILALSLSYGLVAVVGYIVSFDKTAFRLLRGESNLFFSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEE
AQWKDNKLTIAIPPDIDLNFPTLVFIYDDKGKLLWSQRQVPELEKRINKEWLEESGFYEI
EECCCCEEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEE
DTDTRISSEVLGNNPKAQDQLKDYDDNDQNALTHSVAVNTYAATARLPALSIVVVDTIPQ
CCCCCHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCHH
ELQRSDVVWEWFSYVLLANLLLVVPLLWLAAYWSLRPIQALVNQVGELENGEREQLDENP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCCCC
PSELRGLVRNLNILVRNERQRYTKYRTTLSDLTHSLKTPLAVLQTTLRSLRTGKQTTIEE
CHHHHHHHHHCHHEEECHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHH
VEPIMLDQIGRISQQIGYYLHRASINSGQTVLTREIHSVPALLDSLTVALNKVYQRKGVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
ITLDISPEVTFMGEKNDFMEVMGNVLENACKYCLEFVEITSLHSDKYLTIVIDDDGPGIP
EEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
ESKRELIFQRGQRVDTLRPGQGLGLSVAAEIIEQYEGSITISDSPLGGARMQVTFARQHD
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECCC
SHHNE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA