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The map label for this gene is lolE [H]

Identifier: 157370245

GI number: 157370245

Start: 2193698

End: 2194945

Strand: Direct

Name: lolE [H]

Synonym: Spro_2003

Alternate gene names: 157370245

Gene position: 2193698-2194945 (Clockwise)

Preceding gene: 157370244

Following gene: 157370246

Centisome position: 40.26

GC content: 57.37

Gene sequence:

>1248_bases
ATGGCAGGCGCGTCACTTTCCTTTCTGACGGCCCTGCGTTTCAGCCGTGGACGCAAGCGTGGCGGTATGGTGTCACTGAT
TTCGGTGATTTCAACTATCGGTATTGCGCTGGGCGTGGCGGTGCTGATCGTCGGCCTGAGTGCCATGAACGGTTTTGAGC
GCGAACTGAAAAACCGCATTCTGGCGGTGGTGCCGCACGGTGAAATCGAACCGGTGAAACAGCCGTTCAAAGACTGGTCG
TCGATTCTGCAACGGGTGGAGAAGGTGCCGGGCATCCTCGCCGCCGCCCCCTATATCAACTTTACCGGCCTGATGGAAAA
TGGCGCGCAGCTGCGTGCGGTCGGTGTCAAAGGCGTTGATCCTCAGCAGGAAAACCAGCTCAGTGCGCTGCCGAAATACG
TGCAGGGCGATGCCTGGGCCAATTTCAAAAGCGGTGAGCAACAGGTGATCCTCGGTAAGGGCGTCGCCGACGCCCTTGGC
GTCAAGCAGGGCAGTTATGTGACGGTGATGATCCCCAACAGCGATCCGCAAATGAAGCTGTTGCAACCCAAACGCATTCG
TCTGCACGTGACCGGAATTTTGCAGCTCAGCGGGCAGCTCGATCACAGCCTGGCGATGGTGCCGTTGGCCGATGCCCAGC
AGTATCTGGATATGGGCGACAGCGTGACCGGCATAGCCATCAAGGTGAACGACGTGTTTGCCGCCAACAAACTGGTGCGT
GACGCCGGTGAAGTCACCAACTCCTACGTTTACATCAAGAGTTGGATTGGCACCTACGGCTATATGTACCGCGATATCCA
GATGATCCGCGCCATCATGTATCTGGCGATGGTGCTGGTGATCGGCGTTGCCTGCTTTAATATCGTTTCTACTCTAGTGA
TGGCGGTGAAGGACAAGAGCGGCGATATCGCCGTGCTGCGCACCCTGGGCGCCAAAGACGGGTTTATCCGCGCCATATTT
ATTTGGTACGGCCTGTTGGCCGGGCTGGTGGGCAGCGTCAGTGGCGTGGTGGTCGGGGTGATCGCCTCGCTGCAGCTGAC
CAATATCATCAAAGGGTTGGAAAAACTGATGGGGCACTCATTCCTGTCGGGAGATATTTACTTCATCGACTTCCTGCCTT
CCGAGCTGCACTGGCTGGACGTGGTGATTGTATTGGTGACCGCGCTGGTACTCAGCCTGTTGGCTAGCTGGTATCCGGCC
AGGCGTGCCAGCCGTATCGATCCGGCACGAGTGTTGAGCGGACAATAA

Upstream 100 bases:

>100_bases
TGGTGACCCATGATCTGCAATTGGCCAAGCGCCTCAGTCGCCAGCTGGAAATGGCTGACGGCCATCTGCAGGCCCAGTTG
ACCCTGTTGGGGGCTGAGTA

Downstream 100 bases:

>100_bases
TCAAAATCAGGGGAGGCAGAGATGCCGCCCCATTTTTTTAGCCTGAGGGTGGGTTATGTACTACGGTTTCGATATGGGCG
GCACCAAGATTGAGCTGGGC

Product: outer membrane-specific lipoprotein transporter subunit LolE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MAGASLSFLTALRFSRGRKRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELKNRILAVVPHGEIEPVKQPFKDWS
SILQRVEKVPGILAAAPYINFTGLMENGAQLRAVGVKGVDPQQENQLSALPKYVQGDAWANFKSGEQQVILGKGVADALG
VKQGSYVTVMIPNSDPQMKLLQPKRIRLHVTGILQLSGQLDHSLAMVPLADAQQYLDMGDSVTGIAIKVNDVFAANKLVR
DAGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGFIRAIF
IWYGLLAGLVGSVSGVVVGVIASLQLTNIIKGLEKLMGHSFLSGDIYFIDFLPSELHWLDVVIVLVTALVLSLLASWYPA
RRASRIDPARVLSGQ

Sequences:

>Translated_415_residues
MAGASLSFLTALRFSRGRKRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELKNRILAVVPHGEIEPVKQPFKDWS
SILQRVEKVPGILAAAPYINFTGLMENGAQLRAVGVKGVDPQQENQLSALPKYVQGDAWANFKSGEQQVILGKGVADALG
VKQGSYVTVMIPNSDPQMKLLQPKRIRLHVTGILQLSGQLDHSLAMVPLADAQQYLDMGDSVTGIAIKVNDVFAANKLVR
DAGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGFIRAIF
IWYGLLAGLVGSVSGVVVGVIASLQLTNIIKGLEKLMGHSFLSGDIYFIDFLPSELHWLDVVIVLVTALVLSLLASWYPA
RRASRIDPARVLSGQ
>Mature_414_residues
AGASLSFLTALRFSRGRKRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELKNRILAVVPHGEIEPVKQPFKDWSS
ILQRVEKVPGILAAAPYINFTGLMENGAQLRAVGVKGVDPQQENQLSALPKYVQGDAWANFKSGEQQVILGKGVADALGV
KQGSYVTVMIPNSDPQMKLLQPKRIRLHVTGILQLSGQLDHSLAMVPLADAQQYLDMGDSVTGIAIKVNDVFAANKLVRD
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGFIRAIFI
WYGLLAGLVGSVSGVVVGVIASLQLTNIIKGLEKLMGHSFLSGDIYFIDFLPSELHWLDVVIVLVTALVLSLLASWYPAR
RASRIDPARVLSGQ

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=410, Percent_Identity=82.9268292682927, Blast_Score=658, Evalue=0.0,
Organism=Escherichia coli, GI1787360, Length=419, Percent_Identity=28.1622911694511, Blast_Score=141, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44859; Mature: 44727

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00027 HOMEOBOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGASLSFLTALRFSRGRKRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELKNRI
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCE
LAVVPHGEIEPVKQPFKDWSSILQRVEKVPGILAAAPYINFTGLMENGAQLRAVGVKGVD
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCCCEEEEECCCCCC
PQQENQLSALPKYVQGDAWANFKSGEQQVILGKGVADALGVKQGSYVTVMIPNSDPQMKL
CCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHCCCCCCEEEEEECCCCCCEEE
LQPKRIRLHVTGILQLSGQLDHSLAMVPLADAQQYLDMGDSVTGIAIKVNDVFAANKLVR
CCCCEEEEEEEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHH
DAGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKS
HHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDIAVLRTLGAKDGFIRAIFIWYGLLAGLVGSVSGVVVGVIASLQLTNIIKGLEKLMGHS
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FLSGDIYFIDFLPSELHWLDVVIVLVTALVLSLLASWYPARRASRIDPARVLSGQ
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC
>Mature Secondary Structure 
AGASLSFLTALRFSRGRKRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELKNRI
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCE
LAVVPHGEIEPVKQPFKDWSSILQRVEKVPGILAAAPYINFTGLMENGAQLRAVGVKGVD
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHCCCCEEEEECCCCCC
PQQENQLSALPKYVQGDAWANFKSGEQQVILGKGVADALGVKQGSYVTVMIPNSDPQMKL
CCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHCCCCCCEEEEEECCCCCCEEE
LQPKRIRLHVTGILQLSGQLDHSLAMVPLADAQQYLDMGDSVTGIAIKVNDVFAANKLVR
CCCCEEEEEEEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHH
DAGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMVLVIGVACFNIVSTLVMAVKDKS
HHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDIAVLRTLGAKDGFIRAIFIWYGLLAGLVGSVSGVVVGVIASLQLTNIIKGLEKLMGHS
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FLSGDIYFIDFLPSELHWLDVVIVLVTALVLSLLASWYPARRASRIDPARVLSGQ
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]