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The map label for this gene is hemA

Identifier: 157370231

GI number: 157370231

Start: 2177050

End: 2178312

Strand: Direct

Name: hemA

Synonym: Spro_1989

Alternate gene names: 157370231

Gene position: 2177050-2178312 (Clockwise)

Preceding gene: 157370227

Following gene: 157370232

Centisome position: 39.95

GC content: 58.75

Gene sequence:

>1263_bases
ATGACCCTGCTGGCGTTAGGTATAAATCACAAAACCGCTCCGGTTTCTCTGCGTGAAAGGGTGACCTTCTCCCCAGAGTC
TATCGAACAGGCGCTAACCAGCTTGCTCCAACAACCGTTGGTGCAGGGCGGTGTCGTGTTGTCTACCTGCAACCGCACCG
AGCTGTATCTTAGCGTGGAGCAACAGGAACATATTCACGAACAGCTGGTCTCCTGGCTGTGTGAGTACCACCACCTGCGC
CCGGAAGAGGTGAGTAAAAGCCTGTACTGGCACCACGGCAACGAAGCCGTTAGCCACCTGATGCGCGTGGCCAGCGGGTT
GGATTCACTGGTGCTGGGCGAACCGCAAATTCTTGGGCAGGTGAAGAAAGCCTTTGCCGAGTCCCAACGCGGGCAGTCAC
TGTCTGGTGAGCTTGAGCGCCTGTTCCAAAAATCCTTCTCCGTCGCCAAACGCGTACGTACCGAAACCGAAATCGGCGCC
AGTGCGGTATCCGTGGCCTTTGCCGCCTGTACCCTGGCACGCCAGATATTCGAATCTCTTGCCGAACTGAACGTCCTGTT
GGTGGGGGCCGGTGAAACCATTGAACTGGTGGCGCGTCATCTGCGCGAGCATAAAGTACGGCATATGATTATTGCCAACC
GTACCCGCGAGCGCGCCCAGCTGCTGGCGGACGAAGTCGGCGCAGAAGTGATCACCTTGCCGGAAATCGACGAACGCCTG
GCGGACGCCGACATTATTATCAGTTCTACCGCCAGCCCACTGCCGATCATCGGTAAAGGGATGGTGGAGCGAGCGCTGAA
AGCGCGCCGCAACCAGCCAATGCTGCTGGTGGATATTGCCGTACCGCGCGATATCGAACCGGAAGTGGGCAAGCTGGCTA
ACGCCTATTTATATAGCGTGGACGATCTGCACGCCATCATTCAGAGCAACCTGGCGCAGCGCAAGGCCGCGGCGGTGCAG
GCTGAGTCTATCGTCCAGCAGGAAAGCATCAACTTTATGGCCTGGTTGCGCTCGCAGGGCGCAGTGGAAACCATCCGCGA
CTACCGTTCGCAGGCCGATCAGATCCGTGCGGAAATGGAAGCCAAAGCCCTGGCCGCCATTGCGCAGGGCGCGGACGTGG
AGCAGGTTATCCACGAGCTGGCCCACCGGCTGACCAACCGTCTTATTCATGCCCCTACCAAATCCCTCCAACAGGCCGCC
GGCGATGGCGACGTGGAGCGGTTGCAATTATTACGCGACAGCCTCGGGCTGGATCAGCATTAG

Upstream 100 bases:

>100_bases
GATTGGACGGAAGATGCGGTTGTGCCTTTTATTGATCCCGCGCATCAAGTAGAATGCCGTTCAACGAGAACCCGTACCAA
AAGAAGTATTACTCGAAGCA

Downstream 100 bases:

>100_bases
TTTTCTCTTTATTAACAGGGTTTAATACCACGCATGAAGCCTTCTATTGTTGCCAAACTGGAAGCGTTACAAGAGCGCCA
TGAAGAAGTGCAGGCGCTGC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTLLALGINHKTAPVSLRERVTFSPESIEQALTSLLQQPLVQGGVVLSTCNRTELYLSVEQQEHIHEQLVSWLCEYHHLR
PEEVSKSLYWHHGNEAVSHLMRVASGLDSLVLGEPQILGQVKKAFAESQRGQSLSGELERLFQKSFSVAKRVRTETEIGA
SAVSVAFAACTLARQIFESLAELNVLLVGAGETIELVARHLREHKVRHMIIANRTRERAQLLADEVGAEVITLPEIDERL
ADADIIISSTASPLPIIGKGMVERALKARRNQPMLLVDIAVPRDIEPEVGKLANAYLYSVDDLHAIIQSNLAQRKAAAVQ
AESIVQQESINFMAWLRSQGAVETIRDYRSQADQIRAEMEAKALAAIAQGADVEQVIHELAHRLTNRLIHAPTKSLQQAA
GDGDVERLQLLRDSLGLDQH

Sequences:

>Translated_420_residues
MTLLALGINHKTAPVSLRERVTFSPESIEQALTSLLQQPLVQGGVVLSTCNRTELYLSVEQQEHIHEQLVSWLCEYHHLR
PEEVSKSLYWHHGNEAVSHLMRVASGLDSLVLGEPQILGQVKKAFAESQRGQSLSGELERLFQKSFSVAKRVRTETEIGA
SAVSVAFAACTLARQIFESLAELNVLLVGAGETIELVARHLREHKVRHMIIANRTRERAQLLADEVGAEVITLPEIDERL
ADADIIISSTASPLPIIGKGMVERALKARRNQPMLLVDIAVPRDIEPEVGKLANAYLYSVDDLHAIIQSNLAQRKAAAVQ
AESIVQQESINFMAWLRSQGAVETIRDYRSQADQIRAEMEAKALAAIAQGADVEQVIHELAHRLTNRLIHAPTKSLQQAA
GDGDVERLQLLRDSLGLDQH
>Mature_419_residues
TLLALGINHKTAPVSLRERVTFSPESIEQALTSLLQQPLVQGGVVLSTCNRTELYLSVEQQEHIHEQLVSWLCEYHHLRP
EEVSKSLYWHHGNEAVSHLMRVASGLDSLVLGEPQILGQVKKAFAESQRGQSLSGELERLFQKSFSVAKRVRTETEIGAS
AVSVAFAACTLARQIFESLAELNVLLVGAGETIELVARHLREHKVRHMIIANRTRERAQLLADEVGAEVITLPEIDERLA
DADIIISSTASPLPIIGKGMVERALKARRNQPMLLVDIAVPRDIEPEVGKLANAYLYSVDDLHAIIQSNLAQRKAAAVQA
ESIVQQESINFMAWLRSQGAVETIRDYRSQADQIRAEMEAKALAAIAQGADVEQVIHELAHRLTNRLIHAPTKSLQQAAG
DGDVERLQLLRDSLGLDQH

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=79.6650717703349, Blast_Score=667, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_SERP5 (A8GDA2)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478220.1
- ProteinModelPortal:   A8GDA2
- SMR:   A8GDA2
- STRING:   A8GDA2
- GeneID:   5603230
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1989
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   SPRO399741:SPRO_1989-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR13812
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46453; Mature: 46322

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLALGINHKTAPVSLRERVTFSPESIEQALTSLLQQPLVQGGVVLSTCNRTELYLSVE
CEEEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEH
QQEHIHEQLVSWLCEYHHLRPEEVSKSLYWHHGNEAVSHLMRVASGLDSLVLGEPQILGQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCHHHHHH
VKKAFAESQRGQSLSGELERLFQKSFSVAKRVRTETEIGASAVSVAFAACTLARQIFESL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELNVLLVGAGETIELVARHLREHKVRHMIIANRTRERAQLLADEVGAEVITLPEIDERL
HHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEECCCHHHHH
ADADIIISSTASPLPIIGKGMVERALKARRNQPMLLVDIAVPRDIEPEVGKLANAYLYSV
CCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
DDLHAIIQSNLAQRKAAAVQAESIVQQESINFMAWLRSQGAVETIRDYRSQADQIRAEME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AKALAAIAQGADVEQVIHELAHRLTNRLIHAPTKSLQQAAGDGDVERLQLLRDSLGLDQH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLLALGINHKTAPVSLRERVTFSPESIEQALTSLLQQPLVQGGVVLSTCNRTELYLSVE
EEEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEH
QQEHIHEQLVSWLCEYHHLRPEEVSKSLYWHHGNEAVSHLMRVASGLDSLVLGEPQILGQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCHHHHHH
VKKAFAESQRGQSLSGELERLFQKSFSVAKRVRTETEIGASAVSVAFAACTLARQIFESL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELNVLLVGAGETIELVARHLREHKVRHMIIANRTRERAQLLADEVGAEVITLPEIDERL
HHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEECCCHHHHH
ADADIIISSTASPLPIIGKGMVERALKARRNQPMLLVDIAVPRDIEPEVGKLANAYLYSV
CCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
DDLHAIIQSNLAQRKAAAVQAESIVQQESINFMAWLRSQGAVETIRDYRSQADQIRAEME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AKALAAIAQGADVEQVIHELAHRLTNRLIHAPTKSLQQAAGDGDVERLQLLRDSLGLDQH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA