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The map label for this gene is dcuR [H]

Identifier: 157370200

GI number: 157370200

Start: 2138859

End: 2139572

Strand: Reverse

Name: dcuR [H]

Synonym: Spro_1958

Alternate gene names: 157370200

Gene position: 2139572-2138859 (Counterclockwise)

Preceding gene: 157370201

Following gene: 157370197

Centisome position: 39.27

GC content: 54.2

Gene sequence:

>714_bases
ATGATTAACGTATTGATTATCGACGACGACCCGATGGTGGCGGAGTTAAACAAATACTACCTGAGCCAGGTGAGCGGCTT
TCACTGCCTGGCGACGGTCGCCACCCTGGCACAGGCACGCGCACTGCTGGCCGACGCCGAAGTCAGTATCGATCTGGTGC
TGCTGGATATCTATATGCAGCAGGAAAACGGACTGGACTTGCTGCCCGGCCTGCGCGAATTGGGTGAAAAAACCGACGTC
ATCATTATCTCTTCCGCCAGCGACGTGGATACGGTGCAACGCGCCCTGCATTACGGCGTGGTGGATTACCTGATCAAACC
TTTCCAATTTGGGCGTTTCAAAGAGGCGTTGAATAACTATCAGCAACAGTCGCAAATTCTGGCGCAGCGCGAATTCTCGC
AGGGGGATGTGGACAGCCTGTTACGTCGCCAACCCGCCAGCACCGAAGGAAAAAAACTGCCGAAGGGTCTGACCAGCATC
ACGCTGAGTACGGTGTGTGAATGGATTGAGCAACAGCACGACGGGGAGTTTTCGACCGATAATCTGGCGAACGCCATCGG
CATTTCACGCGTTTCCTGCCGAAAATATCTGATTTATTTGGCGGAAAGCGGCATTTTGGGCACCCGTATTCTCTACGGCA
CCACCGGCAGACCGGTCTATCTTTATCAGTTGAAGCAGGACGCGATCGCCCTGCTGAAAGAGTATTGCCGCTAG

Upstream 100 bases:

>100_bases
CAGCCTGGAAAAACTGGGCGGCAGCATTGATTTCGAATCTGAACCGGGTGAGCTAACCCAATTTTTTGTACATATCCCCT
ATCAGGCCAAGGGCTGAACC

Downstream 100 bases:

>100_bases
CCGATATCCCCCGGAGCAGACCGGGGGCGTCGCCGAGCATTATTTCGTTTTACGGATCAGACCAAAATCACGTAGTGCGA
CATACGGGTTCCAATATTCG

Product: DNA-binding transcriptional activator DcuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MINVLIIDDDPMVAELNKYYLSQVSGFHCLATVATLAQARALLADAEVSIDLVLLDIYMQQENGLDLLPGLRELGEKTDV
IIISSASDVDTVQRALHYGVVDYLIKPFQFGRFKEALNNYQQQSQILAQREFSQGDVDSLLRRQPASTEGKKLPKGLTSI
TLSTVCEWIEQQHDGEFSTDNLANAIGISRVSCRKYLIYLAESGILGTRILYGTTGRPVYLYQLKQDAIALLKEYCR

Sequences:

>Translated_237_residues
MINVLIIDDDPMVAELNKYYLSQVSGFHCLATVATLAQARALLADAEVSIDLVLLDIYMQQENGLDLLPGLRELGEKTDV
IIISSASDVDTVQRALHYGVVDYLIKPFQFGRFKEALNNYQQQSQILAQREFSQGDVDSLLRRQPASTEGKKLPKGLTSI
TLSTVCEWIEQQHDGEFSTDNLANAIGISRVSCRKYLIYLAESGILGTRILYGTTGRPVYLYQLKQDAIALLKEYCR
>Mature_237_residues
MINVLIIDDDPMVAELNKYYLSQVSGFHCLATVATLAQARALLADAEVSIDLVLLDIYMQQENGLDLLPGLRELGEKTDV
IIISSASDVDTVQRALHYGVVDYLIKPFQFGRFKEALNNYQQQSQILAQREFSQGDVDSLLRRQPASTEGKKLPKGLTSI
TLSTVCEWIEQQHDGEFSTDNLANAIGISRVSCRKYLIYLAESGILGTRILYGTTGRPVYLYQLKQDAIALLKEYCR

Specific function: Member of the two-component regulatory system dcuR/dcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-di

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=239, Percent_Identity=53.9748953974895, Blast_Score=269, Evalue=1e-73,
Organism=Escherichia coli, GI1786838, Length=226, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR012287
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26499; Mature: 26499

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVLIIDDDPMVAELNKYYLSQVSGFHCLATVATLAQARALLADAEVSIDLVLLDIYMQ
CEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEHH
QENGLDLLPGLRELGEKTDVIIISSASDVDTVQRALHYGVVDYLIKPFQFGRFKEALNNY
CCCCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QQQSQILAQREFSQGDVDSLLRRQPASTEGKKLPKGLTSITLSTVCEWIEQQHDGEFSTD
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCH
NLANAIGISRVSCRKYLIYLAESGILGTRILYGTTGRPVYLYQLKQDAIALLKEYCR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MINVLIIDDDPMVAELNKYYLSQVSGFHCLATVATLAQARALLADAEVSIDLVLLDIYMQ
CEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEHH
QENGLDLLPGLRELGEKTDVIIISSASDVDTVQRALHYGVVDYLIKPFQFGRFKEALNNY
CCCCCCCHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QQQSQILAQREFSQGDVDSLLRRQPASTEGKKLPKGLTSITLSTVCEWIEQQHDGEFSTD
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCCH
NLANAIGISRVSCRKYLIYLAESGILGTRILYGTTGRPVYLYQLKQDAIALLKEYCR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]