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The map label for this gene is dcuS [H]

Identifier: 157370201

GI number: 157370201

Start: 2139576

End: 2141177

Strand: Reverse

Name: dcuS [H]

Synonym: Spro_1959

Alternate gene names: 157370201

Gene position: 2141177-2139576 (Counterclockwise)

Preceding gene: 157370202

Following gene: 157370200

Centisome position: 39.3

GC content: 54.56

Gene sequence:

>1602_bases
ATGCCAAAACAACGGATACCGCTTAAGCTCAGCACCACGCTCACGCTGATGGTGTCTGCCATCATCGCTTCGGTGCTATT
GGTGGTATATGCGCTGTTTTTTGTGCAGATGAATCACCAGGGACAAGATCAGCAACGCCAAAAAGCGATGGCGATTGCCG
AAACGCTGGCGCTATCGAGTAATGTTATTGAGGGGTTGCTGCGTGAAGATCACAGTGGCGCGGTGCAGCGCTTTGCCGAG
CAGGTGCGCCAGCGGAATGAATTACTGTTTGTCGTCGTGGTGGACATGAAAGGTATCCGCTACTCGCACCCCAAACCCTG
GTTAATCGGTCAGCATTTTATCGGTGACGATTTGGAACCGGCGCTACGCGGCGAAACCAACAGCGCCATTAATCGCGGCG
CATTAGCCCCTTCGCTGCGGGTTTTTGCCCCGGTTTACGACAGCGAACGGCGGCAGATTGGCGTGGTCGCTCTCGGTATT
GCGCTCGACACCGTTCAGCGCGTGGTGGGCGAAAGCCGCTGGATCATCTACTGGACACTGGCCTTCGCCGCGCTGGTCGG
CACGCTCGGCATTTTCTTCCTGGTGAAGGCCCTGAAACGCATTATGCTCGGCTTTGAACCCTACGAGATCTCTAATCTGT
TCGAGCAGCGCAACGCCATGCTGCAATCAATTAAAGAAGGCGTCATTGCGGTCGATAACCAGTCACGCATTACCATTGTC
AACGACGAAGCCAAACGGCTGTTGCGCCAAAATGGGCCTTTCGAAAACCTGCTGTTGGAATCCGCCAGCAAATACTGGCC
GACGCAGCTGCATCTGGCGGAGGTGCTGGAAAGCGGTCAACCGCTGCGTGACCAGCAGATCAGCTTTAACGGCAGCGAAC
TGCTGACCAATACCGTGCCGGTAATCGTTAAGGGCCAGGTGATTGGTGCTATCGCCACCTTCCGCGATAAAACCGAAATC
AGCCAGTTGGTGCAACGCCTGAGCGGCATGGCGCACTATGCCGACGCATTGCGCGTCCAGTCACATGAGTTTATGAACAA
GCTGCATGTGATCCTCGGTATGCTGCACATGAAGGCCTACCAGCAGTTGGAAAACTACATCATCAATACTGCCAGCACCT
ATCAGGAAGAGATCGGTGCGCTGCTGAGGAAAATCCAGTCGCCAGAGGTGGCGGGCTTCTTTATCGGCAAGATCAATCGC
GCCCATGAAGCCGGTATTGAGCTGACCATTGACGAAACCAGCCTGCTACCAGAAACCGACGATGCGGAAACTACCCACGT
GCTGATCAGCGTGCTGGGCAATTTGATTGAAAATGCCATTGACGCTATCGATGGCGTAGAGGGGCACGAGATCAACCTGA
GCTTTCATCACAATGAGAATCACTTACACTGTATAGTCAGCGATGACGGCCCCGGTATCGATCCGGCTCTCGGCGCACGT
ATCTTTGAACAGGGAGTTTCAACCAAAGGGCCGGGGCGCGGTATTGGGCTGGCGTTGATCCGCAGCAGCCTGGAAAAACT
GGGCGGCAGCATTGATTTCGAATCTGAACCGGGTGAGCTAACCCAATTTTTTGTACATATCCCCTATCAGGCCAAGGGCT
GA

Upstream 100 bases:

>100_bases
AATCCCTCCCCCGGCGGCAGCATGTTATAACCTGCTGCCGGTCGCGGCCCCGCGCTCCAATCCCCGCTATTATCCTGACA
GGCCCATTCGGAGAATCGCC

Downstream 100 bases:

>100_bases
ACCATGATTAACGTATTGATTATCGACGACGACCCGATGGTGGCGGAGTTAAACAAATACTACCTGAGCCAGGTGAGCGG
CTTTCACTGCCTGGCGACGG

Product: sensory histidine kinase DcuS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MPKQRIPLKLSTTLTLMVSAIIASVLLVVYALFFVQMNHQGQDQQRQKAMAIAETLALSSNVIEGLLREDHSGAVQRFAE
QVRQRNELLFVVVVDMKGIRYSHPKPWLIGQHFIGDDLEPALRGETNSAINRGALAPSLRVFAPVYDSERRQIGVVALGI
ALDTVQRVVGESRWIIYWTLAFAALVGTLGIFFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDNQSRITIV
NDEAKRLLRQNGPFENLLLESASKYWPTQLHLAEVLESGQPLRDQQISFNGSELLTNTVPVIVKGQVIGAIATFRDKTEI
SQLVQRLSGMAHYADALRVQSHEFMNKLHVILGMLHMKAYQQLENYIINTASTYQEEIGALLRKIQSPEVAGFFIGKINR
AHEAGIELTIDETSLLPETDDAETTHVLISVLGNLIENAIDAIDGVEGHEINLSFHHNENHLHCIVSDDGPGIDPALGAR
IFEQGVSTKGPGRGIGLALIRSSLEKLGGSIDFESEPGELTQFFVHIPYQAKG

Sequences:

>Translated_533_residues
MPKQRIPLKLSTTLTLMVSAIIASVLLVVYALFFVQMNHQGQDQQRQKAMAIAETLALSSNVIEGLLREDHSGAVQRFAE
QVRQRNELLFVVVVDMKGIRYSHPKPWLIGQHFIGDDLEPALRGETNSAINRGALAPSLRVFAPVYDSERRQIGVVALGI
ALDTVQRVVGESRWIIYWTLAFAALVGTLGIFFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDNQSRITIV
NDEAKRLLRQNGPFENLLLESASKYWPTQLHLAEVLESGQPLRDQQISFNGSELLTNTVPVIVKGQVIGAIATFRDKTEI
SQLVQRLSGMAHYADALRVQSHEFMNKLHVILGMLHMKAYQQLENYIINTASTYQEEIGALLRKIQSPEVAGFFIGKINR
AHEAGIELTIDETSLLPETDDAETTHVLISVLGNLIENAIDAIDGVEGHEINLSFHHNENHLHCIVSDDGPGIDPALGAR
IFEQGVSTKGPGRGIGLALIRSSLEKLGGSIDFESEPGELTQFFVHIPYQAKG
>Mature_532_residues
PKQRIPLKLSTTLTLMVSAIIASVLLVVYALFFVQMNHQGQDQQRQKAMAIAETLALSSNVIEGLLREDHSGAVQRFAEQ
VRQRNELLFVVVVDMKGIRYSHPKPWLIGQHFIGDDLEPALRGETNSAINRGALAPSLRVFAPVYDSERRQIGVVALGIA
LDTVQRVVGESRWIIYWTLAFAALVGTLGIFFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDNQSRITIVN
DEAKRLLRQNGPFENLLLESASKYWPTQLHLAEVLESGQPLRDQQISFNGSELLTNTVPVIVKGQVIGAIATFRDKTEIS
QLVQRLSGMAHYADALRVQSHEFMNKLHVILGMLHMKAYQQLENYIINTASTYQEEIGALLRKIQSPEVAGFFIGKINRA
HEAGIELTIDETSLLPETDDAETTHVLISVLGNLIENAIDAIDGVEGHEINLSFHHNENHLHCIVSDDGPGIDPALGARI
FEQGVSTKGPGRGIGLALIRSSLEKLGGSIDFESEPGELTQFFVHIPYQAKG

Specific function: Member of the two-component regulatory system dcuR/dcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-di

COG id: COG3290

COG function: function code T; Signal transduction histidine kinase regulating citrate/malate metabolism

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790567, Length=532, Percent_Identity=53.0075187969925, Blast_Score=566, Evalue=1e-162,
Organism=Escherichia coli, GI1786837, Length=533, Percent_Identity=29.0806754221388, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1790300, Length=344, Percent_Identity=25, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=350, Percent_Identity=24.2857142857143, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR016120
- InterPro:   IPR005467
- InterPro:   IPR016121 [H]

Pfam domain/function: PF02518 HATPase_c; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59073; Mature: 58942

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKQRIPLKLSTTLTLMVSAIIASVLLVVYALFFVQMNHQGQDQQRQKAMAIAETLALSS
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NVIEGLLREDHSGAVQRFAEQVRQRNELLFVVVVDMKGIRYSHPKPWLIGQHFIGDDLEP
HHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCEECCHHCCCCCCH
ALRGETNSAINRGALAPSLRVFAPVYDSERRQIGVVALGIALDTVQRVVGESRWIIYWTL
HHCCCCCHHHHCCCCCCCHHEEECCCCCCCCEEEHEEEHHHHHHHHHHHCCCCEEEEHHH
AFAALVGTLGIFFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDNQSRITIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEE
NDEAKRLLRQNGPFENLLLESASKYWPTQLHLAEVLESGQPLRDQQISFNGSELLTNTVP
CHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
VIVKGQVIGAIATFRDKTEISQLVQRLSGMAHYADALRVQSHEFMNKLHVILGMLHMKAY
EEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQLENYIINTASTYQEEIGALLRKIQSPEVAGFFIGKINRAHEAGIELTIDETSLLPETD
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHCCCEEEECCCCCCCCCC
DAETTHVLISVLGNLIENAIDAIDGVEGHEINLSFHHNENHLHCIVSDDGPGIDPALGAR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHH
IFEQGVSTKGPGRGIGLALIRSSLEKLGGSIDFESEPGELTQFFVHIPYQAKG
HHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEEECCCCCCC
>Mature Secondary Structure 
PKQRIPLKLSTTLTLMVSAIIASVLLVVYALFFVQMNHQGQDQQRQKAMAIAETLALSS
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NVIEGLLREDHSGAVQRFAEQVRQRNELLFVVVVDMKGIRYSHPKPWLIGQHFIGDDLEP
HHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCEECCHHCCCCCCH
ALRGETNSAINRGALAPSLRVFAPVYDSERRQIGVVALGIALDTVQRVVGESRWIIYWTL
HHCCCCCHHHHCCCCCCCHHEEECCCCCCCCEEEHEEEHHHHHHHHHHHCCCCEEEEHHH
AFAALVGTLGIFFLVKALKRIMLGFEPYEISNLFEQRNAMLQSIKEGVIAVDNQSRITIV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEE
NDEAKRLLRQNGPFENLLLESASKYWPTQLHLAEVLESGQPLRDQQISFNGSELLTNTVP
CHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCC
VIVKGQVIGAIATFRDKTEISQLVQRLSGMAHYADALRVQSHEFMNKLHVILGMLHMKAY
EEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQLENYIINTASTYQEEIGALLRKIQSPEVAGFFIGKINRAHEAGIELTIDETSLLPETD
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHCCCEEEECCCCCCCCCC
DAETTHVLISVLGNLIENAIDAIDGVEGHEINLSFHHNENHLHCIVSDDGPGIDPALGAR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHH
IFEQGVSTKGPGRGIGLALIRSSLEKLGGSIDFESEPGELTQFFVHIPYQAKG
HHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]