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The map label for this gene is tmk

Identifier: 157370153

GI number: 157370153

Start: 2094499

End: 2095137

Strand: Direct

Name: tmk

Synonym: Spro_1911

Alternate gene names: 157370153

Gene position: 2094499-2095137 (Clockwise)

Preceding gene: 157370152

Following gene: 157370154

Centisome position: 38.44

GC content: 57.43

Gene sequence:

>639_bases
ATGAAAAGTAAATTCGTGGTTATCGAAGGGCTTGAAGGTGCGGGCAAAACGACCGCACGCGATACCGTAGTCGACGTACT
GCGCGAACATGGTATCAACGACATTGCCTTTACCCGTGAACCCGGCGGTACGCCGTTGGCAGAAAAACTGCGCGACCTGT
TCAAACGCGGCGTGGAGGGCGAACTGCCAACCATCAAGGCCGAGGTTCTGATGCTGTATGCGGCCCGTGTACAGTTGGTG
GAAACGGTGATCAAACCGGCTTTGGCGCGCGGTGCCTGGGTGGTTGGCGATCGGCACGACCTGTCTTCTCAAGCCTACCA
GGGCGGTGGTCGGGGTGTGGATCAACAACTTATGGCCTCGCTGCGTGACACGGTATTAGGGGAGTTTCGTCCCGATCTGA
CGCTTTATCTGGATTTGCCGCCGATAGTGGGTCTGCAGCGTGCCCGAGCACGGGGCGAACTGGATCGTATCGAACAGGAA
GCACTGCCATTCTTTGAACGTACCCGCGCACGTTATCGGGAGTTGGCGGCGCAAGATGCGTCCATCATCACCGTAGATGC
TTCTCAATCGCTTGATCAGGTGACGGCGGCGATTCGTCGTTGCGTCAGCCAATGGTTACAGCAGCAGGAAGGCGCGTAA

Upstream 100 bases:

>100_bases
TACTTTGTTGCCGACGGTAAGGGCGGGCATCAATTTACCACCAACCTGGCCAGCCATAATCAGGCGGTGCGTGCCTATCG
TCAGGCGTTAAAGGAAAAGA

Downstream 100 bases:

>100_bases
TGAACTGGTACCCGTGGCTGAATACCCCTTACCGCCAGTTGGTCGGGCAATATGCTACCGGGCGCGGTCATCACGCACTG
TTGTTGCATGCCGCTGCCGG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKSKFVVIEGLEGAGKTTARDTVVDVLREHGINDIAFTREPGGTPLAEKLRDLFKRGVEGELPTIKAEVLMLYAARVQLV
ETVIKPALARGAWVVGDRHDLSSQAYQGGGRGVDQQLMASLRDTVLGEFRPDLTLYLDLPPIVGLQRARARGELDRIEQE
ALPFFERTRARYRELAAQDASIITVDASQSLDQVTAAIRRCVSQWLQQQEGA

Sequences:

>Translated_212_residues
MKSKFVVIEGLEGAGKTTARDTVVDVLREHGINDIAFTREPGGTPLAEKLRDLFKRGVEGELPTIKAEVLMLYAARVQLV
ETVIKPALARGAWVVGDRHDLSSQAYQGGGRGVDQQLMASLRDTVLGEFRPDLTLYLDLPPIVGLQRARARGELDRIEQE
ALPFFERTRARYRELAAQDASIITVDASQSLDQVTAAIRRCVSQWLQQQEGA
>Mature_212_residues
MKSKFVVIEGLEGAGKTTARDTVVDVLREHGINDIAFTREPGGTPLAEKLRDLFKRGVEGELPTIKAEVLMLYAARVQLV
ETVIKPALARGAWVVGDRHDLSSQAYQGGGRGVDQQLMASLRDTVLGEFRPDLTLYLDLPPIVGLQRARARGELDRIEQE
ALPFFERTRARYRELAAQDASIITVDASQSLDQVTAAIRRCVSQWLQQQEGA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=210, Percent_Identity=70, Blast_Score=297, Evalue=4e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_SERP5 (A8GD24)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478142.1
- ProteinModelPortal:   A8GD24
- SMR:   A8GD24
- STRING:   A8GD24
- GeneID:   5606491
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1911
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   SPRO399741:SPRO_1911-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23440; Mature: 23440

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKFVVIEGLEGAGKTTARDTVVDVLREHGINDIAFTREPGGTPLAEKLRDLFKRGVEG
CCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCCC
ELPTIKAEVLMLYAARVQLVETVIKPALARGAWVVGDRHDLSSQAYQGGGRGVDQQLMAS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCHHHHHHHH
LRDTVLGEFRPDLTLYLDLPPIVGLQRARARGELDRIEQEALPFFERTRARYRELAAQDA
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
SIITVDASQSLDQVTAAIRRCVSQWLQQQEGA
CEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSKFVVIEGLEGAGKTTARDTVVDVLREHGINDIAFTREPGGTPLAEKLRDLFKRGVEG
CCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCCCCC
ELPTIKAEVLMLYAARVQLVETVIKPALARGAWVVGDRHDLSSQAYQGGGRGVDQQLMAS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCHHHHHHHH
LRDTVLGEFRPDLTLYLDLPPIVGLQRARARGELDRIEQEALPFFERTRARYRELAAQDA
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
SIITVDASQSLDQVTAAIRRCVSQWLQQQEGA
CEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA