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The map label for this gene is mdtG [H]

Identifier: 157370124

GI number: 157370124

Start: 2068156

End: 2069391

Strand: Reverse

Name: mdtG [H]

Synonym: Spro_1882

Alternate gene names: 157370124

Gene position: 2069391-2068156 (Counterclockwise)

Preceding gene: 157370125

Following gene: 157370123

Centisome position: 37.98

GC content: 58.01

Gene sequence:

>1236_bases
ATGGCTCCGGCACCCAAACTCATCAACTGGAAACGCAATCTTTTTGTCGCCTGGCTGGGGTGTTTCCTCACCGGTGCCGC
CTTCAGTCTGATCATGCCATTCCTGCCGCTGTATGTAGAAACCCTCGGTGTTACCGGCCACCAGGCACTGAATATGTGGT
CTGGGCTGGTATTTAGCATTACCTTCCTGTTCTCTGCGATTGCCTCCCCATTCTGGGGCGGTTTGGCCGATCGCCGTGGG
CGCAAACTGATGCTGTTACGATCGGCATTGGGCATGTCGATAGTGATGCTGCTGATGGGCATGGCGCAGAATATTTGGCA
GTTTTTGGCGCTACGCGCGGTGCTGGGCCTGCTCGGCGGTTTTATCCCCAACGCCAATGCGCTGATTGCCACACAGGTGC
CGCGCAATCGCAGCGGTTGGGCACTGGGTACCCTGTCCACCGGCGGCGTCAGCGGTGCATTGATTGGGCCGCTGATTGGC
GGCCTGCTAGCCGACCAGTATGGCCTGAGGCCGGTGTTCTACATTACCGCCGGTGTGCTGCTGACCTGCTTTGTGCTGAC
GCTGCTGTATGTCAAAGAGCAGTTCACCCCGGTGCAGAAAAAAGACATGCTGCACGCCCGTCAGGTCTTCGCGGCGCTAA
AAAGCCCCAAGCTGATCCTCAGCCTGTTTGTCACCACCATGATTATTCAGATTGCCACCGGATCCATCGCACCGATCCTG
ACGCTGTACGTCCGTGATTTGGCCGGTGACATTCATAATCTGGCCTTTGTCAGCGGCCTGATCGCTTCAGTGCCGGGCGT
CGCCGCGCTAATGAGTGCGCCACGGCTGGGCAAACTGGGCGACAGGATCGGCCCGGAGCGCATTCTGGTGTTTATGCTGA
TCGTATCGGTGCTGTTACTGATCCCGATGGCGTTTGTGCAAACCCCGTGGCAACTCGGCGTACTTCGCTTCCTGCTAGGC
GCTGCCGATGGCGCACTGCTGCCGGCGGTACAAACCTTGCTGATCTACAACTGCACCAATCAGGTTGCCGGGCGGATCTT
CAGCTATAACCAATCGTTCCGCGATATCGGCAACGTCAGTGGCCCATTAATGGGGGCCGCCGTCTCCGCCAGTTATGGCT
TCCGTGCAGTATTCTGCGTCACCGCTCTGGTGGTGCTGTTCAACGCCGTTTATTCCTGGTGGTGTTTGCAACGTCGCCCG
ACGCGAATGAGAGAAGACACCCTGCAGGAAGAGTAA

Upstream 100 bases:

>100_bases
CACCTATAATTAAGCGCATACTTACCAGGCTAACTTTTTTTGCTTTGCACGATTGACTGCTTTTGCAAACATAGCCCTCT
ACCTTACGCAACAGGAACTT

Downstream 100 bases:

>100_bases
TAGCCGTATTTATCACCACTTCCTTCACTAAAATGGGTCGACGGCCCGTTTACCCTACTTTTAGTATTGATACCTTTCAC
ACCCGCCTTGCCGGCCCCCT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MAPAPKLINWKRNLFVAWLGCFLTGAAFSLIMPFLPLYVETLGVTGHQALNMWSGLVFSITFLFSAIASPFWGGLADRRG
RKLMLLRSALGMSIVMLLMGMAQNIWQFLALRAVLGLLGGFIPNANALIATQVPRNRSGWALGTLSTGGVSGALIGPLIG
GLLADQYGLRPVFYITAGVLLTCFVLTLLYVKEQFTPVQKKDMLHARQVFAALKSPKLILSLFVTTMIIQIATGSIAPIL
TLYVRDLAGDIHNLAFVSGLIASVPGVAALMSAPRLGKLGDRIGPERILVFMLIVSVLLLIPMAFVQTPWQLGVLRFLLG
AADGALLPAVQTLLIYNCTNQVAGRIFSYNQSFRDIGNVSGPLMGAAVSASYGFRAVFCVTALVVLFNAVYSWWCLQRRP
TRMREDTLQEE

Sequences:

>Translated_411_residues
MAPAPKLINWKRNLFVAWLGCFLTGAAFSLIMPFLPLYVETLGVTGHQALNMWSGLVFSITFLFSAIASPFWGGLADRRG
RKLMLLRSALGMSIVMLLMGMAQNIWQFLALRAVLGLLGGFIPNANALIATQVPRNRSGWALGTLSTGGVSGALIGPLIG
GLLADQYGLRPVFYITAGVLLTCFVLTLLYVKEQFTPVQKKDMLHARQVFAALKSPKLILSLFVTTMIIQIATGSIAPIL
TLYVRDLAGDIHNLAFVSGLIASVPGVAALMSAPRLGKLGDRIGPERILVFMLIVSVLLLIPMAFVQTPWQLGVLRFLLG
AADGALLPAVQTLLIYNCTNQVAGRIFSYNQSFRDIGNVSGPLMGAAVSASYGFRAVFCVTALVVLFNAVYSWWCLQRRP
TRMREDTLQEE
>Mature_410_residues
APAPKLINWKRNLFVAWLGCFLTGAAFSLIMPFLPLYVETLGVTGHQALNMWSGLVFSITFLFSAIASPFWGGLADRRGR
KLMLLRSALGMSIVMLLMGMAQNIWQFLALRAVLGLLGGFIPNANALIATQVPRNRSGWALGTLSTGGVSGALIGPLIGG
LLADQYGLRPVFYITAGVLLTCFVLTLLYVKEQFTPVQKKDMLHARQVFAALKSPKLILSLFVTTMIIQIATGSIAPILT
LYVRDLAGDIHNLAFVSGLIASVPGVAALMSAPRLGKLGDRIGPERILVFMLIVSVLLLIPMAFVQTPWQLGVLRFLLGA
ADGALLPAVQTLLIYNCTNQVAGRIFSYNQSFRDIGNVSGPLMGAAVSASYGFRAVFCVTALVVLFNAVYSWWCLQRRPT
RMREDTLQEE

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=392, Percent_Identity=82.3979591836735, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI87082404, Length=301, Percent_Identity=28.2392026578073, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319871, Length=144, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44612; Mature: 44481

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPAPKLINWKRNLFVAWLGCFLTGAAFSLIMPFLPLYVETLGVTGHQALNMWSGLVFSI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TFLFSAIASPFWGGLADRRGRKLMLLRSALGMSIVMLLMGMAQNIWQFLALRAVLGLLGG
HHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FIPNANALIATQVPRNRSGWALGTLSTGGVSGALIGPLIGGLLADQYGLRPVFYITAGVL
CCCCCCEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LTCFVLTLLYVKEQFTPVQKKDMLHARQVFAALKSPKLILSLFVTTMIIQIATGSIAPIL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHH
TLYVRDLAGDIHNLAFVSGLIASVPGVAALMSAPRLGKLGDRIGPERILVFMLIVSVLLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHH
IPMAFVQTPWQLGVLRFLLGAADGALLPAVQTLLIYNCTNQVAGRIFSYNQSFRDIGNVS
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
GPLMGAAVSASYGFRAVFCVTALVVLFNAVYSWWCLQRRPTRMREDTLQEE
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC
>Mature Secondary Structure 
APAPKLINWKRNLFVAWLGCFLTGAAFSLIMPFLPLYVETLGVTGHQALNMWSGLVFSI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TFLFSAIASPFWGGLADRRGRKLMLLRSALGMSIVMLLMGMAQNIWQFLALRAVLGLLGG
HHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FIPNANALIATQVPRNRSGWALGTLSTGGVSGALIGPLIGGLLADQYGLRPVFYITAGVL
CCCCCCEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LTCFVLTLLYVKEQFTPVQKKDMLHARQVFAALKSPKLILSLFVTTMIIQIATGSIAPIL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHH
TLYVRDLAGDIHNLAFVSGLIASVPGVAALMSAPRLGKLGDRIGPERILVFMLIVSVLLL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHH
IPMAFVQTPWQLGVLRFLLGAADGALLPAVQTLLIYNCTNQVAGRIFSYNQSFRDIGNVS
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
GPLMGAAVSASYGFRAVFCVTALVVLFNAVYSWWCLQRRPTRMREDTLQEE
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA