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The map label for this gene is cvrA [H]

Identifier: 157370109

GI number: 157370109

Start: 2052276

End: 2053997

Strand: Reverse

Name: cvrA [H]

Synonym: Spro_1867

Alternate gene names: 157370109

Gene position: 2053997-2052276 (Counterclockwise)

Preceding gene: 157370110

Following gene: 157370105

Centisome position: 37.7

GC content: 56.16

Gene sequence:

>1722_bases
TTGGATGCCAGCACCATTAACAGTTTGTTCATCATCGGTGCCGTGTTGGTGGGAGCAAGTATTCTTCTCAGTTCATTTTC
TTCACGCCTGGGTATTCCCATTTTGGTGATCTTCCTCGCTATCGGCATGCTGGCGGGGGTCGATGGTCCGGGCGGTATCG
TTTTCAGTAATTACCCGGTGGCCTATCTGGTCAGTAACCTGGCACTGGCCGTGATCCTGCTCGATGGCGGCATGCGCACC
CGCGTCAGTTCATTTCGTGTGGCACTTTGGCCGGCACTTTCCCTCGCCACCGTTGGCGTGGTGATCACCGCCGGGCTGAC
CGGGCTGGCTGCCGCCTGGTTGTTCAACCTCGATCTGCTACAAGGTATGCTGATTGGTGCCATTATCGGCTCCACCGACG
CCGCAGCGGTATTTTCACTCCTCGGCGGTAAAGGGCTTAACGAACGCGTCAGCGCCACGCTGGAAATTGAGTCCGGTAGC
AACGATCCGATGGCGGTGTTTCTTACCATTACCCTGATTGCGATGATCTCCGCCGGCGAAACCACGCTGAGCTGGATGTT
CCCTGTCCATCTGCTTCAGCAGTTTGGTATGGGCATTGTCTTTGGGCTGGGCGGCGGCTGGCTGCTGCTGACCTTGATCA
ACCACATCAAACTGGCCGAAGGTCTCTACCCACTGCTGGCCGTCAGCGGCGGCATTTTGATTTTTGCGCTGACCACTGCG
CTGGATGGTAGCGGCATACTGGCGGTGTACCTGTGTGGGTTGACGCTGGGCAACCGGCCAATCCGTAACCGACACGGCAT
TGTCCAAACCTTTGACGGTCTGGCCTGGCTGAGCCAGATCGGCATGTTCCTGGTGCTGGGGTTGCTGCTCAACCCGCACG
AGTTGTTACCTATTGCCATCCCTGCCCTGCTGCTGTCGTTATGGATGATCCTGTTCGCCCGACCGCTCTCCGTGTTTATC
GGGTTACTGCCGTTTCGCAGTTTTACTCTCCGTGAACGCAGTTTTATTTCCTGGGTCGGTTTGCGCGGCGCCGTACCGGT
TATTTTGGCCGTATTCCCGATGATGGCCGGGTTGCCAAATGCGCAGCTGTTCTTCAACGTGGCCTTTTTTGTGGTGCTGG
TTTCACTGTTGTTGCAAGGCACGACACTGTCGTTCGCCGCGAAGAAAGCCAAGGTTATAGTACCGCCGGCCCTGGCGCCT
ATTTCACGGGTCGGGTTGGACGTACACCCGGAAAACCAGTGGGAACAGTTTGTTTATCAGCTCTCGTCGGAAAACTGGTG
TGTGGGTGCTGCACTGCGTGAATTGAAAATGCCACCCGGCACGCGTATTGCCGCACTGTTCCGTGGCAAAGAGTTGTTGC
ACCCTAGCGGGAGCACGCGGTTGCGCGAAGATGACATTCTGTGCGTTATCGGCCACGAGCATGACCTGCCAGTGCTGGGT
AAACTGTTTAGCCAGGCGCCGGTGGTCACAATGGATGAGCGTTTCTTCGGCGACTTTATCCTGCAGTCGGACGCACGCCT
GAGCGATATTTCGCAGGTGTATGGGCTTAACCTGCAAGAAGGTGTGGACGAACAACAAACACTGGGCCAATTCGTCATTA
AACTGATTGGCGGCGAACCCGTGGTAGGCGATCAGGTCGAATGGGATGGCCTGACCTGGACCATAGCCGAGATGGATGGC
AATGCCATCAGTAAAATCGGCGTAAAAATTGTGACTGACTGA

Upstream 100 bases:

>100_bases
CGAATCACCCTTGGCGTTTTACCTAAAAAACAGGCTATCATCATGGGGTATCTGCGCCCGCGCGCAACGCCTTTCCCCCA
GCCTGCAGGAGAACGTTATT

Downstream 100 bases:

>100_bases
CCCGCCCTCGACACCGGTCGCTGTGTGGCAATCCCCGCAGCGACCGCCTCAAAACAGACGGAACTTATAGACCCGGAAAG
GTTCTTAAACTCTGTGATTA

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MDASTINSLFIIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVFSNYPVAYLVSNLALAVILLDGGMRT
RVSSFRVALWPALSLATVGVVITAGLTGLAAAWLFNLDLLQGMLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGS
NDPMAVFLTITLIAMISAGETTLSWMFPVHLLQQFGMGIVFGLGGGWLLLTLINHIKLAEGLYPLLAVSGGILIFALTTA
LDGSGILAVYLCGLTLGNRPIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVFI
GLLPFRSFTLRERSFISWVGLRGAVPVILAVFPMMAGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPALAP
ISRVGLDVHPENQWEQFVYQLSSENWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLREDDILCVIGHEHDLPVLG
KLFSQAPVVTMDERFFGDFILQSDARLSDISQVYGLNLQEGVDEQQTLGQFVIKLIGGEPVVGDQVEWDGLTWTIAEMDG
NAISKIGVKIVTD

Sequences:

>Translated_573_residues
MDASTINSLFIIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVFSNYPVAYLVSNLALAVILLDGGMRT
RVSSFRVALWPALSLATVGVVITAGLTGLAAAWLFNLDLLQGMLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGS
NDPMAVFLTITLIAMISAGETTLSWMFPVHLLQQFGMGIVFGLGGGWLLLTLINHIKLAEGLYPLLAVSGGILIFALTTA
LDGSGILAVYLCGLTLGNRPIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVFI
GLLPFRSFTLRERSFISWVGLRGAVPVILAVFPMMAGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPALAP
ISRVGLDVHPENQWEQFVYQLSSENWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLREDDILCVIGHEHDLPVLG
KLFSQAPVVTMDERFFGDFILQSDARLSDISQVYGLNLQEGVDEQQTLGQFVIKLIGGEPVVGDQVEWDGLTWTIAEMDG
NAISKIGVKIVTD
>Mature_573_residues
MDASTINSLFIIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVFSNYPVAYLVSNLALAVILLDGGMRT
RVSSFRVALWPALSLATVGVVITAGLTGLAAAWLFNLDLLQGMLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGS
NDPMAVFLTITLIAMISAGETTLSWMFPVHLLQQFGMGIVFGLGGGWLLLTLINHIKLAEGLYPLLAVSGGILIFALTTA
LDGSGILAVYLCGLTLGNRPIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVFI
GLLPFRSFTLRERSFISWVGLRGAVPVILAVFPMMAGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPALAP
ISRVGLDVHPENQWEQFVYQLSSENWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLREDDILCVIGHEHDLPVLG
KLFSQAPVVTMDERFFGDFILQSDARLSDISQVYGLNLQEGVDEQQTLGQFVIKLIGGEPVVGDQVEWDGLTWTIAEMDG
NAISKIGVKIVTD

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=574, Percent_Identity=75.9581881533101, Blast_Score=806, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 61291; Mature: 61291

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDASTINSLFIIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVFSNYPV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEECCCCH
AYLVSNLALAVILLDGGMRTRVSSFRVALWPALSLATVGVVITAGLTGLAAAWLFNLDLL
HHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGMLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMAVFLTITLIAMISAGE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
TTLSWMFPVHLLQQFGMGIVFGLGGGWLLLTLINHIKLAEGLYPLLAVSGGILIFALTTA
CHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHH
LDGSGILAVYLCGLTLGNRPIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAI
CCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
PALLLSLWMILFARPLSVFIGLLPFRSFTLRERSFISWVGLRGAVPVILAVFPMMAGLPN
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
AQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPALAPISRVGLDVHPENQWEQFVYQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCHHHHCCCCCCCCHHHHHHHHH
LSSENWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLREDDILCVIGHEHDLPVLG
HCCCCEEHHHHHHHHCCCCCCEEHHHHCCCHHCCCCCCCCCCCCCEEEEECCCCCCHHHH
KLFSQAPVVTMDERFFGDFILQSDARLSDISQVYGLNLQEGVDEQQTLGQFVIKLIGGEP
HHHCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHCCCC
VVGDQVEWDGLTWTIAEMDGNAISKIGVKIVTD
CCCCCEEECCEEEEEEECCCCCCHHCCEEEECC
>Mature Secondary Structure
MDASTINSLFIIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVFSNYPV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEECCCCH
AYLVSNLALAVILLDGGMRTRVSSFRVALWPALSLATVGVVITAGLTGLAAAWLFNLDLL
HHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGMLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMAVFLTITLIAMISAGE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
TTLSWMFPVHLLQQFGMGIVFGLGGGWLLLTLINHIKLAEGLYPLLAVSGGILIFALTTA
CHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHH
LDGSGILAVYLCGLTLGNRPIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAI
CCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
PALLLSLWMILFARPLSVFIGLLPFRSFTLRERSFISWVGLRGAVPVILAVFPMMAGLPN
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
AQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPALAPISRVGLDVHPENQWEQFVYQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCHHHHCCCCCCCCHHHHHHHHH
LSSENWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLREDDILCVIGHEHDLPVLG
HCCCCEEHHHHHHHHCCCCCCEEHHHHCCCHHCCCCCCCCCCCCCEEEEECCCCCCHHHH
KLFSQAPVVTMDERFFGDFILQSDARLSDISQVYGLNLQEGVDEQQTLGQFVIKLIGGEP
HHHCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHCCCC
VVGDQVEWDGLTWTIAEMDGNAISKIGVKIVTD
CCCCCEEECCEEEEEEECCCCCCHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA