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The map label for this gene is macA [H]

Identifier: 157370105

GI number: 157370105

Start: 2048952

End: 2050133

Strand: Reverse

Name: macA [H]

Synonym: Spro_1863

Alternate gene names: 157370105

Gene position: 2050133-2048952 (Counterclockwise)

Preceding gene: 157370109

Following gene: 157370104

Centisome position: 37.63

GC content: 54.99

Gene sequence:

>1182_bases
ATGAAAGTCACTCCGCGCCGCTTGGCGTTTATCCTGATCGGTGCTCTGCTGGTCATTATTGCCCTGGTGGTATTCTCTTT
ACAAAGCCCCCCGCAAGCCGCTTCGGTGACCGCACCGGTTCGTCTGGGCGATATTGAAAATGCCGTACTGGCCACCGGCA
AACTTGATGCGATAGAACGGGTCAACGTCGGTGCACAGGTCTCCGGCCAGGTCAAATCCCTGAAGGTCAAACTTGGCGAC
AAGGTCACCAAAGGCCAACCTATTGCCGATATCGACGATCTGCCACAACGCAACGACCTGCGTAACGCCGAAGCGGCGCT
GAACGTCGCCAAGGCAGATTTGCAGGCCAAACAGGCACTGTTGAAACAGGCTGAGTCCCGCTTTAAACGCCAAAAGCGCA
TGTTGAGTGATGAAGCCGGCTCCCGCGAAGATTTTGAGACGGCAGAGGCCACGCTCGCCGCCACCCGCGCCGAACTGATC
GCGTTGAATGCTCGCATCGTGCAGGCACAGATTGAAGTAGACAAGAAAAAGGTCGACCTGAGTTACACCCGTATTCTGGC
GCCGATGGATGGCATCGTTATCGCGGTGATTACTCAGCAAGGCCAAACGGTGAATGCCAACCAGAGCGCGCCCACCATCG
TCAAACTGGCGCAGTTGGACGTAATGACCATCAAGGCGCAGATTTCCGAGGCCGACATTACCCGCGTTTCTCAGGGGCAA
AAGGCCTACTTCACGATTTTCTCCGAACCCGATAAACGTTACGACGCCACGCTACGCACCGTTGAACTGGCGCCAGAATC
GGTGATGAAAGACGATTCAGTCTCCGGTAGCAGTTCGTCCTCCGGCTCCGGTAGCTCCAATGCTTCGGTGTATTACAACG
CCTTGCTGGACGTCCCAAACCCGGATAACCGGCTGCGGATTGCCATGACGGCGCAAGTTTCATTGCTGCTCGGCGAGGCG
AAAAACGCACTGTTGGTACCGATCCAAGCGGTACATAAAACCGCAGATAATAAGCAACAGGTACAAGTGCTGACCGGGGA
CAACCGGTTGGAAATGCGCGAGGTGAAAACCGGCATTACCAATAACGTCGATATTCAAATCCTGTCCGGATTGAAGGCAG
GTGAAAACGTGGTGCTGGTACAGGAAAATACCAAACCTGGCGAGGAAGGTCTCTCACTGTGA

Upstream 100 bases:

>100_bases
ACTTTTATTTGGCCGTCTGCGGCATGTTTATTGTTAGTTAATGCGCTGGATGCCACTATAGCGCCTTCTGGGATCATCGT
TTTCTGTTACGGATAACACT

Downstream 100 bases:

>100_bases
ACGCTATCATTGAGCTGAAAGGCATCGGCCGCACCTACACCAACAGCAGCCAGCCGCTCACCGTCCTGAAAGACATTAAC
CTCAGCATCGCTGCCGGGGA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKVTPRRLAFILIGALLVIIALVVFSLQSPPQAASVTAPVRLGDIENAVLATGKLDAIERVNVGAQVSGQVKSLKVKLGD
KVTKGQPIADIDDLPQRNDLRNAEAALNVAKADLQAKQALLKQAESRFKRQKRMLSDEAGSREDFETAEATLAATRAELI
ALNARIVQAQIEVDKKKVDLSYTRILAPMDGIVIAVITQQGQTVNANQSAPTIVKLAQLDVMTIKAQISEADITRVSQGQ
KAYFTIFSEPDKRYDATLRTVELAPESVMKDDSVSGSSSSSGSGSSNASVYYNALLDVPNPDNRLRIAMTAQVSLLLGEA
KNALLVPIQAVHKTADNKQQVQVLTGDNRLEMREVKTGITNNVDIQILSGLKAGENVVLVQENTKPGEEGLSL

Sequences:

>Translated_393_residues
MKVTPRRLAFILIGALLVIIALVVFSLQSPPQAASVTAPVRLGDIENAVLATGKLDAIERVNVGAQVSGQVKSLKVKLGD
KVTKGQPIADIDDLPQRNDLRNAEAALNVAKADLQAKQALLKQAESRFKRQKRMLSDEAGSREDFETAEATLAATRAELI
ALNARIVQAQIEVDKKKVDLSYTRILAPMDGIVIAVITQQGQTVNANQSAPTIVKLAQLDVMTIKAQISEADITRVSQGQ
KAYFTIFSEPDKRYDATLRTVELAPESVMKDDSVSGSSSSSGSGSSNASVYYNALLDVPNPDNRLRIAMTAQVSLLLGEA
KNALLVPIQAVHKTADNKQQVQVLTGDNRLEMREVKTGITNNVDIQILSGLKAGENVVLVQENTKPGEEGLSL
>Mature_393_residues
MKVTPRRLAFILIGALLVIIALVVFSLQSPPQAASVTAPVRLGDIENAVLATGKLDAIERVNVGAQVSGQVKSLKVKLGD
KVTKGQPIADIDDLPQRNDLRNAEAALNVAKADLQAKQALLKQAESRFKRQKRMLSDEAGSREDFETAEATLAATRAELI
ALNARIVQAQIEVDKKKVDLSYTRILAPMDGIVIAVITQQGQTVNANQSAPTIVKLAQLDVMTIKAQISEADITRVSQGQ
KAYFTIFSEPDKRYDATLRTVELAPESVMKDDSVSGSSSSSGSGSSNASVYYNALLDVPNPDNRLRIAMTAQVSLLLGEA
KNALLVPIQAVHKTADNKQQVQVLTGDNRLEMREVKTGITNNVDIQILSGLKAGENVVLVQENTKPGEEGLSL

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=377, Percent_Identity=39.7877984084881, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1789929, Length=338, Percent_Identity=25.7396449704142, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082036, Length=327, Percent_Identity=23.8532110091743, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42240; Mature: 42240

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTPRRLAFILIGALLVIIALVVFSLQSPPQAASVTAPVRLGDIENAVLATGKLDAIER
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCEEECCCCCCEEECCCCCHHHH
VNVGAQVSGQVKSLKVKLGDKVTKGQPIADIDDLPQRNDLRNAEAALNVAKADLQAKQAL
CCCCCEECCCEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LKQAESRFKRQKRMLSDEAGSREDFETAEATLAATRAELIALNARIVQAQIEVDKKKVDL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEECEEEEEEEEEECCHHCCC
SYTRILAPMDGIVIAVITQQGQTVNANQSAPTIVKLAQLDVMTIKAQISEADITRVSQGQ
HHHHHHCCCCCEEEEEEECCCCEECCCCCCCCEEEEHHEEEEEEEEECCHHHHHHHCCCC
KAYFTIFSEPDKRYDATLRTVELAPESVMKDDSVSGSSSSSGSGSSNASVYYNALLDVPN
EEEEEEECCCCCHHCCEEEEEEECCHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEECCC
PDNRLRIAMTAQVSLLLGEAKNALLVPIQAVHKTADNKQQVQVLTGDNRLEMREVKTGIT
CCCCEEEEEEEEEEEEEECCCCEEEEEHHHHHCCCCCCEEEEEEECCCCEEHHHHHCCCC
NNVDIQILSGLKAGENVVLVQENTKPGEEGLSL
CCCEEEEEECCCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKVTPRRLAFILIGALLVIIALVVFSLQSPPQAASVTAPVRLGDIENAVLATGKLDAIER
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCEEECCCCCCEEECCCCCHHHH
VNVGAQVSGQVKSLKVKLGDKVTKGQPIADIDDLPQRNDLRNAEAALNVAKADLQAKQAL
CCCCCEECCCEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LKQAESRFKRQKRMLSDEAGSREDFETAEATLAATRAELIALNARIVQAQIEVDKKKVDL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEECEEEEEEEEEECCHHCCC
SYTRILAPMDGIVIAVITQQGQTVNANQSAPTIVKLAQLDVMTIKAQISEADITRVSQGQ
HHHHHHCCCCCEEEEEEECCCCEECCCCCCCCEEEEHHEEEEEEEEECCHHHHHHHCCCC
KAYFTIFSEPDKRYDATLRTVELAPESVMKDDSVSGSSSSSGSGSSNASVYYNALLDVPN
EEEEEEECCCCCHHCCEEEEEEECCHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEECCC
PDNRLRIAMTAQVSLLLGEAKNALLVPIQAVHKTADNKQQVQVLTGDNRLEMREVKTGIT
CCCCEEEEEEEEEEEEEECCCCEEEEEHHHHHCCCCCCEEEEEEECCCCEEHHHHHCCCC
NNVDIQILSGLKAGENVVLVQENTKPGEEGLSL
CCCEEEEEECCCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]