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The map label for this gene is 157370082

Identifier: 157370082

GI number: 157370082

Start: 2025128

End: 2026075

Strand: Direct

Name: 157370082

Synonym: Spro_1840

Alternate gene names: NA

Gene position: 2025128-2026075 (Clockwise)

Preceding gene: 157370076

Following gene: 157370083

Centisome position: 37.17

GC content: 61.18

Gene sequence:

>948_bases
ATGGCACTTTCTTCGCACTTCACCGCGCTGCGGGCGATCGATTCCCATACCGCCGGGGAACCCACCCGACTGATTGTCGA
AGGATTCCCCGATTTGGGCACTGGCAGCATGGCGGAACGCAAGGCGCTGTTTGCTCAACAATATGACGACTGGCGCAGCG
CCATCATTCTGGAGCCTCGCGGCAACGACGTGCTGGTGGGAGCCTTACTGTGCCAGCCCTGCTCACCGCAGGCCGCCGCC
GGGGTGATTTTTTTCAACAACAGCGGCTATTTGGGCATGTGTGGCCATGGCACCATCGGTCTGGTGGCCTCACTGGCCTA
TCTGGGGAAAATCGGCGTCGGTGAGCACCTGATCGAAACTCCGGTGGGCACGGTGAACGCCACCTTGCATCAGGATGGCA
GCGTGACGGTGGAAAACGTACCGGCCTATCGTTATCGCCGGCAGGTCAGGGTTGAGGTCAACGGCTACGGGCCGGTGGTG
GGCGATATTGCCTGGGGCGGTAACTGGTTTTTTCTGATCGGCGAACATCATCTGGCGATCAATACGCAAAATCTGGATGC
GCTGACCGCCTTTAGCTGGGCGGTACGTCAGGCGCTTGAGGGCGCAGGGATATATGGCGAAGACGGCGGCGTTATCGACC
ATATCGAGCTGTTTGCCGCCGACCCGCAGGCCGACAGCCGCAACTTTGTGCTGTGCCCCGGCAAGGCTTACGATCGCTCG
CCCTGCGGCACCGGGACCAGCGCCAAGCTGGCCTGTCTGGCGGCCGACGGCAAACTGCAGCCGGGTGAGATTTGGCACCA
GGCGAGCGTGATTGGCAGTAGATTCAGCGGCTATTACCAGCGCAGTGGCGATCGCGTGACGCCGTTTATTCGTGGGCAAG
CTTACGTTTGCGCCGACAGCCAACTGCTGCTGGATGAGCGCGATCCCTTCGTTTGGGGGATCCGCTGA

Upstream 100 bases:

>100_bases
TGATTTCGGCATTTGCCGCGCCGAAATGCATCAAGCCGCCGCCAGCAGATTCGGTCAGTCTAGCTCCATCGGTAACATTT
CATTAACCCAGGAGACTCCG

Downstream 100 bases:

>100_bases
TGATTGCCGGCAGGCGGGCGGATGCGATTGTGGTGGGGGCCGGCATTATCGGCGCTGCCTGCGCCTGGCGGCTGGCGCAG
CAAGGATTACAAGTTTTGCT

Product: proline racemase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; PaHyPRE [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MALSSHFTALRAIDSHTAGEPTRLIVEGFPDLGTGSMAERKALFAQQYDDWRSAIILEPRGNDVLVGALLCQPCSPQAAA
GVIFFNNSGYLGMCGHGTIGLVASLAYLGKIGVGEHLIETPVGTVNATLHQDGSVTVENVPAYRYRRQVRVEVNGYGPVV
GDIAWGGNWFFLIGEHHLAINTQNLDALTAFSWAVRQALEGAGIYGEDGGVIDHIELFAADPQADSRNFVLCPGKAYDRS
PCGTGTSAKLACLAADGKLQPGEIWHQASVIGSRFSGYYQRSGDRVTPFIRGQAYVCADSQLLLDERDPFVWGIR

Sequences:

>Translated_315_residues
MALSSHFTALRAIDSHTAGEPTRLIVEGFPDLGTGSMAERKALFAQQYDDWRSAIILEPRGNDVLVGALLCQPCSPQAAA
GVIFFNNSGYLGMCGHGTIGLVASLAYLGKIGVGEHLIETPVGTVNATLHQDGSVTVENVPAYRYRRQVRVEVNGYGPVV
GDIAWGGNWFFLIGEHHLAINTQNLDALTAFSWAVRQALEGAGIYGEDGGVIDHIELFAADPQADSRNFVLCPGKAYDRS
PCGTGTSAKLACLAADGKLQPGEIWHQASVIGSRFSGYYQRSGDRVTPFIRGQAYVCADSQLLLDERDPFVWGIR
>Mature_314_residues
ALSSHFTALRAIDSHTAGEPTRLIVEGFPDLGTGSMAERKALFAQQYDDWRSAIILEPRGNDVLVGALLCQPCSPQAAAG
VIFFNNSGYLGMCGHGTIGLVASLAYLGKIGVGEHLIETPVGTVNATLHQDGSVTVENVPAYRYRRQVRVEVNGYGPVVG
DIAWGGNWFFLIGEHHLAINTQNLDALTAFSWAVRQALEGAGIYGEDGGVIDHIELFAADPQADSRNFVLCPGKAYDRSP
CGTGTSAKLACLAADGKLQPGEIWHQASVIGSRFSGYYQRSGDRVTPFIRGQAYVCADSQLLLDERDPFVWGIR

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=335, Percent_Identity=28.0597014925373, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 33873; Mature: 33741

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSSHFTALRAIDSHTAGEPTRLIVEGFPDLGTGSMAERKALFAQQYDDWRSAIILEPR
CCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCC
GNDVLVGALLCQPCSPQAAAGVIFFNNSGYLGMCGHGTIGLVASLAYLGKIGVGEHLIET
CCCEEEEEEECCCCCCCHHEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHC
PVGTVNATLHQDGSVTVENVPAYRYRRQVRVEVNGYGPVVGDIAWGGNWFFLIGEHHLAI
CCCCEEEEEECCCCEEEECCCCHHEEEEEEEEECCCCCEEEEEEECCEEEEEEECEEEEE
NTQNLDALTAFSWAVRQALEGAGIYGEDGGVIDHIELFAADPQADSRNFVLCPGKAYDRS
ECCCCHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEEEECCCCCCCCEEECCCCCCCCC
PCGTGTSAKLACLAADGKLQPGEIWHQASVIGSRFSGYYQRSGDRVTPFIRGQAYVCADS
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHCCCCEECEEECCCEEEEECC
QLLLDERDPFVWGIR
EEEEECCCCEEEECC
>Mature Secondary Structure 
ALSSHFTALRAIDSHTAGEPTRLIVEGFPDLGTGSMAERKALFAQQYDDWRSAIILEPR
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCC
GNDVLVGALLCQPCSPQAAAGVIFFNNSGYLGMCGHGTIGLVASLAYLGKIGVGEHLIET
CCCEEEEEEECCCCCCCHHEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHC
PVGTVNATLHQDGSVTVENVPAYRYRRQVRVEVNGYGPVVGDIAWGGNWFFLIGEHHLAI
CCCCEEEEEECCCCEEEECCCCHHEEEEEEEEECCCCCEEEEEEECCEEEEEEECEEEEE
NTQNLDALTAFSWAVRQALEGAGIYGEDGGVIDHIELFAADPQADSRNFVLCPGKAYDRS
ECCCCHHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEEEECCCCCCCCEEECCCCCCCCC
PCGTGTSAKLACLAADGKLQPGEIWHQASVIGSRFSGYYQRSGDRVTPFIRGQAYVCADS
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHCCCCEECEEECCCEEEEECC
QLLLDERDPFVWGIR
EEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]