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The map label for this gene is yveA [H]

Identifier: 157370078

GI number: 157370078

Start: 2019591

End: 2021156

Strand: Reverse

Name: yveA [H]

Synonym: Spro_1836

Alternate gene names: 157370078

Gene position: 2021156-2019591 (Counterclockwise)

Preceding gene: 157370079

Following gene: 157370077

Centisome position: 37.09

GC content: 57.54

Gene sequence:

>1566_bases
ATGACAACCCAAGGCAAATTCAAGAAGCAGCTTACGCTCACCGATTTGACGTTTATCGGCCTGGGCGCAATCTTTGGTTC
CGGCTGGCTGTTCGCCGCCAGCCACGTCTCCTCCATTGCCGGCCCCGCCGGCATTTACTCCTGGCTGATCGGCGGGTTGG
CCGTGCTACTGCTCGGCATTGTTTATTGCGAGCTGGGTGCTGCACTGCCCCGGGCCGGCGGCATTATCCGCTACCCGGTA
TTCTCCCACGGCGAACTGATGGGTTATCTGCTGGGGTTTATTACCCTGATCGCCTTCTCCAGCCTGATATCGATTGAGAT
CGTCGCGGCCCGCCAGTACGCCGCCGCCTGGTTTCCTTTTCTGAGCCAGCCCGGCTCCGGCAACCCAACGCTAATCGGTT
GGCTGGTCCAGCTCCTGCTGCTGTGCTTTTTCTTCGCCCTGAATTACTACAGCGTCAAAACCTTTGCCAAATCCAACAAT
CTGATCAGCGTGATTAAATTTGTGGTACCGCTGCTGGTGATTGTGGTGCTGTTCAGCTTCTTCAAACCCGAAAACCTGCA
CAGCCAGGGGTTTGCGCCCTTTGGCTCCGCCGGGGTGGAAGCGGCCATTTCTGCCGGGGGAATTATCTTCGCCTATCTGG
GCCTGACGCCGATTATCTCGGTCGCCAGCGAAGTGCAAAATCCGCAGCGTACCATTCCTGTCGCGCTGATCCTGTCGGTG
GTGCTGTCCACCATCATTTATGTGCTGCTGCAGGTGGCCTTCCTCGGCAGTATTCCCAGTGAGATGCTGAGCGGCGGCTG
GGCCGGTATCAGTCAGCAATTCTCACTGCCTTACCGTGATATCGCCATCACCCTGGGGATGGGCTGGCTGGCGTTTCTGG
TGGTGAGCGATGCGATTATCTCACCGAGCGGCACCGGCAATATTTACATGAACGCCACCCCACGCGTGATATACGGCTGG
GCTCGTGCAGGCACTTTCTTTAAGATCTTTACCCGCGTCGACGGTGAGTCCGGCATTCCGCGCCCTGCCCTGTGGCTGAC
CTTTGCGTTGTCGATCTTCTGGACGCTGCCCTTCCCCTCCTGGGAGAAGTTGATCGGCGTGGTTTCCGCCGCGCTGGTGC
TGAGCTACGCCATTGCGCCGGTGACTGCTGCCGGTCTGCGCCGCAATGCGCCAGATCTGCCGCGTCCCTTCTTCGTGCGC
GGCTTCTGCGTGCTCGGTCCGGTGTCATTTATCATTTCGGCGCTGATTGTCTATTGGTCCGGCTGGAACACCGTTTCCTG
GCTGCTGGGCCTGCAGATCCTGATGTTCGTGGTTTATATCCTGTTCAAAAACAAGGTGCCAACCCACGCCGTTAGTCTGA
AGCAACAGATTTGGTCGTCGCTGTGGCTGATAGCCTTCTATGCGCTGATTATTGTCGCGTCCTATCTCGGCAGCTTTGGT
GGCATCAACGCTATTGGTCACCCGTGGGACACCCTCACGGTGGCGGTCATTGCGTTGGCAATCTATTACTGGGGCGCCTA
TACCTGTTTACCTCAGGCAAATTTTGCCGGTGATGAGGAAGAGTAA

Upstream 100 bases:

>100_bases
GGCTGGTGAACGGTATTTACACCCGAGATCCGATCCACTCACCTGCCAACAACTAGCCCGGCCGCATCTGCATGCCACCT
AATAACAAAAGGGTAAACCC

Downstream 100 bases:

>100_bases
CCGTAAAGGAGATATGTAATGACGCAAACCCAGAGTCTGACGCTGAAAGAAGCCTATGAACTAGCATTGCGCGCATTGCG
CAGCAACGGTTTCAGTGCCG

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: L-aspartate transporter [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MTTQGKFKKQLTLTDLTFIGLGAIFGSGWLFAASHVSSIAGPAGIYSWLIGGLAVLLLGIVYCELGAALPRAGGIIRYPV
FSHGELMGYLLGFITLIAFSSLISIEIVAARQYAAAWFPFLSQPGSGNPTLIGWLVQLLLLCFFFALNYYSVKTFAKSNN
LISVIKFVVPLLVIVVLFSFFKPENLHSQGFAPFGSAGVEAAISAGGIIFAYLGLTPIISVASEVQNPQRTIPVALILSV
VLSTIIYVLLQVAFLGSIPSEMLSGGWAGISQQFSLPYRDIAITLGMGWLAFLVVSDAIISPSGTGNIYMNATPRVIYGW
ARAGTFFKIFTRVDGESGIPRPALWLTFALSIFWTLPFPSWEKLIGVVSAALVLSYAIAPVTAAGLRRNAPDLPRPFFVR
GFCVLGPVSFIISALIVYWSGWNTVSWLLGLQILMFVVYILFKNKVPTHAVSLKQQIWSSLWLIAFYALIIVASYLGSFG
GINAIGHPWDTLTVAVIALAIYYWGAYTCLPQANFAGDEEE

Sequences:

>Translated_521_residues
MTTQGKFKKQLTLTDLTFIGLGAIFGSGWLFAASHVSSIAGPAGIYSWLIGGLAVLLLGIVYCELGAALPRAGGIIRYPV
FSHGELMGYLLGFITLIAFSSLISIEIVAARQYAAAWFPFLSQPGSGNPTLIGWLVQLLLLCFFFALNYYSVKTFAKSNN
LISVIKFVVPLLVIVVLFSFFKPENLHSQGFAPFGSAGVEAAISAGGIIFAYLGLTPIISVASEVQNPQRTIPVALILSV
VLSTIIYVLLQVAFLGSIPSEMLSGGWAGISQQFSLPYRDIAITLGMGWLAFLVVSDAIISPSGTGNIYMNATPRVIYGW
ARAGTFFKIFTRVDGESGIPRPALWLTFALSIFWTLPFPSWEKLIGVVSAALVLSYAIAPVTAAGLRRNAPDLPRPFFVR
GFCVLGPVSFIISALIVYWSGWNTVSWLLGLQILMFVVYILFKNKVPTHAVSLKQQIWSSLWLIAFYALIIVASYLGSFG
GINAIGHPWDTLTVAVIALAIYYWGAYTCLPQANFAGDEEE
>Mature_520_residues
TTQGKFKKQLTLTDLTFIGLGAIFGSGWLFAASHVSSIAGPAGIYSWLIGGLAVLLLGIVYCELGAALPRAGGIIRYPVF
SHGELMGYLLGFITLIAFSSLISIEIVAARQYAAAWFPFLSQPGSGNPTLIGWLVQLLLLCFFFALNYYSVKTFAKSNNL
ISVIKFVVPLLVIVVLFSFFKPENLHSQGFAPFGSAGVEAAISAGGIIFAYLGLTPIISVASEVQNPQRTIPVALILSVV
LSTIIYVLLQVAFLGSIPSEMLSGGWAGISQQFSLPYRDIAITLGMGWLAFLVVSDAIISPSGTGNIYMNATPRVIYGWA
RAGTFFKIFTRVDGESGIPRPALWLTFALSIFWTLPFPSWEKLIGVVSAALVLSYAIAPVTAAGLRRNAPDLPRPFFVRG
FCVLGPVSFIISALIVYWSGWNTVSWLLGLQILMFVVYILFKNKVPTHAVSLKQQIWSSLWLIAFYALIIVASYLGSFGG
INAIGHPWDTLTVAVIALAIYYWGAYTCLPQANFAGDEEE

Specific function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=358, Percent_Identity=26.2569832402235, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI258614005, Length=435, Percent_Identity=23.448275862069, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI258614003, Length=435, Percent_Identity=23.448275862069, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI258645169, Length=383, Percent_Identity=23.4986945169713, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI181337167, Length=414, Percent_Identity=24.1545893719807, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI33286428, Length=409, Percent_Identity=24.9388753056235, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI187423910, Length=405, Percent_Identity=22.962962962963, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI7657591, Length=405, Percent_Identity=22.962962962963, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI115648063, Length=441, Percent_Identity=25.1700680272109, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115648022, Length=441, Percent_Identity=25.1700680272109, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788480, Length=357, Percent_Identity=28.0112044817927, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI87081708, Length=360, Percent_Identity=23.8888888888889, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI87082250, Length=359, Percent_Identity=26.1838440111421, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790653, Length=365, Percent_Identity=23.013698630137, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786602, Length=438, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786302, Length=405, Percent_Identity=23.4567901234568, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI2367353, Length=373, Percent_Identity=23.8605898123324, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=412, Percent_Identity=27.6699029126214, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17532491, Length=413, Percent_Identity=24.9394673123487, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17531343, Length=423, Percent_Identity=26.241134751773, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17533459, Length=408, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17568033, Length=396, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32566699, Length=316, Percent_Identity=24.0506329113924, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71995388, Length=407, Percent_Identity=23.0958230958231, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71995382, Length=407, Percent_Identity=23.0958230958231, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24667468, Length=406, Percent_Identity=26.1083743842365, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550968, Length=419, Percent_Identity=26.7303102625298, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19921172, Length=419, Percent_Identity=26.7303102625298, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357367, Length=411, Percent_Identity=26.5206812652068, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221512776, Length=419, Percent_Identity=23.1503579952267, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666159, Length=419, Percent_Identity=23.1503579952267, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24668806, Length=420, Percent_Identity=22.6190476190476, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21356285, Length=420, Percent_Identity=22.6190476190476, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24668802, Length=420, Percent_Identity=22.6190476190476, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221331183, Length=354, Percent_Identity=24.8587570621469, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17647653, Length=354, Percent_Identity=24.8587570621469, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664379, Length=354, Percent_Identity=24.8587570621469, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161077963, Length=353, Percent_Identity=25.7790368271955, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651635, Length=448, Percent_Identity=23.6607142857143, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24651633, Length=448, Percent_Identity=23.6607142857143, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641993, Length=402, Percent_Identity=24.6268656716418, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641995, Length=387, Percent_Identity=25.0645994832041, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56396; Mature: 56265

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TTQGKFKKQLTLTDLTFIGLGAIFGSGWLFAASHVSSIAGPAGIYSWLIGGLAVLLLGI
CCCCCHHHHEEHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH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CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12730183 [H]