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The map label for this gene is fabF [H]

Identifier: 157369992

GI number: 157369992

Start: 1928175

End: 1929449

Strand: Reverse

Name: fabF [H]

Synonym: Spro_1749

Alternate gene names: 157369992

Gene position: 1929449-1928175 (Counterclockwise)

Preceding gene: 157369993

Following gene: 157369985

Centisome position: 35.41

GC content: 59.14

Gene sequence:

>1275_bases
ATGAACACTCGTCGTATAGTCATTACCGGCATGGGCGCCGTTTCGCCACTGGGATGCGGCGTAGAGGCTATCTGGCAGCG
TCTGTTGAACGGCCAGTCCGGCATTCGTCCGCTGCCAGAAGAGATCGTCGCAGACCTGCAGGTGAAAATCGGTGGTCAGG
TGCCCACTTTGGAACAGGATCCCGAGGCGGGCTTCGACCCCGACCTTTCGGTTGCACCAAAAGACCAGAAGAAAATGGAC
CGCTTTATCCTGCTCGCCATGGCAGCGGCCGATGAGGCTATCCGCCAGGCAGGTTGGGTAGCAGACACTGAAGACAAGCA
GGAACGCACCGCAACCGTGATCGCTTCCGGCATTGGCGGCTTCCCGGCTATCGCCCATGCGGTACGCACCACCGACAGCC
GTGGTGCCAAACGCCTGTCGCCTTTCACCATCCCTTCGTTCCTGGTTAATCTGGCTGCCGGTCACGTATCGATTAAACAT
CAGTTCAAGGGCCCTATTGGCGCCCCCGTGACGGCCTGTGCCGCAGGCGTACAGGCCATTGGCGATGCCGTACGTATGAT
TCGTAACGATGAAGCGGATATCGCGCTGTGTGGCGGTACGGAAGCGGCTATCGACACCGTCAGCCTTGGGGGTTTTGCAG
CGGCGCGTGCCATGTCCACAACGCCTGCAGACGCCGCCGCAACAGCCTCACGGCCTTTTGACAGTGCACGCAACGGGTTT
GTTATGGGTGAAGGTGCCGGCATGCTGGTGATTGAGACACTGGAGCATGCGCTGGCCCGTGGGGCAACACCGCTGGCTGA
AATTGTCGGTTATGGCACCAGCGCAGATGCCTACCACATGACTTCGGGGGCCGAGGATGGTGACGGTGCCTACCGTGCCA
TGAAAATTGCCCTCAAACAGGCTGGCGTAGCACCGGAGCAGGTTCAACACCTGAACGCGCATGCGACATCCACACCGGTA
GGGGATTTGGGCGAAATTAACGCCATTAAGCATCTGTTCGGCACGAACGGCAGCGTAGCGGTTACCTCAACCAAATCAGC
AACCGGTCATCTGCTCGGTGCCGCCGGCGGGCTGGAAACCATCTTTACCGCACTGGCGCTGCGTGACCAGATTGCACCCG
CCACGCTGAATTTGGAAAGTCCGGATCCGGCTGCAGAGGGGCTGCACCTGGTTGCGAATAAAGCGGAACCCATGGCCATA
AGCTACGCACTGTCGAACGGCTTTGGTTTTGGTGGTGTGAATGCGAGTATCTTGTTGAAACGCTGGCAGGGGTAA

Upstream 100 bases:

>100_bases
TAGCCCCAGGGCCGGCAGCGACCGACGGCATGCGCCAGCGCGCGGCCCTGATGCTGCAGAACCTTTCTGAATTTCCCCCT
GAATCATCCAAGGAGTCACT

Downstream 100 bases:

>100_bases
TCCCCATTAAACACAAACCTCCGCGCTGGGCGGAGGTTGTTCCTTTTATTTGACAGGGAGCCGCTTAAGCGGTCACAGCC
CTGTCTTCCATGGCTTCTCG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNTRRIVITGMGAVSPLGCGVEAIWQRLLNGQSGIRPLPEEIVADLQVKIGGQVPTLEQDPEAGFDPDLSVAPKDQKKMD
RFILLAMAAADEAIRQAGWVADTEDKQERTATVIASGIGGFPAIAHAVRTTDSRGAKRLSPFTIPSFLVNLAAGHVSIKH
QFKGPIGAPVTACAAGVQAIGDAVRMIRNDEADIALCGGTEAAIDTVSLGGFAAARAMSTTPADAAATASRPFDSARNGF
VMGEGAGMLVIETLEHALARGATPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALKQAGVAPEQVQHLNAHATSTPV
GDLGEINAIKHLFGTNGSVAVTSTKSATGHLLGAAGGLETIFTALALRDQIAPATLNLESPDPAAEGLHLVANKAEPMAI
SYALSNGFGFGGVNASILLKRWQG

Sequences:

>Translated_424_residues
MNTRRIVITGMGAVSPLGCGVEAIWQRLLNGQSGIRPLPEEIVADLQVKIGGQVPTLEQDPEAGFDPDLSVAPKDQKKMD
RFILLAMAAADEAIRQAGWVADTEDKQERTATVIASGIGGFPAIAHAVRTTDSRGAKRLSPFTIPSFLVNLAAGHVSIKH
QFKGPIGAPVTACAAGVQAIGDAVRMIRNDEADIALCGGTEAAIDTVSLGGFAAARAMSTTPADAAATASRPFDSARNGF
VMGEGAGMLVIETLEHALARGATPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALKQAGVAPEQVQHLNAHATSTPV
GDLGEINAIKHLFGTNGSVAVTSTKSATGHLLGAAGGLETIFTALALRDQIAPATLNLESPDPAAEGLHLVANKAEPMAI
SYALSNGFGFGGVNASILLKRWQG
>Mature_424_residues
MNTRRIVITGMGAVSPLGCGVEAIWQRLLNGQSGIRPLPEEIVADLQVKIGGQVPTLEQDPEAGFDPDLSVAPKDQKKMD
RFILLAMAAADEAIRQAGWVADTEDKQERTATVIASGIGGFPAIAHAVRTTDSRGAKRLSPFTIPSFLVNLAAGHVSIKH
QFKGPIGAPVTACAAGVQAIGDAVRMIRNDEADIALCGGTEAAIDTVSLGGFAAARAMSTTPADAAATASRPFDSARNGF
VMGEGAGMLVIETLEHALARGATPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALKQAGVAPEQVQHLNAHATSTPV
GDLGEINAIKHLFGTNGSVAVTSTKSATGHLLGAAGGLETIFTALALRDQIAPATLNLESPDPAAEGLHLVANKAEPMAI
SYALSNGFGFGGVNASILLKRWQG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=43.5714285714286, Blast_Score=329, Evalue=2e-90,
Organism=Homo sapiens, GI223972627, Length=173, Percent_Identity=46.242774566474, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI41872631, Length=434, Percent_Identity=25.5760368663594, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1787337, Length=423, Percent_Identity=44.6808510638298, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1788663, Length=428, Percent_Identity=34.3457943925234, Blast_Score=203, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=37.1158392434988, Blast_Score=254, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=40.9774436090226, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI212642053, Length=434, Percent_Identity=26.2672811059908, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=421, Percent_Identity=22.8028503562945, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=451, Percent_Identity=38.3592017738359, Blast_Score=291, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=42.9928741092637, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24581345, Length=440, Percent_Identity=24.3181818181818, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI221330659, Length=427, Percent_Identity=25.5269320843091, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI19920632, Length=427, Percent_Identity=25.5269320843091, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43615; Mature: 43615

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRRIVITGMGAVSPLGCGVEAIWQRLLNGQSGIRPLPEEIVADLQVKIGGQVPTLEQD
CCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHEEEECCCCCCCCCC
PEAGFDPDLSVAPKDQKKMDRFILLAMAAADEAIRQAGWVADTEDKQERTATVIASGIGG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
FPAIAHAVRTTDSRGAKRLSPFTIPSFLVNLAAGHVSIKHQFKGPIGAPVTACAAGVQAI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHH
GDAVRMIRNDEADIALCGGTEAAIDTVSLGGFAAARAMSTTPADAAATASRPFDSARNGF
HHHHHHHHCCCCCEEEECCCHHHHHEECCCCHHHHHHCCCCCCHHHHHCCCCCHHHCCCE
VMGEGAGMLVIETLEHALARGATPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALKQ
EEECCCCEEHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHH
AGVAPEQVQHLNAHATSTPVGDLGEINAIKHLFGTNGSVAVTSTKSATGHLLGAAGGLET
CCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHH
IFTALALRDQIAPATLNLESPDPAAEGLHLVANKAEPMAISYALSNGFGFGGVNASILLK
HHHHHHHHHCCCCEEEECCCCCCHHCCEEEEECCCCCEEEEEEECCCCCCCCCCCEEEEE
RWQG
ECCC
>Mature Secondary Structure
MNTRRIVITGMGAVSPLGCGVEAIWQRLLNGQSGIRPLPEEIVADLQVKIGGQVPTLEQD
CCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHEEEECCCCCCCCCC
PEAGFDPDLSVAPKDQKKMDRFILLAMAAADEAIRQAGWVADTEDKQERTATVIASGIGG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
FPAIAHAVRTTDSRGAKRLSPFTIPSFLVNLAAGHVSIKHQFKGPIGAPVTACAAGVQAI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHH
GDAVRMIRNDEADIALCGGTEAAIDTVSLGGFAAARAMSTTPADAAATASRPFDSARNGF
HHHHHHHHCCCCCEEEECCCHHHHHEECCCCHHHHHHCCCCCCHHHHHCCCCCHHHCCCE
VMGEGAGMLVIETLEHALARGATPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALKQ
EEECCCCEEHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHH
AGVAPEQVQHLNAHATSTPVGDLGEINAIKHLFGTNGSVAVTSTKSATGHLLGAAGGLET
CCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHH
IFTALALRDQIAPATLNLESPDPAAEGLHLVANKAEPMAISYALSNGFGFGGVNASILLK
HHHHHHHHHCCCCEEEECCCCCCHHCCEEEEECCCCCEEEEEEECCCCCCCCCCCEEEEE
RWQG
ECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]