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The map label for this gene is kdsB

Identifier: 157369962

GI number: 157369962

Start: 1888244

End: 1888993

Strand: Direct

Name: kdsB

Synonym: Spro_1719

Alternate gene names: 157369962

Gene position: 1888244-1888993 (Clockwise)

Preceding gene: 157369961

Following gene: 157369963

Centisome position: 34.65

GC content: 56.67

Gene sequence:

>750_bases
ATGAGTTTTATCGCAATTATTCCAGCCCGTTATGCATCAACCCGTTTACCGGGTAAACCGCTGGCCGATATCCACGGCAA
GCCGATGGTGGTGCATGTTATGGAACGTGCACGCGAGTCGGGCGCCAGCCGCGTTATTGTCGCGACCGATCACCCGGCAG
TAGCCGAAGCGGTCAAAGCGGCAGGCGGTGAAGTCTGCATGACCCGGGCCGATCACAATTCCGGCACCGAGCGCTTGGCA
GAGGTGATCGAGCATTATGGGTTCGCTGATGACGAAATCATCGTTAACGTTCAGGGTGATGAGCCACTGATCCCACCGGT
GATTGTGCGTCAGGTGGCTGAAAATCTGGCGGGCAGTCAGGCCGGAATGGCTACCCTGGCGGTGCCTATCGAAAGCGCAG
AAGAAGCTTTTAACCCCAATGCGGTCAAAGTGGTGATGGATGCACAGGGTTATGCGCTCTATTTCTCACGCGCCACCATT
CCATGGGATCGCGAACGCTTTGCCCAATCCAAAGAAAGCATCGGCGACAGCCTGTTGCGCCACATAGGTATTTACGCCTA
TCGCGCCGGTTTTGTTCGCCGTTACGTTACCTGGGCGCCAAGCCAGCTGGAGCAAATTGAGCTGCTGGAACAGTTGCGGG
TGCTGTGGTACGGCGAAAAAATCCACGTGGCGGTTGCCAAGGCAATGCCGACCGTGGGTGTCGATACGCAGGAAGATTTG
CAGCGCGTGCGCGACAGTATCAAAGGCTGA

Upstream 100 bases:

>100_bases
TGGTCTGCAAAGTGGATGGCCTGGCCTATCCGTTGCGTGACGGCATTCCCGTGCTGTTGGAAAATGAAGCGCGAGCGCTG
TCATTGGATGAGAAACACGC

Downstream 100 bases:

>100_bases
GCATTGAATGCCGGCGCGTCACGCAACGCGCCGGCAATATGATTTCCCTTCTTAATATCCCCATTTTGTTGATCTGCGTT
GAAGAATTTTTCTGTTCAGC

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSFIAIIPARYASTRLPGKPLADIHGKPMVVHVMERARESGASRVIVATDHPAVAEAVKAAGGEVCMTRADHNSGTERLA
EVIEHYGFADDEIIVNVQGDEPLIPPVIVRQVAENLAGSQAGMATLAVPIESAEEAFNPNAVKVVMDAQGYALYFSRATI
PWDRERFAQSKESIGDSLLRHIGIYAYRAGFVRRYVTWAPSQLEQIELLEQLRVLWYGEKIHVAVAKAMPTVGVDTQEDL
QRVRDSIKG

Sequences:

>Translated_249_residues
MSFIAIIPARYASTRLPGKPLADIHGKPMVVHVMERARESGASRVIVATDHPAVAEAVKAAGGEVCMTRADHNSGTERLA
EVIEHYGFADDEIIVNVQGDEPLIPPVIVRQVAENLAGSQAGMATLAVPIESAEEAFNPNAVKVVMDAQGYALYFSRATI
PWDRERFAQSKESIGDSLLRHIGIYAYRAGFVRRYVTWAPSQLEQIELLEQLRVLWYGEKIHVAVAKAMPTVGVDTQEDL
QRVRDSIKG
>Mature_248_residues
SFIAIIPARYASTRLPGKPLADIHGKPMVVHVMERARESGASRVIVATDHPAVAEAVKAAGGEVCMTRADHNSGTERLAE
VIEHYGFADDEIIVNVQGDEPLIPPVIVRQVAENLAGSQAGMATLAVPIESAEEAFNPNAVKVVMDAQGYALYFSRATIP
WDRERFAQSKESIGDSLLRHIGIYAYRAGFVRRYVTWAPSQLEQIELLEQLRVLWYGEKIHVAVAKAMPTVGVDTQEDLQ
RVRDSIKG

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=248, Percent_Identity=76.2096774193548, Blast_Score=404, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_SERP5 (A8GCI3)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477951.1
- ProteinModelPortal:   A8GCI3
- SMR:   A8GCI3
- STRING:   A8GCI3
- GeneID:   5604487
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1719
- eggNOG:   COG1212
- HOGENOM:   HBG637773
- OMA:   IIPARLK
- ProtClustDB:   PRK05450
- BioCyc:   SPRO399741:SPRO_1719-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 27331; Mature: 27199

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIAIIPARYASTRLPGKPLADIHGKPMVVHVMERARESGASRVIVATDHPAVAEAVKA
CCEEEEECCHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
AGGEVCMTRADHNSGTERLAEVIEHYGFADDEIIVNVQGDEPLIPPVIVRQVAENLAGSQ
CCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCC
AGMATLAVPIESAEEAFNPNAVKVVMDAQGYALYFSRATIPWDRERFAQSKESIGDSLLR
CCCEEEEEEHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
HIGIYAYRAGFVRRYVTWAPSQLEQIELLEQLRVLWYGEKIHVAVAKAMPTVGVDTQEDL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHEEEEEHHCCCCCCCCHHHH
QRVRDSIKG
HHHHHHHCC
>Mature Secondary Structure 
SFIAIIPARYASTRLPGKPLADIHGKPMVVHVMERARESGASRVIVATDHPAVAEAVKA
CEEEEECCHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
AGGEVCMTRADHNSGTERLAEVIEHYGFADDEIIVNVQGDEPLIPPVIVRQVAENLAGSQ
CCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCC
AGMATLAVPIESAEEAFNPNAVKVVMDAQGYALYFSRATIPWDRERFAQSKESIGDSLLR
CCCEEEEEEHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
HIGIYAYRAGFVRRYVTWAPSQLEQIELLEQLRVLWYGEKIHVAVAKAMPTVGVDTQEDL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHEEEEEHHCCCCCCCCHHHH
QRVRDSIKG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA