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The map label for this gene is lpxK

Identifier: 157369956

GI number: 157369956

Start: 1882873

End: 1883853

Strand: Direct

Name: lpxK

Synonym: Spro_1713

Alternate gene names: 157369956

Gene position: 1882873-1883853 (Clockwise)

Preceding gene: 157369955

Following gene: 157369958

Centisome position: 34.56

GC content: 57.9

Gene sequence:

>981_bases
ATGATCGAGCGCATCTGGTCAGGCAGTTCGCTGGTTTATTTGCTGTTGTTACCGCTGTCCTGGCTGTATGGCCTGGTCAG
CGGTCTGATTCGGCTCAGCTACCGTTGCGGCCTGCGTAAAAGCTGGCGCGCACCGGTACCGGTCGTGGTGGTGGGGAACC
TCACTGCCGGTGGCAACGGCAAAACCCCGATGGTGATCTGGCTGGTGGAACAGTTGCAGCAGCGTGGATACCGGGTGGGC
GTGGTTTCTCGCGGTTATGGTGGTAAAGCAGAGGCTTATCCACTGTTACTAAACGCTGGCACTACCACCCAGCAGGCAGG
TGATGAGCCGGTGCTGATTTATCAGCGTACCGCTGCGCCAGTGGCCATCTCACCAAAGCGTTCTGAAGCGGTACAAGCGC
TGCTTAAGCAGCAGCCACTTGACGTGGTGATTACCGATGACGGCCTGCAGCATTACGCTTTACAGCGTGATTTTGAACTG
GTGGTGATCGACGGCGTTCGCCGCTTTGGCAATGGGTGGTGGCTGCCGGCAGGGCCGATGCGCGAACGTGCTTCGCGGCT
GAATAGCGTTGACGCTCTGATTGCCAACGGGGGTGTGGCTCAGCCTGGTGAAATCGCCATGCGGTTGCAGGCGCGCGACG
CGGTAAATGTTGCCAGCGGTGAGCGCCGGCCGGCAGTTGAACTGCCACACGTGGTGGCAATGGCCGGAATAGGCCATCCC
CCGCGCTTCTTCGCCACATTGGAAAAACTGGGTGTAGCGGTCGAAAAGGAAGTGGCGTTTGCCGACCATCAGGAATATCA
GCATGGCCCATTGGCGGCGCTGGTATCTTCAGAGCAGACGTTGTTGATGACCGAGAAAGACGCGGTTAAATGCCGCGCTT
TTGCTCAGCCCAACTGGTGGTATTTACCCGTTGATGCGGTACTTCCCCCCGATCAGGCTGAGCAGTTGCTGCATAATATT
GAAGCGCTGCTGACAAAATAA

Upstream 100 bases:

>100_bases
TGGTTGAGGATGGTCGTATCGTTGAGCGTGGCGAACATGCTGCATTGCTCGAAAAGCAGGGGGCTTATGCCCAGCTTCAT
CGCATGCAGTTTGGTCAATA

Downstream 100 bases:

>100_bases
TTCAGACTGCCAGCGCGTGAAGCCCCAGTGCTTGCGCGCAGGCGTCTATCGAGCGCTGCTGCGTTTGCTGATACAACGCC
AATTCATCGATCACTTCTGC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MIERIWSGSSLVYLLLLPLSWLYGLVSGLIRLSYRCGLRKSWRAPVPVVVVGNLTAGGNGKTPMVIWLVEQLQQRGYRVG
VVSRGYGGKAEAYPLLLNAGTTTQQAGDEPVLIYQRTAAPVAISPKRSEAVQALLKQQPLDVVITDDGLQHYALQRDFEL
VVIDGVRRFGNGWWLPAGPMRERASRLNSVDALIANGGVAQPGEIAMRLQARDAVNVASGERRPAVELPHVVAMAGIGHP
PRFFATLEKLGVAVEKEVAFADHQEYQHGPLAALVSSEQTLLMTEKDAVKCRAFAQPNWWYLPVDAVLPPDQAEQLLHNI
EALLTK

Sequences:

>Translated_326_residues
MIERIWSGSSLVYLLLLPLSWLYGLVSGLIRLSYRCGLRKSWRAPVPVVVVGNLTAGGNGKTPMVIWLVEQLQQRGYRVG
VVSRGYGGKAEAYPLLLNAGTTTQQAGDEPVLIYQRTAAPVAISPKRSEAVQALLKQQPLDVVITDDGLQHYALQRDFEL
VVIDGVRRFGNGWWLPAGPMRERASRLNSVDALIANGGVAQPGEIAMRLQARDAVNVASGERRPAVELPHVVAMAGIGHP
PRFFATLEKLGVAVEKEVAFADHQEYQHGPLAALVSSEQTLLMTEKDAVKCRAFAQPNWWYLPVDAVLPPDQAEQLLHNI
EALLTK
>Mature_326_residues
MIERIWSGSSLVYLLLLPLSWLYGLVSGLIRLSYRCGLRKSWRAPVPVVVVGNLTAGGNGKTPMVIWLVEQLQQRGYRVG
VVSRGYGGKAEAYPLLLNAGTTTQQAGDEPVLIYQRTAAPVAISPKRSEAVQALLKQQPLDVVITDDGLQHYALQRDFEL
VVIDGVRRFGNGWWLPAGPMRERASRLNSVDALIANGGVAQPGEIAMRLQARDAVNVASGERRPAVELPHVVAMAGIGHP
PRFFATLEKLGVAVEKEVAFADHQEYQHGPLAALVSSEQTLLMTEKDAVKCRAFAQPNWWYLPVDAVLPPDQAEQLLHNI
EALLTK

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=324, Percent_Identity=70.9876543209877, Blast_Score=462, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_SERP5 (A8GCH7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477945.1
- STRING:   A8GCH7
- GeneID:   5604430
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1713
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   PRK00652
- BioCyc:   SPRO399741:SPRO_1713-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35706; Mature: 35706

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERIWSGSSLVYLLLLPLSWLYGLVSGLIRLSYRCGLRKSWRAPVPVVVVGNLTAGGNG
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECEECCCCC
KTPMVIWLVEQLQQRGYRVGVVSRGYGGKAEAYPLLLNAGTTTQQAGDEPVLIYQRTAAP
CCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCC
VAISPKRSEAVQALLKQQPLDVVITDDGLQHYALQRDFELVVIDGVRRFGNGWWLPAGPM
EEECCCHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEEEECHHHHCCCCCCCCCHH
RERASRLNSVDALIANGGVAQPGEIAMRLQARDAVNVASGERRPAVELPHVVAMAGIGHP
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
PRFFATLEKLGVAVEKEVAFADHQEYQHGPLAALVSSEQTLLMTEKDAVKCRAFAQPNWW
HHHHHHHHHHCCHHHHHHHHHCCHHCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCEE
YLPVDAVLPPDQAEQLLHNIEALLTK
EEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIERIWSGSSLVYLLLLPLSWLYGLVSGLIRLSYRCGLRKSWRAPVPVVVVGNLTAGGNG
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECEECCCCC
KTPMVIWLVEQLQQRGYRVGVVSRGYGGKAEAYPLLLNAGTTTQQAGDEPVLIYQRTAAP
CCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCC
VAISPKRSEAVQALLKQQPLDVVITDDGLQHYALQRDFELVVIDGVRRFGNGWWLPAGPM
EEECCCHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEEEECHHHHCCCCCCCCCHH
RERASRLNSVDALIANGGVAQPGEIAMRLQARDAVNVASGERRPAVELPHVVAMAGIGHP
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
PRFFATLEKLGVAVEKEVAFADHQEYQHGPLAALVSSEQTLLMTEKDAVKCRAFAQPNWW
HHHHHHHHHHCCHHHHHHHHHCCHHCCCCCEEEEECCCCEEEEECCCCCEEEEECCCCEE
YLPVDAVLPPDQAEQLLHNIEALLTK
EEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA