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The map label for this gene is macA [H]

Identifier: 157369913

GI number: 157369913

Start: 1826647

End: 1827693

Strand: Direct

Name: macA [H]

Synonym: Spro_1670

Alternate gene names: 157369913

Gene position: 1826647-1827693 (Clockwise)

Preceding gene: 157369911

Following gene: 157369914

Centisome position: 33.52

GC content: 57.5

Gene sequence:

>1047_bases
ATGGCGGCCTGGCACTTCAGCCACCCGGCCCCGACTCCATTTAAAACGGTGAAGGTGGTCAAGGGCGATCTACAGCAAAA
CGTACTGGCAACCGGCCAGCTTGACGCGGTACGCAAGGTTGACGTGGGTGCGCAGGTGAGTGGGCAGTTGGAAAGCCTGT
ATGTCGAGATCGGCGATCGGGTTAAAAAAGGCCAGTTGCTTGGGGTAATTGATCCGCAACAGGCGCAAAACAGCATCCGT
GAGGGTGAGGCGACGTTGCGTGAGCTGCACGCCCAATTGCAACAGGCGCAGGCTGAGCAACAGCTGGCGGCGGTAACGCT
GCAGCGTAATCAGGCGTTGGCCAAACTGCAGGCGGTGTCACGCCAGGATCTGGATCAGGCGGCGACACAGTTGGCGGTGA
AGAAGGCGCAGGTGGGTACCATTCAGGCGCAGATCGCCAGGAATCAGGCCAGCCTGGATACCGCCAAGATCAATCTGGCG
TTTACCCGTATAGAAGCACCGATGGACGGTGACGTGGTGCAAATCACCACGCTGCAGGGCCAGACGGTGATAGCCGCGCA
GCAGGCACCGAACATTTTGACGCTGGCGGATCTCAGCACCATGCTGGTGAAGGCTCAGGTGTCGGAAGCGGACGTCATCA
GCCTCAAGCCGGGCCAAAAAGCCTGGTTTACCGTGTTGGGCGATCCTAACCGACGCTTTGACGGCGTGCTGAAAGATATT
CAGCCAACGCCGGAAAAGGTCAATAACGCCATCTTTTACTATGCGCGTTTTGAAGTGCCCAATCCCGAGGGATTATTGCG
ACTGCAGATGACGGCGCAGGTGCATATTCAACTGGCGGGCGTCAACCAGGTGCAGGTCATTCCTCTGGCCGCGTTGGGCG
ATCAAATCGCCGATAATCGCTACCATGTTTCGATATTGAAACAGGGCAAGGAGGAAAAGCGCGAGGTGGCCATTGGCCTG
CGAAATAATATCGACGTGCAAATTCTCAGCGGGTTGAACATTGGCGATGAAGTGATTGTCAGCCGCGGCGGCGCGGAGGC
TCTCTGA

Upstream 100 bases:

>100_bases
CAGCATGAATTGCAACAGGCAGGAACCTATTTTGACGTGGTTTAAAGGACATAAGCGACGCTGGGTCATGGCGCTAATCG
TACTGGTGGCGATCGTGGCG

Downstream 100 bases:

>100_bases
TGGCCGCGCTGTTGGAACTGAGCGGCATCAGCCGCAGCTATCAGTCGGGCGACCAGACCGTAGCGGTGTTGAAGGACGTG
AGCCTGAGCATCAATGCCGG

Product: macrolide transporter subunit MacA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MAAWHFSHPAPTPFKTVKVVKGDLQQNVLATGQLDAVRKVDVGAQVSGQLESLYVEIGDRVKKGQLLGVIDPQQAQNSIR
EGEATLRELHAQLQQAQAEQQLAAVTLQRNQALAKLQAVSRQDLDQAATQLAVKKAQVGTIQAQIARNQASLDTAKINLA
FTRIEAPMDGDVVQITTLQGQTVIAAQQAPNILTLADLSTMLVKAQVSEADVISLKPGQKAWFTVLGDPNRRFDGVLKDI
QPTPEKVNNAIFYYARFEVPNPEGLLRLQMTAQVHIQLAGVNQVQVIPLAALGDQIADNRYHVSILKQGKEEKREVAIGL
RNNIDVQILSGLNIGDEVIVSRGGAEAL

Sequences:

>Translated_348_residues
MAAWHFSHPAPTPFKTVKVVKGDLQQNVLATGQLDAVRKVDVGAQVSGQLESLYVEIGDRVKKGQLLGVIDPQQAQNSIR
EGEATLRELHAQLQQAQAEQQLAAVTLQRNQALAKLQAVSRQDLDQAATQLAVKKAQVGTIQAQIARNQASLDTAKINLA
FTRIEAPMDGDVVQITTLQGQTVIAAQQAPNILTLADLSTMLVKAQVSEADVISLKPGQKAWFTVLGDPNRRFDGVLKDI
QPTPEKVNNAIFYYARFEVPNPEGLLRLQMTAQVHIQLAGVNQVQVIPLAALGDQIADNRYHVSILKQGKEEKREVAIGL
RNNIDVQILSGLNIGDEVIVSRGGAEAL
>Mature_347_residues
AAWHFSHPAPTPFKTVKVVKGDLQQNVLATGQLDAVRKVDVGAQVSGQLESLYVEIGDRVKKGQLLGVIDPQQAQNSIRE
GEATLRELHAQLQQAQAEQQLAAVTLQRNQALAKLQAVSRQDLDQAATQLAVKKAQVGTIQAQIARNQASLDTAKINLAF
TRIEAPMDGDVVQITTLQGQTVIAAQQAPNILTLADLSTMLVKAQVSEADVISLKPGQKAWFTVLGDPNRRFDGVLKDIQ
PTPEKVNNAIFYYARFEVPNPEGLLRLQMTAQVHIQLAGVNQVQVIPLAALGDQIADNRYHVSILKQGKEEKREVAIGLR
NNIDVQILSGLNIGDEVIVSRGGAEAL

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=338, Percent_Identity=70.414201183432, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI87082036, Length=337, Percent_Identity=26.7062314540059, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790519, Length=239, Percent_Identity=27.6150627615063, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789637, Length=201, Percent_Identity=28.8557213930348, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37750; Mature: 37619

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAWHFSHPAPTPFKTVKVVKGDLQQNVLATGQLDAVRKVDVGAQVSGQLESLYVEIGDR
CCCEECCCCCCCCHHHHHHHHHHHHHHHEECCCCCHHEEECCCCCCCCCHHHHHHHHCCC
VKKGQLLGVIDPQQAQNSIREGEATLRELHAQLQQAQAEQQLAAVTLQRNQALAKLQAVS
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQDLDQAATQLAVKKAQVGTIQAQIARNQASLDTAKINLAFTRIEAPMDGDVVQITTLQG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCCCCCEEEEEEECC
QTVIAAQQAPNILTLADLSTMLVKAQVSEADVISLKPGQKAWFTVLGDPNRRFDGVLKDI
CEEEEECCCCCEEEEHHHHHHHHHEECCCCCEEEECCCCCEEEEEECCCCCHHHHHHHCC
QPTPEKVNNAIFYYARFEVPNPEGLLRLQMTAQVHIQLAGVNQVQVIPLAALGDQIADNR
CCCCHHHCCEEEEEEEEECCCCCCEEEEEEEEEEEEEEECCCEEEEEEEHHHCHHHCCCC
YHVSILKQGKEEKREVAIGLRNNIDVQILSGLNIGDEVIVSRGGAEAL
EEEEEECCCCHHHHHEEEECCCCCCEEEEECCCCCCHHEEECCCCCCC
>Mature Secondary Structure 
AAWHFSHPAPTPFKTVKVVKGDLQQNVLATGQLDAVRKVDVGAQVSGQLESLYVEIGDR
CCEECCCCCCCCHHHHHHHHHHHHHHHEECCCCCHHEEECCCCCCCCCHHHHHHHHCCC
VKKGQLLGVIDPQQAQNSIREGEATLRELHAQLQQAQAEQQLAAVTLQRNQALAKLQAVS
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQDLDQAATQLAVKKAQVGTIQAQIARNQASLDTAKINLAFTRIEAPMDGDVVQITTLQG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCCCCCEEEEEEECC
QTVIAAQQAPNILTLADLSTMLVKAQVSEADVISLKPGQKAWFTVLGDPNRRFDGVLKDI
CEEEEECCCCCEEEEHHHHHHHHHEECCCCCEEEECCCCCEEEEEECCCCCHHHHHHHCC
QPTPEKVNNAIFYYARFEVPNPEGLLRLQMTAQVHIQLAGVNQVQVIPLAALGDQIADNR
CCCCHHHCCEEEEEEEEECCCCCCEEEEEEEEEEEEEEECCCEEEEEEEHHHCHHHCCCC
YHVSILKQGKEEKREVAIGLRNNIDVQILSGLNIGDEVIVSRGGAEAL
EEEEEECCCCHHHHHEEEECCCCCCEEEEECCCCCCHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]