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The map label for this gene is ltaE [H]

Identifier: 157369906

GI number: 157369906

Start: 1816748

End: 1817764

Strand: Reverse

Name: ltaE [H]

Synonym: Spro_1663

Alternate gene names: 157369906

Gene position: 1817764-1816748 (Counterclockwise)

Preceding gene: 157369907

Following gene: 157369904

Centisome position: 33.36

GC content: 61.65

Gene sequence:

>1017_bases
ATGCTTATCGATCTACGCAGTGACACCGTGACCCGCCCCAGCGCCGCGATGCGCGAGGCCATGGCCCAGGCAGAAGTGGG
TGATGATGTTTACGGCGATGACCCCACGGTCAACGCTCTGGAGGCAGAAGCGGTCCGTCTGTCCGGTAAAGAGGCGGCGC
TGTTCTTGCCAAGCGGCACTCAGGCCAACCTGGTGGCGTTGCTGAGCCATTGCCAGCGCGGTGACGAGTACATTGTCGGC
CAGCAGGCGCATAACTATAAATACGAGGCCGGCGGCGCGGCGGTGCTCGGCAGCATCCAGCCACAACCGATTGAAGCTAA
CCCGGACGGCACCCTGCCGCTCGATAAGGTCGCGGCGGCCATCAAACCCGACGATATCCACTTTGCCAAAACGCGCCTGC
TGAGCCTGGAAAACACCATCAGCGGCCGTGTGCTGCCCTTGGCGTACCTGCAGCAGGCCTGGCAATTCAGCCGCGAGCAT
CAACTGGCGTTACACATCGACGGCGCACGTATCTTTAACGCCGCCGTCGCGCTAAATGTGCCGTTGAAAGAGATTGTGCA
GTACTGCGACACCTTCACCATTTGCCTGTCGAAAGGGCTGGGCGCGCCGGTGGGTTCGTTGCTGTGCGGCAGCGAAGCCT
TTATCCAGCAGGCCCTGCGCTGGCGTAAAATGACCGGCGGTGGCCTGCGCCAGGCCGGTATTCTGGCGGCGGCCGGTCTC
TATGCGCTGGAGCACAATGTCAAACGGCTGCGTGAAGATCACGACAATGCCAAATGGCTGGAACAGCAACTGCGACAGAT
TGGCGTGGAAATCGTCGAACCGGGCGCGCAGACCAACGTACTGTACCTGCGCCAGTCACCAGAGCTGGCAGCCAGGCTGG
GTCCCTGGATGCGTGAGCGCGGCGTGCTGATCAGCAGCGGGCCACTGACGCGCATTCTGACCCACCTTGACGTCAGCCGT
CAGGATTTGCAGCAAGTGGTCGATTTATGGCAGCAGTTCCTCAGGCAGCACGCCTGA

Upstream 100 bases:

>100_bases
TTAATAATCGTGTCCTCTTTTAGCTAAAACTATCTCCAACAAATTTCAAGTTGCAGCCAACAACGCTGCGGCTTGAAAGA
TGAAGGGGAAAAGGATTTTT

Downstream 100 bases:

>100_bases
GTGCTTGTCTGTACGGGGCGTCAACGCGCCCCGCATTCAGAGTATCCAGCGGCCATAGACCCAGTACCAAATCGCCAGCG
TCGCCACAATATTCAGCACC

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLIDLRSDTVTRPSAAMREAMAQAEVGDDVYGDDPTVNALEAEAVRLSGKEAALFLPSGTQANLVALLSHCQRGDEYIVG
QQAHNYKYEAGGAAVLGSIQPQPIEANPDGTLPLDKVAAAIKPDDIHFAKTRLLSLENTISGRVLPLAYLQQAWQFSREH
QLALHIDGARIFNAAVALNVPLKEIVQYCDTFTICLSKGLGAPVGSLLCGSEAFIQQALRWRKMTGGGLRQAGILAAAGL
YALEHNVKRLREDHDNAKWLEQQLRQIGVEIVEPGAQTNVLYLRQSPELAARLGPWMRERGVLISSGPLTRILTHLDVSR
QDLQQVVDLWQQFLRQHA

Sequences:

>Translated_338_residues
MLIDLRSDTVTRPSAAMREAMAQAEVGDDVYGDDPTVNALEAEAVRLSGKEAALFLPSGTQANLVALLSHCQRGDEYIVG
QQAHNYKYEAGGAAVLGSIQPQPIEANPDGTLPLDKVAAAIKPDDIHFAKTRLLSLENTISGRVLPLAYLQQAWQFSREH
QLALHIDGARIFNAAVALNVPLKEIVQYCDTFTICLSKGLGAPVGSLLCGSEAFIQQALRWRKMTGGGLRQAGILAAAGL
YALEHNVKRLREDHDNAKWLEQQLRQIGVEIVEPGAQTNVLYLRQSPELAARLGPWMRERGVLISSGPLTRILTHLDVSR
QDLQQVVDLWQQFLRQHA
>Mature_338_residues
MLIDLRSDTVTRPSAAMREAMAQAEVGDDVYGDDPTVNALEAEAVRLSGKEAALFLPSGTQANLVALLSHCQRGDEYIVG
QQAHNYKYEAGGAAVLGSIQPQPIEANPDGTLPLDKVAAAIKPDDIHFAKTRLLSLENTISGRVLPLAYLQQAWQFSREH
QLALHIDGARIFNAAVALNVPLKEIVQYCDTFTICLSKGLGAPVGSLLCGSEAFIQQALRWRKMTGGGLRQAGILAAAGL
YALEHNVKRLREDHDNAKWLEQQLRQIGVEIVEPGAQTNVLYLRQSPELAARLGPWMRERGVLISSGPLTRILTHLDVSR
QDLQQVVDLWQQFLRQHA

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=333, Percent_Identity=68.7687687687688, Blast_Score=483, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=41.3294797687861, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=41.3294797687861, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=41.3294797687861, Blast_Score=251, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6320789, Length=329, Percent_Identity=38.9057750759878, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21355439, Length=305, Percent_Identity=44.9180327868852, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 37062; Mature: 37062

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDLRSDTVTRPSAAMREAMAQAEVGDDVYGDDPTVNALEAEAVRLSGKEAALFLPSGT
CEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCC
QANLVALLSHCQRGDEYIVGQQAHNYKYEAGGAAVLGSIQPQPIEANPDGTLPLDKVAAA
CHHHHHHHHHHHCCCCEEECCCCCCCEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHH
IKPDDIHFAKTRLLSLENTISGRVLPLAYLQQAWQFSREHQLALHIDGARIFNAAVALNV
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHEECC
PLKEIVQYCDTFTICLSKGLGAPVGSLLCGSEAFIQQALRWRKMTGGGLRQAGILAAAGL
CHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YALEHNVKRLREDHDNAKWLEQQLRQIGVEIVEPGAQTNVLYLRQSPELAARLGPWMRER
HHHHHHHHHHHHCCCCHHHHHHHHHHHCHHEECCCCCCCEEEEECCCHHHHHHCHHHHHC
GVLISSGPLTRILTHLDVSRQDLQQVVDLWQQFLRQHA
CEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLIDLRSDTVTRPSAAMREAMAQAEVGDDVYGDDPTVNALEAEAVRLSGKEAALFLPSGT
CEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCC
QANLVALLSHCQRGDEYIVGQQAHNYKYEAGGAAVLGSIQPQPIEANPDGTLPLDKVAAA
CHHHHHHHHHHHCCCCEEECCCCCCCEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHH
IKPDDIHFAKTRLLSLENTISGRVLPLAYLQQAWQFSREHQLALHIDGARIFNAAVALNV
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHEECC
PLKEIVQYCDTFTICLSKGLGAPVGSLLCGSEAFIQQALRWRKMTGGGLRQAGILAAAGL
CHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YALEHNVKRLREDHDNAKWLEQQLRQIGVEIVEPGAQTNVLYLRQSPELAARLGPWMRER
HHHHHHHHHHHHCCCCHHHHHHHHHHHCHHEECCCCCCCEEEEECCCHHHHHHCHHHHHC
GVLISSGPLTRILTHLDVSRQDLQQVVDLWQQFLRQHA
CEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]