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The map label for this gene is dacC [H]

Identifier: 157369871

GI number: 157369871

Start: 1783695

End: 1784900

Strand: Direct

Name: dacC [H]

Synonym: Spro_1628

Alternate gene names: 157369871

Gene position: 1783695-1784900 (Clockwise)

Preceding gene: 157369868

Following gene: 157369876

Centisome position: 32.74

GC content: 54.89

Gene sequence:

>1206_bases
ATGATGAAAAGAAACTTACCTAGCACTCTGAAAAAATTAACTTTTAGCGTCAGCATATTGTTGCTGGCCGTACCTGTTGT
TCAGGCGGCCGAAGCGCCGGCCGCGCCACAGGTTGACGCCAAGGCCTATGTGCTGATGGATTACAACAGCGGAAAAATCC
TGGCGGAAGGCAATGCCGACACCCGTCTTGACCCCGCCAGCCTGACCAAGATCATGTCCAGCTATGTGATCGGCCAGGCG
ATCAAGGCCGGCAAGATTAAACCTGAGGATATGGTGACCGTGGGTAAGGATGCCTGGGCAACCGGCAACCCGGCGCTGCG
CGGCTCCTCGTTGATGTTTATCAAGCCGGGCGATCAGGTGCCGGTCATGGAACTGAACAAGGGCATCGTTATTCAGTCGG
GTAATGATGCCAGCATCGCGTTGGCTGATTATGTCGCGGGCAGCCAGGATTCGTTTGTTGGCTTGATGAACAACTACGCC
AAATCCCTGGGCCTGCAGAATACCCATTTCCTGACGGTGCACGGCCTGGATGCGGAAGGGCAGTACAGCACCGCACGCGA
TATGGCGCTGCTCGGCCAGGCACTGATCCGCGATGTGCCGGATGAGTACGCGTTGCACAAAGAAAAAGAGTTCACCTTCA
ATAAAATTCGTCAGGTTAACCGCAACCGTCTGTTGTGGAGCACCAACCTGAGCGTCGATGGCATCAAAACCGGTTATACC
GGTGGCGCCGGGCATAACCTGGTAGCCTCCGCTACCGACGGGCCAATGCGTTTGATTTCGGTAGTGCTGGGGGCGCCAAG
CGACCGTATCCGCTTTAGTGAAAGTGAAAAACTGCTGACCTGGGGTTTCCGCTTCTACGAAACCGCCACGCCAATCAAGA
CTGACAAGCCGTTTGTGACCCAGAAAGTGTGGTTTGGCGACGTCGGCGAAGTGCCATTGGGCGTAGCAAAAGACGCAGCC
GTCACCATCCCGAAAGGGCAGATGAAAAACCTGAAGGCCAGTTACAAGCTGAACCAGCCGACGCTGGAAGCCCCGCTGGC
AAAAAATCAGGTGGTCGGCACCATTGATTTCCAGCTTGATGGTAAAACCATTGAGCAGTACCCGCTGGTGGCGATGCAGG
AAGTGAAAGAAGGTAACTTCTTCAGCCGCATCTGGGACATGGTGATGATGAAGCTGACCCAGTGGTTCGGTAGCGTGTTT
GGTTAA

Upstream 100 bases:

>100_bases
TAAATGCGTGCCGGGCCACTCTCGCTGGTTGGCTGAAAACGTGAATATGTTTGAAAGTTAACGCTATTTCAATGATTTGA
ATGGATACTCTGGCGACGTC

Downstream 100 bases:

>100_bases
GGGTTACAGCAATAAGCTTTAAGAAGAGGGCGCCGTCATTGATGATTGCGCCCTCTTTTTTTATCAGTTACAGGCCACTA
CCTTGATCGCCAATCCCCCT

Product: Serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MMKRNLPSTLKKLTFSVSILLLAVPVVQAAEAPAAPQVDAKAYVLMDYNSGKILAEGNADTRLDPASLTKIMSSYVIGQA
IKAGKIKPEDMVTVGKDAWATGNPALRGSSLMFIKPGDQVPVMELNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYA
KSLGLQNTHFLTVHGLDAEGQYSTARDMALLGQALIRDVPDEYALHKEKEFTFNKIRQVNRNRLLWSTNLSVDGIKTGYT
GGAGHNLVASATDGPMRLISVVLGAPSDRIRFSESEKLLTWGFRFYETATPIKTDKPFVTQKVWFGDVGEVPLGVAKDAA
VTIPKGQMKNLKASYKLNQPTLEAPLAKNQVVGTIDFQLDGKTIEQYPLVAMQEVKEGNFFSRIWDMVMMKLTQWFGSVF
G

Sequences:

>Translated_401_residues
MMKRNLPSTLKKLTFSVSILLLAVPVVQAAEAPAAPQVDAKAYVLMDYNSGKILAEGNADTRLDPASLTKIMSSYVIGQA
IKAGKIKPEDMVTVGKDAWATGNPALRGSSLMFIKPGDQVPVMELNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYA
KSLGLQNTHFLTVHGLDAEGQYSTARDMALLGQALIRDVPDEYALHKEKEFTFNKIRQVNRNRLLWSTNLSVDGIKTGYT
GGAGHNLVASATDGPMRLISVVLGAPSDRIRFSESEKLLTWGFRFYETATPIKTDKPFVTQKVWFGDVGEVPLGVAKDAA
VTIPKGQMKNLKASYKLNQPTLEAPLAKNQVVGTIDFQLDGKTIEQYPLVAMQEVKEGNFFSRIWDMVMMKLTQWFGSVF
G
>Mature_401_residues
MMKRNLPSTLKKLTFSVSILLLAVPVVQAAEAPAAPQVDAKAYVLMDYNSGKILAEGNADTRLDPASLTKIMSSYVIGQA
IKAGKIKPEDMVTVGKDAWATGNPALRGSSLMFIKPGDQVPVMELNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYA
KSLGLQNTHFLTVHGLDAEGQYSTARDMALLGQALIRDVPDEYALHKEKEFTFNKIRQVNRNRLLWSTNLSVDGIKTGYT
GGAGHNLVASATDGPMRLISVVLGAPSDRIRFSESEKLLTWGFRFYETATPIKTDKPFVTQKVWFGDVGEVPLGVAKDAA
VTIPKGQMKNLKASYKLNQPTLEAPLAKNQVVGTIDFQLDGKTIEQYPLVAMQEVKEGNFFSRIWDMVMMKLTQWFGSVF
G

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=394, Percent_Identity=73.3502538071066, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1786851, Length=397, Percent_Identity=63.2241813602015, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI87082022, Length=385, Percent_Identity=45.4545454545455, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI87082054, Length=288, Percent_Identity=25.6944444444444, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43731; Mature: 43731

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKRNLPSTLKKLTFSVSILLLAVPVVQAAEAPAAPQVDAKAYVLMDYNSGKILAEGNAD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEECCCCC
TRLDPASLTKIMSSYVIGQAIKAGKIKPEDMVTVGKDAWATGNPALRGSSLMFIKPGDQV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCCCCCCCCCCCEEEEECCCCCC
PVMELNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYAKSLGLQNTHFLTVHGLDAEG
CCEECCCCEEEECCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
QYSTARDMALLGQALIRDVPDEYALHKEKEFTFNKIRQVNRNRLLWSTNLSVDGIKTGYT
CCCHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
GGAGHNLVASATDGPMRLISVVLGAPSDRIRFSESEKLLTWGFRFYETATPIKTDKPFVT
CCCCCCEEEECCCCHHHHHHHHHCCCCCCEEECCCCCEEEECEEEEECCCCCCCCCCCEE
QKVWFGDVGEVPLGVAKDAAVTIPKGQMKNLKASYKLNQPTLEAPLAKNQVVGTIDFQLD
EEEEECCCCCCCCCCCCCCEEECCCCHHHCCEEEEEECCCCCCCCCCCCCEEEEEEEEEC
GKTIEQYPLVAMQEVKEGNFFSRIWDMVMMKLTQWFGSVFG
CCCHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMKRNLPSTLKKLTFSVSILLLAVPVVQAAEAPAAPQVDAKAYVLMDYNSGKILAEGNAD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEECCCCC
TRLDPASLTKIMSSYVIGQAIKAGKIKPEDMVTVGKDAWATGNPALRGSSLMFIKPGDQV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCCCCCCCCCCCEEEEECCCCCC
PVMELNKGIVIQSGNDASIALADYVAGSQDSFVGLMNNYAKSLGLQNTHFLTVHGLDAEG
CCEECCCCEEEECCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
QYSTARDMALLGQALIRDVPDEYALHKEKEFTFNKIRQVNRNRLLWSTNLSVDGIKTGYT
CCCHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
GGAGHNLVASATDGPMRLISVVLGAPSDRIRFSESEKLLTWGFRFYETATPIKTDKPFVT
CCCCCCEEEECCCCHHHHHHHHHCCCCCCEEECCCCCEEEECEEEEECCCCCCCCCCCEE
QKVWFGDVGEVPLGVAKDAAVTIPKGQMKNLKASYKLNQPTLEAPLAKNQVVGTIDFQLD
EEEEECCCCCCCCCCCCCCEEECCCCHHHCCEEEEEECCCCCCCCCCCCCEEEEEEEEEC
GKTIEQYPLVAMQEVKEGNFFSRIWDMVMMKLTQWFGSVFG
CCCHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]