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The map label for this gene is metC [H]

Identifier: 157369869

GI number: 157369869

Start: 1780703

End: 1781848

Strand: Reverse

Name: metC [H]

Synonym: Spro_1626

Alternate gene names: 157369869

Gene position: 1781848-1780703 (Counterclockwise)

Preceding gene: 157369870

Following gene: 157369867

Centisome position: 32.7

GC content: 59.51

Gene sequence:

>1146_bases
ATGGCCAAGTTTGATACGTTGACCGTTCACGCCGGTTATACCCCGGACGCTACCGGCGCAGTGATGCCGGCCATTTATGC
CACCTCCACCTATGCCCAACCGGCACCGGGGGAACATACCGGCTATGAATATTCGCGCAGCGCCAACCCAACACGCACTG
CGTTGGAGAGCGCCATCGCCGAACTGGAAAGCGGCAGCCGCGGCTACGCTTTCGCTTCTGGTCTGGCGGCCTGCTCGACG
GTGCTGGAGCTGCTCGATCAGGGCAGCCACCTGGTGGCGGTTGACGATCTGTACGGCGGGACCTATCGCCTGCTGGAAAA
GGTGCGTAGCCGCACCGCCGGATTGCGGGTTACCTATGTTTCCCCGGCGGACATTACCGCACTGGAGCAGGCGATCGAAC
CGGATACCAAAATGATCTGGGTGGAAACGCCGACCAATCCGCTGTTGAAGCTGGCGGACTTGAGTGCGATCGCGGCGATC
GCCAAAAAACACGATTTAATCAGCGTGGCGGACAACACCTTCGCCTCACCTTATATTCAACGTCCGCTGGAACTCGGCTT
TGACGTGGTGGTGCATTCCGCCACCAAATACCTCAATGGCCATTCCGACGTGGTGGCCGGTGTGGCCGCGGTAGGGAATA
ACCCGGAGTTGGCCGAACAGCTAGGTTTCCTGCAAAACGCGGTAGGTGGCATTCTCGATCCGTTCAGCAGCTTCCTGACG
TTGCGCGGTATCCGCACGCTGGCGCTGCGCATGGAGCGTCACAGTAATAGCGCCTTGCGCATCGCCCAGTGGCTGGAAAG
CCAACCGCAGGTGGAAGAAGTCTACTATCCGGGCCTGCCGAGCCATCCACAACACGCGCTGGCGGCCAAGCAGATGAGCA
GTTTCGGCGGCATGATTTCGGTGCGCCTGAAAGGTGACGATGCCTTTGCCCGTCGGGTGATCAAACGTTCAAAACTGTTC
ACCCTGGCAGAAAGCCTGGGCGGCGTGGAAAGCCTGATTAGCCAGCCGTTTAGCATGACTCATGCGTCGATCCCGCTGGA
ACAGCGGCTGAAAACCGGCATCACGCCACAGTTACTGCGTCTGTCGGTAGGTATTGAGGATGCGGATGATCTGATCGCCG
ATTTGCAGCAGGCGCTGGCGGAGTAA

Upstream 100 bases:

>100_bases
GTGGCGGTGGTGCTTGACGGTGAGCGTTTCCTCGGTCTGATTACCCGCACAGACGTACTTAACGCCTGGCGCCAAAAATT
ACGTTAATAAGGATGATTGT

Downstream 100 bases:

>100_bases
TCGCAGCCCTGATGTAAAACCGTAGGGGTCGAACATGTTCGACCCGATTTAACCCATTGGGCGCTGCATGCGGCGCCCCC
TTCCATTAGGCGACAACGTC

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MAKFDTLTVHAGYTPDATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELESGSRGYAFASGLAACST
VLELLDQGSHLVAVDDLYGGTYRLLEKVRSRTAGLRVTYVSPADITALEQAIEPDTKMIWVETPTNPLLKLADLSAIAAI
AKKHDLISVADNTFASPYIQRPLELGFDVVVHSATKYLNGHSDVVAGVAAVGNNPELAEQLGFLQNAVGGILDPFSSFLT
LRGIRTLALRMERHSNSALRIAQWLESQPQVEEVYYPGLPSHPQHALAAKQMSSFGGMISVRLKGDDAFARRVIKRSKLF
TLAESLGGVESLISQPFSMTHASIPLEQRLKTGITPQLLRLSVGIEDADDLIADLQQALAE

Sequences:

>Translated_381_residues
MAKFDTLTVHAGYTPDATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELESGSRGYAFASGLAACST
VLELLDQGSHLVAVDDLYGGTYRLLEKVRSRTAGLRVTYVSPADITALEQAIEPDTKMIWVETPTNPLLKLADLSAIAAI
AKKHDLISVADNTFASPYIQRPLELGFDVVVHSATKYLNGHSDVVAGVAAVGNNPELAEQLGFLQNAVGGILDPFSSFLT
LRGIRTLALRMERHSNSALRIAQWLESQPQVEEVYYPGLPSHPQHALAAKQMSSFGGMISVRLKGDDAFARRVIKRSKLF
TLAESLGGVESLISQPFSMTHASIPLEQRLKTGITPQLLRLSVGIEDADDLIADLQQALAE
>Mature_380_residues
AKFDTLTVHAGYTPDATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIAELESGSRGYAFASGLAACSTV
LELLDQGSHLVAVDDLYGGTYRLLEKVRSRTAGLRVTYVSPADITALEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIA
KKHDLISVADNTFASPYIQRPLELGFDVVVHSATKYLNGHSDVVAGVAAVGNNPELAEQLGFLQNAVGGILDPFSSFLTL
RGIRTLALRMERHSNSALRIAQWLESQPQVEEVYYPGLPSHPQHALAAKQMSSFGGMISVRLKGDDAFARRVIKRSKLFT
LAESLGGVESLISQPFSMTHASIPLEQRLKTGITPQLLRLSVGIEDADDLIADLQQALAE

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=379, Percent_Identity=49.868073878628, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI299473759, Length=379, Percent_Identity=45.910290237467, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI25453487, Length=378, Percent_Identity=43.6507936507937, Blast_Score=283, Evalue=1e-76,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=44.4148936170213, Blast_Score=307, Evalue=6e-85,
Organism=Escherichia coli, GI1789383, Length=398, Percent_Identity=31.1557788944724, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=380, Percent_Identity=49.4736842105263, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17538055, Length=380, Percent_Identity=50.2631578947368, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71980708, Length=397, Percent_Identity=39.5465994962217, Blast_Score=261, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=48.3204134366925, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6323333, Length=435, Percent_Identity=34.7126436781609, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6321254, Length=407, Percent_Identity=33.6609336609337, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321170, Length=326, Percent_Identity=30.3680981595092, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6321904, Length=347, Percent_Identity=29.3948126801153, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19922554, Length=380, Percent_Identity=49.4736842105263, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 40963; Mature: 40832

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFDTLTVHAGYTPDATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIA
CCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELESGSRGYAFASGLAACSTVLELLDQGSHLVAVDDLYGGTYRLLEKVRSRTAGLRVTYV
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHHHHHHHCCEEEEEE
SPADITALEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKKHDLISVADNTFASPYIQ
CCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHH
RPLELGFDVVVHSATKYLNGHSDVVAGVAAVGNNPELAEQLGFLQNAVGGILDPFSSFLT
CHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGIRTLALRMERHSNSALRIAQWLESQPQVEEVYYPGLPSHPQHALAAKQMSSFGGMIS
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCEEE
VRLKGDDAFARRVIKRSKLFTLAESLGGVESLISQPFSMTHASIPLEQRLKTGITPQLLR
EEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHCCCCHHHHHHCCCCHHHHH
LSVGIEDADDLIADLQQALAE
EECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKFDTLTVHAGYTPDATGAVMPAIYATSTYAQPAPGEHTGYEYSRSANPTRTALESAIA
CCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELESGSRGYAFASGLAACSTVLELLDQGSHLVAVDDLYGGTYRLLEKVRSRTAGLRVTYV
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHHHHHHHCCEEEEEE
SPADITALEQAIEPDTKMIWVETPTNPLLKLADLSAIAAIAKKHDLISVADNTFASPYIQ
CCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHH
RPLELGFDVVVHSATKYLNGHSDVVAGVAAVGNNPELAEQLGFLQNAVGGILDPFSSFLT
CHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGIRTLALRMERHSNSALRIAQWLESQPQVEEVYYPGLPSHPQHALAAKQMSSFGGMIS
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCEEE
VRLKGDDAFARRVIKRSKLFTLAESLGGVESLISQPFSMTHASIPLEQRLKTGITPQLLR
EEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHCCCCHHHHHHCCCCHHHHH
LSVGIEDADDLIADLQQALAE
EECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]