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The map label for this gene is cbs [H]

Identifier: 157369870

GI number: 157369870

Start: 1781862

End: 1783229

Strand: Reverse

Name: cbs [H]

Synonym: Spro_1627

Alternate gene names: 157369870

Gene position: 1783229-1781862 (Counterclockwise)

Preceding gene: 157369872

Following gene: 157369869

Centisome position: 32.73

GC content: 59.58

Gene sequence:

>1368_bases
ATGGCCATACCTCATTCCGTCATCGATATGATCGGCAATACTCCGATGCTGGAACTGACCGGGTTCGATACCGGCCCCTG
TCGGCTGTTCGTCAAACTGGAGAATCAAAACCCCGGCGGTTCGATCAAGGACCGCGTGGCACTATCGATGATCGAACAGG
CGGAGCGTGACGGCAGCCTGCAGCCAGGCGGTACCATCATTGAAGCCACCGCCGGCAATACCGGCCTGGGGCTGGCGCTG
GTGGCTGCCCTGAAGGGATATAAACTGCTGCTGGTGGTACCGGACAAAATGAGCCGGGAGAAGATTTTCCATTTGCGTGC
GCTGGGTGTGGAAGTTTTGCTGACCCGTTCCGACGTGGGCAAGGGCCACCCGGCTTACTATCAGGATTACGCCAAACGCC
TGGCGAGCGAGACGCCCGGCGCGTTCTATATCGATCAGTTTAACAACCCTGCCAATCCGGCGGCCCATTCCCGCACCACC
GCCCCGGAACTGTGGCAACAGATGGAGCATCAGGTGGATGCTATCGTGGTCGGTGTCGGCTCCGGTGGCACGCTGGGCGG
TCTTAGCCACTATTTTGCCGAAGTATCGCCGCAGACCGAATTTGTGCTGGCTGACCCGGCCGGTTCGATCCTGGCGGATT
ATCTCGATAACGGCCAGATAGGCGAGGCCGGCAGTTGGCTGGTGGAAGGCATAGGTGAGGATTTCGTCCCGCCGTTAAGC
GATTTCAACCAGGTGCGCAACGCCTACCGCATCGGTGATGCCGAGGCCTTTACCACCGCACGCGACCTGCTGCGTAAAGA
GGGCGTGCTGGCCGGCTCGTCTACCGGCACCCTGTTGGCCGCCGCGCTGCGCTATTGCCAGGCGCAGACGGAACCGAAAC
GGGTGGTCACCTTCGTGTGCGACAGCGGCAACAAGTACCTGTCTAAAATGTATAACGATCACTGGATGCTGGAACAGGGC
CTGTTGAGCAAACCGCAGCATGGCGATCTGCGCGATCTGATCGCCTACCGCCATGACGAGGGCGCGGCAGTATCAGTGGC
CTCGGAAGATACCCTTGCGATCGTCCATGCCCGCATGCGGCTGTATGACATTTCACAGTTGCCGGTGCTGGAGGGCGATC
GGGTGATCGGTCTGATCGACGAGTGGGATCTGCTGAATGCCGTGCAGGCGGACGCCAAACATTTCAGCCTGCCGGCCTCC
CGCGCCATGACCCCTTCGGTCAAAACCTTGCAAAAGGAAGCCAGCTATCAGGATTTGCTCGCCACCTTCAACCATGGCCA
CGTGGCGGTGGTGCTTGACGGTGAGCGTTTCCTCGGTCTGATTACCCGCACAGACGTACTTAACGCCTGGCGCCAAAAAT
TACGTTAA

Upstream 100 bases:

>100_bases
AAATGCATATTGAACGGTTATTTGTTCTTTTTAATGCGCTTATTGGCAGAGCTATCATCCATATAACGGCTTTTAAACCG
CATTATTTTGGAGACACCCC

Downstream 100 bases:

>100_bases
TAAGGATGATTGTATGGCCAAGTTTGATACGTTGACCGTTCACGCCGGTTATACCCCGGACGCTACCGGCGCAGTGATGC
CGGCCATTTATGCCACCTCC

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MAIPHSVIDMIGNTPMLELTGFDTGPCRLFVKLENQNPGGSIKDRVALSMIEQAERDGSLQPGGTIIEATAGNTGLGLAL
VAALKGYKLLLVVPDKMSREKIFHLRALGVEVLLTRSDVGKGHPAYYQDYAKRLASETPGAFYIDQFNNPANPAAHSRTT
APELWQQMEHQVDAIVVGVGSGGTLGGLSHYFAEVSPQTEFVLADPAGSILADYLDNGQIGEAGSWLVEGIGEDFVPPLS
DFNQVRNAYRIGDAEAFTTARDLLRKEGVLAGSSTGTLLAAALRYCQAQTEPKRVVTFVCDSGNKYLSKMYNDHWMLEQG
LLSKPQHGDLRDLIAYRHDEGAAVSVASEDTLAIVHARMRLYDISQLPVLEGDRVIGLIDEWDLLNAVQADAKHFSLPAS
RAMTPSVKTLQKEASYQDLLATFNHGHVAVVLDGERFLGLITRTDVLNAWRQKLR

Sequences:

>Translated_455_residues
MAIPHSVIDMIGNTPMLELTGFDTGPCRLFVKLENQNPGGSIKDRVALSMIEQAERDGSLQPGGTIIEATAGNTGLGLAL
VAALKGYKLLLVVPDKMSREKIFHLRALGVEVLLTRSDVGKGHPAYYQDYAKRLASETPGAFYIDQFNNPANPAAHSRTT
APELWQQMEHQVDAIVVGVGSGGTLGGLSHYFAEVSPQTEFVLADPAGSILADYLDNGQIGEAGSWLVEGIGEDFVPPLS
DFNQVRNAYRIGDAEAFTTARDLLRKEGVLAGSSTGTLLAAALRYCQAQTEPKRVVTFVCDSGNKYLSKMYNDHWMLEQG
LLSKPQHGDLRDLIAYRHDEGAAVSVASEDTLAIVHARMRLYDISQLPVLEGDRVIGLIDEWDLLNAVQADAKHFSLPAS
RAMTPSVKTLQKEASYQDLLATFNHGHVAVVLDGERFLGLITRTDVLNAWRQKLR
>Mature_454_residues
AIPHSVIDMIGNTPMLELTGFDTGPCRLFVKLENQNPGGSIKDRVALSMIEQAERDGSLQPGGTIIEATAGNTGLGLALV
AALKGYKLLLVVPDKMSREKIFHLRALGVEVLLTRSDVGKGHPAYYQDYAKRLASETPGAFYIDQFNNPANPAAHSRTTA
PELWQQMEHQVDAIVVGVGSGGTLGGLSHYFAEVSPQTEFVLADPAGSILADYLDNGQIGEAGSWLVEGIGEDFVPPLSD
FNQVRNAYRIGDAEAFTTARDLLRKEGVLAGSSTGTLLAAALRYCQAQTEPKRVVTFVCDSGNKYLSKMYNDHWMLEQGL
LSKPQHGDLRDLIAYRHDEGAAVSVASEDTLAIVHARMRLYDISQLPVLEGDRVIGLIDEWDLLNAVQADAKHFSLPASR
AMTPSVKTLQKEASYQDLLATFNHGHVAVVLDGERFLGLITRTDVLNAWRQKLR

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=321, Percent_Identity=42.6791277258567, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI295821200, Length=321, Percent_Identity=42.6791277258567, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI4557415, Length=321, Percent_Identity=42.6791277258567, Blast_Score=263, Evalue=2e-70,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=38.6666666666667, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788754, Length=302, Percent_Identity=39.4039735099338, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=40.5487804878049, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17562970, Length=309, Percent_Identity=38.8349514563107, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=39.4039735099338, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=38.3435582822086, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=36.8421052631579, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=334, Percent_Identity=37.7245508982036, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17561720, Length=308, Percent_Identity=36.3636363636364, Blast_Score=168, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=36.322869955157, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71996324, Length=345, Percent_Identity=28.695652173913, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17539800, Length=345, Percent_Identity=24.3478260869565, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=494, Percent_Identity=33.8056680161943, Blast_Score=249, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=31.9277108433735, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24643623, Length=419, Percent_Identity=35.5608591885441, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI20129101, Length=419, Percent_Identity=35.5608591885441, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49539; Mature: 49408

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPHSVIDMIGNTPMLELTGFDTGPCRLFVKLENQNPGGSIKDRVALSMIEQAERDGSL
CCCCHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
QPGGTIIEATAGNTGLGLALVAALKGYKLLLVVPDKMSREKIFHLRALGVEVLLTRSDVG
CCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCEEEEEEECCCC
KGHPAYYQDYAKRLASETPGAFYIDQFNNPANPAAHSRTTAPELWQQMEHQVDAIVVGVG
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEEECC
SGGTLGGLSHYFAEVSPQTEFVLADPAGSILADYLDNGQIGEAGSWLVEGIGEDFVPPLS
CCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHH
DFNQVRNAYRIGDAEAFTTARDLLRKEGVLAGSSTGTLLAAALRYCQAQTEPKRVVTFVC
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
DSGNKYLSKMYNDHWMLEQGLLSKPQHGDLRDLIAYRHDEGAAVSVASEDTLAIVHARMR
CCCCHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHEECCCCCEEEECCCCHHHHHHHHHH
LYDISQLPVLEGDRVIGLIDEWDLLNAVQADAKHFSLPASRAMTPSVKTLQKEASYQDLL
HEECCCCCEECCCCEEEEECCHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHH
ATFNHGHVAVVLDGERFLGLITRTDVLNAWRQKLR
HHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIPHSVIDMIGNTPMLELTGFDTGPCRLFVKLENQNPGGSIKDRVALSMIEQAERDGSL
CCCHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
QPGGTIIEATAGNTGLGLALVAALKGYKLLLVVPDKMSREKIFHLRALGVEVLLTRSDVG
CCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCEEEEEEECCCC
KGHPAYYQDYAKRLASETPGAFYIDQFNNPANPAAHSRTTAPELWQQMEHQVDAIVVGVG
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEEECC
SGGTLGGLSHYFAEVSPQTEFVLADPAGSILADYLDNGQIGEAGSWLVEGIGEDFVPPLS
CCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHH
DFNQVRNAYRIGDAEAFTTARDLLRKEGVLAGSSTGTLLAAALRYCQAQTEPKRVVTFVC
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
DSGNKYLSKMYNDHWMLEQGLLSKPQHGDLRDLIAYRHDEGAAVSVASEDTLAIVHARMR
CCCCHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHEECCCCCEEEECCCCHHHHHHHHHH
LYDISQLPVLEGDRVIGLIDEWDLLNAVQADAKHFSLPASRAMTPSVKTLQKEASYQDLL
HEECCCCCEECCCCEEEEECCHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHH
ATFNHGHVAVVLDGERFLGLITRTDVLNAWRQKLR
HHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]