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The map label for this gene is modE [H]

Identifier: 157369539

GI number: 157369539

Start: 1425697

End: 1426488

Strand: Reverse

Name: modE [H]

Synonym: Spro_1296

Alternate gene names: 157369539

Gene position: 1426488-1425697 (Counterclockwise)

Preceding gene: 157369549

Following gene: 157369538

Centisome position: 26.18

GC content: 57.32

Gene sequence:

>792_bases
ATGCAGGCCGAAATTCTTCTTACTCTAAAACTCCAGCAAAAACTGTTCGCCGATCCGCGCCGTATCGCGCTGCTTAAGCA
GGTCCGACACACCGGCTCCATCAGTCAGGGGGCTAAACTGGCAGGCATCAGCTATAAGAGCGCCTGGGATGCAATTAACG
AAATGAACCAGTTGGCGGAGCAAACGGTGGTGGAGCGCGCTACCGGCGGCAAAGGTGGCGGCGGTGCTCAGGTAACCCAT
TATGGTGAACGGCTGATCCAGCTTTACGACCTGCTGGGGCAGATCCAGCAAAAAGCCTTCGACGTACTGCAGCAAGACAA
CCTGCCACTCGACAGCCTGCTGGCGGCCATCTCACGCTTTTCGCTGCAAACCAGCGCGCGCAACCAATTTTTCGGTACGG
TGATCGAACGCGACCATCAGCAAGTGCAGCAACATCTGGATATTTTACTGAACGACGGCAAAACCCGCCTCAGTGCAGCC
ATTACCCAACAAAGCGCCGATCGACTGCAGCTCTCGCCCGGTAAGGAAGTGCTGGCGCTGATTAAAGCCCCGTGGGTAAA
GCTGAACACCGATCCGGCACTGGCCGGCGCGGCGGACAACTCGCTGGCAGGCGTAGTGGCCAGCATCCAGCCAGGTGCCG
ATCACAGCGAAGTTTTGGTCACGCTCACCGGGGGCGAAACCCTGTGCGCTACCATAACCAACGCAGAACTACAGCAGCTT
AAACTGCAGCCCGGCAGTGCGGTGTATGCCTTGTTTAACGCCGATCGGGTGATTGTCGCCACGTTGTGTTAA

Upstream 100 bases:

>100_bases
GTCCCTGTGTAACCGCGCCTATCACGGTTGGCGACGCATCATTTGGCGCTTTCGCCACAAATCAGCGACAATAACCCTTT
TGCAGCCGACAGGACGTGTT

Downstream 100 bases:

>100_bases
ACGCAACGTAACGTTGCATTTTTGCCGATTGACATCACCCTGCAATGCGCCTATTTCTAAACAAAATAATTGCATAAAAA
GGAACAGGTGATGTCGTCGT

Product: DNA-binding transcriptional regulator ModE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MQAEILLTLKLQQKLFADPRRIALLKQVRHTGSISQGAKLAGISYKSAWDAINEMNQLAEQTVVERATGGKGGGGAQVTH
YGERLIQLYDLLGQIQQKAFDVLQQDNLPLDSLLAAISRFSLQTSARNQFFGTVIERDHQQVQQHLDILLNDGKTRLSAA
ITQQSADRLQLSPGKEVLALIKAPWVKLNTDPALAGAADNSLAGVVASIQPGADHSEVLVTLTGGETLCATITNAELQQL
KLQPGSAVYALFNADRVIVATLC

Sequences:

>Translated_263_residues
MQAEILLTLKLQQKLFADPRRIALLKQVRHTGSISQGAKLAGISYKSAWDAINEMNQLAEQTVVERATGGKGGGGAQVTH
YGERLIQLYDLLGQIQQKAFDVLQQDNLPLDSLLAAISRFSLQTSARNQFFGTVIERDHQQVQQHLDILLNDGKTRLSAA
ITQQSADRLQLSPGKEVLALIKAPWVKLNTDPALAGAADNSLAGVVASIQPGADHSEVLVTLTGGETLCATITNAELQQL
KLQPGSAVYALFNADRVIVATLC
>Mature_263_residues
MQAEILLTLKLQQKLFADPRRIALLKQVRHTGSISQGAKLAGISYKSAWDAINEMNQLAEQTVVERATGGKGGGGAQVTH
YGERLIQLYDLLGQIQQKAFDVLQQDNLPLDSLLAAISRFSLQTSARNQFFGTVIERDHQQVQQHLDILLNDGKTRLSAA
ITQQSADRLQLSPGKEVLALIKAPWVKLNTDPALAGAADNSLAGVVASIQPGADHSEVLVTLTGGETLCATITNAELQQL
KLQPGSAVYALFNADRVIVATLC

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=264, Percent_Identity=69.6969696969697, Blast_Score=316, Evalue=1e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 28329; Mature: 28329

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEILLTLKLQQKLFADPRRIALLKQVRHTGSISQGAKLAGISYKSAWDAINEMNQLAE
CCCEEEEEEEHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHH
QTVVERATGGKGGGGAQVTHYGERLIQLYDLLGQIQQKAFDVLQQDNLPLDSLLAAISRF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SLQTSARNQFFGTVIERDHQQVQQHLDILLNDGKTRLSAAITQQSADRLQLSPGKEVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCEECCCCHHHHHH
IKAPWVKLNTDPALAGAADNSLAGVVASIQPGADHSEVLVTLTGGETLCATITNAELQQL
HHCCCEEECCCCCCCCCCCCCHHHEEEECCCCCCCCEEEEEEECCCEEEEEECCHHHHHH
KLQPGSAVYALFNADRVIVATLC
CCCCCCEEEEEECCCEEEEEEEC
>Mature Secondary Structure
MQAEILLTLKLQQKLFADPRRIALLKQVRHTGSISQGAKLAGISYKSAWDAINEMNQLAE
CCCEEEEEEEHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHH
QTVVERATGGKGGGGAQVTHYGERLIQLYDLLGQIQQKAFDVLQQDNLPLDSLLAAISRF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SLQTSARNQFFGTVIERDHQQVQQHLDILLNDGKTRLSAAITQQSADRLQLSPGKEVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCCEECCCCHHHHHH
IKAPWVKLNTDPALAGAADNSLAGVVASIQPGADHSEVLVTLTGGETLCATITNAELQQL
HHCCCEEECCCCCCCCCCCCCHHHEEEECCCCCCCCEEEEEEECCCEEEEEECCHHHHHH
KLQPGSAVYALFNADRVIVATLC
CCCCCCEEEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]